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The association of aromatase （CYP19） gene variants wil sperm concentration and motility

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Asian Journal of Andrology 2011年第2期13卷 292-297页

作者： leandros Lazaros Nectaria Xita Apostolos Kaponis Elissavet Hatzi Nicolaos Plachouras Nicolaos Sofikitis Konstantinos Zikopoulos Ioannis Georgiou Genetics and IVF Unit Department of Obstetrics and Gynaecology Medical School University of Ioannina Ioannina 45110 Greece Department of Endocrinology MedicalSchool University of Ioannina Ioannina 45110 Greece Department of Urology Medical School University of Ioannina Ioannina 45110 Greece

The irreversible transformation of androgens into oestrogens is catalysed by cytochrome P450 aromatase. In the present study, we explored the contribution of the （TTTA）n polymorphism in the aromatase gene （CYP19） to sperm concentration and motility. Ninety normozoospermic and 60 oligospermic men were examined during infertility examinations. DNA was extracted from spermatozoa, and the CYP19（TTTA）n polymorphism was genotyped by PCR. Genotype analysis revealed six CYP19（TTTA）n alleles with 7-12 repeats. The allelic distribution of the CYP19（TTTA）n polymorphism differed between normozoospermic and oligospermic men （P〈0.01）. Oligospermic men less frequently had long CYP19 alleles than did normozoospermic men （25 and 37.8%, respectively; P〈0.02）. The higher frequency of short CYP19alleles in oligospermic men compared to normozoospermic men （43.3 and 28.3%, respectively; P〈0.01） was primarily due to the distribution of the CYP19 （TTTA）7 allele. The CYP19 （TTTA）7 allele was associated with lower sperm concentration in normozoospermic men {P〈0.01） and in the total study population {P〈0.01）; it was also associated with lower sperm motility in normozoospermic men （P〈0.05） and in the total study population （P〈0.01）. In conclusion, the CYP19 （TTTA）7 allele probably impairs aromatase activity, which in turn alters aromatase and oestrogen levels in the testis, leading to decreased sperm concentration and motility. These findings support the significance of cytochrome P450 aromatase in human spermatogenesis and consequently in semen quality.

关键词： androgen male infertility oestrogen semen quality spermatogenesis

Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration

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Asian Journal of Andrology 2012年第5期14卷 778-783页

作者： leandros Lazaros Nectaria Xita Elissavet Hatzi Apostolos Kaponis Georgios Makrydimas Atsushi Takenaka Nikolaos Sofikitis Theodoros Stefos Konstantinos Zikopoulos Ioannis Georgiou Genetics and IVF Unit Department of Obstetrics and Gynecology Medical School University of Ioannina Ioannina 45110 Greece Department of Endocrinology Medica School University of Ioannina Ioannina 45110 Greece Department of Urology Tottori University Faculty of Medicine Totteri 683-8504 Japan Department of Urology Medical School University of Ioannina Ioannina 45110 Greece

Choline is a crucial factor in the regulation of sperm membrane structure and fluidity, and this nutrient plays an important role in the maturation and fertilizing capacity of spermatozoa. Transcripts of phosphatidylethanolamine N-methyltransferase （PEMT） and choline dehydrogenase （CHDH）, two basic enzymes of choline metabolism, have been observed in the human testis, demonstrating their gene expression in this tissue. In the present study, we explored the contribution of the PEMTand CHDHgene variants to sperm parameters. Two hundred oligospermic and 250 normozoospermic men were recruited. DNA was extracted from the spermatozoa, and the PEMT -774G〉C and CHDH ＋432G〉T polymorphisms were genotyped. The genotype distribution of the PEMT-774G〉C polymorphism did not differ between oligospermic and normozoospermic men. In contrast, in the case of the CHDH ＋432G〉T polymorphism, oligospermic men presented the CHDH432GIG genotype more frequently than normozoospermic men （62% vs. 42%, P〈0.001）. The PEMT774GIG genotype was associated with a higher sperm concentration compared to the PEMT774GIC and 774C/C genotypes in oligospermic men （12.5±5.6× 10^6 spermatozoa m1-1 vs. 8.3±5.2×10^6 spermatozoa m1-1, P〈0.002） and normozoospermic men （81.5±55.6×10^6 vs. 68.1±44.5×10^6 spermatozoa m1-1, P〈0.006）. In addition, the CHDH432G/G genotype was associated with higher sperm concentration compared to CHDH432G.T and 432T/T genotypes in oligospermic （11.8±5.1×10^6 vs. 7.8±5.3×10^6 spermatozoa m1-1, P〈0.003） and normozoospermic men （98.6±62.2×10^6 vs. 58.8±＋33.6×10^6 spermatozoa m1-1, P〉0.001）. In our series, the PEMT-774G〈C and CHDH ＋432G〈T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality.

