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C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 61-78页

作者： Bai-Bei Li lei-jie Chen Shi-Liu Lu Biao lei Gui-Lin Yu Shui-Ping Yu Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021Guangxi Zhuang Autonomous RegionChina Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology The Second Xiangya Hospital of Central South UniversityNanning 410011Guangxi Zhuang Autonomous RegionChina Department of Emergency The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Over the years,programmed cell death-1(PD-1)inhibitors have been routinely used for hepatocellular carcinoma(HCC)treatment and yielded improved survival ***,significant heterogeneity surrounds the outcomes of most ***,it is critical to search for biomarkers that predict the efficacy of PD-1 inhibitors in patients with *** To investigate the role of the C-reactive protein to albumin ratio(CAR)in evaluating the efficacy of PD-1 inhibitors for *** The clinical data of 160 patients with HCC treated with PD-1 inhibitors from January 2018 to November 2022 at the First Affiliated Hospital of Guangxi Medical University were retrospectively *** The optimal cut-off value for CAR based on progression-free survival(PFS)was determined to be 1.20 using x-tile *** proportional risk model was used to determine the factors affecting *** Cooperative Oncology Group performance status[hazard ratio(HR)=1.754,95%confidence interval(95%CI)=1.045-2.944,P=0.033],CAR(HR=2.118,95%CI=1.057-4.243,P=0.034)and tumor number(HR=2.932,95%CI=1.246-6.897,P=0.014)were independent prognostic factors for overall ***(HR=2.730,95%CI=1.502-4.961,P=0.001),tumor number(HR=1.584,95%CI=1.003-2.500,P=0.048)and neutrophil to lymphocyte ratio(HR=1.120,95%CI=1.022-1.228,P=0.015)were independent prognostic factors for *** nomograms were constructed based on independent prognostic *** C-index index and calibration plots confirmed that the nomogram is a reliable risk prediction *** ROC curve and decision curve analysis confirmed that the nomogram has a good predictive effect as well as a net clinical *** Overall,we reveal that the CAR is a potential predictor of short-and long-term prognosis in patients with HCC treated with PD-1 *** further verified,CAR-based nomogram may increase the number of markers that predict individualized prognosis.

关键词： C-reactive protein to albumin ratio Hepatocellular carcinoma Programmed cell death-1 inhibitors Prognosis Nomogram

Low Surface Brightness Galaxies Selected by Different Model Fitting

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Research in Astronomy and Astrophysics 2024年第1期24卷 223-236页

作者： Bing-Qing Zhang Hong Wu Wei Du Pin-Song Zhao Min He Feng-jie lei Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

We present a study of low surface brightness galaxies(LSBGs) selected by fitting the images for all the galaxies inα.40 SDSS DR7 sample with two kinds of single-component models and two kinds of two-component models(disk+bulge):single exponential,single sersic,exponential+deVaucular(exp+deV),and exponential+sérsic(exp+ser).Under the criteria of the B band disk central surface brightness μ_(0,disk)(B)≥22.5 mag arcsec^(-2) and the axis ratio b/a> 0.3,we selected four none-edge-on LSBG samples from each of the models which contain 1105,1038,207,and 75 galaxies,*** are 756 galaxies in common between LSBGs selected by exponential and sersic models,corresponding to 68.42% of LSBGs selected by the exponential model and 72.83% of LSBGs selected by the sersic model,the rest of the discrepancy is due to the difference in obtaining μ_(0) between the exponential and sersic *** on the fitting,in the range of 0.5≤n≤1.5,the relation of μ_(0) from two models can be written as μ_(0,sérsic)-μ_(0,exp)=-1.34(n-1).The LSBGs selected by disk+bulge models(LSBG_(2)comps) are more massive than LSBGs selected by single-component models(LSBG_1comp),and also show a larger disk *** the bulges in the majority of our LSBG_(2)comps are not prominent,more than 60% of our LSBG_(2)comps will not be selected if we adopt a single-component model *** also identified 31 giant low surface brightness galaxies(gLSBGs) from LSBG_(2)*** are located at the same region in the color-magnitude diagram as other *** we compared different criteria of gLSBGs selection,we find that for gas-rich LSBGs,M_(*)> 10^(10)M_⊙ is the best to distinguish between gLSBGs and normal LSBGs with bulge.

