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Role of hepatitis A virus in diabetes mellitus

World Journal of Diabetes 2021年第11期12卷 1928-1941页

作者： James Lin Horng-Yih Ou Rudruidee Karnchanasorn Raynald Samoa lee-ming chuang Ken C Chiu Department of Gastroenterology City of Hope National Medical CenterDuarteCA 91010United States Division of Endocrinology and Metabolism Department of Internal MedicineNational Cheng-Kung University Medical College and HospitalTainan 700Taiwan Division of Endocrinology Metabolism and GeneticsDepartment of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160United States Department of Clinical Diabetes Endocrinologyand MetabolismDiabetes and Metabolism Research InstituteCity of Hope National Medical CenterDuarteCA 91010United States Division of Endocrinology Metabolism and NutritionDepartment of Internal MedicineHarbor-UCLA Medical CenterTorranceCA 90502United States of America Department of Internal Medicine National Taiwan University HospitalTaipei 102Taiwan Graduate Institute of Preventive Medicine School of Public HealthTaipei 102Taiwan

BACKGROUND Although much information is available regarding hepatitis C virus infection and diabetes,less is known about the relationship between hepatitis A virus(HAV)infection and *** To examine the roles of HAV in diabetes *** This cross-sectional study population included data from the National Health and Nutrition Examination Survey collected between *** subjects(≥20 years old)with available body mass index measurements,defined diabetes status,history of HAV vaccination,and HAV serology were *** vaccination was based on self-reported *** HAV immunization was defined as the presence of both vaccination and anti-HAV *** infection was defined by the absence of vaccination but presence of anti-hepatitis A *** odds ratio(OR)for diabetes with 95%confidence intervals(95%CI)was calculated for each HAV status and then adjusted for *** tests,based on different definitions of diabetes,were performed to verify the *** Among 19942 subjects,4229 subjects(21.21%)received HAV vaccination and HAV antibody was present in 9224 subjects(46.25%).Although HAV infection was associated with an increased risk of diabetes(OR:1.13;95%CI:1.08-1.18),HAV vaccination was not associated with diabetes(OR:1.06;95%CI:0.95-1.18),and successful HAV immunization had no impact on the risk of diabetes(OR:1.11;95%CI:0.97-1.27).Thus,HAV infection was an unlikely cause of ***,in non-vaccinated subjects,diabetes increased the risk of HAV infection by 40%(OR:1.40,95%CI:1.27-1.54).CONCLUSION An association between HAV infection and diabetes is observed which is best explained by an increased risk of HAV infection in diabetic *** subjects are more susceptible to ***,HAV vaccination is highly recommended in diabetic patients.

关键词： Vaccination Immunization Viral hepatitis Liver Glucose metabolism Diabetes mellitus

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Early detection of diabetic kidney disease: Present limitations and future perspectives

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World Journal of Diabetes 2016年第14期7卷 290-301页

作者： Chih-Hung Lin Yi-Cheng Chang lee-ming chuang Depart-ment of Internal Medicine National Taiwan University Hospital Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Graduate Institute of Medical Genomics and Proteomics College of Medicine National Taiwan University Institute of Biomedical Science Academia Sinica

Diabetic kidney disease(DKD) is one of the most common diabetic complications, as well as the leading cause of chronic kidney disease and end-stage renal disease around the world. To prevent the dreadful consequence, development of new assays for diagnostic of DKD has always been the priority in the research field of diabetic complications. At present, urinary albumin-to-creatinine ratio and estimated glomerular filtration rate(eG FR) are the standard methods for assessing glomerular damage and renal function changes in clinical practice. However, due to diverse tissue involvement in different individuals, the so-called "non-albuminuric renal impairment" is not uncommon, especially in patients with type 2 diabetes. On the other hand, the precision of creatinine-based GFR estimates is limited in hyperfiltration status. These facts make albuminuria and eG FR less reliable indicators for early-stage DKD. In recent years, considerable progress has been made in the understanding of the pathogenesis of DKD, along with the elucidation of its genetic profiles and phenotypic expression of different molecules. With the help of ever-evolving technologies, it has gradually become plausible to apply the thriving information in clinical practice. The strength and weakness of several novel biomarkers, genomic, proteomic and metabolomic signatures in assisting the early diagnosis of DKD will be discussed in this article.

