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Particuology 2024年第1期84卷 45-52页

作者： le-le zhang lei Tong Yanwei Ding Wanqun zhang Hai-Wei Liang Hefei National Research Center for Physical Sciences at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei230026China

Hierarchically porous carbons(HPCs)with multimodal pores have attracted considerable attention due to their unique physical and chemical properties and various application potentials in heterogeneous catalysis,environmental treatment,and energy storage and ***,we report a general and simple zinc salts-assisted method for the synthesis of HPCs with varied porosity and chemical func-tionalities by the direct carbonization of diverse biomass and *** the carbonization,zinc salts are thermally decomposed into nanoparticles that serve as in-situ templates to introduce nanopores in *** prepared HPCs exhibit high specific surface areas(up to 2432 m2 g-1),large pore volumes(up to 4.30 cm^(3)g^(-1)),and broad pore size ***,the zinc salts can be recovered and recycled,supporting the sustainable production of HPCs on large *** prepared HPCs-supported catalysts with atomically dispersed metal sites exhibit promising electrocatalytic performance for the oxygen reduction reaction.

关键词： Hierarchical porous carbon Zinc salts Biomass Wastes Electrocatalysis

Extraction of full energy peak of ^(137)Cs from in situ NaI(Tl)gamma-ray spectrum

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Nuclear Science and Techniques 2016年第4期27卷 53-59页

作者： le-le zhang Nan-Ping Wang Bao-Chuan Li School of Geophysics and Information Technology China University of Geosciences

A levenberg–Marquardt Gaussian fitting algorithm has been used for analyzing the overlap of three peaks(the 583-ke V peak of^(208)Tl, the 609-ke V peak of214 Bi, and the 662-ke V peak of^(137)Cs) using an in situ Na I(Tl) scintillation spectrometer. The algorithm, in addition,was compared with a genetic algorithm used for multiple deconvolution. The three fitted peak areas(583, 609, and662 ke V) were calculated from the measured gamma-ray spectra obtained from a simulation experiment in which a^(137) Cs source was buried at different soil depths(from 18 to38 cm). The application of the levenberg–Marquardt algorithm yielded similar results compared to the genetic algorithm. A lack-of-fit test showed that the fitting is good when the instrumental noise levels were estimated from replicated analyses. The relative fitting error of the total net area and the residual standard deviation were within 5 %and 0.04, respectively, and the goodness of the fitting was better than 0.98. While the methods used in this paper give high performance, the results may lead to incorrect estimation when the signal-to-noise ratio is smaller than-30 d B. This study is useful for the determination of radioactive specific activity of^(137) Cs by in situ spectrometry.

关键词： 137Cs γ射线谱 Marquardt算法全能峰 Gaussian 拟合算法提取相对拟合误差

Is irreversible electroporation safe and effective in the treatment of hepatobiliary and pancreatic cancers?

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 117-124页

作者： Li-Ming Wu le-le zhang Xin-Hua Chen Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital Zhejiang University School of Medicine

Background: Irreversible electroporation(IRE) is a novel ablative technique for hepatobiliary and pancreatic cancers. This review summarizes the data regarding the safety and efficacy of IRE in the treatment of hepatobiliary and pancreatic cancers. Data sources: Studies were identified by searching Pub Med and Embase for articles published in English from database inception through July 31, 2017. For inclusion, each clinical study had to report morbidity and survival data on hepatobiliary and pancreatic cancers treated with IRE and contain at least 10 patients. Studies that met these criteria were included for analysis. Two authors assessed each clinical study for data extraction. The controversial parts were resolved through discussion with seniors. Results: A total of 24 clinical studies were included. Fourteen focused on hepatic ablation with IRE comprising 437 patients with 666 lesions of different tumor types. Two patients(0.5%) died after the IRE procedure. Morbidity of hepatic ablation with IRE ranged from 7% to 35%. Most complications were mild. Complete response for hepatic tumors was reported as 57%–97%. Ten studies with 455 patients focused on pancreatic IRE. The overall mortality of IRE in pancreatic cancer was 2%. Overall severe morbidity of IRE in pancreatic cancer ranged from 0 to 20%. The median overall survival after IRE ranged from 7 to 23 months. Patients treated with IRE combined with surgical resection showed a longer overall survival. Conclusions: IRE significantly improves the prognosis of advanced hepatobiliary and pancreatic malignances, and companied with less complications. Hence, IRE is a relatively safe and effective non-thermal ablation strategy and potentially recommended as an option for therapy of patients with hepatobiliary and pancreatic malignances.

