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Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

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*** dissection of myocilin(MYOC)-induced glaucoma reveals that the modifier of glaucoma 1(MOG1)locus encodes a gene which prevents ocular hypertension

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Annals of Eye Science 2019年第1期 199-199页

作者： Vincent Raymond Pascal Belleau Rose Arseneault Jean-Louis Anctil Gilles Côté Marcel Amyot Patrick Laplante laurent lamalice Stéphane Dubois Fahed Elian Michael A.Walter Québec Glaucoma Network CHUL at CHU de Québec-UniversitéLaval Québec CityQCCanada Molecular Medicine UniversitéLavalQuébec CityQCCanada Cold Spring Harbor Laboratory NYUSA Department of Ophthalmology UniversitéLavalQuébec CityQCCanada Department of Ophthalmology Universitéde MontréalMontréalQCCanada Medical Genetics University of AlbertaEdmontonABCanada Ophthalmologists from Province of Québec QuébecQCCanada

Background:Pathogenic mechanisms leading to open-angle glaucoma(OAG)are genetically *** involve neuroinflammation,elevation of intra-ocular pressures(IOP)and optic nerve hypersensitivity to cellular *** mapped a locus at chromosome 20q13 that contains a modifier gene for glaucoma *** searching for its identity,we named this gene modifier of glaucoma 1(MOG1).The goal of this study is to characterize the mechanism by which MOG1 delays the age of onset of glaucoma when OAG is caused by mutations in the MYOC *** hypothesized that MOG1 mechanism may be linked to a specific endophenotype and thus dissected ocular phenotypes present in a large French-Canadian MYOC glaucoma ***:We studied 375 members of the CA pedigree in which autosomal dominant OAG is caused by the MYOCK423E *** this family,wild-type MOG1(normal form)delays the age-at-onset(AAO)of *** records of MYOCK423E carriers were reviewed to extract the values of four quantitative traits portraying four endophenotypes:(I)age of maximal intra-ocular pressure(IOP max),(II)IOP progression,(III)rate of optic nerve degeneration and,(IV)AAO defined as the age at which IOP≥22 mmHg or age at which optic disk degeneration was first *** were tested for their heritability.A three-stage algorithm was designed to detect double mutants who carry the MYOCK423E mutation and putative MOG1 *** traits values of double-mutants were then ***:We found 156 individuals who were heterozygotes(HTZ)for *** hundred and twenty of these were classified affected as they were OAG or had treatment for ocular hypertension(OHT)with IOP≥22 *** other 36 HTZ were *** two endophenotypes,AAO and IOP max,showed significant *** was the 1st symptom detected in 99%of the affecteds;it always preceded optic nerve *** of the affecteds ranged from 7 to 63 years old while rates of optic nerve degenera

关键词： Blindness glaucoma genetics modifier myocilin

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Words as tracers in the history of science and technology:the case of photogrammetry and remote sensing

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Geo-Spatial Information Science 2021年第1期24卷 167-177,I0018页

作者： laurent Polidori CESBIO Universitéde ToulouseCNES/CNRS/INRAE/IRD/UPSToulouseFrance

The evolution of terminology in a given field of science and technology is a good indicator of the context in which inventions originated and how concepts have *** is the case of photogrammetry,remote sensing and related methods,whose terminology evolved,first under the influence of the early inventors Laussedat and Meydenbauer,in French and German,respectively,and then in English and other languages as an international professional community *** development of space remote sensing and analytical photogrammetry led to the modification of old concepts and the renewal of terminology,and more recently,the advent of digital photography has blurred the boundaries between different fields and the meaning of the *** article proposes an analysis of the evolution of technical terms through the Google Ngram Viewer tool,which allows the visualization of the occurrence of terms in documents accessible on the *** its biases,this tool allows an interpretation of the evolution of the terminology over a long period of time,as well as a comparison of the evolution observed in the different *** particular,it makes it possible to highlight the periods when these methods were very popular,as well as a recent decline in the use of classical terms such as photogrammetry and remote sensing in favor of a new vocabulary,due to the blurring of boundaries between disciplines and to the emergence of new solutions related to UAVs,computer vision,etc.,which have renewed the potential of classical methods.

