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Shielding Effects on Dragload and Downdrag in a Pile Group

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Shielding Effects on Dragload and Downdrag in a Pile Group

Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

中国土木工程学会第九届土力学及岩土工程学术会议

作者： C.j.lee C.W.W.Ng Hong Kong University of sicence and Technology Hong Kong Hong Kong University of sicence and Technology Hong Kong

＜正＞ Shielding effects on dragload and downdrag in a pile group consisting of 5×5 piles at 2 . 5 D spacing were studied by carrying out a series of three-dimensional numerical parametric analyses, in which plastic soil slip at the pile - soil interface was considered. The investigation included the influence of location of piles in the group , surface loading, and interface friction coefficient on shielding effects . Insights into the reduction in dragload and downdrag due to the shielding effects are reported and discussed .

关键词： downdrag dragload pile group numerical analysis shielding effects soil slip soil/structure interaction

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Acta Pharmaceutica Sinica B 2020年第6期10卷 1106-1121页

作者： Yan Chen Chen Chen Xiaojuan Zhang Chuanchuan He Pengxuan Zhao Minsi Li Ting Fan Ruicong Yan Yao Lu Robert j.lee Muhammad Waseem Khan Muhammad Sarfraz Xiang Ma Tan Yang Guangya Xiang School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China College of Pharmacy the Ohio State UniversityColumbusOH 43210USA

Platinum-based chemotherapy is used for non-small cell lung cancer(NSCLC).However,it has side effects and minimum efficacy against lung cancer *** this study,platinum-curcumin complexes were loaded into pH and redox dual-responsive nanoparticles(denoted as Pt-CUR@PSPPN)to facilitate intracellular release and synergistic anti-cancer ***-CUR@PSPPN was prepared by a nano-precipitation method and had a diameter of^100 *** nanoparticles showed increased anticancer effects both in vivo and in *** addition,Pt-CUR@PSPPN blocked PI3K/AKT signal transduction pathway and inhibited MMP2 and VEGFR2,resulting in enhanced anti-metastatic ***,reduced side effects were also *** conclusion,Pt-CUR@PSPPN provided a novel and attractive therapeutic strategy for NSCLC.

关键词： Platinum Curcumin Complex Nanoparticles Non-small cell lung cancer Anti-metastasis Drug delivery

3-D bioprinting technologies in tissue engineering and regenerative medicine:Current and future trends

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Genes & Diseases 2017年第4期4卷 185-195页

作者： Elliot S.Bishop Sami Mostafa Mikhail Pakvasa Hue H.Luu Michael j.lee jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago MedicineChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Biomedical Engineering Department Northwestern UniversityEvanstonIL 60208USA Department of Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL 60616USA

Advances in three-dimensional(3D)printing have increased feasibility towards the synthesis of living *** as 3D bioprinting,this technology involves the precise layering of cells,biologic scaffolds,and growth factors with the goal of creating bioidentical tissue for a variety of *** successes have demonstrated distinct advantages over conventional tissue engineering *** surprisingly,there are current challenges to address before 3D bioprinting becomes clinically *** we provide an overview of 3D bioprinting technology and discuss key advances,clinical applications,and current *** 3D bioprinting is a relatively novel tissue engineering strategy,it holds great potential to play a key role in personalized medicine.

关键词： Additive manufacturing Bioprinting CAD/CAM 3D printing Tissue engineering

High Performance of Blue Light-emitting Diodes Based on a New Blue Dopant

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High Performance of Blue Light-emitting Diodes Based on a Ne...

The Metabolic Response of Arabidopsis Roots to Oxidative Stress is Distinct from that of Heterotrophic Cells in Culture and Highlights a Complex Relationship between the Levels of Transcripts, Metabolites, and Flux

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作者： j.H.Park j.H.Seo j.H.Kim H.j.lee K.H.lee S.S.Yoon Y.K.Kim Department of Information Display Hongik University Seoul121-791Korea Center for Organic Materials and Information DevicesHongik UniversitySeoul121-791Korea Center for Organic Materials and Information Devices Hongik University Seoul121-791Korea Department of Electronic EngineeringHongik UniversityHongik UniversitySeoul121-791Korea Deptartment of Chemistry Sungkyunkwan University Suwon440-746Korea

The characteristics of organic light-emitting diodes (OLEDs) using two kinds of hole transporting layers with various doping concentration of a new dopant material (Blue-1) were *** type of devices having various doping concentration (15 wt%,10 wt%,5 wt%) showed a different electroluminescent characteristics,which seemed to be due to the different hole mobility between the N,N′-diphenyl-N,N′-(2-napthyl)-(1,1′-phenyl)-4,4′-diamine (NPB) and the 4,4′,4″-Tris(N-(2-naphthyl)-N-phenyl-amino)-triphenylamine(2-TNATA).

