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Moxibustion upregulates hippocampal progranulin expression

Neural Regeneration Research 2016年第4期11卷 610-616页

作者： Tao Yi Li Qi Ji Li jing-jing le lei Shao Xin Du jing-cheng Dong Department of Integrative Medicine Huashan HospitalFudan University College of Integrated Traditional Chinese and Western Medicine Fudan University E-institute of Shanghai Municipal Education Committee Shanghai University of Traditional Chinese Medicine

In China,moxibustion is reported to be useful and has few side effects for chronic fatigue syndrome,but its mechanisms are largely *** recently,the focus has been on the wealth of information supporting stress as a factor in chronic fatigue syndrome,and largely concerns dysregulation in the stress-related hypothalamic-pituitary-adrenal *** the present study,we aimed to determine the effect of moxibustion on behavioral symptoms in chronic fatigue syndrome rats and examine possible *** were subjected to a combination of chronic restraint stress and forced swimming to induce chronic fatigue *** acupoints Guanyuan（CV4） and Zusanli（ST36,bilateral） were simultaneously administered *** chronic fatigue syndrome rats and normal rats were used as *** from the forced swimming test,open field test,tail suspension test,real-time PCR,enzyme-linked immunosorbent assay,and western blot assay showed that moxibustion treatment decreased m RNA expression of corticotropin-releasing hormone in the hypothalamus,and adrenocorticotropic hormone and corticosterone levels in plasma,and markedly increased progranulin m RNA and protein expression in the *** findings suggest that moxibustion may relieve the behavioral symptoms of chronic fatigue syndrome,at least in part,by modulating the hypothalamic-pituitary-adrenal axis and upregulating hippocampal progranulin.

关键词： nerve regeneration traditional Chinese medicine moxibustion chronic fatigue syndrome hypothalamic-pituitary-adrenal axis corticotrophin-releasing hormone adrenocorticotropic hormone behavioral symptoms corticosterone hippocampus progranulin neural regeneration

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The Dual Role of Non-coding RNAs in the Development of Periodontitis

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Biomedical and Environmental Sciences 2023年第8期36卷 743-755页

作者： XU Xi LANG Guang Ping CHEN Zhong Lan WANG jing le HAN Ying Ying Special Key Laboratory of Oral Diseases Research Hospital/School of StomatologyZunyi Medical UniversityZunyi 563099GuizhouChina Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563099GuizhouChina School of Preclinical Medicine of Zunyi Medical University Zunyi Medical UniversityZunyi 563099GuizhouChina

This review aims to sum up how Non-coding RNAs(ncRNAs)regulate the development of periodontitis and provides a new perspective for understanding the pathogenesis of *** explored the ncRNA's dual role in the development of periodontitis by summarizing evidence from previous in vivo and in vitro studies as well as clinical *** our review,the downregulation of 18 miRNAs,22 lncRNAs and 10 circRNAs demonstrates protective roles in *** contrast,the expression of other 11 miRNAs,7 lncRNAs and 6 circRNAs are upregulated in periodontitis,which promote the progression of *** dysregulated ncRNAs exert their protective or destructive roles by mainly influencing cell proliferation,differentiation and apoptosis via cross-talking with various molecules or signaling *** findings suggested which and how ncRNAs promote or delay the progression of periodontitis,which may greatly contribute to diagnose and therapy development of periodontitis based on ncRNAs in the future.

关键词： Periodontitis MicroRNA Long non-coding RNA Circular RNA Non-coding RNA

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Radiological insights of ectopic thyroid in the porta hepatis: A case report and review of the literature

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World Journal of Clinical Cases 2021年第14期9卷 3432-3441页

作者： Outesh Chooah jing Ding jing-le Fei Fang-Yi Xu Ting Yue Cai-Ling Pu Hong-Jie Hu Department of Radiology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Ectopic thyroid is defined as a rare developmental anomaly where thyroid tissues are atypically found in locations other than its normal anatomical position:Anterolateral to the second,third,and fourth tracheal *** intemperate descent or a migration failure of the thyroid anlage results in sub-diaphragmatic thyroid ectopia,a sparse clinical *** SUMMARY This case portrays a 63-year-old female patient presenting with chronic abdominal discomfort at a local hospital whereby a computed tomography(CT)scan revealed a well-defined mass in the hepatic *** further examination,the patient underwent a CT scan with contrast,magnetic resonance imaging(MRI),and CT-angiography(CTA)at our *** CT scan showed a welldefined and high attenuated mass measuring 43 mm×38 mm in the hepatic entrance with *** CTA revealed an additional finding:Blood supply to the mass from the right hepatic *** of the upper abdomen demonstrated a mass with mixed signal intensity on T1 and T2 weighted images in the hepatic *** patient underwent surgery with resection of the mass which was sent for *** thyroid at the level of porta hepatis with nodules was the definitive diagnosis since histopathological report revealed presence of thyroid tissue in the resected liver *** This case delivers a rare insight of pre-operative radiological imaging of an ectopic thyroid located in the *** findings can aid in narrowing down potential differential diagnosis when managing a patient with those subsequent findings.