关键词： Photogrammetry remote sensing terminology Ngram Viewer

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Topics on the Geometry of Rational Homogeneous Spaces

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Acta Mathematica Sinica,English Series 2020年第8期36卷 851-872页

作者： laurent MANIVEL Toulouse Mathematics Institute UMR 5219 UPSF-31062 Toulouse Cedex 9France

This is a survey paper about a selection of results in complex algebraic geometry that appeared in the recent and less recent litterature,and in which rational homogeneous spaces play a prominent *** selection is larg... 详细信息

关键词： Calabi-Yau manifold derived category Hyperkahler manifold rational homogeneous space grassmannian flop fano variety abelian surface

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Auger effect in weakly confined nanocrystals

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Light(Science & Applications) 2023年第8期12卷 1454-1456页

作者： Jiawen Liu laurent Coolen Laboratoire de Physique de I'Ecole Normale Superieure ENSUniversite PSLCNRSSorbonne UniversiteUniversite Paris CiteF-75005 ParisFrance Sorbonne Universite CNRSInstitut de NanoSciences de ParisINSPF-75005 ParisFrance

An extensive analysis of biexciton luminescence in high-quality,large perovskite CsPbBr_(3) nanocrystals shows how the biexciton Auger decay rate deviates from the"universal"volume scaling as the exciton confinement b... 详细信息

关键词： weakly confined perovskite

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Assessing the predictive capabilities of precipitation strengthening models for deformation twinning in Mg alloys using phase-field simulations

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Journal of Magnesium and Alloys 2023年第12期11卷 4525-4541页

作者： Darshan Bamney laurent Capolungo Materials Science&Technology Division Los Alamos National LaboratoryUSA

Precipitation strengthening is a key strategy for improving the overall mechanical properties of Mg alloys. In Mg-Al alloys, basal precipitates are known to strengthen against twinning, resulting in an increase in the critical resolved shear stress(CRSS) necessary for continued deformation. Although several models have been proposed to quantify the influence of precipitate shape, size, and distribution on the CRSS, the accuracy, scope, and applicability of these models has not been fully assessed. Accordingly, the objectives of this study are:(i)to analyze the accuracy of analytical models proposed in the literature for precipitation strengthening against twin thickening and propagation(in Mg-Al alloys) using phase-field(PF) simulations,(ii) to propose modifications to these model forms to better capture the observed trends in the PF data, and(iii) to subsequently test the predictiveness of the extended models in extrapolating to experimental strengthening ***, using an atomistically-informed phase-field method, the interactions between migrating twin boundaries(during the propagation and thickening stages) and basal plates are simulated for different precipitate sizes and arrangements. In general, comparison of the increase in CRSS determined from the PF simulations and the predictions from four precipitation strengthening models reveals that modifications are necessary to the model forms to extend their applicability to precipitation strengthening against both twin thickening and propagation. A subsequent comparison between predictions from the extended models and experimental strengthening data for peak age-hardened samples reveals that the(extended) single dislocation and dislocation wall models provide reasonably accurate values of the increase in ***, the results presented here help elucidate the fidelity and applicability of the various hardening models in predicting precipitation strenghtening effects in technologically important alloys.

关键词： Twinning Twin precipitate interactions Strengthening Magnesium alloys Phase field Mechanical behavior

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BESTP——An automated Bayesian modeling tool for asteroseismology

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Research in Astronomy and Astrophysics 2021年第9期21卷 135-145页

作者： Chen Jiang laurent Gizon Max-Planck-Institut für Sonnensystemforschung Justus-von-Liebig-Weg 337077 GöttingenGermany Institut für Astrophysik Georg-August-Universität GöttingenFriedrich-Hund-Platz 137077 GöttingenGermany School of Physics and Astronomy Sun Yat-Sen UniversityNo.135Xingang Xi RoadGuangzhou 510275China Center for Space Science NYUAD InstituteNew York University Abu DhabiAbu DhabiUAE

