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C-reactive protein in gallbladder diseases:diagnostic and therapeutic insights

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Biophysics Reports 2020年第Z1期6卷 49-67页

作者： Ibraheem m.Rajab Daniel majerczyk margaret E.Olson Jenna m.B.Addams mihee L.Choe matthew S.Nelson lawrence A.Potempa College of Pharmacy Roosevelt University

The gallbladder is an important component of the hepatobiliary system whose primary function is to aid in digestion of foodstuffs, excretion of drugs and facilitate removal of waste products from the *** gall bladder is principally a storage organ for bile, chemically modified salts and acids of cholesterol which are synthesized in the liver and which function as surfactants to solubilize fatty substances of limited aqueous solubility. Any disruption in the amount or activity of bile surfactant can lead to an accumulation of insoluble molecular clumps(e.g., gallstones) that deposit in and obstruct fluid movement within the gallbladder, and which can lead to pathological congestion and tissue *** natural host defense response to any event that causes tissue damage is to stimulate inflammation,which non-specifically but aggressively reacts to the stimuli so to remove the cause and repair damaged tissues. The C-reactive protein(CRP) is a primarily hepatically produced serum protein whose blood levels increase within 6–10 h of any tissue-damaging event. The extent with which it increases correlates with the level of tissue damage and associated inflammation. CRP levels are reported to be of value in diagnosing acute cholecystitis severity, in predicting the outcome and prognosis of cancerassociated gallbladder resection, and in helping identify cystic structures during emergency laparoscopic cholecystectomies. As an understanding of distinctive CRP structural isoforms is evolving, its role not only as a biomarker but as regulator of both physiologic and pathophysiologic processes of inflammation may be relevant in the understanding of and treatment approaches for gallbladderassociated disease.

关键词： C-reactive protein monomeric C-reactive Inflammation Gallbladder Gallstone Cholecystitis Cholesterol

A Review of Pediatric Cardiovascular Risk Factors and Current Guidelines

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World Journal of Cardiovascular Surgery 2018年第4期8卷 61-92页

作者： Deeksha Sarma lawrence m. Benedict Achintya moulick Randy Stevens Vicki mahan Department of Pediatric Cardiothoracic Surgery Drexel University College of Medicine St. Christopher’s Hospital for Children Philadelphia USA

Dyslipidemia is a highly prevalent condition, and includes a collection of diseases that cause increased levels of plasma triglycerides and/or cholestrol, or decreased levels of HDL-C, with a prototypical disease being familial hypercholesterolemia. Dyslipidemic conditions promote increased atherogenesis through the oxidation of lipids by macrophages, and an increased response to injury by the vascular endothelium. This vascular damage, loss of vascular compliance, and overall hardening of arteries lead to sequellae such as cardiovascular disease, cerebrovascular events, and aneurysm formation. It has been established that certain risk factors predispose individuals to the sequellae of atherosclerosis, including smoking, diabetes, hypertension, and hyperlipidemia. However, studies show that these risk factors can be seen in children as well. This review aims to assess the effect of these risk factors and demonstrate their effects through adolescence into adulthood.

关键词： Cardiovascular Disease Familial Hypercholesterolemia Dyslipidemia Atherosclerosis

muscarinic Acetylcholine Receptors in Alcohol Use Disorder

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神经药理学报 2019年第Z1期 30-31页

作者： Andrew J lawrence Florey Institute of Neuroscience and mental Health ParkvilleVictoriaFlorey Department of Neuroscience and Mental HealthUniversity of Melbourne

Background:Despite the large socioeconomic burden of alcohol use disorders(AUD),therapeutic treatment options are limited. There is a need to characterise the underlying neurochemistry driving alcohol seeking to identify and evaluate novel targets. AUDs are characterised by a transition to compulsive seeking,which is hypothesized to involve a shift from ventral to dorsal striatum and a medial to lateral dorsal striatal shift in the transition from goaldirected to habitual alcohol-seeking behaviours. muscarinic acetylcholine receptors(mAChRs) are a potential target for AUD;they are expressed within the mesocorticolimbic reward system,including dense expression in the dorsal striatum,where they modulate dopamine and glutamate release,which may regulate reward processing. methods:To assess the role of mAChRs in AUD,we first conducted genome-wide RNA sequencing in the caudate/putamen of 10 human alcoholics and 10 healthy controls and concurrently examined muscarinic receptor expression in the corresponding regions in rat(dorsolateral and dorsomedial striatum) following chronic alcohol consumption/withdrawal using qPCR. Next we examined the role of select muscarinic and nicotinic receptor subtypes in alcohol consumption and seeking using selective allosteric modulators. Finally,we probed the role of select muscarinic and nicotinic receptor subtypes in the dorsal striatum in alcohol consumption and seeking. Results:In human alcoholics m4 receptor expression was significantly decreased in the putamen. In line with this,m4 receptor expression was decreased in the rat dorsolateral striatum. Further,administration of VU154(30 mg·kg-1,p.o.) reduced alcohol self-administration and cue-induced relapse,without effects on natural reward consumption or sedation. We also found that a centrally active and selective negative allosteric modulator(NAm) for the rat m5 muscarinic receptor(mAChR),mL375,selectively decreases ethanol self-administration and attenuates cue-induced reinstateme

关键词： AUD muscarinic Acetylcholine Receptors in Alcohol Use Disorder

CHINA’S POLITICAL LEADERSHIP IS OPTImUm FOR ITS DEVELOPmENT

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China Report ASEAN 2021年第12期6卷 50-51页

作者： Robert lawrence Kuhn the Kuhn Foundation

I’m Robert lawrence Kuhn.I’d like to share with you my experiences in telling China’s story to the world and my views on the Communist Party of China(CPC).I have been coming to China for more than 30 years.I have traveled all across China,visiting over 100 cities,with my long-term partner,Adam Zhu,for research and interviews,books and essays,television and documentaries.I have given thought,over the years,as to what has brought about China’s developmental *** twelve principles.

