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Response of the sensorimotor cortex of cerebral palsy rats receiving transplantation of vascular endothelial growth factor 165-transfected neural stem cells

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Neural Regeneration Research 2014年第19期9卷 1763-1769页

作者： Jielu Tan Xiangrong zheng Shanshan Zhang Yujia Yang Xia Wang Xiaohe Yu le Zhong Department of Pediatrics Xiangya HospitalCentral South University

Neural stem cells are characterized by the ability to differentiate and stably express exogenous ge- nes. Vascular endothelial growth factor plays a role in protecting local blood vessels and neurons of newborn rats with hypoxic-ischemic encephalopathy. Transplantation of vascular endothelial growth factor-transfected neural stem cells may be neuroprotective in rats with cerebral palsy. In this study, 7-day-old Sprague-Dawley rats were divided into five groups：（1） sham operation （control）, （2） cerebral palsy model alone or with （3） phosphate-buffered saline, （4） vascular en- dothelial growth factor 165 ＋ neural stem cells, or （5） neural stem cells alone. The cerebral palsy model was established by ligating the left common carotid artery followed by exposure to hypox- ia. Phosphate-buffered saline, vascular endothelial growth factor ＋ neural stem cells, and neural stem cells alone were administered into the sensorimotor cortex using the stereotaxic instrument and microsyringe. After transplantation, the radial-arm water maze test and holding test were performed. Immunohistochemistry for vascular endothelial growth factor and histology using hematoxylin-eosin were performed on cerebral cortex. Results revealed that the number of vas- cular endothelial growth factor-positive cells in cerebral palsy rats transplanted with vascular endothelial growth factor-transfected neural stem cells was increased, the time for finding water and the finding repetitions were reduced, the holding time was prolonged, and the degree of cell degeneration or necrosis was reduced. These findings indicate that the transplantation of vascu- lar endothelial growth factor-transfected neural stem cells alleviates brain damage and cognitive deficits, and is neuroprotective in neonatal rats with hypoxia ischemic-mediated cerebral palsy.

关键词： nerve regeneration vascular endothelial growth factor neural stem cells cerebral palsy animal model transplantation neuroprotection NSFC grant neural regeneration

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Estimation of lunar titanium content: Based on absorption features of Chang’E-1 interference imaging spectrometer (ⅡM)

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Science China(Physics,Mechanics & Astronomy) 2010年第12期53卷 2136-2144页

作者： LIU FuJiang QIAO le LIU zheng YANG Rong SHI JinPing ZHANG Ying WU WeiLong Faculty of Information Engineering China University of GeosciencesWuhan 430074China

Two linear regression models based on absorption features extracted from CE-1 IIM image data are presented to discuss the relationship between absorption features and titanium content. We computed five absorption parameters (Full Wave at Half Maximum (FWHM), absorption position, absorption area, absorption depth and absorption asymmetry) of the spectra collected at Apollo 17 landing sites to build two regression models, one with FWHM and the other without FWHM due to the low relation coefficient between FWHM and Ti content. Finally Ti content measured from Apollo 17 samples and Apollo 16 samples was used to test the accuracy. The results show that the predicted values of the model with FWHM have many singular values and the result of model without FWHM is more stable. The two models are relatively accurate for high-Ti districts, while seem inexact and disable for low-Ti districts.

关键词： titanium content linear regression absorption features Moon Chang’E-1

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Impact of climate simulation resolutions on future energy system reliability assessment:A Texas case study

iEnergy

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iEnergy 2023年第3期2卷 222-230页

作者： Xiangtian zheng le Xie Kiyeob lee Dan Fu Jiahan Wu Ping Chang Department of Electrical and Computer Engineering Texas A&M UniversityCollege StationTX 77843USA Texas A&M Energy Institute Texas A&M UniversityCollege StationTX 77843USA Department of Oceangraphy Texas A&M UniversityCollege StationTX 77843USA

The reliability of energy systems is strongly influenced by the prevailing climate *** the increasing prevalence of renewable energy sources,the interdependence between energy and climate systems has become even *** study examines the impact of different spatial resolutions in climate modeling on energy grid reliability assessment,with the Texas interconnection between 2033 and 2043 serving as a pilot case *** preliminary findings indicate that while low-resolution climate simulations can provide a rough estimate of system reliability,high-resolution simulations can provide more informative assessment of low-adequacy extreme ***,both high-and low-resolution assessments suggest the need to prepare for severe blackout events in winter due to extremely low temperatures.

