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Interactive mobile equipment safety task-training in surface mining

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International Journal of Mining Science and Technology 2021年第4期31卷 743-751页

作者： lazar Zujovic Vladislav Kecojevic Dragan Bogunovic Department of Mining Engineering West Virginia UniversityMorgantown 26501USA North American Coal Corporation Farmington 87401USA

Improving the quality of equipment training for the Heavy Equipment Operators(HEO)is a critical task in improving safety and eliminating equipment-related injuries in *** of major responsibilities for the HEOs is proper machine *** miner safety training includes the use of hardcopy documents and video ***,modern mobile and computer technology offers tremendous potential to improve the training *** this study,we apply a 360-degree camera,opensource platform WordPress^(TM),and the software Unity3D in order to create materials and tools for the HEOs safety training to help trainees better understand the pre-shift safety machine *** computer-based safety task training developed in this research is tested and implemented at a surface mine in the southern United States.

关键词： Heavy equipment operators Safety task training 360-degree image/video Virtual reality

A resilience-based approach in managing the closure and abandonment of large mine tailing ponds

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International Journal of Mining Science and Technology 2020年第5期30卷 737-746页

作者： Dragan Komljenovic lazar Stojanovic Vladimir Malbasic Aleksandar Lukic Hydro-Québec Research Institute(IREQ) VarennesQC J3X 1S1Canada Faculty of Mining University of Banja Luka79101 PrijedorBosnia and Herzegovina ArcelorMittal Prijedor d.o.o.Prijedor 79101 PrijedorBosnia and Herzegovina

Mining tailing ponds are large infrastructure objects whose life cycle spans over several *** are indispensable for certain types of mines where technological process produces and rejects *** also have potential to generate risks for human life,property and *** that reason,it is essential to adequately manage them throughout all the stages of their life *** phase of their closure and abandonment is less studied and *** paper proposes a holistic resilience-based approach for analyzing this phase of their life *** proposed methodology is validated through a case study at an actual surface iron ore mine in Bosnia and Herzegovina.

关键词： Mine tailing ponds Closure Abandonment Resilience Risks Uncertainties Complexity

Channeling of fast ions through the bent carbon nanotubes： The extended two-fluid hydrodynamic model

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Chinese Physics B 2016年第4期25卷 274-283页

作者： lazar Karbunar Dusko Borka Ivan Radovic Zoran L Miskovic School of Electrical Engineering University of Belgrade Bulevar Kralja Aleksandra 73 11120 Belgrade Serbia Vinca Institute of Nuclear Sciences University of Belgrade P. O. Box 522 11001 Belgrade Serbia Department of Applied Mathematics and Waterloo Institute for Nanotechnology University of Waterloo Waterloo Ontario Canada N2L 3G1

We investigate the interactions of charged particles with straight and bent single-walled carbon nanotubes （SWNTs） under channeling conditions in the presence of dynamic polarization of the valence electrons in carbon, This polarization is described by a cylindrical, two-fluid hydrodynamic model with the parameters taken from the recent modelling of several independent experiments on electron energy loss spectroscopy of carbon nano-structures. We use the hydrodynamic model to calculate the image potential for protons moving through four types of SWNTs at a speed of 3 atomic units. The image potential is then combined with the Doyle-Turner atomic potential to obtain the total potential in the bent carbon nanotubes. Using that potential, we also compute the spatial and angular distributions of protons channeled through the bent carbon nanotubes, and compare the results with the distributions obtained without taking into account the image potential.

关键词： nanotubes channeling dynamic polarization

Fekete-Gauss Spectral Elements for Incompressible Navier-Stokes Flows:The Two-Dimensional Case

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Communications in Computational Physics 2013年第5期13卷 1309-1329页

作者： Laura lazar Richard Pasquetti Francesca Rapetti Lab.J.A.Dieudonne UMR 7351 CNRS UNSUniversite de Nice-Sophia Antipolis06108 Nice Cedex 02France

Spectral element methods on simplicial meshes,say TSEM,show both the advantages of spectral and finite element methods,i.e.,spectral accuracy and geometrical *** present a TSEM solver of the two-dimensional(2D)incompressible Navier-Stokes equations,with possible extension to the 3D *** uses a projection method in time and piecewise polynomial basis functions of arbitrary degree in *** so-called Fekete-Gauss TSEM is employed,i.e.,Fekete(***)points of the triangle are used as interpolation(***)*** the sake of consistency,isoparametric elements are used to approximate curved *** resolution algorithm is based on an efficient Schur complement method,so that one only solves for the element boundary ***,the algebraic system is never assembled,therefore the number of degrees of freedom is not *** accuracy study is carried out and results are provided for classical benchmarks:the driven cavity flow,the flow between eccentric cylinders and the flow past a cylinder.

