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High density lipoprotein as a therapeutic target:Focus on its functionality

BIOCELL 2023年第11期47卷 2361-2383页

作者： leonardo gómez rosso BELÉN DAVICO EZEQUIEL LOZANO CHIAPPE WALTER TETZLAFF LAURA BOERO FERNANDO BRITES MAXIMILIANO MARTÍN School of Pharmacy and Biochemistry Laboratory of Lipids and AtherosclerosisDepartment of Clinical BiochemistryUniversity of Buenos AiresNational Scientific and Technical Research Council(CONICET)Buenos Aires1113Argentina

Cardiovascular diseases(CVDs)are the leading cause of death *** are a group of disorders of the heart and blood vessels and include coronary heart disease,cerebrovascular disease and rheumatic heart disease among other *** are multiple independent risk factors for CVD,including hypertension,age,smoking,insulin resistance,elevated low-density lipoprotein cholesterol(LDL-C)levels,and triglyceride ***-C levels have traditionally been the target for therapies aimed at reducing CVD *** density lipoprotein(HDL)constitutes the only lipoprotein fraction with atheroprotective *** HDL-targeted therapies have focused on increasing HDL-C ***,clinical trials have shown that raising HDL-C with niacin failed to achieve CVD reduction.A possible explanation for these findings is that these drugs could interfere with lipid metabolism and cause alterations in HDL structure and composition,leading to loss of *** a result,targeting HDL-C levels would be insufficient to achieve CVD risk reduction,making HDL functionality a more desirable focus for HDL-directed *** are several drugs which show the potential to improve HDL *** drugs include molecules already approved for human use,such as statins and niacin,and particularly,compounds currently undergoing development such as apolipoprotein A-I mimetics and reconstituted HDL *** therapies show promising potential to improve HDL functionality *** therapeutic strategies should incorporate HDL functionality as a main target of interest.

关键词： HDL Cholesterol efflux rHDL Apo A-I mimetics Statins Paraoxonase

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Adipocyte MED23 regulates adipose development and liver growth hormone resistance via NAMPT-NAD+-STAT5-IgF1 axis in mice

Adipocyte MED23 regulates adipose development and liver grow...

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第三届中国生物物理学会代谢生物学分会学术研讨会

作者： Zhichao Wang Qijiang Li leonardo gomez rosso gang Wang 复旦大学生命科学学院 State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyUniversity of Chinese Academy of Sciences School of Life Sciences and Zhongshan Hospital Fudan University

＜正＞Adipose tissue can act as an endocrine organ in addition to be a simple storage depot,thereby capable of cross-talking with other peripheral ***,the sophisticated functional crosstalk and the underlying mechanisms are not fully ***,we characterized the mice with adipocyte-specific deletion of Mediator MED23,a transcription cofactor known to be critical for adipogenesis in *** adipocyte-specific Med23 knockout mice show impaired adipose

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