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Moderate deviations and central limittheorem for small perturbationWishart processes

Frontiers of Mathematics in China 2014年第1期9卷 1-15页

作者： lei chen fuqing gao shaochen wang School of Mathematics and Statistics Wulhan University Wuhan 430072 China

Let X^ε be a small perturbation Wishart process with values in the set of positive definite matrices of size m, i.e., the process X^ε is the solution of stochastic differential equation with non-Lipschitz diffusion coefficient： dXt^ε = √εXt^εtdBt＇＋ dBt＇√εXt^ε ＋ ρImdt, X0 = x, where B is an rn x m matrix valued Brownian motion and B＇ denotes the transpose of the matrix B. In this paper, we prove that { （Xt^ε-Xt^0）/√εh^2（ε）,ε 〉 0} satisfies a large deviation principle, and （Xt^ε - Xt^0）/√ε converges to a Gaussian process, where h（ε） → ＋∞ and √ε h（ε） →0 as ε →0. A moderate deviation principle and a functional central limit theorem for the eigenvalue process of X^ε are also obtained by the delta method.

关键词： Large deviation moderate deviation central limit theorem Wishart vprocess eigenvalue

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Berry-Esseen bounds and Cramér type large deviations for eigenvalues of random matrices.

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Science China Mathematics 2015年第9期58卷 1959-1980页

作者： chen lei gao fuqing wang shaochen School of Mathematics and Statistics Wuhan University School of Mathematics and Statistics Jiangsu Normal University

We establish Berry-Esseen bounds and Cramér type large deviations for the eigenvalues of Wigner Hermitian matrices in the bulk and at the edge cases. Similar results are also obtained for covariance matrices.

关键词： random matrices eigenvalues Berry-Esseen bounds Cramér type large deviations

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Association of functional nucleotide polymorphisms at DTH2 with the northward expansion of rice cultivation in Asia

Association of functional nucleotide polymorphisms at DTH2 w...

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2013全国植物生物学大会

作者： WU Weixun ZHENG Xiaoming LU Guangwen ZHONG Zhengzheng gao He chen Liping WU Chuanyin wang Hongjun wang Qi ZHOU Kunneng wang Jiulin WU fuqing ZHANG Xin GUO Xiuping chenG Zhijun lei Cailin LIN Qibing JIANG Ling wang Haiyang GE Song WAN Jianmin National key Laboratory for Crop Genetics and Germplasm Enhancement Jiangsu Plant Gene Engineering Research CenterNanjing Agricultural University National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural Sciences National key Laboratory for Crop Genetics and Germplasm Enhancement Jiangsu Plant Gene Engineering Research CenterNanjing Agricultural Universit State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of Sciences

Flowering time is an important ecological trait that determines growing seasons and regional adaptability of plants to specific natural *** is a short-day plant that originated in the *** evidence suggests that the northward expansion of cultivated rice was accompanied by human selection of the heading date under non-inductive long-day conditions(LDs).We report here the molecular cloning and characterization of DTH2,a minor -effect QTL that promotes heading under *** show that DTH2 encodes a CO-like protein that promotes heading by inducing the florigen genes Hd3a and RFT1,and it acts independently of the known floral integrators Hdl and ***,association analysis and transgenic experiments identified two FNPs in DTH2 that correlated with early heading and increased reproductive fitness under natural LDs in northern *** combined population genetics and network analyses suggest that DTH2 likely represents a target of human selection for adaptation to LDs during rice domestication and/or improvement,demonstrating an important role of minor-effect QTLs in crop adaptation and breeding.

