Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain

作     者：Kyle Taing Lawrence Chen Han-Rong Weng Kyle Taing;Lawrence Chen;Han-Rong Weng

作者机构：Department of Basic SciencesCalifornia Northstate University College of MedicineElk GroveCAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第4期

页      面：763-768页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the NIH RO1 grant(NS107569)to HRW 

主　　题：β-hydroxybutyrate cytokines HCAR2 lupus neuroinflammation neuropathic niacin nociception synaptic 

摘      要：Neuroinflammation plays a critical role in the pathological process of multiple neurological disorders and pathological pain ***109A,a Gi protein-coupled receptor,has emerged as an important therapeutic target for controlling inflammation in various tissues and *** this review,we summarized current data about the role of GPR109A in ***,we focused on the pharmacological features of GPR109A and signaling pathways used by GPR109A to ameliorate neuroinflammation and symptoms in Alzheimer’s disease,Parkinson’s disease,multiple sclerosis,stroke,and pathological pain conditions.