检索结果-南通市图书馆

Severe thrombocytopaenia in patients with vivax malaria compared to falciparum malaria:a systematic review and metaanalysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2018年第1期7卷 113-122页

作者： Cho Naing Maxine A.whittaker Institute for Research Development and Innovation(IRDI)International Medical UniversityKuala LumpurMalaysia College of Public Health Medical and Veterinary SciencesJames Cook UniversityQueenslandAustralia

Background:Plasmodium vivax is the most geographically widespread species among human malaria *** studies have shown that platelets are an important component of the host innate immune response against malaria *** objectives of this study were to quantify thrombocytopaenia in *** malaria patients and to determine the associated risks of severe thrombocytopaenia in patients with vivax malaria compared to patients with *** *** body:A systematic review and meta-analysis of the available literature on thrombocytopaenia in *** malaria patients was *** studies in health-related electronic databases were identified and *** Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were ***-eight observational studies(n=29664)were included in the current *** thrombocytopaenia(<50000/mm3)to very severe thrombocytopaenia(<20000/mm3)was observed in 10.1%of patients with *** infection.A meta-analysis of 11 observational studies showed an equal risk of developing severe/very severe thrombocytopaenia between the patients with *** malaria and those with *** malaria(OR:1.98,95%CI:0.92-4.25).This indicates that thrombocytopaenia is as equally a common manifestation in *** and *** malaria *** study showed a higher risk of developing very severe thrombocytopaenia in children with severe *** malaria than with severe *** malaria(OR:2.80,95%CI:1.48-5.29).However,a pooled analysis of two studies showed an equal risk among adult severe cases(OR:1.19,95%CI:0.51-2.77).This indicates that the risk of developing thrombocytopaenia in *** malaria can vary with immune status in both children and *** study reported higher levels of urea and serum bilirubin in patients with *** malaria and severe thrombocytopaenia compared with patients mild thrombocytopaenia or no thrombocytopaenia,(P<0.001 in all compariso

关键词： Thrombocytopaenia Malaria Plasmodium vivax Systematic review

Gender-specific associations between coronary heart disease and other chronic diseases: cross-sectional evaluation of national survey data from adult residents of Germany

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2019年第9期16卷 663-670,I0002-I0005页

作者： Marie-Isabel K Murray Kerstin Bode Peter whittaker Department of Cardiology University Hospital Frankfurt am Main Frankfurt Germany Department of Electrophysiology Heart Center Leipzig Leipzig Germany Cardiovascular Research Institute and Department of Emergency Medicine Wayne State University Detroit MI USA

Background Combinations of coronary heart disease(CHD) and other chronic conditions complicate clinical management and increase healthcare costs. The aim of this study was to evaluate gender-specific relationships between CHD and other comorbidities. Methods We analyzed data from the German Health Interview and Examination Survey(DEGS1), a national survey of 8152 adults aged 18-79 years. Female and male participants with self-reported CHD were compared for 23 chronic medical conditions. Regression models were applied to determine potential associations between CHD and these 23 conditions. Results The prevalence of CHD was 9%(547 participants): 34%(185) were female CHD participants and 66%(362) male. In women, CHD was associated with hypertension(OR = 3.28(1.81-5.9)), lipid disorders(OR = 2.40(1.50-3.83)), diabetes mellitus(OR = 2.08(1.24-3.50)), kidney disease(OR = 2.66(1.101-6.99)), thyroid disease(OR = 1.81(1.18-2.79)), gout/high uric acid levels(OR = 2.08(1.22-3.56)) and osteoporosis(OR = 1.69(1.01-2.84)). In men, CHD patients were more likely to have hypertension(OR = 2.80(1.94-4.04)), diabetes mellitus(OR = 1.87(1.29-2.71)), lipid disorder(OR = 1.82(1.34-2.47)), and chronic kidney disease(OR = 3.28(1.81-5.9)). Conclusion Our analysis revealed two sets of chronic conditions associated with CHD. The first set occurred in both women and men, and comprised known risk factors: hypertension, lipid disorders, kidney disease, and diabetes mellitus. The second set appeared unique to women: thyroid disease, osteoporosis, and gout/high uric acid. Identification of shared and unique gender-related associations between CHD and other conditions provides potential to tailor screening, preventive, and therapeutic options.

