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Prognostic impact of hypernatremia for septic shock patients in the intensive care unit

World Journal of Clinical Cases 2025年第7期13卷 28-38页

作者： Mai-Qing Shi Jun Chen Fu-Hai Ji Hao Zhou Ke Peng Jun Wang Chun-lei fan Xu Wang Yang Wang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of General Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Intensive Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevance in patients with septic shock remains *** To identify independent risk factors and their predictive efficacy for IAH to improve outcomes in patients with septic *** In the present retrospective single-center study,a cohort of 157 septic shock patients with concurrent hypernatremia in the ICU at The First Affiliated Hospital of Soochow University,between August 1,2018,and May 31,2023,were *** were categorized based on the timing of hypernatremia occurrence into the IAH group(n=62),the non-IAH group(n=41),and the normonatremia group(n=54).RESULTS In the present study,there was a significant association between the high serum sodium concentrations,excessive persistent inflammation,immunosuppression and catabolism syndrome and chronic critical illness,while rapid recovery had an apparent association with ***,multivariable analyses revealed the following independent risk factors for IAH:Total urinary output over the preceding three days[odds ratio(OR)=1.09;95%CI:1.02–1.17;P=0.014],enteral nutrition(EN)sodium content of 500 mg(OR=2.93;95%CI:1.13–7.60;P=0.027),and EN sodium content of 670 mg(OR=6.19;95%CI:1.75–21.98;P=0.005)were positively correlated with the development of ***,the area under the curve for total urinary output over the preceding three days was 0.800(95%CI:0.678–0.922,P=0.001).Furthermore,maximum serum sodium levels,the duration of hypernatremia,and varying sodium correction rates were significantly associated with 28-day in-hospital mortality in septic shock patients(P<0.05).CONCLUSION The present findings illustrate that elevated serum sodium level was significantly associated with a poor prognosis in septic shock patients in the *** is highly recommended that hypernatremia be

关键词： Hypernatremia Hypernatremia acquired in the intensive care unit Septic shock Persistent inflammation Immunosuppression Catabolism syndrome Chronic critical illness Prognosis

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Investigating the Head Impact Force-Induced Evolution of Hyperphosphorylated Tau Proteins in Brain Tissue Through Mechanical Mesoscale Finite Element Simulation

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Acta Mechanica Solida Sinica 2022年第4期35卷 705-715页

作者： Ge He lei fan Shanghai Key Laboratory of Mechanics in Energy Enginering Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Department of Mechanical Engineering Michigan State UniversityEast LansingMI 48824USA

For human heads that experienced repetitive subconcussive impacts,abnormal accumulation of hyperphosphorylated tau(p-tau)proteins was found in the postmortem brain *** numerically understand the cause–effect relationship between the external force and the microscopic volume change of the p-tau protein,we created a mesoscale finite element model of the multilayer brain tissue containing microscopic voids representing the p-tau *** model was applied under the loading boundary conditions obtained from a larger length scale simulation.A formerly developed internal state variable elastoplasticity model was implemented to describe the constitutive behaviors of gray and white matters,while the cerebrospinal fluid was assumed to be purely *** effects of the initial sizes and distances of p-tau proteins located at four different brain regions(frontal,parietal,temporal and occipital lobes)on their volumetric evolutions were *** is concluded that both the initial sizes and distances of the proteins have more or less(depending on the specific brain region)influential effects on the growth or contraction rate of the p-tau *** p-tau proteins located within the brain tissue at the frontal and occipital lobes are more heavily affected by the frontal impact load compared with those at the parietal and temporal *** summary,the modeling approach presented in this paper provides a strategy for mechanically studying the evolution of p-tau proteins in the brain tissue and gives insight into understanding the correlation between macroscopic force and microstructure change of the brain tissue.

关键词： Traumatic head injury Hyperphosphorylated tau(p-tau)protein Internal state variable Brain tissue

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Bounded Tiles in ■_p are Compact Open Sets

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Acta Mathematica Sinica,English Series 2020年第2期36卷 189-195页

作者： Ai Hua fan Shi lei fan LA MFA UMR 7352 CNRSUniversity of Picardie33 rue Saint Leu80039 AmiensFrance School of Mathematics and Statistics&Hubei Key Laboratory of Mathematical Sciences Central China Normal UniversityWuhan430079P.R.China

Any bounded tile of the field Qp of p-adic numbers is a compact open set up to a set of zero Haar *** this note,we present two simple and direct proofs of this fact.