关键词： High-resolution climate model power system reliability resource adequacy

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Different aspects of cognitive function in adult patients with moyamoya disease and its clinical subtypes

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Stroke & Vascular Neurology 2020年第1期5卷 86-96页

作者： Zhiyong Shi Yu-Jie Wen zheng Huang le-Bao Yu Dong Zhang Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders&Beijing Institute for Brain Disorders Center of Schizophrenia Beijing Anding HospitalCapital Medical UniversityBeijing100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing100069China Department of Neurosurgery Xiangya HospitalXiangya Hospital Central South UniversityChangshaChina

Objective Although a few reports suggested that cognitive function impairment could be found in adult patients with moyamoya disease(MMD),there were still many aspects that are *** aim of our study was to assess the cognitive function of adult patients with MMD and its clinical *** 49 patients with MMD and 23 healthy controls were asked to take cognitive function *** function tests included IQ,prospective memory(PM),immediate memory(IM),verbal fluency(VF),visual breadth,attention,retrospective memory(RM),Stroop test,Wisconsin Card Sorting Test,Trail-Making Test Part A(TMT-A)and Continuous Performance Test(CPT).Independent t-analysis,one-way analysis of variance and Pearson correlation were used to seek for differences between subgroups and the correlation between cognitive *** Compared with healthy controls,adult patients with MMD had a comprehensive cognitive impairment,including IQ,PM,VF,attention,RM,Stroop,CPT and TMT-A,with more serious impairment in PM and *** and RM were separated,indicating that they were independent of each *** of attention was significantly different from healthy *** patients were better than male patients,where significant differences in PM,IM,Stroop and WCST could be *** haemorrhagic patients exhibited poorer in the dimension of PM and RM than the *** headache subtype exhibited poorer than healthy ***,RM,attention and executive function were moderately correlated with each *** Adult patients with MMD had a wide range of cognitive impairment with more serious impairment in memory and *** in cognitive function existed between the different subtypes of adult MMD.

关键词： patients clinical function

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Application of Delayed Surgical Managements in Patients with Stensen＇s Duct Injury

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Current Medical Science 2018年第3期38卷 519-523页

作者： Chuan-yu HU zheng-jun SHANG Xu QIN le-nan SHAO Department of Oral and Maxillofacial-Head and Neck Oncology School and Hospital of Stomatology Wuhan UniversityWuhan 430060 China Center of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China

The study aimed to retrospectively evaluate surgical treatment outcomes after delayed parotid gland and duct injuries. Nine patients subjected to parotid gland and duct injuries with l- to 3-month treatment delay were retrospectively evaluated with special reference of etiology, past medical history, and injury location. Conservative treatment, microsurgical anastomosis, and diversion of salivary flow or ligation were chosen for delayed parotid gland and duct injuries concerning to their site of injury, time of repair and procedures. Assistant treatment as pressure dressing was adopted thereafter. All patients experienced an uneventful recovery at the time of finalizing the study. Two patients received Stensen＇s duct ligation, 5 received microsurgical anastomosis and 2 accepted salivary flow diversion for 5 patients with sialoceles and 4 patients with fistulas, and no re-occurrence was found. Facial paralysis occurred after surgery in 4 patients, and 3 of them recovered after the nerve nutrition treatment. Our study suggested that appropriate surgical treatment is efficient for the re-establishment of the tissue function and facial aesthetic for delayed injury of the parotid and its duct.