关键词： rice DTH2 FNP heading date minor-effect QTL

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Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)

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中华神经外科杂志(英文) 2024年第3期10卷 1页

作者： Ge Peicong Yin Zihan Tao Chuming Zeng Chaofan Yu Xiaofan lei Shixiong Li Junsheng Zhai Yuanren Ma Long He Qiheng Liu chenglong Liu Wei Zhang Bojian Zheng Zhiyao Mou Siqi Zhao Zhikang wang Shuang Sun Wei Guo Min Zheng Shuai Zhang Jia Deng Xiaofeng Liu Xingju Ye Xun Zhang Qian wang Rong Zhang Yan Zhang Shaosen wang chengjun Yang Ziwen Zhang Nijia Wu Mingxing Sun Jian Zhou Yujia Shi Zhiyong Ma Yonggang Zhou Jianpo Yu shaochen Li Jiaxi Lu Junli gao Faliang wang Wenjing chen Yanming Zhu Xingen Zhang Dong Zhao Jizong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China China National Clinical Research Center for Neurological Diseases Beijing China Department of Neurosurgery Beijing Hospital National Center of Gerontology Beijing China Department of Radiology Beijing Tiantan Hospital Beijing China Department of Ultrasound Beijing Tiantan Hospital Capital Medical University Beijing China Department of Neurology Beijing Tiantan Hospital Beijing China Department of Neurosurgery Beijing Friendship Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Chaoyang Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Childrens Hospital Capital Medical University Beijing China Department of Neurosurgery The Affiliated Children’s Hospital Capital Institute of Pediatrics Beijing China Department of Neurosurgery Beijing Changping District Hospital Beijing China Department of Neurosurgery Dongfang Hospital Beijing University of Chinese Medicine Beijing China Department of Neurosurgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China Department of NeuroInterventional Surgery Binzhou Medical University Hospital Binzhou Shandong China Department of Neurosurgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Neurosurgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Neurosurgery The First Affiliated Hospital of Xi’an Jiaotong University Shaanxi Xi’an China Department of Neurosurgery West China Hospital Sichuan University Chengdu China Department of Neurosurgery Center for Rehabilitation Medicine Zhejiang Provincial Peoples Hospital Affiliated Peoples Hospital Hangzhou Medical College Hangzhou Zhejiang China Beijing Institute of Hepatology Beijing YouAn Hospital Capital Medical University Beijing China Department of Neu

Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiology of MMD remains enigmatic, making diagnosis and management challenging. The MOYAOMICS project was initiated to investigate the molecular underpinnings of MMD and explore potential diagnostic and therapeutic *** The MOYAOMICS project employs a multidisciplinary approach, integrating various omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, to comprehensively examine the molecular signatures associated with MMD pathogenesis. Additionally, we will investigate the potential influence of gut microbiota and brain-gut peptides on MMD development, assessing their suitability as targets for therapeutic strategies and dietary interventions. Radiomics, a specialized field in medical imaging, is utilized to analyze neuroimaging data for early detection and characterization of MMD-related brain changes. Deep learning algorithms are employed to differentiate MMD from other conditions, automating the diagnostic process. We also employ single-cellomics and mass cytometry to precisely study cellular heterogeneity in peripheral blood samples from MMD *** The MOYAOMICS project represents a significant step toward comprehending MMD’s molecular underpinnings. This multidisciplinary approach has the potential to revolutionize early diagnosis, patient stratification, and the development of targeted therapies for MMD. The identification of blood-based biomarkers and the integration of multiple omics data are critical for improving the clinical management of MMD and enhancing patient outcomes for this complex disease.

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen fuqing chen Fusan chen Gang chen Guoming chen Hua-Xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen Xiang chen Xiaoyu chen Xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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痤疮患者继发敏感性皮肤的流行病学调查与影响因素分析

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中国皮肤性病学杂志 2024年第11期38卷 1229-1240页