关键词： Diabetic kidney disease Early diagnosis Genomics Biomarkers

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Enabling superior electrochemical performance of NCA cathode in Li_(5.5)PS_(4.5)Cl_(1.5)-based solid-state batteries with a dual-electrolyte layer

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Chinese Chemical Letters 2024年第4期35卷 231-236页

作者： Ziling Jiang Shaoqing Chen Chaochao Wei Ziqi Zhang Zhongkai Wu Qiyue Luo Liang ming Long Zhang chuang Yu School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China Innovation Center for Chemical Sciences College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China College of Physics and Energy Fujian Normal UniversityFuzhou 350117 China

LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2)(NCA) is a promising cathode for sulfide-based solid-state lithium batteries(ASSLBs)profiting from its high specific capacity and voltage plateau, which yielding high energy density. However, the inferior interfacial stability between the bare NCA and sulfides limits its electrochemical performance. Hereien, the dual-electrolyte layer is proposed to mitigate this effect and enhance the battery performances of NCA-based ASSLIBs. The Li_(3)InCl_6 wih high conductivity and excellent electrochemcial stability act both as an ion additives to promote Li-ion diffusion across the interface in the cathode and as a buffer layer between the cathode layer and the solid electrolyte layer to avoid side reactions and improve the interface stability. The corresponding battery exhibits high discharge capacities and superior cyclabilities at both room and elevated temperatures. It exhibits discharge performance of 237.04 and216.07 m Ah/g at 0.1 and 0.5 C, respectively, when cycled at 60 ℃, and sustains 95.9% of the capacity after100 cycles at 0.5 C. The work demonstrates a simple strategy to ensure the superior performances of NCA in sulfide-based ASSLBs.

关键词： LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2) Li_(5.5)PS_(4.5)Cl_(1.5) Double solid electrolyte layer configuration Operating temperatures Electrochemical performances

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Revealing the size effect of Fe S2on solid-state battery performances at different operating temperatures

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Chinese Chemical Letters 2024年第6期35卷 189-194页

作者： Chaochao Wei Ru Wang Zhongkai Wu Qiyue Luo Ziling Jiang Liang ming Jie Yang Liping Wang chuang Yu School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China

FeS_(2) shows significant potential as cathode material for all-solid-state lithium batteries(ASSLBs)due to its high theoretical specific capacity,low cost,and environmental ***,the poor ion/electron conductivity and large volume variation effect of FeS_(2) inhibit its practical ***,the influence of particle size of FeS_(2) on the corresponding sulfide-based solid-state batteries is carefully investigated by tuning FeS_(2) ***,low operating temperature is chosen to mitigate the large volume changes during cycling in the battery.S-FeS_(2) with smaller particle sizes delivers superior electrochemical performances than that of the larger L-FeS_(2) in Li_(5.5)PS_(4.5)Cl_(1.5)-based ASSLBs under different operating temperatures.S-FeS_(2) shows stable discharge capacities during 50 cycles with a current density of 0.1 m A/cm^(2)under -20℃.When the current density rises to 1.0 m A/cm^(2),it delivers an initial discharge capacity of 146.9 m Ah/g and maintains 63% of the capacity after 100 *** work contributes to constructing ASSLBs enables excellent electrochemical performances under extreme operating temperatures.

关键词： FeS_(2) Size effect Li_(5.5)PS_(4.5)Cl_(1.5) electrolytes Operating temperatures Electrochemical performances

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Reconfigurable and polarization-dependent optical filtering for transflective full-color generation utilizing low-loss phase-change materials

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Journal of Semiconductors 2024年第7期45卷 46-53页

作者： Shuo Deng Mengxi Cui Jingru Jiang chuang Wang Zengguang Cheng Huajun Sun ming Xu Hao Tong Qiang He Xiangshui Miao School of Integrated Circuits Huazhong University of Science and TechnologyWuhan 430074China Hubei Yangtze Memory Laboratories Wuhan 430205China School of Microelectronics Fudan UniversityShanghai 200433China

All-dielectric metasurface, which features low optical absorptance and high resolution, is becoming a promising candidate for full-color generation. However, the optical response of current metamaterials is fixed and lacks active tuning. In this work, we demonstrate a reconfigurable and polarization-dependent active color generation technique by incorporating low-loss phase change materials(PCMs) and CaF_2 all-dielectric substrate. Based on the strong Mie resonance effect and low optical absorption structure, a transflective, full-color with high color purity and gamut value is achieved. The spectrum can be dynamically manipulated by changing either the polarization of incident light or the PCM state. High transmittance and reflectance can be simultaneously achieved by using low-loss PCMs and substrate. The novel active metasurfaces can bring new inspiration in the areas of optical encryption, anti-counterfeiting, and display technologies.

