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Toripalimab combined with targeted therapy and chemotherapy achieves pathologic complete response in gastric carcinoma:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6184-6191页

作者： Rui Liu Xia Wang Zhi Ji Ting deng Hong-Li Li Yan-Hui Zhang Yu-Chong Yang Shao-Hua Ge le Zhang Ming Bai Tao Ning Yi Ba National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300000China

BACKGROUND Neoadjuvant or perioperative chemotherapy combined with surgery can reduce postoperative recurrence and improve the long-term survival rate of patients with locally advanced resectable gastric *** combined with chemotherapy has been recommended by the National Comprehensive Cancer Network guidelines as a first-line therapy for advanced gastric carcinoma/adenocarcinoma of the gastroesophageal junction and serves as the basis for immunotherapy combined with chemotherapy to become a neoadjuvant ***,we report a case in which pathologic complete response was achieved by neoadjuvant administration of toripalimab,Herceptin,and docetaxel,oxaliplatin,calcium folinate,and fluorouracil(FLOT)chemotherapy followed by surgery for human epidermal growth factor receptor 2(HER2)-and programmed deathligand 1(PD-L1)-positive locally advanced gastric *** hope that this case will shed some light on neoadjuvant therapy for gastric *** SUMMARY The patient was diagnosed with locally advanced adenocarcinoma of the *** of the baseline tissues suggested that the tissues were HER2-(fluorescent in situ hybridization)and PD-L1-positive(combined positive score=1).The patient underwent surgery following a four-cycle neoadjuvant therapy comprising Herceptin,toripalimab,and FLOT *** postoperative pathological findings showed mild atypical hyperplasia of the local glands with chronic mucosal inflammation(proximal stomach),no clear residual tumor(tumor regression grade 0),no regional lymph node metastasis,and negative upper and lower cut *** levels of tumor markers were reduced to normal levels after *** good postoperative recovery,the four-cycle preoperative chemotherapy was continued at the same dosage as that previously *** the treatment,the patient was monitored every 3 mo with a follow-up of 12 mo(4 times).As of February 27,2022,he was in a good condition without dise

关键词： Toripalimab Targeted therapy Chemotherapy Perioperative management Gastric carcinoma Case report

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华语地区的最早分级制度与电影迷思——澳门地区20世纪70年代的电影放映

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北京电影学院学报 2023年第7期 120-128页

作者：罗乐邓涛澳门科技大学人文艺术学院/电影学院中国澳门四川传媒学院融合媒体学院

在华人观影社会中,澳门地区的电影分级制度于20世纪70年代率先出现并延续发展至今。然而表面的规范化管理景象下,蕴藏着与这一时代相伴的地域社会问题及整体城市形象的变化。如何从社会电影史的角度理解澳门地区制度的变迁和社会情境?... 详细信息

在华人观影社会中,澳门地区的电影分级制度于20世纪70年代率先出现并延续发展至今。然而表面的规范化管理景象下,蕴藏着与这一时代相伴的地域社会问题及整体城市形象的变化。如何从社会电影史的角度理解澳门地区制度的变迁和社会情境?特殊时代的电影放映造就了怎样的地域本土性与电影迷思?一时间趋于“无政府”状态的社会业态以及澳门地区回归中国内地议程的明朗化,分别与本地放映格局有着怎样的关联?为求实证资料的客观和全面,本文将基于计量电影的方法,一方面力图还原澳门地区整十年的电影放映版图和风貌特征,另一方面通过史料文献和图文话语分析进一步揭示分级制度在此时、此地率先出现的多重动因及具体实施上的问题。

关键词：历史分级审查计量广告

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Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer

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Protein & Cell 2016年第2期7卷 141-151页

作者： Haiyang Zhang Jingjing Duan Yanjun Qu Ting deng Rui Liu le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba Tianjin Medical University Cancer Institute and Hospital Key Laboratory of Cancer Prevention and Therapy National ClinicalResearch Center for Cancer Tianjin 300060 China Department of Gastroenterology Tianjin First Center Hospital Tianjin 300192 China Changchun GeneScience Pharmaceuticals Co. Ltd Changchun 130012 China

Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR- 24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3＇UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.