关键词： Irreversible electroporation Hepatic cancer Pancreatic cancer

Linearized waveform inversion for vertical transversely isotropic elastic media:Methodology and multi-parameter crosstalk analysis

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Petroleum Science 2024年第1期21卷 252-271页

作者： Ke Chen Lu Liu Li-Nan Xu Fei Hu Yuan Yang Jia-Hui Zuo le-le zhang Yang Zhao National Key Laboratory of Petroleum Resources and Engineering Unconventional Petroleum Research InstituteChina University of Petroleum(Beijing)Beijing102249China Aramco Beijing Research Center Aramco AsiaBeijing100102China University of Lausanne LausanneCH-1015Switzerland Bureau of Geophysical Prospecting China National Petroleum CorporationZhuozhou 072750HebeiChina

Seismic migration and inversion are closely related techniques to portray subsurface images and identify hydrocarbon *** migration aims at obtaining structural images of subsurface geologic *** specifically,seismic migration estimates the reflectivity function(stacked average reflectivity or pre-stack angle-dependent reflectivity)from seismic reflection *** the other hand,seismic inversion quantitatively estimates the intrinsic rock properties of subsurface *** seismic inversion methods are applicable to detect hydrocarbon reservoirs that may exhibit lateral variations in the inverted *** there exist many differences,pre-stack seismic migration is similar with the first iteration of the general linearized seismic ***,seismic migration and inversion techniques assume an acoustic or isotropic elastic *** reservoirs such as shale and tight sand formation have notable anisotropic *** present a linearized waveform inversion(LWI)scheme for weakly anisotropic elastic media with vertical transversely isotropic(VTI)*** is based on two-way anisotropic elastic wave equation and simultaneously inverts for the localized perturbations(ΔVp_(0)/Vp_(0)/Vs_(0)/Vs_(0)/,Δ∈,Δδ)from the long-wavelength reference *** proposed VTI-elastic LWI is an iterative method that requires a forward and an adjoint operator acting on vectors in each *** derive the forward Born approximation operator by perturbation theory and adjoint operator via adjoint-state *** inversion has improved the quality of the images and reduces the multi-parameter crosstalk comparing with the adjoint-based *** have observed that the multi-parameter crosstalk problem is more prominent in the inversion images for Thomsen anisotropy ***,the Thomsen parameter is the most difficult to *** also analyze the multi-parameter crosstalk using scattering radiation patte

关键词： Elastic Anisotropy least-squares imaging Waveform inversion Computational geophysics

Extracting angle-domain common-image gathers in VTI media using ansiotropic-Helmholtz P/S wave-mode decomposition

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Petroleum Science 2023年第3期20卷 1546-1561页

作者： le-le zhang Yang Zhao Lu Liu Ke Chen Jia-Hui Zuo Yi-Xin Wang Ji-Dong Yang State Key Laboratory of Petroleum Resource and Prospecting Unconventional Petroleum Research InstituteChina University of PetroleumBeijing102249China Aramco Beijing Research Center Aramco AsiaBejing100102China Department of Geophysics China University of Petroleum(East China)QingdaoShandong266580China

Common-image gathers are extensively used in amplitude versus angle(AVA)and migration velocity analysis(MVA).The current state of methods for anisotropic angle gathers extraction use slant-stack,local Fourier transform or low-rank approximation,which requires much *** on an anisotropic-Helmholtz P/S wave-mode decomposition method,we propose a novel and efficient approach to produce angle-domain common-image gathers(ADCIGs)in the elastic reverse time migration(ERTM)of VTI *** start with,we derive an anisotropic-Helmholtz decomposition operator from the Christoffel equation in VTI media,and use this operator to derive the decomposed formulations for anisotropic P/S ***,we employ the first-order Taylor expansion to calculate the normalized term of decomposed formulations and obtain the anisotropic-Helmholtz decomposition method,which generates the separated P/S wavefields with correct amplitudes and ***,we develop a novel way that uses the anisotropic-Helmholtz decomposition operator to define the polari-zation angles for anisotropic P/S waves and substitute these angles to decomposing *** polarization angles are then calculated directly from the separated vector P-and S-wavefields and converted to the phase *** ADCIGs are thusly produced by applying the phase angles to VTI *** addition,we develop a concise approximate expression of residual moveout(RMO)for PP-reflections of flat reflectors in VTI media,which avoids the complex transformations between the group angles and the phase *** approximate RMO curves show a good agreement with the exact solution and can be used as a tool to assess the migration velocity *** demonstrated by two selected examples,our ADCIGs not only produce the correct kinematic responses with regards to different velocity pertubatation,but also generate the reliable amplitude responses versus different *** final stacking images of ADCIGs data exhibit the identical im

