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The role of altered fatty acid in pathological scars and their dermal fibroblasts

Chinese Journal of Traumatology 2022年第4期25卷 218-223页

作者： Jin-Xiu Yang Shi-Yi Li Min-Liang Chen le-ren he Department of Burn and Plastic Surgery The Fourth Medical CentreChinese PLA(People's Liberation Army)General HospitalBeijing100038China th Department of Plastic Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing10005China

Purpose The proposed pathological mechanism for scar formation is controversial,and increased attention has been paid to the fatty acids(FAs)in the formation of pathological ***,FAs are known to be important in inflammation and mechanotransduction,which is closely related to scar ***,it is necessary to clarify the roles of FA in scar *** Hypertrophic scar and keloid formed for more than a year and without other treatment,as well as normal skin samples were obtained from patients who underwent plastic ***,keloids(n=10),hypertrophic scars(n=10),and normal skin samples(n=10)were collected under informed *** dermal fibroblasts were isolated and *** amount and variety of FAs were detected by lipid chromatography-mass ***,real-time PCR,and western blotting were used to verify the expression of sterol regulatory element-binding protein-1(SREBP1)and fatty acid synthase(FASN)in the samples and their ***'s t-test,ANOVA,and orthogonal partial least square discriminant analysis were performed for statistical analysis(∗phere were 27 differential FAs in keloids and 15 differential FAs in hypertrophic scars(∗ple influence on projection>1.0).The expression of SREBP1 and FASN was lower in pathological scars both at mRNA and protein levels(all∗phe mRNA levels of SREBP1(∗∗∗p=0.0002)and FASN(∗∗∗p=0.0021)in keloid-derived fibroblasts were higher than that in normal skin fibroblasts(NFBs),while the expression in hypertrophic scar-derived fibroblasts was lower than that in NFBs(both∗phereas there was no significant difference in FASN protein expression between keloid-derived fibroblasts and NFBs(p>0.05).Conclusion FAs involved in pathological scars are abnormally changed in scar ***,fatty acid-derived inflammation and de novo synthes

关键词： Hypertrophic scars Keloids Fatty acids Fibroblasts

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Regulation of insect behavior by non-coding RNAs

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Science China(Life Sciences) 2024年第6期67卷 1106-1118页

作者： Jing he le Kang State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institutes of Life Sciences Chinese Academy of SciencesBeijing 100101China College of Life Science Hebei UniversityBaoding 071002China

The adaptation of insects to environments relies on a sophisticated set of behaviors controlled by molecular and physiological *** the past several decades,accumulating studies have unveiled the roles of non-coding RNAs(nc RNAs)in regulating insect *** RNAs assume particularly pivotal roles in the behavioral plasticity of insects by rapidly responding to environmental *** RNAs also contribute to the maintenance of homeostasis of insects by fine-tuning the expression of target ***,a comprehensive review of nc RNAs'roles in regulating insect behaviors has yet to be ***,we present the recent progress in our understanding of how nc RNAs regulate various insect behaviors,including flight and movement,social behavior,reproduction,learning and memory,and *** refine the intricate mechanisms by which nc RNAs modulate the function of neural,motor,reproductive,and other physiological systems,as well as gene expression in insects like fruit flies,social insects,locusts,and ***,we discuss potential avenues for future studies in nc RNA-mediated insect behaviors.

关键词： ncRNAs insect behavior plasticity fine-tuning environmental adaptation

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Conceptual design and control method for a noncontact annular electromagnetic stabilized satellite platform

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Chinese Journal of Aeronautics 2024年第1期37卷 256-270页

作者： he LIAO Daixin WANG Yuan ren Weijie WANG Institute of Astronautics Nanjing University of Aeronautics and AstronauticsNanjing 211106China Department of Basic Course Space Engineering UniversityHuairou DistrictBeijing 101416China