关键词： Chronic diseases Comorbidities Gender Heart disease Risk factors Survey data

维普期刊数据库

Control of neglected tropical diseases in Asia Pacific: implications for health information priorities

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2012年第1期1卷 15-18页

作者： Robert Bergquist Maxine whittaker Ingerod 45494 Brastad Sweden Australian Centre for International and Tropical Health School of Population HealthUniversity of QueenslandHerstonQld 4006Australia

Poverty magnifies limitations posed by traditional biases and environmental *** approach towards disease control needs to recognise that socially embedded vulnerabilities can be as powerful as externally imposed *** Pacific has a specific panorama of infectious diseases,which,in common with other endemic areas,have a tendency to emerge or re-emerge if not carefully *** control aiming at elimination requires strong emphasis on surveillance and ***-designed informatics platforms can improve support systems and strengthen control activities,as they rapidly locate high-risk areas and provide detailed,up-to-date information on the performance of ongoing control programmes.

关键词： Neglected tropical diseases NTD Health information systems Poverty Disease surveillance Control programmes Asia Pacific

FRP Retrofitted RC Slabs Using Finite Difference Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Tianjin University 2008年第5期14卷 344-347页

作者： WU Chengqing OEHLERS DericJohn whittaker Andrew School of Civil Environmental and Mining Engineering The University of Adelaide North Terrace SA 5005 Australia Department of Civil Structural and Environmental Engineering State University of New York at Buffalo Buffalo NY 14260 USA

Current guidelines recommend using single-degree-of-freedom(SDOF) method for dynamic analysis of reinforced concretec (RC) structures against blast loads, which is not suitable for retrofitted members. Thus, a finite difference procedure developed in another study was used to accurately and efficiently analyze the dynamic response of fibre reinforced polymer (FRP) plated members under blast loads. It can accommodate changes in the mechanical properties of a member's cross section along its length and through its depth in each time step, making it possible to directly incorporate both strain rate effects (which will vary along the length and depth of a member) and non-uniform member loading to solve the partial differential equation of motion. The accuracy of the proposed method was validated in part using data from field blast testing. The finite difference procedure is implemented easily and enables accurate predictions of FRP-plated-member response.

关键词： finite difference analysis blast loads retrofit slab

维普期刊数据库

Experimental hydrodynamic assessment of a cylindrical-type floating solar system exposed to waves

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean Engineering and Science 2023年第4期8卷 461-473页

作者： Dallán Friel Madjid Karimirad Trevor whittaker John Doran School of Natural and Built Environment Queen’s University BelfastStranmillis RdBelfastAntrimNorthern IrelandUK The Bryden Centre Letterkenny Institute of TechnologyPort RdLetterkenny Co.DonegalIreland

In this paper,an experimental investigation on the wave loads and structural motions of two semi-fixed semi-immersed horizontal cylinders type rafts in the free surface zone is *** physical mod-els are tested at the 1:4.5 scale and exposed to a range of regular and irregular waves in a wave flume at Queen’s University *** physical models and experimental setup are discussed alongside an in-vestigation of the hydrodynamic phenomena,surge forces,and dynamic responses that each structure ex-hibits in the coastal wave ***,an investigation into the wave attenuation by both mod-els is carried *** results show that the surge forces have a positive correlation with wave steepness for both *** phenomena such as wave runup and overtopping,radiative damping and reflected waves,constructive interference,diffraction and flow separation were identified during the ex-periments.A negative mean heave displacement is observed during the monochromatic sea states which could result in impact loading and submergence of the superstructure components and photovoltaic pan-els at *** results presented in this paper may be used to calibrate and verify numerical models that calculate the global responses and hydrodynamic *** may also benefit the design processes of geometrically similar floating solar technologies by providing data on surge loads,motion responses and hydrodynamic observations.

关键词： Floating photovoltaics Experimental analysis Motion capture system Floating solar

OXYGEN ISOTOPIC RECORD AND ITS PALEOCLIMATIC IMPLICATIONS OF BENTHONIC FORAMINIFERA OF EAST CHINA SEA CORE SHIM-I IN MID-EOCENE,PLIOCENE AND EARLY-PLEISTOCENE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1990年第24期35卷 2076-2080页

作者：王大锐王乃文 S.G.whittaker Scientific Research Institute of Petroleum Exploration & Development Beijing 100083 PRC Institute of Geological Sciences Chinese Academy of Geological Sciences Beijing 100037 PRC Department of Geological Sciences University of Saskatchewan Canada S7N OWO

Oxyegen and carbon isotopic ratios in the Quatermary-Pliocene,Pleistocene and Eocene Benthonic foraminiferahave been investigated from a single core drilled inthe East

关键词： foraminifera stable isotope paleotemperature.

