Severe thrombocytopaenia in patients with vivax malaria compared to falciparum malaria:a systematic review and metaanalysis

作     者：Cho Naing Maxine A.Whittaker 

作者机构：Institute for ResearchDevelopment and Innovation(IRDI)International Medical UniversityKuala LumpurMalaysia College of Public HealthMedical and Veterinary SciencesJames Cook UniversityQueenslandAustralia 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2018年第7卷第1期

页      面：113-122页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Thrombocytopaenia Malaria Plasmodium vivax Systematic review 

摘      要：Background:Plasmodium vivax is the most geographically widespread species among human malaria *** studies have shown that platelets are an important component of the host innate immune response against malaria *** objectives of this study were to quantify thrombocytopaenia in *** malaria patients and to determine the associated risks of severe thrombocytopaenia in patients with vivax malaria compared to patients with *** *** body:A systematic review and meta-analysis of the available literature on thrombocytopaenia in *** malaria patients was *** studies in health-related electronic databases were identified and *** Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were ***-eight observational studies(n=29664)were included in the current *** thrombocytopaenia(50000/mm3)to very severe thrombocytopaenia(20000/mm3)was observed in 10.1%of patients with *** infection.A meta-analysis of 11 observational studies showed an equal risk of developing severe/very severe thrombocytopaenia between the patients with *** malaria and those with *** malaria(OR:1.98,95%CI:0.92-4.25).This indicates that thrombocytopaenia is as equally a common manifestation in *** and *** malaria *** study showed a higher risk of developing very severe thrombocytopaenia in children with severe *** malaria than with severe *** malaria(OR:2.80,95%CI:1.48-5.29).However,a pooled analysis of two studies showed an equal risk among adult severe cases(OR:1.19,95%CI:0.51-2.77).This indicates that the risk of developing thrombocytopaenia in *** malaria can vary with immune status in both children and *** study reported higher levels of urea and serum bilirubin in patients with *** malaria and severe thrombocytopaenia compared with patients mild thrombocytopaenia or no thrombocytopaenia,(P0.001 in all compariso