Disturbance-Free Payload(DFP)spacecraft can meet the requirements of ultra-high attitude pointing accuracy and stability for future space ***,as the main control actuators of DFP spacecraft,Linear Non-Contact Lorentz Actuators(LNCLAs)have control output problems with six-degree-of-freedom coupling and nonlinear effects,which will affect the attitude control performance of DFP *** solve this problem,a novel concept for Non-Contact Annular Electromagnetic Stabilized Satellite Platform(NCAESSP)is proposed in this *** concept is centered on replacing the LNCLAs with a non-contact annular electromagnetic actuator to solve the two problems mentioned ***,for the different control requirements of the payload module and the support module of the NCAESSP,a high-precision attitude controller based on the robust model matching method and a dual quaternion-based adaptive sliding mode controller are ***,the simulation results verify the feasibility and effectiveness of the proposed approach.

关键词： Disturbance-free payload Robust model matching Dual quaternion Sliding mode control Collision avoidance

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Rapid Energy Exchange between In Situ Formed Bromine Vacancies and CO_(2)Molecules Enhances CO_(2)Photoreduction

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Research 2024年第2期2023卷 763-771页

作者： Qin ren Ye he Hong Wang Yanjuan Sun Fan Dong Research Center for Environmental and Energy Catalysis Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China

Photocatalytic reduction of CO_(2)into fuels provides a prospective tactic for regulating the global carbon balance utilizing renewable solar ***,CO_(2)molecules are difficult to activate and reduce due to the thermodynamic stability and chemical *** this work,we develop a novel strategy to promote the adsorption and activation of CO_(2)molecules via the rapid energy exchange between the photoinduced Br vacancies and CO_(2)*** in situ continuous wave-electron paramagnetic resonance(cw-EPR)and pulsed EPR technologies,we observe that the spin-spin relaxation time(T_(2))of BiOBr is decreased by 198 ns during the CO_(2)photoreduction reaction,which is further confirmed by the broadened EPR *** result reveals that there is an energy exchange interaction between in situ formed Br vacancies and CO_(2)molecules,which promotes the formation of high-energy CO_(2)molecules to facilitate the subsequent reduction *** addition,theoretical calculations indicate that the bended CO_(2)adsorption configuration on the surface of BiOBr with Br vacancies caused the decrease of the lowest unoccupied molecular orbital of the CO_(2)molecule,which makes it easier for CO_(2)molecules to acquire electrons and get *** situ diffuse reflectance infrared Fourier transform spectroscopy further shows that the activated CO_(2)molecules are favorably converted to key intermediates of COOH*,resulting in a CO generation rate of 9.1μmol g^(-1)h^(-1)and a selectivity of 100%.This study elucidates the underlying mechanism of CO_(2)activation at active sites and deepens the understanding of CO_(2)photoreduction reaction.

关键词： reaction. adsorption activation

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Metal–phenolic coordination crystals derived magnetic hollow carbon spheres for ultrahigh electromagnetic wave absorption

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Nano Research 2024年第3期17卷 1616-1624页

作者： Hanxiao Xu Zizhuang he Yiruo Wang Xiangru ren Panbo Liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129China

Owing to the tunable compositions and versatile functionality,the development of eco-friendly metal–phenolic coordination crystals derivatives is highly anticipated for electromagnetic wave *** this study,three kinds of magnetic hollow carbon spheres(HCSs)with macro-meso-microporous characteristics,including Fe/HCS,Co/HCS,and CoNi/HCS,are successfully fabricated via the co-operative hard template and self-assembling process,in which magnetic particles are encapsulated in carbon shell matrix after the pyrolysis of metal–polyphenol coordination crystals and further subsequent template *** the one hand,hierarchical macro-meso-micropores effectively balance the impedance gap between absorbers and air and introduce structural defects or distortion,leading to matched impedance and enhanced dipolar/defect *** the other hand,wrapped magnetic particles provide uncountable hetero-interfaces and induce ferromagnetic resonance,resulting in strengthened interfacial polarization and additional magnetic *** particular,enhanced minimum reflection loss(RL,min)and broadband effective absorption bandwidth(EAB)are achieved with only 10 wt.%filler ***,the RL,min and EAB values are-57.5 dB and 7.2 GHz for Fe/HCS,-50.0 dB and 5.8 GHz for Co/HCS,and-52.1 dB and 6.7 GHz for CoNi/HCS,***,this work provides us a modular-assembly strategy to regulate the hollow cavity of absorbers and simultaneously manipulates the chemical components of absorbers to regulate electromagnetic wave absorption performance.