关键词： Stensen's duct ureteral catheter salivary fistula sialocele surgical management

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Effects of tillage practices on nutrient loss and soybean growth in red-soil slope farmland

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International Soil and Water Conservation Research 2013年第3期1卷 49-55页

作者： Yang Jie zheng Haijin Chen Xiaoan Shen le Jiangxi Institute of Soil and Water Conservation Jiangxi Provincial Key Laboratory of Soil Erosion and PreventionNanchangChina

Field experiments were conducted to examine the effect of tillage practices on sediment and nutrient loss and soybean growth under natural rainfall *** tillage practices were applied:downslope ridge(check),downslope ridge+contour living hedgerow,and cross *** ridge tillage reduced surface runoff by 69%and sediment yield by 86%,compared to the check *** downslope ridge with a contour living hedgerow reduced surface runoff by 24%and sediment yield by 53%.Additionally,compared to the check plot,nutrient losses carried by runoff were reduced by over 68%and that carried in the sediment was reduced more than 85%in the cross ridge *** losses in runoff were reduced by 20%to 30%in the downslope ridge and contour living hedgerow plot and those carried in the sediment were reduced by 44%to 57%.Cross ridge tillage soybean yields exceeded those of the downslope ridge and downslope ridge+contour living hedgerow treatments by 16%-18%.Cross ridge tillage could contribute to the prevention sediment and nutrient loss and could improve crop yield,and thus it is recommended to be applied to mild slopes in the red soil region.

关键词： Red soil Slope farmland Tillage practices Nutrient loss Crop growth

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β-环糊精与系列无机盐分子-离子加合物的粉末X射线衍射分析(英文)

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物理化学学报 2010年第7期26卷 1837-1841页

作者：党政宋乐新中国科学技术大学高分子科学与工程学系中国科学院软物质化学重点实验室合肥230026

糖类物质和无机盐之间的分子-离子相互作用无论是在生物物理学还是在生物化学方面都有很重要的意义.本文利用粉末X射线衍射法(PXRD)来考察β-环糊精(β-CD)与一系列无机盐加合物之间的分子-离子相互作用.结果显示,同系无机盐与β-CD加... 详细信息

糖类物质和无机盐之间的分子-离子相互作用无论是在生物物理学还是在生物化学方面都有很重要的意义.本文利用粉末X射线衍射法(PXRD)来考察β-环糊精(β-CD)与一系列无机盐加合物之间的分子-离子相互作用.结果显示,同系无机盐与β-CD加合物的PXRD谱之间存在着微妙的差异性.这些PXRD谱主要反映β-CD的堆积方式,因此,它们的差异性揭示了分子-离子相互作用的多样性与复杂性.造成PXRD谱差异性的影响因素包括制备条件、阴离子和阳离子的性质、离子电荷等.由糖和盐之间的分子-离子相互作用所诱导的结晶行为多样性将为碳水化合物在生物物理、分子生物学、临床医学、纳米科学与技术等方面的学术与应用研究提供重要的启示.

关键词： β-环糊精加合物分子-离子相互作用无机盐粉末X射线衍射

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TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts

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Neural Regeneration Research 2019年第10期14卷 1765-1771页

作者： Mei-Ge zheng Wen-Yuan Sui Zhen-Dan He Yan Liu Yu-Lin Huang Shu-Hua Mu xin-Zhong Xu Ji-Sen Zhang Jun-le Qu Jian Zhang Dong Wang Department of Orthopedics The Seventh Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedics The Second Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina School of Medicine Shenzhen UniversityShenzhenGuangdong ProvinceChina Department of Scientific Research The Seventh Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Psychology & Social College of Shenzhen University ShenzhenGuangdong ProvinceChina Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhenGuangdong ProvinceChina