关键词： Helmholtz decomposition Angle gathers Anisotropy Elastic-RTM

Building the bridge of small organic molecules to porous carbons via ionic solid principle

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Nano Research 2023年第1期16卷 80-87页

作者： lei Tong Qian-Qian Yang Shuai Li le-le zhang Wei-Jie Zeng Yan-Wei Ding Liangdong Fan Hai-Wei Liang Department of New Energy Science and Technology College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China Hefei National Research Center for Physical Sciences at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei 230026China

Replacing traditional polymer-based precursors with small molecules is a promising pathway toward facile and controllable preparation of porous carbons but remains a prohibitive challenge because of the high volatility of small ***,a simple,general,and controllable method is reported to prepare porous carbons by converting small organic molecules into organic molecular salts followed by *** robust electrostatic force holding organic molecular salts together leads to negligible volatility and thus ensures the formation of carbons under high-temperature ***,metal moieties in organic molecular salts can be evolved into in-situ templates or activators during pyrolysis to create *** modular nature of organic molecular salts allows easy control of the porosity and chemical doping of carbons at a molecular *** sulfur-doped carbon prepared by the ionic solid strategy can serve as robust support to prepare small-sized intermetallic PtCo catalysts,which exhibit a high mass activity of 1.62 A·mgPt^(−1)in catalyzing oxygen reduction reaction for fuel cell applications.

关键词： porous carbon small organic molecules organic molecular salts ionic solid oxygen reduction reaction

c-MYC-mediated TRIB3/P62^(+) aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1240-1253页

作者： Min-Xia Su Yu-Lian Xu Xiao-Ming Jiang Mu-Yang Huang le-le zhang Luo-Wei Yuan Xiao-Huang Xu Qi Zhu Jian-Li Gao Jia-Hong Lu Xiuping Chen Ming-Qing Huang Yitao Wang Jin-Jian Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310000China College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350000China Mo E Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China

The mammalian target of rapamycin(m TOR) pathway is abnormally activated in lung ***, the anti-lung cancer effect of m TOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an active component of Panax ginseng C. A. Mey., enhanced the anti-cancer effect of the m TOR inhibitor everolimus both in vitro and in vivo. Moreover, ginsenoside Rh2 alleviated the hepatic fat accumulation caused by everolimus in xenograft nude mice models. The combination of everolimus and ginsenoside Rh2(labeled Eve-Rh2) induced caspase-independent cell death and cytoplasmic vacuolation in lung cancer cells, indicating that Eve-Rh2 prevented tumor progression by triggering paraptosis. EveRh2 up-regulated the expression of c-MYC in cancer cells as well as tumor tissues. The increased cMYC mediated the accumulation of tribbles homolog 3(TRIB3)/P62+ aggresomes and consequently triggered paraptosis, bypassing the classical c-MYC/MAX pathway. Our study offers a potential effective and safe strategy for the treatment of lung cancer. Moreover, we have identified a new mechanism of TRIB3/P62+ aggresomes-triggered paraptosis and revealed a unique function of c-MYC.