关键词： choline dehydrogenase male infertility phosphatidylethanolamine N-methyltransferase phospholipids spermconcentration

A Triethyleneglycol C60 Mono-adduct Derivative for Efficient Electron Transport in Inverted Perovskite Solar Cells

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Chinese Journal of Chemistry 2023年第4期41卷 431-442页

作者： Azhar Fakharuddin Konstantina-Kalliopi Armadorou leandros P.Zorba Marinos Tountas Tobias Seewald Anastasia Soultati Polychronis Tsipas Emilia R.Schütz Nikolaos Tzoganakis Stylianos Panagiotakis Konstantina Yannakopoulou Athanasios Dimoulas Vassilis Psycharis Emmanuel Kymakis Abd Rashid bin Mohd Yusoff Konstantinos Aidinis Lukas Schmidt-Mende Georgios C.Vougioukalakis Mohammad Khaja Nazeeruddin Maria Vasilopoulou Department of Physics University of Konstanz78457 KonstanzGermany Institute of Nanoscience and Nanotechnology National Center for Scientific Research DemokritosAgia Paraskevi15341 AthensGreece Department of Chemistry National and Kapodistrian University of Athens15771 AthensGreece Department of Electrical&Computer Engineering Hellenic Mediterranean UniversityEstavromenosHeraklionGR-71410 CreteGreece Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)PohangGyeongbuk37673 Republic of Korea Department of Electrical and Computer Engineering Ajman UniversityP.O.Box 346AjmanUnited Arab Emirates Center of Medical and Bio-allied Health Sciences Research AjmanUnited Arab Emirates Institute of Chemical Sciences and Engineering École Polytechnique Fédérale de Lausanne(EPFL)Rue de l'Industrie 17CH-1951 SionSwitzerland

Inverted perovskite solar cells(PSCs)have attracted increasing attention in recent years owing to their low-temperature fabrication proces ***,they suffer from a limited number of electron transport materials available with[6,6]-phenyl C61 butyric acid methyl ester(PCBM)to be the most widely studied based on its appropriate energy levels and high electron *** low relative permittivity and aggregation tendency upon illumination of PCBM,however,compromises the solar cell efficiency whereas its modest hydrophobicity negatively impacts on the device *** electron transport materials with desired properties and appropriate degree of hydrophobicity are thus desirable for further developments in inverted ***,we synthesize a triethyleneglycol C60 mono-adduct derivative(termed as EPF03)and test it as a novel electron transport material to replace PCBM in inverted PSCs based on a quadruple cation(RbCsMAFA)*** also compare this derivative with two novel fullerenes decorated with two(EPF01)or one dodecyl(EPF02)long side *** latter two fail to perform efficiently in inverted PSCs whereas the former enabled a power conversion efficiency of 18.43%,which represents a 9%improvement compared to the reference device using PCBM(17.21%).The enhanced performance mainly stems from improved electron extraction and reduced recombination enabled by the insertion of the large relative permittivity amongst other properties of ***,our results indicate that triethylene glycol side chains can also passivate perovskite trap states,suppress ion migration and enhance photostability and long-term stability of EPF03 based perovskite solar cells.

关键词： Electron transport layer Defect passivation Biexponential trap flling Charge transfer Fullerenes

FROM DANGGUI LONGHUI WAN TO BIOACTIVE INDIRUBIN ANALOGUES

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 84-85页

作者： leandros A.Skaltsounis Department of Pharmacognosy and natural products chemistry University of Athens

Indirubin,indigo and isoindigo are the core representatives of a rather small category of bisindole alkaloids referred to as *** compounds are the coloured constituents of the natural dyes Indigo and the famous molluscan Tyrian purple,used throughout the centuries for textile *** contrast with Indigo dyes,the major constituents of molluscan purple dyes are

关键词： FROM DANGGUI LONGHUI WAN TO BIOACTIVE INDIRUBIN ANALOGUES

Plexiform Schwannoma: A Report of Two Unusual Cases, and a Review of the Literature

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Open Journal of Stomatology 2014年第4期4卷 174-178页

作者： Shabnum Ali leandros Vassiliou Philip Stenhouse Department of Oral and Maxillofacial Surgery Queen Mary’s Hospital Sidcup UK

Plexiform schwannoma is a benign tumour arising from the sheath of myelinated nerve fibres that may occur in any part of the body. It is very rare in the head and neck region and poses diagnostic challenges. Here we present two unusual cases. The first is about a fifteen-year-old boy with a large plexiform schwannoma in the right retro maxillary region, extending up to but not invading the orbit. Initial cytology reported it as a pleomorphic adenoma, but histological findings after excision confirmed it to be a benign plexiform schwannoma. A zygomatic osteotomy was required to excise the tumour in its entirety. The second reported case is about solitary lesion on the tongue of a 46-year-old Chinese man, clinically mimicking a mucocoele. This case report highlights the diagnostic challenges posed by plexiform schwannoma, and the role of imaging and cytopathology, as well as the importance of definitive histopathological analysis. It also describes the surgical management of these lesions, and provides a review of the literature, in particular of cases occurring in the head and neck region.

