检索结果-南通市图书馆

Engineered Regeneration 2022年第4期3卷 365-373页

作者： Xuefeng Yao Huaqiong Li Liping Chen lay poh tan School of Materials Science and Engineering Nanyang Technological University639798Singapore Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325000PR China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000PR China

As a hallmark of skin aging,senescent human dermal fibroblasts(HDFs)are known to lose the ability to ***,they can still interact with their cellular environment and the surrounding *** the skin ages,the progressive slowing down of HDFs function decreases the skin’s structural integrity,which is more serious than if there is the dermal collagen matrix *** leads to matters of the unbalanced barrier under the skin,skin fragility,inadequate wound healing,as well as other cosmetic *** is also well documented that skin aging comes with significant stiffness ***,understanding the interactions between HDFs and the surrounding microenvironments during senescence may provide insights into skin *** we aim to inves-tigate matrix stiffness’effect on HDF senescence and elucidate possible mechanisms that make HDFs *** our experiments,HDFs were cultivated on Polydimethylsiloxane(PDMS)with various stiffnesses and exposed to UV light to trigger *** show that HDFs are significantly affected by senescence when cultured on a matrix with ***,the cells are not significantly affected when cultured on a low stiffness *** following characterization revealed cells cultured on stiffsubstrates under UV exposure had stimu-lated the nucleus factor kappa-B(NF-κB)*** contrast,cells on a matrix of softness only displayed low activation of NF-κ***-κB activity suppression with ammonium pyrrolidine dithiocarbamate(PDTC)decreases UV-induced HDFs senescence on *** together,we demonstrated that soft matrix defends HDFs against ultraviolet-induced senescence by inhibiting the activation of NF-κB.

关键词： Human dermal fibroblasts Matrix stiffness Senescence NF-κB

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Investigation of bone reconstruction using an attenuated immunogenicity xenogenic composite scaffold fabricated by 3D printing

引用

Bio-Design and Manufacturing 2020年第4期3卷 396-409页

作者： Qiongxi Pan Chenyuan Gao Yingying Wang Yili Wang Cong Mao Quan Wang Sophia N.Economidou Dennis Douroumis Feng Wen lay poh tan Huaqiong Li School of Biomedical Engineering School of Ophthalmology and Optometry and Eye HospitalWenzhou Medical UniversityWenzhou 325035Zhejiang ProvincePeople’s Republic of China Engineering Research Center of Clinical Functional Materials and Diagnosis and Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011Zhejiang ProvincePeople’s Republic of China Key Laboratory of Orthopedics of Zhejiang Province Department of OrthopedicsThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvincePeople’s Republic of China Medway School of Pharmacy University of KentMedway CampusCentral AvenueChatham MaritimeChathamKent ME44TBUK CIPER Centre for Innovation and Process Engineering ResearchKent ME44TBUK School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637459Singapore School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore

Bone is known to have a natural function to heal ***,if the bone damage is beyond a critical degree,intervention such as bone grafting may be *** this work,the fabrication of a novel bone scaffold composed of natural bone components and polycaprolactone(PCL)using 3D printing is put forward.α1,3-galactosyltransferase deficient pigs were used as the donor source of a *** porcine bone(DCB)with attenuated immunogenicity was used as the natural component of the scaffold with the aim to promote bone *** 3D printed DCB-PCL scaffolds combined essential advantages such as uniformity of the interconnected macropores and high porosity and enhanced compressive *** biological properties of the DCB-PCL scaffolds were evaluated by studying cell adhesion,viability,alkaline phosphatase activity and osteogenic gene expression of human bone marrow-derived mesenchymal stem *** in vitro results demonstrated that the DCB-PCL scaffolds exhibit an enhanced performance in promoting bone differentiation,which is correlated to the DCB ***,critical-sized cranial rat defects were used to assess the effect of DCB-PCL scaffolds on bone regeneration in *** results confirm that in comparison with PCL scaffolds,the DCB-PCL scaffolds can significantly improve new bone formation in cranial ***,the proposed 3D printed DCB-PCL scaffolds emerge as a promising regeneration alternative in the clinical treatment of large bone defects.

关键词： Polycaprolactone 3D printing Decellularized porcine bone Cranial bone regeneration Attenuated immunogenicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：