关键词： p-adic field tile bounded compact open

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A Rapid and Automatic Optimal Design Method for Six-Stage Axial-Flow Industry Compressor

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Journal of Thermal Science 2021年第5期30卷 1658-1673页

作者： lei fan JU Yaping ZHANG Chuhua School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an710049China

Existing aerodynamic design systems for multi-stage axial-flow compressor suffer from several limitations,such as experience dependent models and time costly *** attempts,however,have been devoted to the rapid and automatic optimization of aerodynamic performance at the preliminary design phase,which plays a crucial role in the final aerodynamic *** this work,a rapid and automatic aerodynamic optimal design method is developed for the multi-stage axial-flow compressor based on one-dimensional meanline design method,radial-equilibrium equation and genetic *** one-dimensional performance prediction model includes some popular empirical correlations to calculate the flow loss,incidence angle,deviation angle and flow *** radial-equilibrium equation is solved to obtain the spanwise distribution of aerodynamic and thermodynamic parameters at the inlet and outlet of each blade *** genetic algorithm is used for an automatic search of the global optimal compressor configuration aiming at maximizing the design *** developed method is illustrated with the aerodynamic optimal design of a 6-stage axial-flow industry compressor and verified by computational fluid dynamics *** results show that the developed method is capable of improving effectively the design efficiency and predicting accurately the aerodynamic performance of the 6-stage axial-flow industry compressor in a few *** work is of scientific significance to improve the axial-flow compressor design system and of engineering importance to release the designers from the heavy experience dependence especially at the preliminary design phase.

关键词： one-dimensional meanline design two-dimensional throughflow design three-dimensional CFD simulation optimal design genetic algorithm multi-stage axial-flow compressor

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Multi-factor high-order intuitionistic fuzzy timeseries forecasting model

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Journal of Systems Engineering and Electronics 2016年第5期27卷 1054-1062页

作者： Ya'nan Wang Yingjie lei Yang lei Xiaoshi fan Air and Missile Defense College Air Force Engineering UniversityXi'an 710051China Department of Electronics Technology Engineering University of Armed Police ForceXi'an 710051China

Fuzzy sets theory cannot describe the neutrality degreeof data, which has largely limited the objectivity of fuzzy time seriesin uncertain data forecasting. With this regard, a multi-factor highorderintuitionistic fuzzy time series forecasting model is built. Inthe new model, a fuzzy clustering algorithm is used to get unequalintervals, and a more objective technique for ascertaining membershipand non-membership functions of the intuitionistic fuzzy setis proposed. On these bases, forecast rules based on multidimensionalintuitionistic fuzzy modus ponens inference are ***, contrast experiments on the daily mean temperature ofBeijing are carried out, which show that the novel model has aclear advantage of improving the forecast accuracy.

关键词： multi-factor high-order intuitionistic fuzzy time series,forecasting model intuitionistic fuzzy inference.

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Dispersion–tribological property relationship in mineral oils containing 2D layered α-zirconium phosphate nanoplatelets

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Friction 2020年第4期8卷 695-707页

作者： Feng JIANG Haoyang SUN lei CHEN fan lei Dazhi SUN Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

Inorganic nanomaterials exhibit superior friction-reduction and anti-wear properties in oils. In this study, 2D layered α-zirconium phosphate (α-ZrP) nanosheets intercalated with different amines have been synthesized to study their dispersion stabilities in lubricating oil and tribological applications. The intercalated amines should be sufficiently long and lipophilic to provide stabilization to α-ZrP nanosheets in mineral oil. The results of tribological tests illustrate that with the addition of well-dispersed nanosheets, the coefficient of friction (COF) and pin volume loss reduce by ~47% and 75%, respectively. The excellent dispersion stability enables the nanosheets to flow into the contact area at the beginning, and thereby protect the rubbing surface. A reduction in the van der Waals forces between the adjacent layers induced by the intercalated amines transforms the friction between adjacent layers from pin disk to sliding, leading to a decrease in the COF under hydrodynamic lubrication. The study provides a new method to enhance the tribological properties via tuning the dispersion stabilities of nanomaterials in oils.

关键词： friction-reduction and anti-wear nanoadditive layered nanosheet α-zirconium phosphate(α-ZrP) dispersion tribology

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Dynamics of Commuting Rational Maps on Berkovich Projective Space over C_p

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Acta Mathematica Sinica,English Series 2013年第8期29卷 1459-1478页

作者： Shi lei fan Yue Fei WANG Institute of Applied Mathematics AMSSChinese Academy of Sciences Institute of Mathematics AMSSChinese Academy of Sciences

We study the dynamics of commuting rational maps with coefficients in Cp. By lifting the dynamics from P1（Cp） to Berkovich projective space P1 Berk, we prove that two nonlinear commuting maps have the same Berkovich Julia set and the same canonical measure. As a consequence, two nonlinear commuting maps with coefficient in Cp have the same classical Julia set. We also prove that they have the same pre-periodic Berkovich Fatou components.