关键词： Plexiform Schwannoma Benign Nerve Sheath Tumour

Predictors of common bile duct lithiasis in laparoscopic era

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World Journal of Gastroenterology 2005年第21期11卷 3267-3272页

作者： George Sgourakis Georgia Dedemadi Athanasios Stamatelopoulos Emmanuel leandros Dionysius Voros Konstantinos Karaliotas 2nd Surgical Department of Korgialenio-Mpenakio Red Cross Hospital Athens Greece Surgical Department of Hippocration University Hospital of AthensGreece Surgical Department of Areteion University Hospital of Athens Greece

AIM: To analyze retrospectively the records of 294 conse-cutive patients operated upon for gallbladder stones, to determine the predictive factors of synchronous common bile duct (CBD) stones and validate prospectively the generated model. METHODS: The prognostic estimation of a biochemical test and ultrasonography alone to differentiate between the absence and presence of choledocholithiasis was assessed using receiver operating characteristics curve analysis. Multivariate analysis was employed using discriminant analysis for establishment of a best model. Prospective validation of the model was ***: Discriminant forward stepwise analysis disclosed that high values (≥ 2×normal) of SGOT, ALP, conjugated bilirubin and CBD diameter on ultrasound ≥ 10 mm were all prognostic factors of CBD lithiasis in univariate and multivariate analysis, P＜0.01. History was not included in the model. Prospective validation of the model was performed by multivariate analysis using Visual General Stepwise Regression. Positive predictive value,when considering all these predictors, was 93.3%, while the negative predictive value was 88.8%. Sensitivity of the model was 96.5% and specificity 80%.CONCLUSION: The above model can be objectively applied to predict the presence of CBD stones.

关键词：胆管结石症病理机制胆红素

Molecular markers(PECAM-1,ICAM-3,HLA-DR)determine prognosis in primary non-Hodgkin's gastric lymphoma patients

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World Journal of Gastroenterology 2006年第12期12卷 1924-1932页

作者： Alexander Darom Ilias P Gomatos Emmanuel leandros Emmu Chatzigianni Dimitris Panousopoulos Manousos M Konstadoulakis George Androulakis Laboratory of Surgical Research First Department of Propaedeutic SurgeryAthens Medical SchoolHippokration Hospital of Athens114 Q.Sofia Ave11527 AthensGreece

瞄准：与主要 non-Hodgkin 的胃的淋巴瘤在病人调查 PECAM-1， ICAM-3 和 HLA 医生抗原的预示的意义。方法：我们免疫组织化学地在 36 个 B 房间麦芽类型主要胃的淋巴瘤病人学习了 PECAM-1， ICAM-3 和 HLA 医生抗原表示。十非恶意并且... 详细信息

瞄准：与主要 non-Hodgkin 的胃的淋巴瘤在病人调查 PECAM-1， ICAM-3 和 HLA 医生抗原的预示的意义。方法：我们免疫组织化学地在 36 个 B 房间麦芽类型主要胃的淋巴瘤病人学习了 PECAM-1， ICAM-3 和 HLA 医生抗原表示。十非恶意并且十个健康胃的织物标本被用作控制。Clinicopathological 和幸存数据与染色的结果被相关。结果：HLA 医生抗原表示在 33 个胃的淋巴瘤病人(91.7%) 和 6 个非恶意的病人(54.5%) 被检测。PECAM-1 染色了 10 个病人(27.8%) 的肿瘤房间， 9 个病人(25%) 的 endothelial 并且煽动性有良性的胃的疾病的 4 个病人(40%) 渗入。ICAM-3 表示在 17 个病人(47.2%) 的肿瘤房间上被观察，当 5 个非恶意的病人(50%) 被染色时积极也。任何一个都没为任何学习的基因健康控制被染色。在里面多，变量分析， HLA 医生抗原和 PECAM-1 被证明是与联系的统计上重要的独立预示的因素一赞成并且不利预后分别地(P=0.009 和 P=0.003 ) 。在 univariate 分析， PECAM-1 (+)/ICAM-3 (-) 和 HLA 医生(-)/ICAM-3 (-) 病人与确切相反的基因表示模式与那些相比展出了显著地减少的全面幸存(P=0.0041 和 P=0.0091，分别地) 。是 HLA 医生(+)/ICAM-3 (+)/PECAM-1 (-)(n=8 ) 的那些病人让显著地更高的幸存与这个组(n=24 )(P=0.0289 ) 的其余部分相比评价。结论：PECAM-1， ICAM-3 和 HLA 医生分别地是肿瘤扩大潜力和主人免疫者监视的代表性的标记。他们的联合使用可以帮助我们识别能得益于更好攻击的治疗学的协议的高风险的病人。

关键词：分子标记 PECAM-1 ICAM-3 HLA-DR 疾病预防非霍奇金胃病胃淋巴瘤