关键词： Ectopic thyroid Porta hepatis Computed tomography Computed tomography

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Down-regulation of miR-622 in gastric cancer promotes cellular invasion and tumor metastasis by targeting ING1 gene

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World Journal of Gastroenterology 2011年第14期17卷 1895-1902页

作者： Xiao-Bo Guo Chang-Qing jing le-Ping Li Li Zhang Yu- Long Shi Jin-Shen Wang jing-lei Liu Chen-Sheng Li Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong University 324 Jingwu Weiqi Road Jinan 250021 Shandong Province China

AIM:To evaluate the biological and clinical characteristics of miR-622 in gastric cancer. METHODS:We analyzed the expression of miR-622 in 57 pair matched gastric neoplastic and adjacent non-neoplastic tissues by quantitative real-time polymerase chain reaction. Functional analysis of miR-622 expression was assessed in vitro in gastric cancer cell lines with miR-622 precursor and inhibitor. The roles of miR-622 in tumorigenesis and tumor metastasis were analyzed using a stable miR-622 expression plasmid in nude mice. A luciferase reporter assay was used to assess the effect of miR-622 on inhibitor of growth family,member 1 (ING1) expression. RESULTS:Expression of miR-622 was down-regulated in gastric cancer. MiR-622 was found involved in differentia-tion and lymphatic metastasis in human gastric cancer. Ectopic expression of miR-622 promoted invasion,tumorigenesis and metastasis of gastric cancer cells both in vitro and in vivo. ING1 is a direct target of miR-622. CONCLUSION:These findings help clarify the molecular mechanisms involved in gastric cancer metastasis and indicate that miR-622 modulation may be a bona fide treatment of gastric cancer.

关键词： MicroRNA MiR-622 Gastric cancer Metastasis Inhibitor of growth family member 1

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Construction and validation of a personalized prediction model for postpartum anxiety in pregnant women with preeclampsia

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World Journal of Psychiatry 2023年第10期13卷 763-771页

作者： le-jing Lin Hai-Xian Zhou Zhi-Yun Ye Qi Zhang Shu Chen Department of Obstetrics and Gynecology Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhou 325000Zhejiang ProvinceChina Department of Gynecology Wenzhou Traditional Chinese Medicine HospitalWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Preeclampsia is a pregnancy-specific multi-system disease with multi-factor and multi-mechanism *** cure for preeclampsia is to terminate the pregnancy and deliver the ***,it will reduce the perinatal survival rate,prolong the pregnancy cycle,and increase the incidence of maternal *** relaxation of the birth policy,the number of elderly pregnant women has increased significantly,and the prevalence rate of preeclampsia has *** treatment can seriously affect the normal postpartum life of pregnant *** have shown that postpartum anxiety in women with preeclampsia can affect physical and mental health,as well as infant growth and *** To analyze the factors influencing preeclampsia in pregnant women complicated with postpartum anxiety,and to construct a personalized predictive *** We retrospectively studied 528 pregnant women with preeclampsia who delivered in Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine between January 2018 and December *** basic data were collected,and various physiological and biochemical indicators were obtained by laboratory *** self-rating anxiety scale was used to determine whether the women had postpartum anxiety 42 d after *** independent factors influ-encing postpartum anxiety in early pregnant women with eclampsia were analyzed with multifactor logistic regression and a predictive model was *** Hosmer-lemeshow test and receiver operating characteristic(ROC)curve were used to evaluate the calibration and discrimination of the predictive *** pregnant women with preeclampsia admitted to our hospital from January 2022 to May 2022 were retrospectively selected to verify the prediction *** We excluded 46 of the 528 pregnant women with preeclampsia because of loss to follow-up and adverse outcomes.A total of 482 cases completed the assessment of postpartum anxie

关键词： Preeclampsia Postpartum anxiety Risk factors Predictive model

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THE PROPAGATION OF ELASTIC STRESS WAVES IN A CONICAL SHELL UNDER AXIAL IMPULSIVE LOADING

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Acta Mechanica Sinica 1987年第2期3卷 173-186页

作者： Chen Yuze le Guopei jing Erli Xue Jindi (Southwest Institute of Structural Mechanics) 四川绵阳中国工程物理研究院结构力学所，621900 四川绵阳中国工程物理研究院结构力学所，621900 四川绵阳中国工程物理研究院结构力学所，621900 四川绵阳中国工程物理研究院结构力学所，621900

The propagation of elastic stress waves in a conical shell subjected to axial impulsiveloading is studied in this paper by means of the finite element calculation and model *** shown that there are two axisymmetrical elastic stress waves propagating with different velocities,i.e.,the longitudinal wave and the bending *** attenuation of these waves while propagatingalong the shell surface is *** is found in experiments that the bending wave is also,generatedwhen a longitudinal wave reflects from the fixed end of the shell,and both reflected waves willseparate during the propagation due to their different velocities.