关键词： structural color reconfigurable all-dielectric metasurfaces phase change material

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Producing circularly polarized luminescence by radiative energy transfer from achiral metal-organic cage to chiral organic molecules

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Chinese Chemical Letters 2024年第8期35卷 498-502页

作者： Zhao-Xia Lian Xue-Zhi Wang chuang-Wei Zhou Jiayu Li ming-De Li Xiao-Ping Zhou Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China College of Chemistry and Chemical Engineering Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China

The development of circularly polarized luminescence(CPL)materials with high performance is signifi-cantly ***,we develop a facial strategy for fabricating a CPL-active system by employing an achiral luminescent metal-organic cage(MOC)and chiral boron dipyrromethene(BODIPY)*** is achieved by taking advantage of the radiative energy transfer process,in which BODIPY molecules act as energy acceptors and MOCs act as *** CPL performance(maximum luminescence dissymme-try factor up to±1.5×10^(−3))can be tuned by adjusting the ratio between MOCs and ***-light emission with the CPL feature is obtained by using a ternary system including MOC,chiral BODIPY,and Rhodamine *** present work provides a facile and universal strategy to construct a CPL-active system by integrating achiral luminophores and chiral molecules.

关键词： Circularly polarized luminescence Metal-organic cage Radiative energy transfer Chiral small molecules Bodipy Chirality

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Construction of LiCl/LiF/LiZn hybrid SEI interface achieving high-performance sulfide-based all-solid-state lithium metal batteries

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Science China Chemistry 2024年第6期67卷 1990-2001页

作者： Chaochao Wei Yujie Xiao Zhongkai Wu Chen Liu Qiyue Luo Ziling Jiang Lin Li Liang ming Jie Yang Shijie Cheng chuang Yu State Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan430074China School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan430074China

Sulfide-based all-solid-state lithium metal batteries(ASSLMBs)have received extensive attention due to their high energy density and high safety,while the poor interface stability between sulfide electrolyte and lithium metal anode limits their ***,a hybrid SEI(LICl/Li F/Li Zn)was constructed at the interface between Li_(5.5)PS_(4.5)Cl_(1.5)sulfide electrolyte and lithium *** Li Cl and Li F interface phases with high interface energy effectively induce the uniform deposition of Li^(+)and reduce the overpotential of Li^(+)deposition,while the Li Zn alloy interface phase accelerates the diffusion of lithium *** synergistic effect of the above functional interface phases inhibits the growth of lithium dendrites and stabilizes the interface between the sulfide electrolyte and lithium *** hybrid SEI strategy exhibits excellent electrochemical performance on symmetric batteries and all-solid-state *** symmetrical cell exhibits stable cycling performance over long duration over 500 h at 1.0 mA cm^(-2).Moreover,the LiNbO_(3)@NCM712/Li_(5.5)PS_(4.5)Cl_(1.5)/Li-10%Zn F_(2)battery exhibits excellent cycle stability at a high rate of 0.5 C,with a capacity retention rate of 76.4%after 350 cycles.

关键词： argyrodite electrolytes ASSLMBs electrochemical stability Li-ZnF_2 anode electrochemical performance

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Si-doped Li6PS5I with enhanced conductivity enables superior performance for all-solid-state lithium batteries

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Chinese Chemical Letters 2024年第10期35卷 505-510页

作者： Liang ming Dan Liu Qiyue Luo Chaochao Wei Chen Liu Ziling Jiang Zhongkai Wu Lin Li Long Zhang Shijie Cheng chuang Yu State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic Engineering Huazhong University of Science and Technology School of Chemistry and Chemical Engineering Huazhong University of Science and Technology State Grid Hubei Electric Power Research Institute College of Physics and Energy Fujian Normal University

Lithium argyrodites Li6PS5X（X = Cl, Br, I） show great potential as solid electrolytes for solid-state lithium batteries due to their high Li-ion conductivities and excellent electrode compatibility. However, the relatively low conductivity of Li6PS5I(10-6m S/cm) compared to the other two compositions limits its applications. Herein, Si-doped Li6.5P0.5Si0.5S5I electrolyte is designed and synthesized with superior high conductivity of 3.6 mS/cm. Structural characterization proves the increase due to the anion disorder and volume expansion caused by Si-doping. However, the poor interfacial stability between layered oxide cathode Li Ni0.6Co0.2Mn0.2O2and Li6.5P0.5Si0.5S5I inhibits its battery performance. By introducing Li3InCl6electrolyte in the configuration, the corresponding battery delivers high initial discharge capacity of 150.2m Ah/g and superior cyclability during 250 cycles at 0.5 C. This work offers design strategy to obtain Li6PS5I-based electrolytes for high performance solid-state batteries.

