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Epstein-Barr virus at 50——future perspectives

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Chinese Journal of Cancer 2014年第11期33卷 527-528页

作者： lawrence s.young Warwick Medical school University of WarwickCoventryCV4 7ALUK

The special November and December issues of the Chinese Journal of Cancer celebrate the 50th anniversary of the discovery of Epstein-Barr virus(EBV) with a series of reviews covering the association of the virus with various cancers, with special emphasis on the role of EBV in the pathogenesis of nasopharyngeal cancer(NPC). The restricted geographic prevalence of NPC along with the tumor's consistent association with EBV infection has fascinated scientists and clinicians ever since it was first suggested in 1966. As in all cancers, NPC development reflects the complex interplay between host genes and environmental factors, but the essential role of EBV infection provides important insight into the etiology of this tumor. Indeed, it is this understanding that is now translating into exciting diagnostic and therapeutic opportunities.

关键词： Epstein-Barr病毒病毒感染 NPC 发病机制 EB病毒临床医生相互作用环境因素

Epstein-Barr virus and nasopharyngeal carcinoma

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Chinese Journal of Cancer 2014年第12期33卷 581-590页

作者： lawrence s.young Christopher W.Dawson Warwick Medical school The University of Warwick school of Cancer sciences University of Birmingham

since its discovery 50 years ago,Epstein-Barr virus(EBV)has been linked to the development of cancers originating from both lymphoid and epithelial *** 95%of the world’s population sustains an asymptomatic,life-long infection with *** virus persists in the memory B-cell pool of normal healthy individuals,and any disruption of this interaction results in virus-associated B-cell *** association of EBV with epithelial cell tumors,specifically nasopharyngeal carcinoma(NPC)and EBVpositive gastric carcinoma(EBV-GC),is less clear and is currently thought to be caused by the aberrant establishment of virus latency in epithelial cells that display premalignant genetic *** the precise role of EBV in the carcinogenic process is currently poorly understood,the presence of the virus in all tumor cells provides opportunities for developing novel therapeutic and diagnostic *** study of EBV and its role in carcinomas continues to provide insight into the carcinogenic process that is relevant to a broader understanding of tumor pathogenesis and to the development of targeted cancer therapies.

关键词： Epstein-Barr病毒鼻咽癌肿瘤细胞上皮细胞 EB病毒癌症治疗细胞起源世界人口

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with self‑supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑young Kim Yang Li Guozhen shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea school of Microelectronics Shandong UniversityJinan 250101People’s Republic of China state Key Laboratory of Integrated Chips and systems Fudan UniversityShanghai 200433People’s Republic of China school of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun young Choi Department of Brain science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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抗微生物疗法

江西医药 1988年第3期 279-296页

作者： Lowell s.young

抗微生物疗法的问世是使很多传染病得以治疗和控制的历史性里程碑事件。像细菌性心内膜炎之类难免死亡的感染,第一次得以治疗。以后积累到的大量资料还证明:早期治疗局限性细菌感染,可以防止合并症的发生。这里有两个显见的例证:(1)治... 详细信息

抗微生物疗法的问世是使很多传染病得以治疗和控制的历史性里程碑事件。像细菌性心内膜炎之类难免死亡的感染,第一次得以治疗。以后积累到的大量资料还证明:早期治疗局限性细菌感染,可以防止合并症的发生。这里有两个显见的例证:(1)治疗急性细菌性中耳炎,已使乳突炎的发生率明显减少,(2)及时治疗链球菌性咽喉感染,已使风湿热和风湿性心脏病的发生率大为减低。现代抗微生物疗法的最大成就是对急性细菌性感染的治疗,但也有少数慢性病如结核病,也已得到良好的控制。抗微生物疗法的新近发展,使得很多人深受威胁的病毒性疾患和寄生虫感染,也有希望得到控制。在抗霉菌领域方面,也已取得一些进展。虽然如此,当初由于具有抗菌作用的新药问世所激