维普期刊数据库

Robust Machine Learning Mapping of sEMG Signals to Future Actuator Commands in Biomechatronic Devices

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第1期21卷 270-287页

作者： Ali Nasr Sydney Bell Rachel L.whittaker Clark R.Dickerson John McPhee Systems Design Engineering University of WaterlooWaterloo N2L 3G1Canada Kinesiology and Health Sciences University of WaterlooWaterloo N2L3G3Canada

A machine learning model for regression of interrupted Surface Electromyography(sEMG)signals to future control-oriented signals(e.g.,robot’s joint angle and assistive torque)of an active biomechatronic device for high-level myoelectric-based hierarchical control is proposed.A Recurrent Neural Network(RNN)was trained using output data,initially obtained from offline optimization of the biomechatronic(human–robot)device and shifted by the prediction *** input of the RNN consisted of interrupted sEMG signals(to mimic signal disconnections)and previous kinematic signals of the assistive *** RNN with a 0.1-s prediction horizon could predict the control-oriented joint angle and assistive torque with 92%and 86.5%regression accuracy,respectively,for the test *** proposed approach permits a fast,predictive,and direct estimation of control-oriented signals instead of an iterative process that optimizes assistive torque in the inverse dynamic simulation of a multibody human–robot *** with these interrupted input signals significantly improves the regression accuracy in the case of sEMG signal *** Robust Predictive Control-oriented Machine Learning(Robust-MuscleNET)model can support volitional high-level myoelectric-based control of biomechatronic devices,such as exoskeletons,prostheses,and assistive/resistive *** work should study the application to prosthesis control as well as the repeatability of the high-level controller with electrode *** low-level hierarchical controller that manages the human–robot interaction,the assistance/resistance strategy,and the actuator coordination should also be studied.

关键词： Myoelectric-based control-Surface electromyography Machine learning Multibody system dynamics Exoskeleton Bionic

Mitotic phosphorylation of PRC1 at Thr470 is required for PRC1 oligomerization and proper central spindle organization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cell Research 2007年第5期17卷 449-457页

作者： Joseph whittaker Department of Anatomy & Neurobiology Morehouse School of Medicine Atlanta GA 30310 USA

During cell division, chromosome segregation is orchestrated by the interaction of spindle microtubules with thecentromere. A dramatic remodeling of interpolar microtubules into an organized central spindle between the separatingchromatids is required for the initiation and execution of cytokinesis. Central spindle organization requires mitotic kine-sins, the chromosomal passenger protein complex, and microtubule bundling protein PRC1. PRC1 is phosphorylated byCdc2 at Thr470 and Thr481 during mitosis. However, the functional relevance of PRC1 phosphorylation at Thr470 hasremained elusive. Here we show that expression of the non-phosphorylatable mutant PRC1but not the phospho-mimi-cking mutant PRC1causes aberrant organization of the central spindle. Immunoprecipitation experiment indicatesthat both PRC1and PRC1mutant proteins associate with wild-type PRC1, suggesting that phosphorylationof Thr470 does not alter PRC1 self-association. In addition, in vitro co-sedimentation experiment showed that PRC1binds to microtubule independent of the phosphorylation state of Thr470. Gel-filtration experiment suggested that phos-phorylation of Thr470 promotes oligomerization of PRC1. Given the fact that prevention of the Thr470 phosphorylationinhibits PRC1 oligomerization in vitro and causes an aberrant organization of central spindle in vivo, we propose thatthis phosphorylation-dependent PRC1 oligomerization ensures that central spindle assembly occurs at the appropriatetime in the cell cycle.

关键词： central spindle microtubule oligomerization PRC1 phosphorylation

Swimming behavior of juvenile silver carp near the separation zone of a channel confluence

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2022年第1期37卷 122-127页

作者： Saiyu Yuan Lei Xu Hongwu Tang Yang Xiao Colin whittaker State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Yangtze Institute for Conservation and Development Department of Civil and Environmental Engineering The University of Auckland

Knowledge of locomotion of fish near river confluences is important for prediction of fish distribution in a river *** flow separation zone near the confluence of a river network is a favorite habitat and feeding place for silver carp,which is one of the four major species of Chinese carp and usually provides positive rheotaxis to water *** the current study,a series of laboratory experiments were done to determine the behavioral responses of juvenile silver carp to the hydrodynamic forces near the separation zone of a channel *** locomotion and trajectory of juvenile silver carp were recorded by infrared thermal imaging,while the flow velocity field near the separation zone was measured by a Particle Image Velocimetry (PIV) system.A total of 60 juvenile silver carp were released near the separation zone among which 40 carp swam in the upstream *** them,24 carp swam to the tributary and the remaining 16 swam into the main *** all these 24 carp travelled initially along the boundary of the separation zone near the corner,where flow shear was strongest,and then swam to the *** of avoiding zones of strong vorticity,they chose and followed a trajectory along which the flow vorticity was *** encountering these vortical flows,they increased the tailbeat frequency and decreased the tail-beat amplitude to maintain body *** observations provide important knowledge on locomotion of fish near river confluences and are beneficial for the fish habitat protection.

关键词： Channel confluence Flow separation Juvenile silver carp Fish locomotion