We previously demonstrated that overexpression of tropomyosin receptor kinase A(TrkA)promotes the survival and Schwann celllike differentiation of bone marrow stromal stem cells in nerve grafts,thereby enhancing the regeneration and functional recovery of the peripheral *** the present study,we investigated the molecular mechanisms underlying the neuroprotective effects of TrkA in bone marrow stromal stem cells seeded into nerve *** marrow stromal stem cells from Sprague-Dawley rats were infected with recombinant lentivirus vector expressing rat TrkA,TrkA-shRNA or the respective *** cells were then seeded into allogeneic rat acellular nerve allografts for bridging a 1-cm right sciatic nerve ***,8 weeks after surgery,hematoxylin and eosin staining showed that compared with the control groups,the cells and fibers in the TrkA overexpressing group were more densely and uniformly arranged,whereas they were relatively sparse and arranged in a disordered manner in the TrkA-shRNA *** blot assay showed that compared with the control groups,the TrkA overexpressing group had higher expression of the myelin marker,myelin basic protein and the axonal marker neurofilament *** TrkA overexpressing group also had higher levels of various signaling molecules,including TrkA,pTrkA(Tyr490),extracellular signal-regulated kinases 1/2(Erkl/2),pErk1/2(Thr202/Tyr204),and the anti-apoptotic proteins Bcl-2 and *** contrast,these proteins were downregulated,while the pro-apoptotic factors Bax and Bad were upregulated,in the TrkA-shRNA *** levels of the TrkA effectors Akt and pAkt(Ser473)were not different among the *** results suggest that TrkA enhances the survival and regenerative capacity of bone marrow stromal stem cells through upregulation of the Erk/Bcl-2 *** procedures were approved by the Animal Ethical and Welfare Committee of Shenzhen University,China in December 2014(approval ***-2014-001219).

关键词： nerve regeneration bone marrow stromal stem cells tropomyosin receptor kinase A receptor lentiviral vector shRNA extracellular signal-regulated protein kinases 1/2 Bcl-2 nerve grafts peripheral nerve regeneration survival neural regeneration

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Incidence of congenital heart diseases in Chinese children with non-syndromic congenital blepharoptosis:a prospective observational study of 1053 patients

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World Journal of Pediatrics 2020年第4期16卷 411-415页

作者： le-Feng Zeng zheng-De Tang Jun Gu Chang-Qian Wang Hui-Li Zhang Department of Cardiology Shanghai Ninth People’s HospitalShanghai Jiaotong University School of Medicine639 Zhizaoju RoadShanghai200011China

Background Congenital blepharoptosis(CBP)may be part of a large spectrum of birth defects presenting with other ocular or systemic ***,the aim of the study was to investigate the incidence of congenital heart diseases(CHD)in CBP children not associated with specific *** A total of 1053 Chinese children diagnosed with non-syndromic CBP were consecutively enrolled and their cardiac structure was evaluated by *** Forty children were identified with ***-four children had one type of structural malformation(simple CHD).Sixteen children had two or more types of structural malformation(complex CHD).CHD and complex CHD were more prevalent in patients with severe or bilateral *** analysis revealed that presence of severe ptosis and bilateral ptosis was independently associated with CHD *** We found an increased frequency of CHD in CBP children,suggesting a clinical need for routine echocardiography evaluation in CBP,especially in children with severe or bilateral ptosis.

关键词： Congenital blepharoptosis Congenital heart diseases Echocardiography

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Influence of acid leaching and calcination on iron removal of coal kaolin

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International Journal of Minerals,Metallurgy and Materials 2014年第4期21卷 317-325页

作者： Pei-wang Zhu Wei-qiang Zeng Xiu-lin Xu le-ming Cheng Xiao Jiang zheng-lun Shi State Key Laboratory of Clean Energy Utilization Zhejiang University

Calcination and acid leaching of coal kaolin were studied to determine an effective and economical preparation method of calcined kaolin. Thermogravimetric-differential thermal analysis （TG-DTA） and X-ray diffraction （XRD） demonstrated that 900＆#176;C was the suitable temperature for the calcination. leaching tests showed that hydrochloric acid was more effective for iron dissolution from raw coal kaolin （RCK）, whereas oxalic acid was more effective on iron dissolution from calcined coal kaolin （CCK）. The iron dissolution from CCK was 28.78wt%, which is far less effective than the 54.86wt% of RCK under their respective optimal conditions. Through analysis by using M？ssbauer spectroscopy, it is detected that nearly all of the structural ferrous ions in RCK were removed by hydrochloric acid. However, iron sites in CCK changed slightly by oxalic acid leaching because nearly all ferrous ions were transformed into ferric species after firing at 900＆#176;C. It can be concluded that it is difficult to remove the structural ferric ions and ferric oxides evolved from the structural ferrous ions. Thus, iron removal by acids should be conducted prior to calcination.

关键词： kaolin iron removal calcination acid leaching extraction MSssbauer spectroscopy

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