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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： h.i Yang Nan Mo le Tong Jianh.ng Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang Sch.ol of Ph.rmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orth.pedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Path.logy Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research.Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

Th. development of neurodegenerative diseases is closely related to th. disruption of central nervous system ***,as innate immune cells,play important roles in th. maintenance of central nervous system h.meostasis,injury response,and neurodegenerative *** h.s been considered a metabolic waste product,but recent studies are revealing ever more of th. ph.siological functions of *** is an important path.ay in lactate function and is involved in glycolysis-related functions,macroph.ge polarization,neuromodulation,and angiogenesis and h.s also been implicated in th. development of various *** review provides an overview of th. lactate metabolic and h.meostatic regulatory processes involved in microglia lactylation,h.stone versus non-h.stone lactylation,and th.rapeutic approach.s targeting ***,we summarize th. current research.on microglia lactylation in central nervous system diseases.A deeper understanding of th. metabolic regulatory mech.nisms of microglia lactylation will provide more options for th. treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Mutual regulation of microglia and astrocytes after Gas6 inh.bits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Ch.n Xiaolin Zeng le Wang Wenwu Zh.ng Gang Li Xing Ch.ng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orth.pedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are th. main reasons for th. difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in th. spinal cord injury micro-environment and sh.re a close ***,th. mech.nisms involved remain *** th.s study,we found th.t after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory ph.notypes(MG1 and MG3),wh.le resting astrocytes were polarized into reactive and scar-forming *** expression of growth.arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments sh.wed th.t Gas6 h.d negative effects on th. polarization of reactive astrocytes and pro-inflammatory microglia,and even inh.bited th. cross-regulation between *** furth.r demonstrated th.t Gas6 can inh.bit th. polarization of reactive astrocytes by suppressing th. activation of th. Yes-associated protein signaling ***,in turn,inh.bited th. polarization of pro-inflammatory microglia by suppressing th. activation of th. nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments sh.wed th.t Gas6 inh.bited th. polarization of pro-inflammatory microglia and reactive astrocytes in th. injured spinal cord,th.reby promoting tissue repair and motor function ***,Gas6 may play a role in th. treatment of spinal cord *** can inh.bit th. inflammatory path.ay of microglia and polarization of astrocytes,attenuate th. interaction between microglia and astrocytes in th. inflammatory microenvironment,and th.reby alleviate local inflammation and reduce scar formation in th. spinal cord.

关键词： astrocytes Axl cell polarization Gas6 h.ppo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Landslide Susceptibility Mapping Using RBFN-Based Ensemble Mach.ne learning Models

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 467-500页

作者： Landslide Susceptibility Mapping Using RBFN-Based Ensemble Mach.ne learning Models Duc-Dam Nguyen Nguyen Viet Tiep Quynh.Anh.Th. Bui h.ep Van le Indra Prakash.Romulus Costach. Manish.Pandey Binh.Th.i Ph.m Faculty of Civil Engineering University of Transport TechnologyThanh XuanHa Noi100000Vietnam Faculty of h.draulic Engineering Hanoi University of Civil EngineeringHa Noi100000Vietnam DDG(R)Geological Survey of India Gandhinagar382010India Research.Institute of th. University of Buch.rest Bucharest050663Romania National Institute of h.drology and Water Management Bucharest013686Romania Department of Civil Engineering Transilvania University of BrasovBrasov500152Romania Danube Delta National Institute for Research.and Development Tulcea820112Romania Marwadi University Research.Center(MURC) Marwadi UniversityRajkotGujaratBharat360003India Department of Civil Engineering Faculty of Engineering&TechnologyMarwadi UniversityRajkotGujaratBharat360003India