关键词： Spectral elements simplicial meshes Fekete-Gauss approximation Navier-Stokes equations projection methods domain decomposition

Predictors of rebleeding and in-hospital mortality in patients with nonvariceal upper digestive bleeding

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World Journal of Clinical Cases 2019年第18期7卷 2687-2703页

作者： Daniela Cornelia lazar Sorin Ursoniu Adrian Goldis Department of Internal Medicine I University Medical ClinicUniversity of Medicine and Pharmacy "Victor Babes"Timisoara 300041Timis CountyRomania Department of Public Health and Health Management University of Medicine and Pharmacy "Victor Babes"Timisoara 300041Timis CountyRomania Department of Gastroenterology and Hepatology University of Medicine and Pharmacy "Victor Babes"Timisoara 300041Timis CountyRomania

BACKGROUND Nonvariceal upper digestive bleeding (NVUDB) represents a severe emergency condition and is associated with significant morbidity and mortality. Despite a decrease in the incidence due to the widespread use of potent therapy with proton pump inhibitors as well as the implementation of modern endoscopic techniques, the mortality rate associated with NVUDB is still high. AIM To identify the clinical, biological, and endoscopic parameters associated with a poor outcome in patients with NVUDB to allow the stratification of risk, which will lead to the implementation of the most accurate management. METHODS We performed a retrospective study including patients who were admitted to the Gastroenterology Department of Clinical Emergency County Hospital Timisoara, Romania, with a diagnosis of NVUDB between 1 January 2008 and 31 December 2016. All the data were collected from the patient’s records, including demographic data, medication history, hemodynamic status, paraclinical tests, and endoscopic features as well as the methods of hemostasis, rate of rebleeding, need for surgery and death;we also assessed the Rockall score of the patients, length of hospitalization and associated comorbidities. All these parameters were evaluated as potential risk factors associated with rebleeding and death in patients with *** We included a batch of 1581 patients with NVUDB, including 523 (33%) females and 1058 (67%) males with a median age of 66 years. The main cause of NVUDB was peptic ulcer (73% of patients). More than one-third of the patients needed endoscopic treatment. Rebleeding rate was 7.72%;surgery due to failure of endoscopic hemostasis was needed in 3.22% of cases;the in-hospital mortality rate was 8.09%, and the bleeding-episode-related mortality rate was 2.97%. Although our predictive models for rebleeding and death had a low sensitivity, the specificity was very high, suggesting a better discriminative capacity for identifying patients with better out

关键词： Nonvariceal upper digestive bleeding Risk factors Rebleeding Death Outcome

A novel LC–MS/MS assay for methylprednisolone in human plasma and its pharmacokinetic application

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 459-468页

作者： Sridhar Siddiraju Mercy lazar Lal Prasanth Tadiboyina Sirisha Department of Pharmaceutical Chemistry Malla Reddy College of Pharmacy Osmania University Department of Pharmacy Shri Jagdishprasad Jhabarmal Tibrewala University Department of Pharmaceutical Chemistry JSS College of Pharmacy JSS University

Methylprednisolone is a synthetic glucocorticoid. In our report, the authors proposed a sensitive and selective liquid chromatography/tandem mass spectrometry(LC–MS/MS) assay for the determination of methylprednisolone applying budesonide as internal standard. Liquid–liquid extraction(LLE) having tert–butyl methyl ether(TBME) have been employed to extract methylprednisolone from the plasma samples. Immediately after reconstitution, the samples were chromatographed on a C18 column using an isocratic mobile phase composed of 10 m M ammonium formate buffer and acetonitrile(35:65, v/v). A flow rate of 1.00 ml/min was used to elute the analyte form the column. Analysis was carried out with an API–4000 LC–MS/MS instrument operated in multiple reaction-monitoring(MRM) mode. The linearity has been proven within the concentration range of 10.1–804 ng/ml in plasma samples. The precision(%CV) and accuracy results in five validation batches across five concentration levels were well within the acceptance limits. The drug was stable under different conditions. The particular assay has been proficiently put on pharmacokinetic study in healthy male subjects.

