Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

作     者：Yan Chen Chen Chen Xiaojuan Zhang Chuanchuan He Pengxuan Zhao Minsi Li Ting Fan Ruicong Yan Yao Lu Robert J.Lee Muhammad Waseem Khan Muhammad Sarfraz Xiang Ma Tan Yang Guangya Xiang Yan Chen;Chen Chen;Xiaojuan Zhang;Chuanchuan He;Pengxuan Zhao;Minsi Li;Ting Fan;Ruicong Yan;Yao Lu;Robert J.Lee;Muhammad Waseem Khan;Muhammad Sarfraz;Xiang Ma;Tan Yang;Guangya Xiang

作者机构：School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China College of Pharmacythe Ohio State UniversityColumbusOH 43210USA 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2020年第10卷第6期

页      面：1106-1121页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Programs of the National Natural Science Foundation of China(Grant Nos.81673368 81603046 81703446 and 81973257) 

主　　题：Platinum Curcumin Complex Nanoparticles Non-small cell lung cancer Anti-metastasis Drug delivery 

摘      要：Platinum-based chemotherapy is used for non-small cell lung cancer(NSCLC).However,it has side effects and minimum efficacy against lung cancer *** this study,platinum-curcumin complexes were loaded into pH and redox dual-responsive nanoparticles(denoted as Pt-CUR@PSPPN)to facilitate intracellular release and synergistic anti-cancer ***-CUR@PSPPN was prepared by a nano-precipitation method and had a diameter of^100 *** nanoparticles showed increased anticancer effects both in vivo and in *** addition,Pt-CUR@PSPPN blocked PI3K/AKT signal transduction pathway and inhibited MMP2 and VEGFR2,resulting in enhanced anti-metastatic ***,reduced side effects were also *** conclusion,Pt-CUR@PSPPN provided a novel and attractive therapeutic strategy for NSCLC.