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Incidence of human cytomegalovirus in pregnant women attending pre-natal clinic in Northern Nigeria

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Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 43-47页

作者： lawrence O Department of Microbiology and Biotechnology College of Natural and Applied SciencesWestern Delta UniversityPMB 10OgharraDelta State

Objective:To investigate the incidence of human cytomegalo virus(HCMV) in pregnant ***: One hundred and twenty two(122) blood samples and 80 umbilical cord fluids were tested for IgG and IgM respectively using the enzyme linked immunosorbent assay(ELISA).Results:Of the 122 samples screened for IgG and IgM only 56(47.1%) tested positive for IgG while 63(52.9%) were positive for IgM with 3 samples *** women with signs of normal pregnancy made up 60%of the positive results while 20%had a history of ectopic pregnancy and 20%with a history of *** the total of 80 umbilical cord fluids tested,only 59(73.8) tested *** of the selected 40 umblical cord fluid was positive to IgG to human cytomegalovirus along with mother and *** titration result gave diagnostic titre for both IgG and IgM from the 40 umbilical cord *** was a significant relationship between mother,child and umbilical cord fluids(χ~2 = 1.360,CI = 99%,P = 0.568).Conclusion:There could be a possible neonatal infection,and the infection is common among toddlers and children of pre-school age.

关键词： Human cytomegalo virus Herpes viridae Neonatal infection Persistent infection Recurrent infection

Laser Stimulation of the Chloroplast/Endoplasmic Reticulum Nexus in Tobacco Transiently Produces Protein Aggregates （Boluses） within the Endoplasmic Reticulum and Stimulates Local ER Remodeling

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Molecular Plant 2011年第5期4卷 886-895页

作者： lawrence R. Griffing1 3258 TAMU Biology Department Texas A＆M University College Station Texas 77843 USA

Does the ER subdomain that associates with the chloroplast in vivo, hereafter referred to as the chloroplast/ER nexus, play a role in protein flow within the ER？ In studies of tobacco cells either constitutively or transiently expressing ER-retained luminal, GFP-HDEL, or trans-membrane, YFP-RHD3, fluorescent fusion proteins, brief 405-nm （3-6-mW） laser stimulation of the nexus causes a qualitative difference in the movement and behavior of proteins in the ER. Photostimulating the nexus produces fluorescent protein punctate aggregates （boluses） within the lumen and membrane of the ER. The aggregation propagates through the membrane network throughout the cell, but within minutes can revert to normal, with disaggregation propagating back toward the originally photostimulated nexus. In the meantime, the ER grows and anastomoses around the chloroplast, forming a dense cisternal and tubular network. If this network is again photostimulated, bolus formation does not recur and, if the photostimulation results in photobleaching, fluorescence recovery after photobleaching occurs as it would typically in areas away from the nexus. Bolus propagation is not mediated by the actin cytoskeleton, but can be reversed by pre-conditioning the cells for 30 min with high, 40-45℃, temperature （heat stress）. Because it is not reversed with heat stress, the reorganization of the ER at the nexus following photostimulation is a separate event.

关键词： ER-chloroplast transport ER movement actin heat stress fluorescence recovery after photobleaching blue light reception.

Second quantization of a covariant relativistic spacetime string in Steuckelberg-Horwitz-Piron theory

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Frontiers of physics 2017年第3期12卷 187-196页

作者： Michael Suleymanov lawrence Horwitz Asher Yahalom Department of Physics Ariel University Ariel Israel Department of Electrical & Electronic Engineering Ariel University Ariel Israel School of Physics Tel Aviv University Ramat Aviv Israel Department of Physics Bar Ilan University Ramat Gan Israel

A relativistic 4D string is described in the framework of the covariant quantum theory first intro- duced by Stueckelberg [Helv. Phys. Acta 14, 588 （1941）], and further developed by Horwitz and Piron [Helv. Phys. Acta 46, 316 （1973）], and discussed at length in the book of Horwitz [Relativistic Quan- tum Mechanics, Springer （2015）]： We describe the space-time string using the solutions of relativistic harmonic oscillator [J. Math. Phys. 30, 66 （1989）]. We first study the problem of the discrete string, both classically and quantum mechanically, and then turn to a study of the continuum limit, which contains a basically new formalism for the quantization of an extended system. The mass and energy spectrum are derived. Some comparison is made with known string models.