关键词： hollow engineering hierarchical pores hetero-interfaces synergetic effect electromagnetic wave absorption

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Comparative evaluation of SPE methods for biotoxicity assessment of water and wastewater:Linkage between chemical extracting efficiency and biotoxicity outcome

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Journal of Environmental Sciences 2024年第8期142卷 33-42页

作者： Jiawei Zhou Shihao Wang Xiwei he Hongqiang ren Xu-Xiang Zhang State Key Laboratory of Pollution Control and Resource Reuse School of EnvironmentNanjing UniversityNanjing 210023China

Biotoxicity assessment results of environmental waters largely depend on the sample extraction protocols that enrich pollutants to meet the effect-trigger thresholds of ***,more chemical mixture does not necessarily translate to higher combined ***,there is a need to establish the link between chemical extracting efficiency and biotoxicity outcome to standardize extraction methods for biotoxicity assessment of environmental *** study compares the performance of five different extraction phases in solid phase extraction(SPE),namely HLB,HLB+Coconut,C18 cartridge,C18 disk and Strata-X,and evaluated their chemical extracting efficiencies and biotoxicity *** quantitatively assessed cytotoxicity,acute toxicity,genotoxicity,estrogenic activity,and neurotoxicity of the extracts using in vitro bioassays and characterized the chemical extracting efficiencies of the SPE methods through chemical recoveries of 23 model compounds with different polarities and total organic *** Pareto ranking,we identified HLB+Coconut as the optimal SPE method,which exhibited the highest level of water sample biotoxicity and recovered the most chemicals in water *** found that the biotoxicity outcomes of the extracted water samples significantly and positively correlated with the chemical extracting efficiencies of the SPE ***,we observed synchronous changing patterns in biotoxicity outcome and chemical extracting efficiencies in response to increasing sample volumes per cartridge(SVPC)during *** findings underscore that higher chemical extracting efficiency of SPE corresponds to higher biotoxicity outcome of environmental water samples,providing a scientific basis for standardization of SPE methods for adequate assessment of biotoxicities of environmental waters.

关键词： Biotoxicity Chemical recovery Solid phase extraction Surface water Wastewater

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Efflcient machining of a complex blisk channel using a disc cutter

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Chinese Journal of Aeronautics 2024年第1期37卷 414-437页

作者： Xiangyu LI Zhaoyu LI Dong he Junxue ren Qian FENG Kai TANG Department of Mechanical and Aerospace Engineering Hong Kong University of Science and TechnologyHong Kong 999077China Key Laboratory of High Performance Manufacturing for Aero Engine(Northwestern Polytechnical University) Ministry of Industry and Information TechnologyXi’an 710072China Xi’an Sanhang Power Technology Co. LtdXi’an 710000China HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute FutianShenzhen 518057China HKUST Shenzhen Research Institute Shenzhen 518057China

For rough machining of a complex narrow cavity,e.g.,a complex blisk channel on an aero-engine,the typically used cutting tools are the slender cylindrical cutter and conical ***,as neither of the two is particularly suited for rough machining,wherein the main purpose is to remove a large volume as quickly as possible,the machining efficiency is low,especially when the part materials are of hard-to-cut types(e.g.,Titanium-alloy)for which it often takes days to rough machine a ***,disc machining provides a new and efficient roughing solution,since a disc cutter with a large radius enables a much larger cutting speed and thus a larger material removal ***,due to the large radius of the disc cutter,its potential collision with narrow and twisted channels becomes a serious *** this paper,we propose a novel twophase approach for efficiently machining a complex narrow cavity workpiece using a disc-shaped cutter,i.e.,3+2-axis disc-slotting of the channel by multiple layers(rough machining)+five-axis disc-milling of the freeform channel side surfaces(semi-finish machining).Both simulation and physical cutting experiments are conducted to assess the effectiveness and advantages of the proposed *** experimental results show that,with respect to a same cusp-height threshold on the channel side surfaces,the total machining time of the tested part by the proposed method is about only 36%of that by the conventional approach of plunging-milling(for roughing)plus milling by a slender cylindrical cutter(for semi-finishing).