关键词： Everolimus Ginsenoside Rh2 Paraptosis Aggresomes P62 TRIB3 c-MYC Lung cancer

Mutation breeding of high 4-androstene-3,17-dione-producing Mycobacterium neoaurum ZADF-4 by atmospheric and room temperature plasma treatment

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第4期16卷 286-295页

作者： Chao LIU Xian zhang Zhi-ming RAO Ming-long SHAO le-le zhang Dan WU Zheng-hong XU Hui LI Key Laboratory of Industrial Biotechnology Ministry of Education School of Biotechnology Jiangnan University Laboratory of Applied Microorganisms and Metabolic Engineering School of Biotechnology Jiangnan University Laboratory of Pharmaceutical Engineering School of Pharmaceutical Science Jiangnan University

Steroid medication is used extensively in clinical applications and comprises a large and vital part of the pharmaceutical industry. However, the difficulty of separating 4-androstene-3,17-dione （AD） from 1,4-androstadiene- 3,17-dione （ADD） restricts the application of the microbial transformation of phytosterols in the industry. A novel at- mospheric and room temperature plasma （ARTP） treatment, which employs helium as the working gas, was used to generate Mycobacterium neoaurum mutants producing large amounts of AD. After treatment of cultures with ARTP, four mutants were selected using a novel screening method with a color assay. Among the mutants, M. neoaurum ZADF-4 was considered the best candidate for industrial application. When the fermentation medium contained 15 g/L phytosterols and was cultivated on a rotary shaker at 160 r/min at 30 ~C for 7 d, （6.28＋0.11） g/L of AD and （0.82＋0.05） g/L of ADD were produced by the ZADF-4 mutant, compared with （4.83＋0.13） g/L of AD and （2.34＋0.06） g/L of ADD by the original strain, Iv~. neoaururn ZAD. Compared with ZAD, the molar yield of AD increased from 48.3% to 60.3% in the ZADF-4 mutant. This result indicates that ZADF-4 may have potential for industrial production of AD.

关键词： Mycobacterium neoaurum Atmospheric and room temperature plasma (ARTP) Mutation breeding 4-Androstene-3 17-dione (AD) 1 4-Androstadiene-3 17-dione (ADD)

SURFACE EFFECTS ON THE PROPAGATION OF LOVE WAVES IN A MAGNETOEleCTRIC NANOSTRUCTURE

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SURFACE EFFECTS ON THE PROPAGATION OF LOVE WAVES IN A MAGNET...

Bicriteria Approximation Algorithm for Quarantining-vaccination-cure Problem

2016年全国压电和声波理论及器件应用研讨会

作者： Shi-jing GAO le-le zhang Xiang-lin LIU Jin-xi LIU Department of Engineering Mechanics Shijiazhuang Tiedao University

Background, Motivation and Objective A nanostructure is defined as a material system or object where at least one of the dimensions lies below 100 nm. At this scale, material properties often exhibit obvious size effect. It is well known that surface effect is one of the most important structure characteristics of nanomaterials and plays a decisive role in the overall properties of materials. Therefore, considering the influence of surface effect is necessary to study the mechanical behavior of nanomaterials. The property of facilitating the conversion among mechanical energy, electric energy and magnetic energy makes magnetoelectric structures more advantageous than other traditional structures. As the nanomaterials are gradually attracting tremendous attention, magnetoelectric structures at the nanoscale show a bright prospect in fabricating nanodevices. In this paper, the dispersion characteristics of love waves propagating in a piezoelectric nanofilm on a piezomagnetic half-space with surface effects are investigated by using the surface piezoelectricity model. Statement of Contribution/Methods Firstly, the general solutions about the displacement and electric potential of both the piezoelectric nanofilm and the piezomagnetic half-space are solved by using the partial wave technique. Secondly, based on the surface piezoelectric constitutive theory, the existence of surface stresses exerting on the boundary conditions of the piezoelectric nanofilm is taken into account through the generalized Young-Laplace equations. Meanwhile, the two kinds of electrical boundary conditions, i.e., electrically shorted case and electrically open case, are both considered to get the dispersion equations. Finally, according to the dispersion equations with respect to wave number and wave velocity, the dispersion curves can be obtained. Furthermore, the impacts of surface parameters and film thickness on the propagation properties of love waves are analyzed in detail, and the disper

关键词： Surface effect Piezoelectric nanofilm Dispersion characteristic Size-dependence Love wave

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Chinese Quarterly Journal of Mathematics 2013年第1期28卷 99-104页

作者： WANG le-le zhang Zhao College of Mathematics and System Sciences Xinjiang University Urumqi 830046 China

In this paper, we propose a model for the epidemic control problem, the goal of which is to minimize the total cost of quarantining, vaccination and cure under the constraint on the maximum number of infected people a... 详细信息

关键词： epidemic control quarantining vaccination cure bicriteria approximation algorithm