关键词： Blue Light-emitting Diodes Hole-only Devices OLEDs

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Molecular Plant 2009年第3期2卷 390-406页

作者： Martin Lehmann Markus Schwarzlander Toshihiro Obata Supaart Sirikantaramas Meike Burow Carl Erik Olsen Takayuki Tohge Mark D. Fricker Birger Lindberg Moiler Alisdair R. Fernie lee j. Sweetlove Miriam Laxa Max-Planck Institute for Molecular Plant Physiology Am M0hlenberg 14476 Potsdam-Golm Germany Department of Plant Sciences University of Oxford South Parks Road Oxford OX1 3RB UK Plant Biochemistry Laboratory Department of Plant Biology and Biotechnology and VKR Research Centre for Pro-Active Plants University of Copenhagen 40 Thorvaldsensvei DK-1871 Frederiksberg C Copenhagen Denmark

Metabolic adjustments are a significant, but poorly understood, part of the response of plants to oxidative stress. In a previous study （Baxter et al., 2007）, the metabolic response of Arabidopsis cells in culture to induction of oxidative stress by menadione was characterized. An emergency survival strategy was uncovered in which anabolic primary metabolism was largely down-regulated in favour of catabolic and antioxidant metabolism. The response in whole plant tissues may be different and we have therefore investigated the response of Arabidopsis roots to menadione treatment, analyzing the transcriptome, metabolome and key metabolic fluxes with focus on primary as well as secondary metabolism. Using a redox-sensitive GFP, it was also shown that menadione causes redox perturbation, not just in the mitochondrion, but also in the cytosol and plastids of roots. In the first 30 min of treatment, the response was similar to the cell culture： there was a decrease in metabolites of the TCA cycle and amino acid biosynthesis and the transcriptomic response was dominated by up-regulation of DNA regulatory proteins. After 2 and 6 h of treatment, the response of the roots was different to the cell culture. Metabolite levels did not remain depressed, but instead recovered and, in the case of pyruvate, some amino acids and aliphatic glucosinolates showed a steady increase above control levels. However, no major changes in fluxes of central carbon metabolism were observed and metabolic transcripts changed largely independently of the corresponding metabolites. Together, the results suggest that root tissues can recover metabolic activity after oxidative inhibition and highlight potentially important roles for glycolysis and the oxidative pentose phosphate pathway.

关键词： Carbon metabolism oxidative and photo oxidative stress secondary metabolism phenylpropanoids and phenolics root biology Arabidopsis.

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Passing the Baton: Substrate Channelling in Respiratory Metabolism

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Research 2018年第1期2018卷 128-143页

作者： Alisdair R.Fernie Youjun Zhang lee j.Sweetlove Max-Planck-Institute of Molecular Plant Physiology Am Muhlenberg 114476 Potsdam-GolmGermany Center of Plant System Biology and Biotechnology 4000 PlovdivBulgaria Department of Plant Sciences University of OxfordSouth Parks RoadOxford OX13RBUK

Despite species-specifc diferences in the pathways of respiratory metabolism are remarkably conserved across the kingdoms of life with glycolysis,the tricarboxylic acid cycle,and mitochondrial electron transport chain representing the major components of the process in the vast majority of *** addition to being of critical importance in fueling life itself these pathways serve as interesting case studies for substrate channelling with research on this theme having been carried out for over 40 *** we provide a cross-kingdom review of the ample evidence for protein-protein interaction and enzyme assemblies within the three component pathways as well as describing the scarcer available evidence for substrate channelling itself.

关键词： life representing metabolism

Bioresorbable Vascular Scaffold in the Midportion of the Left Anterior Descending Artery for Cardiac Allograft Vasculopathy in a Cardiac Transplant Patient

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Cardiovascular Innovations and Applications 2018年第B7期3卷 227-231页

作者： Felicity j.lee Imran Shiekh Thach Nguyen Michael Nguyen Fiona Stanley Hospital Department of CardiologyMurdochWAAustralia Methodist Hospital Department of Cardiovascular ResearchMerrillville INUSA

In an era when cardiac transplant patients are surviving more immediate issues of rejection and infection,the prevalence of more chronic issues such as cardiac allograft vasculopathy(CAV)is *** case describes a man 20 years after cardiac transplant with his first presentation of *** myocardial infarction was diagnosed on the basis of symptoms and biochemical markers and on coronary angiography,and he was found to have a critical stenosis of the midportion of the left anterior descending *** was elected to treat this percutaneously with a fully bioresorbable vascular scaffold(BVS)because of the diffuse nature of the disease *** was successfully performed with optical coherence tomography *** use of BVS in CAV has not been well *** is one of few case reports describing the use of BVS in CAV.

关键词： Coronary artery disease

Characteristics and performance of Al-reinforced LiAlO2 matrices for MCFC

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Characteristics and performance of Al-reinforced LiAlO2 matr...