Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer

作     者：Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba 

作者机构：Tianjin Medical University Cancer Institute and Hospital Key Laboratory of Cancer Prevention and Therapy National ClinicalResearch Center for Cancer Tianjin 300060 China Department of Gastroenterology Tianjin First Center Hospital Tianjin 300192 China Changchun GeneScience Pharmaceuticals Co. Ltd Changchun 130012 China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2016年第7卷第2期

页      面：141-151页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：This work was supported by grants from the National research platform of clinical evaluation technology for new anticancer drugs (No. 2013ZX09303001 ), the National Natural Science Foundation of China (Grant Nos. 81201946 and 81372394) and Tianjin City High School Science & Technology Fund Planning Project (20130122). The funders had no role in study design collection, analysis, and interpretation of data in the writing of the report and in the decision to submit this article for publication 

主　　题：gastric cancer BCL2L11 miR-24,tumorigenesis cell apoptosis proliferation migration 

摘      要：Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR- 24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3＇UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.