The Dual Role of Non-coding RNAs in the Development of Periodontitis

作     者：XU Xi LANG Guang Ping CHEN Zhong Lan WANG Jing Le HAN Ying Ying XU Xi;LANG Guang Ping;CHEN Zhong Lan;WANG Jing Le;HAN Ying Ying

作者机构：Special Key Laboratory of Oral Diseases ResearchHospital/School of StomatologyZunyi Medical UniversityZunyi 563099GuizhouChina Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of EducationZunyi Medical UniversityZunyi 563099GuizhouChina School of Preclinical Medicine of Zunyi Medical UniversityZunyi Medical UniversityZunyi 563099GuizhouChina 

出 版 物：《生物医学与环境科学:英文版》 (Biomedical and Environmental Sciences)

年 卷 期：2023年第36卷第8期

页      面：743-755页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：supported by Guizhou Provincial Science and Technology Foundation(Grant No.1Y292) Science and technology fund project of Guizhou Provincial Health Commission(NO:gzwkj2023-201) Doctor Startup Foundation of Zunyi Medical University(Grant No.5733-044) Zunyi Oral Disease Immune Prevention and Medical Biomaterials Research and Development Innovation Talent Team,Zunyi Science TalentNo.1 

主　　题：Periodontitis MicroRNA Long non-coding RNA Circular RNA Non-coding RNA 

摘      要：This review aims to sum up how Non-coding RNAs(ncRNAs)regulate the development of periodontitis and provides a new perspective for understanding the pathogenesis of *** explored the ncRNA s dual role in the development of periodontitis by summarizing evidence from previous in vivo and in vitro studies as well as clinical *** our review,the downregulation of 18 miRNAs,22 lncRNAs and 10 circRNAs demonstrates protective roles in *** contrast,the expression of other 11 miRNAs,7 lncRNAs and 6 circRNAs are upregulated in periodontitis,which promote the progression of *** dysregulated ncRNAs exert their protective or destructive roles by mainly influencing cell proliferation,differentiation and apoptosis via cross-talking with various molecules or signaling *** findings suggested which and how ncRNAs promote or delay the progression of periodontitis,which may greatly contribute to diagnose and therapy development of periodontitis based on ncRNAs in the future.