Th.s study was aimed to prepare landslide susceptibility maps for th. Pith.ragarh.district in Uttarakh.nd,India,using advanced ensemble models th.t combined Radial Basis Function Networks(RBFN)with.th.ee ensemble learning tech.iques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).Th.s combination resulted in th.ee distinct ensemble models:DG-RBFN,MB-RBFN,and ***,a traditional weigh.ed meth.d,Information Value(IV),and a bench.ark mach.ne learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and *** models were developed using ten landslide conditioning factors,wh.ch.included slope,aspect,elevation,curvature,land cover,geomorph.logy,overburden depth.lith.logy,distance to rivers and distance to *** factors were instrumental in predicting th. output variable,wh.ch.was th. probability of landslide *** analysis of th. models’performance indicated th.t th. DG-RBFN model,with.an Area Under ROC Curve(AUC)of 0.931,outperformed th. oth.r *** AB-RBFN model ach.eved an AUC of 0.929,th. MB-RBFN model h.d an AUC of 0.913,and th. MLP model recorded an AUC of *** results suggest th.t th. advanced ensemble ML model DG-RBFN was more accurate th.n traditional statistical model,single MLP model,and oth.r ensemble models in preparing trustworth. landslide susceptibility maps,th.reby enh.ncing land use planning and decision-making.

关键词： Landslide susceptibility map spatial analysis ensemble modelling information values(IV)

Emotional Vietnamese Speech.Synth.sis Using Style-Transfer learning

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Computer Systems Science & Engineering 2023年第2期44卷 1263-1278页

作者： Th.nh.X.le An T.le Quang h.Nguyen Sch.ol of Information and Communication Tech.ology Hanoi University of Science and TechnologyHanoi10000Vietnam

In recent years,speech.synth.sis systems h.ve allowed for th. produc-tion of very h.gh.quality ***,research.in th.s domain is now turning to th. problem of integrating emotions into ***,th. meth.d of con-structing a speech.synth.sizer for each.emotion h.s some ***,th.s meth.d often requires an emotional-speech.data set with.many *** data sets are very time-intensive and labor-intensive to ***,training each.of th.se models requires computers with.large computational capabilities and a lot of effort and time for model *** addition,each.model for each.emotion failed to take advantage of data sets of oth.r *** th.s paper,we propose a new meth.d to synth.size emotional speech.in wh.ch.th. latent expressions of emotions are learned from a small data set of professional actors th.ough.a Flow-tron *** addition,we provide a new meth.d to build a speech.corpus th.t is scalable and wh.se quality is easy to ***,to produce a h.gh.quality speech.synth.sis model,we used th.s data set to train th. Tacotron 2 *** used it as a pre-trained model to train th. Flowtron *** applied th.s meth.d to synth.size Vietnamese speech.with.sadness and *** opi-nion score(MOS)assessment results sh.w th.t MOS is 3.61 for sadness and 3.95 for *** conclusion,th. proposed meth.d proves to be more effec-tive for a h.gh.degree of automation and fast emotional sentence generation,using a small emotional-speech.data set.

关键词： Emotional speech.synth.sis ﬂowtron speech.synth.sis style transfer vietnamese speech

Mach.ne learning based models for predicting compressive strength.of geopolymer concrete

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1028-1049页

作者： Quang-h.y le Duy-h.ng NGUYEN Th.nh.SANG-TO Samir Kh.TIR h.ang le-MINh.Amir h.GANDOMI Th.nh.CUONG-le Center for Engineering Application and Tech.ology Solutions Ho Chi Minh City Open UniversityHo Chi Minh 700000Vietnam Institute of Civil Engineering Ho Chi Minh City University of TransportHo Chi Minh 700000Vietnam Faculty of Engineering&Information Tech.ology University of Technology SydneyUltimoNSW 2007Australia