关键词： second quantization spacetime string Steuckelberg-Horwitz-Piron theory

Bounded type Siegel disks of finite type maps with few singular values Dedicated to the Memory of Professor Lei Tan

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Science China Mathematics 2018年第12期61卷 2139-2156页

作者： Arnaud Chéritat Adam lawrence Epstein CNRS Institut de Mathematiques de ToulouseUniversite Paul SabatierToulouse F-31062France Mathematics Institute University of WarwickCoventry CV47ALUK

Let U be an open subset of the Riemann sphere C. We give sufficient conditions for which a finite type map f : U →C with at most three singular values has a Siegel disk compactly contained in U and whose boundary is a quasicircle containing a unique critical point. The main tool is quasiconformal surgery à la Douady-Ghys-Herman-(S′)wia tek. We also give sufficient conditions for which, instead, ? has not compact closure in U. The main tool is the Schwarzian derivative and area inequalities à la Graczyk-(S′)wia tek.

关键词： Siegel disks quasicircles quasiconformal surgery Schwarzian derivative

Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain

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Neural Regeneration Research 2023年第4期18卷 763-768页

作者： Kyle Taing lawrence Chen Han-Rong Weng Department of Basic Sciences California Northstate University College of MedicineElk GroveCAUSA

Neuroinflammation plays a critical role in the pathological process of multiple neurological disorders and pathological pain ***109A,a Gi protein-coupled receptor,has emerged as an important therapeutic target for controlling inflammation in various tissues and *** this review,we summarized current data about the role of GPR109A in ***,we focused on the pharmacological features of GPR109A and signaling pathways used by GPR109A to ameliorate neuroinflammation and symptoms in Alzheimer’s disease,Parkinson’s disease,multiple sclerosis,stroke,and pathological pain conditions.

关键词： β-hydroxybutyrate cytokines HCAR2 lupus neuroinflammation neuropathic niacin nociception synaptic

Subwavelength grating devices in silicon photonics

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Science Bulletin 2016年第11期61卷 879-888页

作者： Junjia Wang Ivan Glesk lawrence R.Chen Department of Electrical and Computer Engineering Mc Gill University Department of Electronic and Electrical Engineering University of Strathclyde

Subwavelength grating(SWG) waveguides in silicon-on-insulator are emerging as an enabling technology for implementing compact, high-performance photonic integrated devices and circuits for signal processing and sensing applications. We provide an overview of our recent work on developing wavelength selective SWG waveguide filters based on Bragg gratings and ring resonators, as well as optical delay lines. These components increase the SWG waveguide component toolbox and can be used to realize more complex photonic integrated circuits with enhanced or new functionality.

关键词： Subwavelength gratings Siliconphotonics Integrated optics - Bragg gratings Ringresonators Optical delay lines

A novel Epstein-Barr virus subtype associated with nasopharyngeal carcinoma found in South China

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Cancer Communications 2020年第1期40卷 60-62页

作者： lawrence S.Young Division of Biomedical Sciences Warwick Medical SchoolUniversity of WarwickCoventryCV47AJUnited Kingdom

Nasopharyngeal carcinoma(NPC)is a unique malignancy closely associated with Epstein-Barr virus(EBV)infection and with a restricted geographical distribution[1].According to a recent World Health Organization(WHO)report,there were around 129,000 new NPC cases reported worldwide in 2018 with greater than 70%of cases in South China and Southeast Asia[2].In Hong Kong and Guangdong in South China,NPC incidence is as high as 12.8-25.0/100,000 per year[1,2].

关键词： nasopharyngeal Nasopharyngeal cases

Completely irreducible sequences of meromorphic functions

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Science China Mathematics 2010年第3期53卷 827-830页

作者： NEVO Shahar ZALCMAN lawrence Department of Mathematics Bar-Ilan University

Given a sequence {fn } of meromorphic functions on a plane domain D, there exists a (possibly empty) open set U■D and a subsequence {f n k } which converges uniformly (with respect to the spherical metric on ) on compact subsets of U, while no subsequence of {f n k } converges uniformly on compact subsets of any larger open subset of D.

关键词： meromorphic functions convergence of sequences

Epstein-Barr virus at 50——future perspectives

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Chinese Journal of Cancer 2014年第11期33卷 527-528页

作者： lawrence S.Young Warwick Medical School University of WarwickCoventryCV4 7ALUK

The special November and December issues of the Chinese Journal of Cancer celebrate the 50th anniversary of the discovery of Epstein-Barr virus(EBV) with a series of reviews covering the association of the virus with various cancers, with special emphasis on the role of EBV in the pathogenesis of nasopharyngeal cancer(NPC). The restricted geographic prevalence of NPC along with the tumor's consistent association with EBV infection has fascinated scientists and clinicians ever since it was first suggested in 1966. As in all cancers, NPC development reflects the complex interplay between host genes and environmental factors, but the essential role of EBV infection provides important insight into the etiology of this tumor. Indeed, it is this understanding that is now translating into exciting diagnostic and therapeutic opportunities.

关键词： Epstein-Barr病毒病毒感染 NPC 发病机制 EB病毒临床医生相互作用环境因素