关键词： catalogs galaxies:spiral galaxies:bulges methods:data analysis methods:statistical

Improving treatment plan and mental health in children with abdominal infection for broad-spectrum bacterial infections

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World Journal of Psychiatry 2024年第9期14卷 1319-1325页

作者： Gui-Bo Wang Xue-Feng Zhang Bing Liang jie lei Jun Xue Department of Pediatric Surgery the First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Department of General Surgery the First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Pediatric abdominal infection is a common but serious disease that requires timely and effective *** surgical treatment,accurate diagnosis and rational application of antibiotics are the keys to improving treatment *** To investigate the effect of broad-spectrum bacterial detection on postoperative antibiotic *** A total of 100 children with abdominal infection who received surgical treatment in our hospital from September 2020 to July 2021 were *** observation group collected blood samples upon admission and sent them for broad-spectrum bacterial infection nucleic acid testing,and collected pus or exudate during the operation for bacterial culture and drug sensitivity testing;the control group only sent bacterial culture and drug sensitivity testing during the *** White blood cell count,C-reactive protein,procalcitonin,3 days after surgery,showed better postoperative index than the control group(Pleic acids in pediatric abdominal infections can help identify pathogens sooner and guide the appropriate use of antibiotics,improving treatment outcomes and reducing medical costs to some extent.

关键词： Pediatric abdominal infection Nucleic acid detection of broad-spectrum bacterial infection Bacterial culture Drug sensitivity testing Treatment effect Cost Mental health

Notably Accelerated Nano-Bainite Transformation via Increasing Undissolved Carbides Content on GCr15Si1Mo Bearing Steel

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 703-712页

作者： Yan-Hui Wang Hua-Qiang Sun Wen-Jing Feng lei-jie Zhao Xiang Chen Qing-An Chen Hai-Tao Sun Jian-Jun Wang Zhi-Nan Yang Key Laboratory of Intelligent Industrial Equipment Technology of Hebei Province School of Mechanical and Equipment EngineeringHebei University of EngineeringHandan056038China Collaborative Innovation Center for Modern Equipment Manufacturing of Jinan New Area Hebei University of EngineeringHandan056038China School of Materials Science and Engineering Tsinghua UniversityBeijing100084China Avic Shang da Superalloys Company Limited Xingtai054800China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004China

In this study, a high-carbon nano-bainitic GCr15Si1Mo bearing steel was investigated. Specifically, the effects of content and size of undissolved carbides on the microstructure and transformation kinetics of nano-bainite were analyzed. The results demonstrated that after prolonged austempering at low temperatures, the mixed microstructure composed of nano-bainite (NB), undissolved carbides (UC), and retained austenite (RA) was obtained in GCr15SiMo steel. When the experimental steel was austenitized at 900 ℃, the undissolved carbides gradually dissolved until reaching a stable state with increasing holding time. Furthermore, at the same austempering temperature, despite different volume fractions of undissolved carbides in the substrate, the volume fractions of nano-bainite in the final microstructures remained essentially the same. Moreover, the higher the content of undissolved carbides in steel, the faster the transformation rate of nano-bainite and the shorter the total transformation time.

关键词： Nano-bainite Undissolved carbides Bainitic transformation kinetics Carbon concentration

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构建有限智库体系:一个技术治理视角

自然辩证法研究 2024年第2期40卷 20-28,82页

作者：雷环捷中国社会科学院哲学研究所北京100732

关于中国智库发展史的回顾表明,现代意义上的智库在中国经历了从无到有、愈加重视的变迁过程,可分为思想库阶段和智库阶段,并呈现出自上而下、需求方主导的特征,还带来智库类别有欠多元等结构问题和研究力量分配不匀等功能问题。对此应... 详细信息

关于中国智库发展史的回顾表明,现代意义上的智库在中国经历了从无到有、愈加重视的变迁过程,可分为思想库阶段和智库阶段,并呈现出自上而下、需求方主导的特征,还带来智库类别有欠多元等结构问题和研究力量分配不匀等功能问题。对此应借助有限技术治理理论进行理论重构,将智库视为有限的专家政治,践行智库作为有限工具、智库作为制度力量、智库应当民主控制、智库应当容忍杂音、智库作为渐进工程、智库应当专家平衡等六条原则,构建一种可操作的有限智库体系,为建设中国特色新型智库添砖加瓦。

关键词：决策咨询智库体系思想库技术治理中国特色新型智库

Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： Zi-Yuan Zou Tian-Yi Ren Jia-Qi Li Ting-Ying Jiao Meng-Yu Wang lei-jie Huang Shuang-Zhe Lin Yuan-Yang Wang Xiao-Zhen Guo Ye-Yu Song Rui-Xu Yang Cen Xie Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

突发公共事件网络舆情风险的现代化协同治理机制:基于“事件—传播”的研究

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湘潭大学学报（哲学社会科学版） 2024年第4期48卷 160-164页

作者：向青平雷跃捷湘潭大学文学与新闻学院湖南湘潭411105 湖南大学新闻传播学院湖南长沙410082

随着现代风险社会及深度媒介化时代的到来,突发公共事件网络舆情风险往往由事件与传播双重逻辑耦合引发,常使国家陷入不确定性风险传播的被动响应中,因此需要建立突发公共事件网络舆情风险的现代化协同治理机制。在事件属性层面,应化解... 详细信息