关键词： gastric cancer BCL2L11 miR-24,tumorigenesis cell apoptosis proliferation migration

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Ring artifacts correction based on the projection-field in neutron CT

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Chinese Physics B 2021年第5期30卷 267-271页

作者： Sheng-Xiang Wang Jie Chen Zhi-Jian Tan Si-Hao deng Yao-Da Wu Huai-le Lu Shou-Ding Li Wei-Chang Chen Lun-Hua He Spallation Neutron Source Science Center Dongguan 523803China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Institute of Physics Chinese Academy of SciencesBeijing 100190China Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

Ring artifacts will happen mostly when the detector has inconsistent response among the detector channels,and the characteristic produced rings centered in the iso-center in the reconstructed slices inevitably affect the recognition and analysis of the corresponding sample structures in neutron computed tomography(CT).In this work,a ring correction method based on the projection-field(RCP)is proposed,it is a pre-processing method and provides the corrected projection data directly,which is also conducive to efficient data storage and other algorithmic *** and physical experiments are performed for verifying the effect of the method,and one of the correction methods based on the image-field is used for *** results demonstrate that the RCP can correct the ring artifacts well without reducing the image resolution or over-correction.

关键词： ring artifacts correction neutron CT projection field

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Uncertainty measure in evidence theory

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Science China(Information Sciences) 2020年第11期63卷 5-23页

作者： Yong deng School of Education Shannxi Normal University The Institute of Fundamental and Frontier Science University of Electronic Science and Technology of China

As an extension of probability theory, evidence theory is able to better handle unknown and imprecise information. Owing to its advantages, evidence theory has more flexibility and effectiveness for modeling and processing uncertain information. Uncertainty measure plays an essential role both in evidence theory and probability theory. In probability theory, Shannon entropy provides a novel perspective for measuring uncertainty. Various entropies exist for measuring the uncertainty of basic probability assignment(BPA) in evidence theory. However, from the standpoint of the requirements of uncertainty measurement and physics, these entropies are controversial. Therefore, the process for measuring BPA uncertainty currently remains an open issue in the literature. Firstly, this paper reviews the measures of uncertainty in evidence theory followed by an analysis of some related controversies. Secondly, we discuss the development of deng entropy as an effective way to measure uncertainty, including introducing its definition, analyzing its properties, and comparing it to other measures. We also examine the concept of maximum deng entropy, the pseudo-Pascal triangle of maximum deng entropy, generalized belief entropy, and measures of divergence. In addition, we conduct an analysis of the application of deng entropy and further examine the challenges for future studies on uncertainty measurement in evidence theory. Finally, a conclusion is provided to summarize this study.

关键词： evidence theory uncertainty measure deng entropy Shannon entropy

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子宫肉瘤32例治疗分析

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中国妇幼保健 2005年第9期20卷 1065-1068页

作者：邓乐静湖北省潜江市江汉油田中心医院妇产科 433124

目的:探讨子宫肉瘤的临床特点,了解其预后因素,寻求治疗的改进方法。方法:回顾性分析该院1990年7月～2000年4月收治的32例子宫肉瘤的病理学类型、临床特点、治疗方法及预后因素。结果:总的3年及5年生存率分别为79.17%和68.42%,总复发率... 详细信息

目的:探讨子宫肉瘤的临床特点,了解其预后因素,寻求治疗的改进方法。方法:回顾性分析该院1990年7月～2000年4月收治的32例子宫肉瘤的病理学类型、临床特点、治疗方法及预后因素。结果:总的3年及5年生存率分别为79.17%和68.42%,总复发率为43.75%。临床和手术病理分期对3年及5年生存率差异有显著性(P0.05),但广泛全子宫双附件加盆腔淋巴结清扫术对复发率的影响差异有显著性(P0.05),尚需积累更多经验。