Recently,great attention h.s been paid to geopolymer concrete due to its advantageous mech.nical and environmentally friendly *** effort h.s been made in experimental studies to advance th. understanding of geopolymer concrete,in wh.ch.compressive strength.is one of th. most important *** facilitate engineering work on th. material,an efficient predicting model is *** th.s study,th.ee mach.ne learning(ML)-based models,namely deep neural network(DNN),K-nearest neigh.ors(KNN),and support vector mach.nes(SVM),are developed for forecasting th. compressive strength.of th. geopolymer concrete.A total of 375 experimental samples are collected from th. literature to build a database for th. development of th. predicting models.A careful procedure for data preprocessing is implemented,by wh.ch.outliers are examined and removed from th. database and input variables are standardized before feeding to th. fitting *** standard K-fold cross-validation approach.is applied for evaluating th. performance of th. models so th.t overfitting status is well managed,th.s th. generalizability of th. models is *** effectiveness of th. models is assessed via statistical metrics including root mean squared error(RMSE),mean absolute error(MAE),correlation coefficient(R),and th. recently proposed performance index(PI).Th. basic mean square error(MSE)is used as th. loss function to be minimized during th. model fitting *** th.ee ML-based models are successfully developed for estimating th. compressive strength.for wh.ch.good correlations between th. predicted and th. true values are obtained for DNN,KNN,and *** numerical results suggest th.t th. DNN model generally outperforms th. oth.r two models.

关键词： geopolymer concrete compressive strength.prediction mach.ne-learning based model deep neural network K-nearest neigh.or support vector mach.nes

A reproducible and sensitive meth.d for generating h.gh.quality transcriptomes from single wh.tefly salivary glands and oth.r low-input tissues

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Insect Science 2022年第5期29卷 1318-1328页

作者： Marco Gebiola Brandon h.le Kerry EMauck Department of Entomology University of California RiversideRiversideCalifornia Department of Botany and Plant Sciences University of California RiversideRiversideCalifornia Institute of Integrative Genome Biology University of California RiversideRiversideCaliforniaUSA

Transcriptomic studies are an important tool for understanding th. molecular path.ays underlying h.st plant use by agricultural pests,including vectors of damaging plant *** far,bulk RNA-Seq h.s been th. main approach.for non-model *** meth.d relies on pooling large numbers of wh.le organisms or h.ndreds of individually dissected *** latter approach.is logistically ch.llenging,may introduce artifacts of h.ndling and storage,and is not compatible with.biological ***,we tested an approach.to generate transcriptomes of individual salivary glands and oth.r low-input body tissues from wh.teflies(Bemisia tabaci MEAM1),wh.ch.are major vectors of plant *** comparing our outputs to publish.d bulk RNA-Seq datasets for wh.le wh.tefly bodies and pools of salivary glands,we demonstrate th.t th.s approach.recovers similar numbers of transcripts relative to bulk RNA-Seq in a tissue-specific manner,and for some metrics,exceeds performance of bulk tissue *** generated from individual salivary glands also yielded additional novel transcripts not identified in pooled salivary gland datasets,and h.d h.ndreds of enrich.d transcripts wh.n compared with.wh.le h.ad ***,our study demonstrates th.t it is feasible to produce h.gh.quality,replicated transcriptomes of wh.tefly salivary glands and oth.r low-input *** anticipate th.t our approach.will expand h.poth.sis-driven research.on salivary glands of wh.teflies and oth.r h.miptera,th.s enabling novel control strategies to disrupt feeding and virus transmission.

关键词： Aleyrodidae Bemisia tabaci bulk RNA-Seq insect vectors low-input RNA-Seq plant path.gens

Math.matical modeling and numerical computation of th. effective interfacial conditions for Stokes flow on an arbitrarily rough.solid surface

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Applied Math.matics and Mech.nics(English.Edition) 2021年第5期42卷 721-746页

作者： A.T.TRAN h.le QUANG Q.C.h. D.h.NGUYEN Research.and Application Center for Tech.ology in Civil Engineering University of Transport and CommunicationsHanoi 10000Vietnam Laboratoire Modelisation et Simulation Multi-Ech.lle Unite Mixte de Recherche 8208Centre National de la Recherche ScientifiqueUniversite Gustave EiffelMarne-la-Vallee F-77454France Sch.ol of Mech.nical Engineering Southwest Jiaotong UniversityChengdu 610031China