随着现代风险社会及深度媒介化时代的到来,突发公共事件网络舆情风险往往由事件与传播双重逻辑耦合引发,常使国家陷入不确定性风险传播的被动响应中,因此需要建立突发公共事件网络舆情风险的现代化协同治理机制。在事件属性层面,应化解社会矛盾冲突、建立常态化社会治理机制,将数字技术作为提高舆情治理能力的基础设施,以社会治理现代化推动舆情风险治理的现代化;在媒介属性方面,要提高新型主流媒体突发公共事件舆论引导力,从舆情风险研判、预警及处置等层面进行全过程的舆情风险防范与治理。从整体性治理视角而言,建立网络舆情纵横协同应对,国家与社会、社会治理与传播治理的协同治理机制。通过现代化网络舆情风险协同治理机制的建立以提高国家应对突发公共事件网络舆情风险的韧性,适应中国式现代化国家治理的需要。

关键词：突发公共事件舆论引导风险治理国家韧性

政府购买服务背景下医务社会工作嵌入性发展类型的研究:基于深圳市15家公立医院的医务社工视角

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中国全科医学 2024年第21期27卷 2657-2664页

作者：雷杰欧梦雨林良中山大学社会学与人类学学院广东省广州市510275 重庆大学附属肿瘤医院重庆市400000 广东省深圳市龙岗区春暖社工服务中心 518000

背景随着我国医疗服务模式从单向治疗向全人健康的转变,以“助人自助”为宗旨的医务社会工作获得了更多嵌入医院场域的机会。目的探讨医务社会工作在嵌入医院场域的过程中所呈现的嵌入路径、策略和结果,从而对医务社会工作嵌入性发展的... 详细信息

背景随着我国医疗服务模式从单向治疗向全人健康的转变,以“助人自助”为宗旨的医务社会工作获得了更多嵌入医院场域的机会。目的探讨医务社会工作在嵌入医院场域的过程中所呈现的嵌入路径、策略和结果,从而对医务社会工作嵌入性发展的类型进行归纳,为医疗体系大力发展医务社会工作提供重要启示。方法基于格兰诺维特的嵌入理论,采用目的抽样法对深圳市15家公立医院政府购买服务的33位医务社工进行深度访谈,借助Nvivo12.0软件,运用主题分析法进行资料分析。结果在政府购买服务背景下,医务社会工作的嵌入路径包括结构嵌入和关系嵌入;嵌入策略主要分为结构嵌入下的“迂回顺从”和“被动妥协”以及关系嵌入下的“互惠互利”和“自我增能”;嵌入结果亦产生了“行政化”与“专业化”的两种不同的影响。结论本研究认为可以将医务社会工作嵌入性发展归纳为“浅层嵌入”“行政主导”“互惠发展”和“专业互构”四种类型。

关键词：社会工作医务社会工作嵌入性发展结构嵌入关系嵌入深圳

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氯化十六烷基吡啶改性蒙脱石对赭曲霉毒素A的吸附效果及机理

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硅酸盐学报 2024年第10期52卷 3150-3158页

作者：雷洁孙红娟彭同江白轩豪西南科技大学环境与资源学院四川绵阳621010 固体废物处理与资源化教育部重点实验室四川绵阳621010 西南科技大学矿物材料及应用研究所四川绵阳621010

赭曲霉毒素A (OTA)常见于霉变饲料中,动物食用后会严重损害其身体机能;蒙脱石具有良好的吸附性能,常用作吸附剂,具有保护动物胃肠粘膜的作用。使用氯化十六烷基吡啶(CPC)改性蒙脱石,通过X射线衍射、红外光谱、润湿接触角等揭示改性前后... 详细信息

赭曲霉毒素A (OTA)常见于霉变饲料中,动物食用后会严重损害其身体机能;蒙脱石具有良好的吸附性能,常用作吸附剂,具有保护动物胃肠粘膜的作用。使用氯化十六烷基吡啶(CPC)改性蒙脱石,通过X射线衍射、红外光谱、润湿接触角等揭示改性前后蒙脱石的层间距、官能团和亲疏水性的变化规律,并对比蒙脱石改性前后对OTA的吸附效果。结果表明:CPC成功进入蒙脱石层间且疏水性提升;改性后的蒙脱石(CPC-Mt)对OTA的吸附率高于未改性的蒙脱石。CPC-Mt对OTA的吸附动力学和等温线表明:CPC-Mt吸附OTA符合准二级动力学吸附模型和Linear等温线模型,说明CPC-Mt对OTA以化学吸附为主,且满足吸附/分配模型。根据等温线结果提出吸附机理,CPC-Mt与OTA主要以疏水和静电作用相结合。

关键词：蒙脱石有机改性赭曲霉毒素A 吸附动力学