关键词： elastic stress wave bending wave logitudinal wave axial impulsive loading

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Thermoelectric Properties of Te-Doped Ba_(0.32)Co_(4)Sb_(12-x)TexPrepared at HPHT

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Chinese Physics letters 2011年第4期28卷 235-237页

作者： REN Guo-Zhong LIU Yang MA Hong-An SU Tai-Chao LIN le-jing DENG le JIANG Yi-Ping ZHENG Shi-Zhao JIA Xiao-Peng Faculty of Materials Optoelectronics and PhysicsXiangtan UniversityXiangtan 411105 National Lab of Superhard Materials Jinlin UniversityChangchun 130012

Polycrystalline skutterudites Ba_(0.32)Co_(4)Sb_(12-x)Tex(nominally x=0.1-0.7)are synthesized by the high pressure and high temperature(HPHT)*** influence of Te substitution on electrical transport properties are investigated in the temperature range of *** the samples show n-type *** is found that the presence of Te substantially decreases electrical resistivi by without any detrimental effect on the Seebeck coefficients,which improves the power *** all the samples,Ba_(0.32)Co_(4)Sb_(11.5)Te_(0.5)shows the highest thermoelectric figure of merit of 0.76 at 710K.

关键词： electrical

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荧光激光雷达技术探测水面油污染系统仿真研究

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物理学报 2016年第7期65卷 80-86页

作者：景敏华灯鑫乐静西安理工大学机械与精密仪器工程学院西安710048 陕西理工学院机械工程学院汉中723000

为实现对水面油污染的探测,根据荧光激光雷达系统的发展趋势,采用激光诱导荧光技术,建立了适用于水面油污染探测荧光激光雷达的系统模型.提出采用单激光器结合增强电荷耦合器件的小型荧光激光雷达探测系统,通过分析激光器单脉冲能量与... 详细信息

为实现对水面油污染的探测,根据荧光激光雷达系统的发展趋势,采用激光诱导荧光技术,建立了适用于水面油污染探测荧光激光雷达的系统模型.提出采用单激光器结合增强电荷耦合器件的小型荧光激光雷达探测系统,通过分析激光器单脉冲能量与探测浓度之间的关系,结合荧光激光雷达系统参数,对系统模型的探测能力与信噪比等进行了数值仿真.结果表明,系统选用单脉冲能量50μJ的355 nm Nd:YAG激光器作为激发光源,白天在7 m的距离处探测信噪比可以达到10,满足实验室搭建模拟系统的要求.针对实际探测水面油污染,提出采用增大激光器功率的方法,并通过模拟计算验证了采用50 m J的单脉冲能量激光器在230 m的探测距离处可得到与实验室相同的结果,对实际系统的搭建具有指导意义.

关键词：激光诱导荧光荧光激光雷达水面油污染信噪比

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Clinical and Hereditary Features of Familial Vitreous Amyloidosis in Chinese

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Eye Science 2011年第1期26卷 52-56页

作者： Yining Shi le Yang jing Li Jia Hu Rui Shi Ye Sun Chuntao Zhang Department of Ophthalmology in Shaanxi Provincial People＇s Hospital

Purpose:To investigate the clinical and hereditary features of a Chinese Han pedigree with familial vitreous ***:The hereditary features of familial traits were detected by drawing genealogy,and the clinical menifestations were ***:This family with 4 generations of 32 family members had the characteristics of euchromosome dominant *** age of onset in heterozygotes was over 40 years old in male and over 55 in *** affected individuals had curly *** the 23 family members of the first 3 generations,7 had the final *** of the cases treated by vitrectomy was found to have open angle glaucoma during the ***:We reported a Chinese Han pedigree with familial vitreous amyloidosis which is a rare condition in Chinese and described the clinical and hereditary *** genetic sequencing and animal model are undergoing.

关键词：淀粉样变性中国汉族遗传特征家族性玻璃体临床功能检测显性遗传

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基于多层序列图像的三维表面粗糙度检测

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仪器仪表学报 2010年第9期31卷 2036-2041页

作者：乐静杨洁王建李乐西安理工大学机械与精密仪器工程学院西安710048

提出了一种非接触检测工件表面粗糙度的新方法。利用光学测量显微镜景深小这一特点,将CCD沿金属表面垂直方向等间距拍摄部分聚焦的序列图像,然后采用方差聚焦测度算子确定融合图像中每点所属的高度层次,利用高斯插值方法计算微观物体表... 详细信息

提出了一种非接触检测工件表面粗糙度的新方法。利用光学测量显微镜景深小这一特点,将CCD沿金属表面垂直方向等间距拍摄部分聚焦的序列图像,然后采用方差聚焦测度算子确定融合图像中每点所属的高度层次,利用高斯插值方法计算微观物体表面更准确的高度信息,重构了三维微观形貌。同时探讨了三维表面粗糙度参数表征的可行性,通过与二维表面粗糙度参数的对比实验,验证了其正确性和可靠性。该方法对表面粗糙度的在线检测和更完整地表征3D形貌等方面具有参考价值。

关键词：表面粗糙度方差融合聚焦测度算子三维重构

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