关键词： Methylprednisolone Human plasma Method validation LC–MS/MS Pharmacokinetics

Artificial intelligence as a noninvasive tool for pancreatic cancer prediction and diagnosis

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World Journal of Gastroenterology 2023年第12期29卷 1811-1823页

作者： Alexandra Corina Faur Daniela Cornelia lazar Laura Andreea Ghenciu Department of Anatomy and Embriology “Victor Babeș”University of Medicine and Pharmacy TimișoaraTimișoara 300041TimișRomania Department V of Internal Medicine I Discipline of Internal Medicine IVUniversity of Medicine and Pharmacy“Victor Babes”TimișoaraTimișoara 300041TimișRomania DepartmentⅢ Discipline of Pathophysiology“Victor Babeș”University of Medicine and PharmacyTimișoara 300041TimișRomania

Pancreatic cancer(PC)has a low incidence rate but a high mortality,with patients often in the advanced stage of the disease at the time of the first *** detected,early neoplastic lesions are ideal for surgery,offering the best *** lesions of the pancreas include pancreatic intraepithelial neoplasia and mucinous cystic neoplasms,with intraductal papillary mucinous neoplasms being the most commonly *** study focused on predicting PC by identifying early signs using noninvasive techniques and artificial intelligence(AI).A systematic English literature search was conducted on the PubMed electronic database and other *** obtained a total of 97 studies on the subject of pancreatic *** final number of articles included in our study was 44,34 of which focused on the use of AI algorithms in the early diagnosis and prediction of pancreatic *** algorithms can facilitate diagnosis by analyzing massive amounts of data in a short period of *** can be made through AI algorithms by expanding image and electronic medical records databases,which can later be used as part of a screening program for the general ***-based screening models should involve a combination of biomarkers and medical and imaging data from different *** requires large numbers of resources,collaboration between medical practitioners,and investment in medical infrastructures.

关键词： Pancreatic cancer Early pancreatic lesions Pancreatic neoplasia Artificial intelligence Deep learning Machine learning Radiomics Diagnosis Pancreas

Microfluidic reactors for advancing the MS analysis of fast biological responses

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Microsystems & Nanoengineering 2019年第1期5卷 627-642页

作者： Iulia M.lazar Jingren Deng Mark A.Stremler Shreya Ahuja Department of Biological Sciences Virginia Tech1981 Kraft DriveBlacksburgVA 24061USA Virginia Tech Carilion School of Medicine Virginia Tech2 Riverside CircleRoanokeVA 24016USA Department of Mechanical Engineering Virginia Tech780 Drillfield DriveRoom 333PBlacksburgVA 24061USA

The response of cells to physical or chemical stimuli is complex,unfolding on time-scales from seconds to days,with or without de novo protein synthesis,and involving signaling processes that are transient or *** combining the technology of microfluidics that supports fast and precise execution of a variety of cell handling operations,with that of mass spectrometry detection that facilitates an accurate and complex characterization of the protein complement of cells,in this work,we developed a platform that supports(near)real-time sampling and proteomelevel capturing of cellular responses to a perturbation such as treatment with *** geometric design of the chip supports three critical features:(a)capture of a sufficient number of cells to meet the detection limit requirements of mass spectrometry instrumentation,(b)fluid delivery for uniform stimulation of the resident cells,and(c)fast cell recovery,lysis and processing for accurate sampling of time-sensitive cellular responses to a *** simulations and microscopy were used to predict and evaluate the flow behavior inside the microfluidic *** analysis of the cellular extracts generated by the chip experiments revealed that the identified proteins were representative of all cellular locations,exosomes,and major biological processes related to proliferation and signaling,demonstrating that the device holds promising potential for integration into complex lab-on-chip workflows that address systems biology *** applicability of the chips to study time-sensitive cellular responses is discussed in terms of technological challenges and biological relevance.

关键词： fluid sustained stimulation

New Dimensions for a Challenging Security Environment:Growing Exposure to Critical Space Infrastructure Disruption Risk

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International Journal of Disaster Risk Science 2018年第4期9卷 555-560页

作者： Adrian V.Gheorghe Alexandru Georgescu Olga Bucovetchi Marilena lazar Cezar Scarlat Department of Engineering Management and Systems Engineering Old Dominion UniversityNorfolkVA 23529USA Romanian Association for Space Technology and Industry(ROMSPACE) 061126 BucharestRomania University Politehnica of Bucharest 060042 BucharestRomania Military Equipment and Technologies Research Agency of the Romanian Ministry of Defense(METRA) 077025 ClinceniIlfov CountyRomania

Space systems have become a key enabler for a wide variety of applications that are vital to the functioning of advanced societies. The trend is one of quantitative and qualitative increase of this dependence, so much so that space systems have been described as a new example of critical infrastructure. This article argues that the existence of critical space infrastructures implies the emergence of a new category of disasters related to disruption risks. We inventory those risks and make policy recommendations for what is, ultimately, a resilience governance issue.

关键词： Complex systems Infrastructure disruption Resilience governance Space infrastructure System interdependencies