关键词： Blisk channel CNC machining Disc cutter Roughing efficiency Tool path planning

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Wireless semantic communication based on semantic matching multiple access and intent bias multiplexing

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 26-36页

作者： ren Chao he Zongrui Sun Chen Li Haojin Zhang Haijun University of Science and Technology Beijing Beijing 100083China Research and Development Center Sony(China)LimitedBeijing 100027China

This paper proposes a multi-access and multi-user semantic communication scheme based on semantic matching and intent deviation to address the increasing demand for wireless users and *** scheme enables flexible management of long frames,allowing each unit of bandwidth to support a higher number of *** leveraging semantic classification,different users can independently access the network through the transmission of long concatenated sequences without modifying the existing wireless communication *** overcome the potential disadvantage of incomplete semantic database matching leading to semantic intent misunderstanding,the scheme proposes using intent deviation as an *** allows different receivers to interpret the same semantic information differently,enabling multiplexing where one piece of information can serve multiple users with distinct *** results show that at a bit error rate(BER)of 0.1,it is possible to reduce the transmission by approximately 20 semantic basic units.

关键词： semantic communication multiple access multiplexing multimodal communication

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High-entropy design boosts dielectric energy storage

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Rare Metals 2024年第8期43卷 4013-4015页

作者： Qiu-Ying Xia he Zhu Si Lan Yang ren herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and Technology Department of Physics City University of Hong Kong

Dielectric capacitors are vital for advanced electronic and electrical power systems due to their impressive power density and ***,a persistent challenge has been enhancing their energy densities while maintaining high *** in Science,a novel high-entropy design for relaxor ferroelectric materials has been proposed,promising significant improvements in both energy density and efficiency for multilayer dielectric ceramic *** the crucial role of high-entropy design in energy storage materials and devices,this highlight focuses on interpreting the progress and significance of this innovative work.

关键词： CERAMIC CAPACITORS DENSITY FILMS

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Efficient and robust CNN-LSTM prediction of flame temperature aided light field online tomography

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Science China(Technological Sciences) 2024年第1期67卷 271-284页

作者： NIU ZhiTian QI Hong SUN AnTai ren YaTao he MingJian GAO BaoHai School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Aerospace Thermophysics Ministry of Industry and Information TechnologyHarbin 150001China

Light field tomography,an optical combustion diagnostic technology,has recently attracted extensive attention due to its easy implementation and ***,the conventional iterative methods are high data throughput,low efficiency and time-consuming,and the existing machine learning models use the radiation spectrum information of the flame to realize the parameter field measurement at the current *** is still an offline measurement and cannot realize the online prediction of the instantaneous structure of the actual turbulent combustion *** this work,a novel online prediction model of flame temperature instantaneous structure based on deep convolutional neural network and long short-term memory(CNN-LSTM)is *** method uses the characteristics of local perception,shared weight,and pooling of CNN to extract the threedimensional(3D)features of flame temperature and outgoing radiation ***,the LSTM is used to comprehensively utilize the ten historical time series information of high dynamic combustion flame to accurately predict 3D temperature at three future moments.A chaotic time-series dataset based on the flame radiation forward model is built to train and validate the performance of the proposed CNN-LSTM *** is proven that the CNN-LSTM prediction model can successfully learn the evolution pattern of combustion flame and make accurate predictions.

关键词： temperature prediction convolutional neural network long short-term memory light field imaging online tomography

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