关键词： travel partner Communist

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海底天然气渗漏系统演化特征及对形成水合物的影响

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沉积学报 2005年第2期23卷 323-328页

作者：陈多福冯东陈光谦陈先沛 lawrence m Cathles 中国科学院广州地球化学研究所与南海海洋研究所边缘海地质重点实验室 Department of Earth&Atmospheric Sciences Cornell UniversityIthacaNewYork148531504USA

通过天然气沉淀水合物的动力学模拟计算,研究了墨西哥湾GC185区BushHill海底天然气渗漏系统的演化特征及对水合物沉淀的影响。渗漏早期,天然气渗漏速度大(q>18.4kg/m2a),海底沉积以泥火山为主,渗漏天然气具有与气源天然气几乎一致的组成... 详细信息

通过天然气沉淀水合物的动力学模拟计算,研究了墨西哥湾GC185区BushHill海底天然气渗漏系统的演化特征及对水合物沉淀的影响。渗漏早期,天然气渗漏速度大(q>18.4kg/m2a),海底沉积以泥火山为主,渗漏天然气具有与气源天然气几乎一致的组成,形成的水合物具有最重的天然气成分。渗漏晚期,天然气渗漏速度很慢(qm2a),在海底附近没有水合物沉淀,主要以冷泉碳酸盐岩发育为主,水合物产于海底之下一定深度的沉积层中。介于二者间的渗漏中期(q:0.55～18.4kg/m2a),海底发育水合物、自养生物群为特征,渗漏速度控制了水合物和渗漏天然气的组成及沉淀水合物的天然气比例。BushHill渗漏系统近10年的深潜重复采样显示,渗漏天然气和水合物天然气的化学组成在时空上是多变的,相对应的渗漏速度在时间上的变化约为3倍,在空间上的变化近2个数量级。

关键词：天然气渗漏系统的演化天然气渗漏特征水合物沉淀

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Toxicokinetic behavior assessment prediction of the ADmEProperties of alkylated naphthalenes by consideration of relevant physicochemical and dystemic toxicity data:Proof of concept

作者： (美)Shari lawrence Pfleeger (加)Joanne m. Atlee

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Toxicokinetic behavior assessment prediction of the ADMEProp...

Deductions from the Quaternion Form of maxwell’s Electromagnetic Equations

中国毒理学会第六届全国毒理学大会

作者： ming H KUNG Christine m PALERmO lawrence K LOW Exxonmobil Biomedical Sciences IncAnnandaleNJ

In some cases,it may be possible to predict the toxicokinetic behavior(ADmE) of a substance by considering its physicochemical properties as well as relevant toxicity data,such as data from a series of structurally related chemical *** is the approach supported by the European Union’ s REACH *** present case study aims to validate the toxicokinetic behavior assessment approach via comparison ofthe predicted ADmE properties of a substance to theexperimentally-determined ADmE properties fromrobust toxicokinetic(TK) studies with the radiolabeled *** case study was conducted with an alkylated naphthalene(AN) compound,AN-600,where600 denotes a molecular weight(mW) of 600 g·*** onits physicochemical properties,including molecular weight,water solubility and octanol/water partition coefficient(LogKow),AN-600 is predicted to have inherently low systemic *** was consistent with existing results of severaltoxicity studies in which there was no evidence of systemic absorption or *** was also predicted that among AN structural analogs differing in alkyl chain length and molecular weight,there would be an inverse relationship between molecular weight and bioavailability,consistent with pharmacologic *** inverse relationship prediction was supported byTK data from AN analogs,specifically AN-212(mW =212) and AN-379(mW=379) which had 85%and 10%oral bioavailability,***,there were observedtrends of decreasing systemic absorption in repeat - dose dermal studiesof AN-600 analogs with increasing molecular weight and there was no evidence of absorption found in a dermal study with AN- 600 ***,available basic TK data for analogs suggested that any absorbed material would be metabolized by side chain oxidation of the alkyl group,producing sulfate and glucuronide metabolites which would be ultimately excreted in the *** total,the above evidence led to a prediction that ve

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Journal of modern Physics 2020年第9期11卷 1361-1371页

作者： Jeremy Dunning-Davies Richard lawrence Norman Departments of mathematics and Physics (retd) University of Hull Kingston upon Hull England Institute for Basic Research Palm Harbor FL USA Thunder Energies Corporation Palm Harbor FL USA

It is often claimed that maxwell’s electromagnetic equations were originally written in terms of quaternions. Once returned to that form and treated with left and right hand operators as in the mathematics of P. m. ... 详细信息

It is often claimed that Maxwell’s electromagnetic equations were originally written in terms of quaternions. Once returned to that form and treated with left and right hand operators as in the mathematics of P. M. Jack, a new seventh scalar electromagnetic field component emerges with possible relations to clean energy extraction and gravitation. It is the purpose here to examine this approach afresh and see how it might link up with other fairly recent, but little known, work in the field. Again, as with the usual form of Maxwell’s equations, a new scalar wave equation is derived but, on this occasion, due to the presence of the scalar component of the quaternion, that equation exhibits a wave speed greater than the speed of light. Historical and present uses within military and humanitarian contexts are considered briefly.

关键词： Electromagnetic Field Quaternion Gravity maxwell Energy Scalar Wave

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