Investigating the Head Impact Force-Induced Evolution of Hyperphosphorylated Tau Proteins in Brain Tissue Through Mechanical Mesoscale Finite Element Simulation

作     者：Ge He Lei Fan 

作者机构：Shanghai Key Laboratory of Mechanics in Energy EngineringShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Department of Mechanical EngineeringMichigan State UniversityEast LansingMI 48824USA 

出 版 物：《Acta Mechanica Solida Sinica》 (固体力学学报（英文版）)

年 卷 期：2022年第35卷第4期

页      面：705-715页

核心收录：

学科分类：0820[工学-石油与天然气工程] 080706[工学-化工过程机械] 08[工学] 0807[工学-动力工程及工程热物理] 082003[工学-油气储运工程] 080102[工学-固体力学] 0801[工学-力学（可授工学、理学学位）] 

基　　金：the Shanghai Young Eastern Scholar Fund under Grant No.QD2020015 

主　　题：Traumatic head injury Hyperphosphorylated tau(p-tau)protein Internal state variable Brain tissue 

摘      要：For human heads that experienced repetitive subconcussive impacts,abnormal accumulation of hyperphosphorylated tau(p-tau)proteins was found in the postmortem brain *** numerically understand the cause–effect relationship between the external force and the microscopic volume change of the p-tau protein,we created a mesoscale finite element model of the multilayer brain tissue containing microscopic voids representing the p-tau *** model was applied under the loading boundary conditions obtained from a larger length scale simulation.A formerly developed internal state variable elastoplasticity model was implemented to describe the constitutive behaviors of gray and white matters,while the cerebrospinal fluid was assumed to be purely *** effects of the initial sizes and distances of p-tau proteins located at four different brain regions(frontal,parietal,temporal and occipital lobes)on their volumetric evolutions were *** is concluded that both the initial sizes and distances of the proteins have more or less(depending on the specific brain region)influential effects on the growth or contraction rate of the p-tau *** p-tau proteins located within the brain tissue at the frontal and occipital lobes are more heavily affected by the frontal impact load compared with those at the parietal and temporal *** summary,the modeling approach presented in this paper provides a strategy for mechanically studying the evolution of p-tau proteins in the brain tissue and gives insight into understanding the correlation between macroscopic force and microstructure change of the brain tissue.