作者：何倩涂颖何黎路永红许爱娥邱湘宁陈玉郭燕妮张晋松杨钰鑫杨瑾邓永琼张丽何淑娟王丽雷霞商干伟张建波许昌春肖文侬秀川梁作辉杨婷李彩霞房慧杨滢瑶张玲琳张薇毕晓东方杰李刚杨洪英凌昕高睿迪刁庆春吕新翔冯颖颖胡信林林向飞尤海燕梁羽萍杨凤元李雪莉刘俐陶诗沁孙振亮昆明医科大学第一附属医院云南省皮肤病医院云南昆明650032 昆明医科大学生物医学工程研究院云南昆明650032 成都市第二人民医院皮肤病医院四川成都610000 杭州市第三人民医院皮肤科浙江杭州310009 中南大学湘雅二医院皮肤科湖南长沙410011 福建医科大学附属福清市医院皮肤科福建福清350300 福建医科大学附属第二医院皮肤科福建泉州362000 曲靖市第一人民医院皮肤科云南曲靖655000 简阳市人民医院皮肤科四川简阳641400 云南省中医医院皮肤科云南昆明650021 西南医科大学附属医院皮肤科四川泸州646000 中国医科大学附属第一医院皮肤科辽宁沈阳110001 西安交通大学第二附属医院皮肤科陕西西安710004 河南省中医院皮肤科河南郑州450002 陆军特色医学中心皮肤科重庆400042 盐城市第三人民医院皮肤性病科江苏盐城224000 大理市第二人民医院皮肤科云南大理671003 中国医学科学院皮肤病医院江苏南京210042 柳州市工人医院皮肤科广西柳州545000 文山州皮肤病防治所云南文山663099 玉溪市人民医院皮肤科云南玉溪653100 黄石市中心医院皮肤科湖北黄石435000 昆明市延安医院皮肤科云南昆明650000 遂宁市中心医院皮肤科四川遂宁629000 上海中医药大学附属岳阳中西医结合医院皮肤科上海200437 同济大学附属皮肤病医院上海200443 昭通市中医医院皮肤科云南昭通657000 南阳市第一人民医院皮肤科河南南阳473000 毕节市第一人民医院皮肤科贵州毕节551700 个旧市人民医院皮肤科云南个旧661000 前郭尔罗斯蒙古族自治县医院皮肤科吉林松原131100 苏州市第九人民医院皮肤科江苏苏州215200 阜阳市人民医院皮肤科安徽阜阳236000 重庆市中医院皮肤科重庆400011 内蒙古医科大学附属医院皮肤科内蒙古呼和浩特010050 丽水市中医院皮肤科浙江丽水323000 厦门大学附属医院皮肤科福建厦门361001 苏北人民医院皮肤科江苏扬州225001 黑龙江省医院南岗皮肤病医院皮肤科黑龙江哈尔滨150001 玉林市皮肤病医院医疗美容科广西玉林537000 桂林医学院附属医院皮肤科广西桂林541001 河南省人民医院皮肤科河南郑州450000 大连市皮肤病医院中医美容科辽宁大连116021 无锡市第二人民医院皮肤科江苏无锡214000 上海市奉贤区中心医院皮肤科上海201400

目的明确痤疮患者继发敏感性皮肤的发生现状和影响因素,为防治痤疮患者继发敏感性皮肤提供指导。方法采用分层随机抽样,对全国76家皮肤科参与“痤疮周”义诊的痤疮患者(n=5787)继发敏感性皮肤的情况进行横断面调查,通过总结人口学信息... 详细信息

目的明确痤疮患者继发敏感性皮肤的发生现状和影响因素,为防治痤疮患者继发敏感性皮肤提供指导。方法采用分层随机抽样,对全国76家皮肤科参与“痤疮周”义诊的痤疮患者(n=5787)继发敏感性皮肤的情况进行横断面调查,通过总结人口学信息、痤疮严重程度、皮肤类型、家族史、日常行为、医疗行为、环境因素、地区等资料,明确痤疮患者继发敏感性皮肤的影响因素。结果5787例中,女3979例(68.76%),男1808例(31.24%),平均年龄(25.63±6.66)岁。痤疮继发敏感性皮肤共1840例,检出率为31.80%。Logistic回归分析显示:女性,痤疮严重程度,皮肤类型,家族史,日常行为(如使用护肤品品牌≥4个/d、洗澡/桑拿、使用空调、使用剥脱类洗护用品、运动、洗脸频率>2次/d),医疗行为(如半年内口服维A酸类药物,1个月内外用过壬二酸和维A酸类药物、进行过激光治疗,1周内进行过化学剥脱治疗)和环境因素(如季节交替、粉尘、刮风、夏季、春季、日晒时间4h/d、秋季、地区)可能是痤疮患者继发敏感性皮肤的影响因素。结论本调查初步明确了痤疮患者继发敏感性皮肤的影响因素,提示临床医生在痤疮治疗中应兼顾敏感性皮肤的治疗,以提高痤疮的临床治愈率,降低复发率。

关键词：痤疮敏感性皮肤影响因素

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