Th. present work is concerned with.a two-dimensional(2D)Stokes flow th.ough.a ch.nnel bounded by two parallel solid *** distance between th. walls may be arbitrary,and th. surface of one of th. walls can be arbitrarily *** main objective of th.s work consists in h.mogenizing th. h.terogeneous interface between th. rough.wall and fluid so as to obtain an equivalent smooth.slippery fluid/solid interface ch.racterized by an effective slip *** solve th. corresponding problem,two efficient numerical approach.s are elaborated on th. basis of th. meth.d of fundamental solution(MFS)and th. boundary element meth.ds(BEMs).Th.y are applied to different cases wh.re th. fluid/solid interface is periodically or randomly *** results obtained by th. proposed two meth.ds are compared with.th.se given by th. finite element meth.d and some relevant ones reported in th. *** comparison sh.ws th.t th. two proposed meth.ds are particularly efficient and accurate.

关键词： effective slip length meth.d of fundamental solution(MFS) boundary element meth.d(BEM) Stokeslet micro-ch.nnel fluid/solid interface

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Emerging progress: ph.toch.mical transformation of nitroso compounds

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Science Ch.na Ch.mistry 2025年第1期 118-133页

作者： Ze-le Ch.n Qiang-Qiang Li Armido Studer Jun Xuan Anh.i Province Key Laboratory of Ch.mistry for Inorganic/Organic h.brid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch.Ch.misch.s Institut Universitat Münster

Nitroso compounds h.ve emerged as h.gh.y valuable reaction partners or reagents in organic synth.sis due to th.ir rich.*** versatile profile of th.se compounds allows th.m to function as electroph.les, nucleoph.les, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress h.s been made in h.rnessing ph.toch.mical reactions with.nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites h.ve received significant attention for th.ir ability to introduce NO moieties into complex molecules th.t are oth.rwise difficult to access. In th.s review, we provide an overview of th. recent advancements in th. visible ligh.-induced conversion of nitroso compounds, with.particular emph.sis on th.ir role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

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A novel sch.me for ultrash.rt terah.rtz pulse generation over a gapless wide spectral range:Raman-resonance-enh.nced four-wave mixing

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Ligh.(Science & Applications) 2023年第2期12卷 232-238页

作者： Jiaming le Yudan Su Ch.ansh.n Tian A.h.Kung Y.Ron Sh.n Department of Ph.sics State Key Laboratory of Surface Physics and Key Laboratory of Micro-and Nano-Photonic Structure(MOE)Fudan UniversityShanghai 200433China Department of Ph.sics University of CaliforniaBerkeleyCA 94720USA Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

Ultrash.rt energetic terah.rtz(Th.)pulses h.ve created an exciting new area of research.on ligh. interactions with.*** material studies in small laboratories,widely tunable femtosecond Th. pulses with.peak field strength.close to MV cm-1 are ***,th.y can be largely acquired by optical rectification and difference frequency generation in crystals with.ut inversion *** describe in th.s paper a novel sch.me of Th. pulse generation with.no frequency tuning gap based on Raman-resonance-enh.nced four-wave mixing in centrosymmetric media,particularly *** sh.w th.t we could generate h.gh.y stable,few-cycle pulses with.near-Gaussian spatial and temporal profiles and carrier frequency tunable from 5 to>2o *** h.d a stable and controllable carrier-envelop ph.se and carried~15 nJ energy per pulse at 10 Th.(with.a peak field strength.of~1 MV cm^(-1)at focus)from a O.5-mm-th.ck *** measured Th. pulse ch.racteristics agreed well with.th.oretical *** merits of th. sch.me are discussed,including th. possibility of improving th. Th. output energy to a much.h.gh.r level.

关键词： pulse ultrash.rt tuning