关键词： Non-Archimedean field Berkovich projective line Fatou set Julia set

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Constitutive modeling of viscoelastic-viscoplastic behavior of short fiber reinforced polymers coupled with anisotropic damage and moisture effects

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Acta Mechanica Sinica 2019年第3期35卷 495-506页

作者： Ge He Yucheng Liu Xingqiao Deng lei fan Department of Mechanical Engineering Mississippi State UniversityStarkville 39762USA School of Mechanical Engineering and Automation Xihua UniversityChengdu 610039China Department of Engineering Durham UniversityDurham DH1 3LEUK

In this paper, a combined viscoelasticity-viscoplasticity model, coupled with anisotropic damage and moisture effects, is developed for short fiber reinforced polymers (SFRPs) with different fiber contents and subjected to a variety of strain rates. In our model, a rate-dependent yield surface for the matrix phase is employed to identify initial yielding of the material. When an SFRP is loaded at small deformation before yielding, its viscoelastic behavior can be described using the generalized Maxwell model, while when plasticity occurs, a scalar internal state variable (ISV) is used to capture the hardening behavior caused by the polymeric constituent of the composite. The material degradation due to the moisture absorption of the composite is modeled by employing another type of ISV with different evolution equations. The complicated damage state of the SFRPs is captured by a second rank tensor, which is further decomposed to model the subscale damage mechanisms of micro-voids/cracks nucleation, growth and coalescence. It is concluded that the proposed constitutive model can be used to accurately describe complicated behaviors of SFRPs because the results predicted from the model are in good agreement with the experimental data.

关键词： Short fiber reinforced polymer Internal state variable Anisotropic damage Moisture effect Viscoelasticity-viscoplasticity

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Phase Ⅰ study of ***19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients

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Frontiers of Medicine 2022年第2期16卷 285-294,F0004页

作者： lei fan Li Wang lei Cao Huayuan Zhu Wei Xu Jianyong Li Department of Hematology Pukou CLL CenterJiangsu Province HospitalThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

Anti-CD 19 chimeric antigen receptor(CAR)T cell therapy has shown impressive efficacy in treating B-cell malignancies.A single-center phase I dose-escalation study was conducted to evaluate the safety and efficacy of T cells transduced with ***19 CAR,a second-generation anti-CD19 CAR bearing 4-1BB costimulatory molecule,for the treatment of patients with refractory diffuse large B-cell lymphoma(DLBCL).Ten heavily treated patients with refractory DLBCL were given ***19 CAR-T cell(C-CAR011)*** overall response rate was 20%and 50%at 4 and 12 weeks after the infusion of C-CAR011,respectively,and the disease control rate was 60%at 12 weeks after ***-emergent adverse events occurred in all *** incidence of cytokine release syndrome in all grades and grade^3 was 90%and 0,respectively,which is consistent with the safety profile of axicabtagene ciloleucel and *** or other dose-limiting toxicides was not observed in any dose cohort of C-CAR011 *** efficacy was apparent across dose ***,C-CAR011 is a safe and effective therapeutic option for Chinese patients with refractory DLBCL,and further large-scale clinical trials are warranted.

关键词： CAR-T cell therapy refractory diffuse large B-cell lymphoma cytokine release syndrome dose-limiting toxicity

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Hypothesis, Modern Researches and Clinical Applications of Cutaneous Regions in Traditional Chinese Medicine

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Journal of Acupuncture and Tuina Science 2014年第2期12卷 125-130,I0001,I0002页

作者： fan lei Yin lei-miao Shanghai Research Institute of Acupuncture and Meridian

As one of the most important concepts in traditional Chinese medicine, cutaneous regions have a close relationship with skin in modern medicine. According to the doctrine of traditional Chinese medicine, the cutaneous regions are the corresponding projections of twelve meridians in the superficial layer of the body and play an important role in body surface-viscera correlation. The symptoms of visceral disorders will reflect on cutaneous regions and one of the major patterns of manifestation is referred visceral pain accompanied by tenderness and hyperalgesia on the body surface. On the contrary, cutaneous regions participate in the treatment of visceral disorders. As major clinical applications of the cutaneous regions hypothesis, superficial acupuncture, subcutaneous needling, massage(tuina), moxibustion, and wrist-ankle acupuncture have achieved favorable therapeutic outcomes in clinical practice. Modern researches have gained insights into the biological background of cutaneous regions, however, further studies are needed to clarify the mechanisms.

关键词： Cutaneous Regions Body Surface-viscera Correlation SuperficialAcupuncture Subcutaneous Needling Massage Tuina MoxibustionTherapy Wrist-ankle Acupuncture

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