关键词：青霉素结合蛋白庆大霉素妥布霉素艮他霉素碳水化合物氨基糖磺胺类头抱菌素氯林可霉素利福霉素利福平革兰氏阴性兼性厌气杆菌肠杆菌科抗菌素四环素类药物治疗病原菌红霉素抗微生物药物抗菌药物万古霉素极毛杆菌属假单胞菌属氯胺苯醇氯霉素抗微生物疗法

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

A theoretical justification of the slip index concept in fretting analysis

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Friction 2023年第7期11卷 1265-1275页

作者： Ivan I.ARGATOV young s.CHAI Institut für Mechanik Technische Universität Berlin10623 BerlinGermany school of Mechanical Engineering Yeungnam UniversityGyeongsan 712-749Republic of Korea

Fretting in the partial-slip and gross-slip regimes under a constant normal load is *** tangential force-displacement relations for the forward and backward motions are described based the generalized Cattaneo-Mindlin theory of tangential contact and Masing's hypothesis on modelling the force-displacement hysteretic *** the critical force and displacement parameters(characterizing the triggering of sliding),the model includes one dimensionless fitting parameter that tunes the tangential contact stiffness of the friction-contact *** expressions are derived for the main tribological parameters of the fretting loop,including the slip index and the signal *** presented phenomenological modelling approach has been applied to the analysis of two sets of experimental data taken from the *** has been shown that the experimentally observed simple relation of a rational type between the slip index and the slip ratio corresponds to the gross-slip asymptotics of the corresponding model-based predicted *** known quantitative criteria for the transition from the partial slip regime to the gross slip regime are expressed in terms of the stiffness parameter,and a novel geometric transition criterion is formulated.

关键词： fretting wear slip index signal index partial slip energy ratio

Cytokine analysis of livers from patients with seronegative viral hepatitis

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Cytokine analysis of livers from patients with seronegative ...

strategies for creating living, additively manufactured, open-cellular metal and alloy implants by promoting osseointegration,osteoinduction and vascularization: An overview

第三届全国重型肝病及人工肝血液净化学术年会

作者： susan Wong Atanu Basu Neal s.young Kevin E.Kevin. Hematology Branch NHLBIBethesdaMD 20892

Although the hepatitis viruses A,B,C,D and E account for the majority of cases of acute viral hepatitis,the etiology is unknown in～3% of *** addition,the etiological agent of hepatitis-associated aplastie anemia (HAA,severe bone marrow failure following an episode of acute hepatitis),and most cases of fulminant hepatitis (FH) is unknown,but does not appear to be caused by any of the known hepatitis agents,and including B19V, HGV,TTV,sENV,herpesviruses (including CMV,EBV and HHV-6/7),or adenoviruses (Brown et al NEJM 1997,Wong et al,JID 2003,Brown et al Br J Haematol 1997,Umemura et al JID,2003,our unpublished

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Journal of Materials science & Technology 2019年第2期35卷 231-241页

作者： lawrence E.Murr Department of Metallurgical Materials and Biomedical Engineering The University of Texas at El Paso W.M.Keck Center for 3D Innovation The University of Texas at El Paso

Additive manufacturing of porous, open-cellular metal or alloy implants, fabricated by laser or electron beam melting of a powder bed, is briefly reviewed in relation to optimizing biomechanical compatibility by assuring elastic(young's) modulus matching of proximate bone, along with corresponding pore sizes assuring osseointegration and vasculature development and migration. In addition, associated, requisite compressive and fatigue strengths for such implants are described. strategies for optimizing osteoblast(bone cell) development and osteoinduction as well as vascularization of tissue in 3 D scaffolds and tissue engineering constructs for bone repair are reviewed in relation to the biology of osteogenesis and neovascularization in bone, and the role of associated growth factors, bone morphogenic proteins, signaling molecules and the like. Prospects for infusing hydrogel/collagen matrices containing these cellular and protein components or surgically extracted intramedullary(bone marrow) concentrate/aspirate containing these biological and cell components into porous implants are discussed, as strategies for creating living implants, which over the long term would act as metal or alloy scaffolds.

关键词： Additive manufacturing Open cellular metal and alloy implants Electron beam melting Living implant strategies Vascularization Osseointegration Osteoinduction