Toxicokinetic behavior assessment prediction of the ADMEProperties of alkylated naphthalenes by consideration of relevant physicochemical and dystemic toxicity data:Proof of concept
作者单位：ExxonMobil Biomedical SciencesIncAnnandaleNJ
会议名称：《中国毒理学会第六届全国毒理学大会》
会议日期：2013年
学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学]
摘 要：In some cases,it may be possible to predict the toxicokinetic behavior(ADME) of a substance by considering its physicochemical properties as well as relevant toxicity data,such as data from a series of structurally related chemical *** is the approach supported by the European Union’ s REACH *** present case study aims to validate the toxicokinetic behavior assessment approach via comparison ofthe predicted ADME properties of a substance to theexperimentally-determined ADME properties fromrobust toxicokinetic(TK) studies with the radiolabeled *** case study was conducted with an alkylated naphthalene(AN) compound,AN-600,where600 denotes a molecular weight(MW) of 600 g·*** onits physicochemical properties,including molecular weight,water solubility and octanol/water partition coefficient(LogKow),AN-600 is predicted to have inherently low systemic *** was consistent with existing results of severaltoxicity studies in which there was no evidence of systemic absorption or *** was also predicted that among AN structural analogs differing in alkyl chain length and molecular weight,there would be an inverse relationship between molecular weight and bioavailability,consistent with pharmacologic *** inverse relationship prediction was supported byTK data from AN analogs,specifically AN-212(MW =212) and AN-379(MW=379) which had 85%and 10%oral bioavailability,***,there were observedtrends of decreasing systemic absorption in repeat - dose dermal studiesof AN-600 analogs with increasing molecular weight and there was no evidence of absorption found in a dermal study with AN- 600 ***,available basic TK data for analogs suggested that any absorbed material would be metabolized by side chain oxidation of the alkyl group,producing sulfate and glucuronide metabolites which would be ultimately excreted in the *** total,the above evidence led to a prediction that ve