关键词：子宫肉瘤治疗预后

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一种简单有效的TDOA-FDOA-AOA目标定位闭式解

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西安电子科技大学学报 2018年第2期45卷 171-175,180页

作者：邓兵孙正波杨乐盲信号处理重点实验室四川成都610041 江南大学物联网工程学院江苏无锡214122

针对TDOA-FDOA-AOA联合定位中目标状态求解这一难题,提出了一种简单有效的闭式求解算法.首先根据几何关系,通过测量值变换,将与目标位置、速度高度非线性的时差、频差、角度测量方程转换为关于目标状态的线性函数,再利用加权最小二乘估... 详细信息

针对TDOA-FDOA-AOA联合定位中目标状态求解这一难题,提出了一种简单有效的闭式求解算法.首先根据几何关系,通过测量值变换,将与目标位置、速度高度非线性的时差、频差、角度测量方程转换为关于目标状态的线性函数,再利用加权最小二乘估计求得目标状态估计.性能分析及仿真结果证明了所提算法具有较好的定位性能.

关键词：无源定位到达时间差到达频率差到达角度克拉美罗界

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Molecular and therapeutic landscape of ferroptosis in skin diseases

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Chinese Medical Journal 2024年第15期137卷 1777-1789页

作者： Jiayuan le Yu Meng Ying Wang Daishi Li Furong Zeng Yixiao Xiong Xiang Chen Guangtong deng Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology ChangshaHunan 410008China Furong Laboratory ChangshaHunan 410008China Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and DiseaseXiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunan 410008China Department of Oncology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430030China

Regulated cell death(RCD)is a critical physiological process essential in maintaining skin *** the various forms of RCD,ferroptosis stands out due to its distinct features of iron accumulation,lipid peroxidation,and involvement of various inhibitory antioxidant *** recent years,an expanding body of research has solidly linked ferroptosis to the emergence of skin ***,understanding the mechanisms underlying ferroptosis in skin diseases is crucial for advancing therapy and prevention *** review commences with a succinct elucidation of the mechanisms that underpin ferroptosis,embarks on a thorough exploration of ferroptosis’s role across a spectrum of skin conditions,encompassing melanoma,psoriasis,systemic lupus erythematosus(Sle),vitiligo,and dermatological ailments precipitated by ultraviolet(UV)exposure,and scrutinizes the potential therapeutic benefits of pharmacological interventions aimed at modulating ferroptosis for the amelioration of skin diseases.

关键词： Ferroptosis Skin diseases Regulated cell death Homeostasis Melanoma Psoriasis Systemic lupus erythematosus Vitiligo

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Low-cost adsorbents for urban stormwater pollution control

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Frontiers of Environmental Science & Engineering 2020年第5期14卷 75-82页

作者： Yang deng Department of Earth and Environmental Studies Montclair State UniversityMontclairNJ 07043USA

Stormwater represents a major non-point pollution source at an urban *** improve the treatment efficacy ofstormwater infrastructure,low-cost adsorbents have increasingly gained attention over the past *** article aims to briefly discuss several key aspects and principles for utilization of low-cost adsorbents for urban stormwater *** determine whether a low-cost adsorbent is suitable for stormwater treatment,two aspects should be carefully assessed,including:1)its adsorption mechanisms and behaviors that can influence the binding strength,adsorption kinetics,and treatment capacity;and 2)unwanted chemical leaching patterns that can affect the extent of water quality ***,the application mode of an adsorbent in the system design influences the utilization ***,after dosed to soil media in infrastructure,would eventually become ineffective after *** contrast,standalone filters or innovative composite adsorbents(e.g.,adsorbent-coated mulch chips)can enable a long-lasting adsorption due to periodic replacement with fresh *** aforementioned principles play a key role in the success of urban stormwater treatment with low-cost adsorbents.

关键词： Urban stonnwater Runoff pollutants Low-cost adsorbents Adsorption Chemical leaching

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin Meng Li Weibin Chen Pei Liu Tao Huang Zhencheng Huang Yuying Liu Jiaojiao deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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