关键词： All-solid-state lithium batteries Argyrodite electrolyte Electrochemical performance Li6.5P0.5Si0.5S5I Stability

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Reinforcing oxygen electrocatalytic activity via selective dualphase heterointerface engineering for rechargeable Zn-air batteries

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Rare Metals 2024年第4期43卷 1524-1536页

作者： Chao Cheng chuang Zhi Zhong-Ti Sun Yong-Qiang ming Ting-Ting Xiang Qing-Chao Zhu Zi-Rui Wu Bing Li Yi Li Cheng Jin Yong Cao Juan Yang School of Materials Science and Engineering Jiangsu UniversityZhenjiang212013China Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming650093China

Dual-phase heterointerface electrocatalysts(DPHE)constructed by oxygen reduction reaction(ORR)-and oxygen evolution reaction(OER)-active elements exhibit excellent bifunctional activity and long-term durability due to the abundant interface exposure and synergistic catalytic ***,low-dimensional N-doped graphene nanoribbons(N-GNRs)coupling with ultrathin CoO nanocomposites(N-GNRs/CoO)were controllably fabricated through a facile two-step approach using synthesized Co(OH)_2 nanosheet as CoO *** functional theory(DFT)calculations and experimental characterizations prove that the formation of interface between N-GNRs and CoO can induce local charge redistribution,contributing to the improvement of catalytic activity and *** optimal N-GNRs/CoO DPHE possesses hierarchically porous architectures and presents outstanding bifunctional activities with a small potential gap of 0.729 V between the potential at 10 mA·cm^(-2)for OER and the halfwave potential for ORR,which outperforms Pt/C+IrO_(2)and the majority of noble-metal-free bifunctional ***-and solid-state rechargeable Zn-air batteries assembled with N-GNRs/CoO as the cathode also display high peak power density and fantastic cycle stability,superior to that of benchmark Pt/C+IrO_(2)*** is anticipated to offer significant benefits toward high activity,stability and mechanical flexibility bifunctional oxygen electrocatalysts for rechargeable Zn-air batteries.

关键词： Interface engineering Graphene nanoribbons CoO Bifunctional electrocatalyst Zn-air batteries

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Matrine-loaded self-adhesive swelling microneedle for inflammation regulation to improve eczema treatment

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Marine Life Science & Technology 2024年第3期6卷 535-546页

作者： Jiale Shen Jiarui Wang Meng Wu Yan Shi Minhyeock lee Zhiguo Wang ming Kong College of Marine Life Sciences Ocean University of ChinaQingdao 266003China Department of Burn and Plastic Surgery the Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao 266021China Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841Republic of Korea

Eczema is a common chronic dermatological *** treatments exhibit limited efficacy due to fast drug release resulting in short-term *** of a new treatment strategy that enables sustained drug release and longterm maintenance on the skin surface is necessary.A self-adhesive swelling microneedle patch(SDSMNs)was designed and constructed using a two-step casting *** adhesive substrate was prepared by blending gelatin and dopamine via oxidation of NaIO4,so it could adhere onto the skin surface as well as withstand repeated bending movement without *** swelling needles were fabricated using polyvinyl alcohol(PVA)and polyvinylpyrrolidone(PVP),which could swell by absorbing interstitial fluid and release the drug in a controlled *** also showed desirable antibacterial activities toward *** and *** adhesive microneedles loaded with matrine(MAT-SDSMNs),an antiinflammatory Chinese medicine,dramatically relieved eczema symptoms through IL-17 mediated inflammation *** use of MAT-SDSMNs significantly decreased the infiltration of inflammation cells and level of inflammatory cytokines,reduced the skin thickness,and increased collagen deposition fraction compared with conventional ointment or subcutaneous *** results suggested that MAT-SDSMNs can improve eczema treatment by regulating the local inflammatory microenvironment,providing a simple,self-administered sustainable strategy for eczema treatment.

关键词： Self-adhesive swelling microneedle Eczema Matrine Inflammation regulation

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