Asteroseismic observations are crucial to constrain stellar models with *** Estimation of STellar Parameters(BESTP)is a tool that utilizes Bayesian statistics and nested sampling Monte Carlo algorithm to search for the stellar models that best match a given set of classical and asteroseismic constraints from *** computation and evaluation of models are efficiently performed in an automated and multi-threaded *** illustrate the capabilities of BESTP,we estimate fundamental stellar properties for the Sun and the red-giant star HD *** both cases,we find models that are consistent with *** also evaluate the improvement in the precision of stellar parameters when the oscillation frequencies of individual modes are included as constraints,compared to the case when only the large frequency separation is *** the solar case,the uncertainties of estimated masses,radii and ages are reduced by 0.7%,0.3%and 8%*** HD 222076,they are reduced even more noticeably by 2%,0.5%and 4.7%*** also note an improvement of 10%for the age of HD 222076 when the Gaia parallax is included as a constraint compared to the case when only the large separation is included as a constraint.

关键词： stars:interiors stars:oscillations methods:numerical asteroseismology

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“Smart”nanomaterials for cancer therapy

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Science China Chemistry 2010年第11期53卷 2241-2249页

作者： LE GUYADER laurent Chinese Academy of Sciences Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology

Recent development in nanotechnology has provided new tools for cancer therapy and *** of their small size,nanoscale devices readily interact with biomolecules both on the cell surface and inside the ***,such as fullerenes and their derivatives,are effective in terms of interactions with the immune system and have great potential as anticancer ***,other nanomaterials are able to load active drugs to cancer cells by selectively using the unique tumor environment,such as their enhanced permeability,retention effect and the specific acidic *** and multiplexed nanoparticles,as the next generation of nanoparticles,are now being extensively investigated and are promising tools to achieve personalized and tailored cancer treatments.

关键词： nanotechnology nanomaterials nanocarrier cancer therapy drug delivery passive target active target

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Character recognition based on non-linear multi-projection profiles measure

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Frontiers of Computer Science 2015年第5期9卷 678-690页

作者： K C SANTOSH laurent WENDLING US National Library of Medicine (NLM) National Institutes of Health (NIH) Bethesda MD 20894 USA SIP-LIPADE Universit6 Pads Descartes (Pads V) Pads 75270 Cedex 06 France

In this paper, we study a method for isolated handwritten or hand-printed character recognition using dynamic programming for matching the non-linear multi- projection profiles that are produced from the Radon transform. The idea is to use dynamic time warping （DTW） algorithm to match corresponding pairs of the Radon features for all possible projections. By using DTW, we can avoid compressing feature matrix into a single vector which may miss information. It can handle character images in different shapes and sizes that are usually happened in natural hand- writing in addition to difficulties such as multi-class similarities, deformations and possible defects. Besides, a comprehensive study is made by taking a major set of state-of- the-art shape descriptors over several character and numeral datasets from different scripts such as Roman, Devanagari, Oriya, Bangla and Japanese-Katakana including symbol. For all scripts, the method shows a generic behaviour by providing optimal recognition rates but, with high computational cost.

关键词： character recognition the Radon features dynamic programming shape descriptors

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The kinetics of static recovery by dislocation climb

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npj Computational Materials 2022年第1期8卷 973-982页

作者： Aaron A.Kohnert laurent Capolungo Materials Science and Technology Division Los Alamos National LaboratoryLos AlamosNMUSA

The initial microstructure of a wide range of structural materials is conditioned by thermo-mechanical treatments such as hot-working,tempering,or solution *** the elevated temperatures associated with these treatments the dislocation microstructure evolves,usually decreasing in density through a process known as static *** its technological relevance,static recovery is not fully characterized from a theoretical standpoint,with even the controlling mechanisms subject to *** this study,a climb-enabled discrete dislocation dynamics(DDD)capability is leveraged to explore the kinetics of static recovery in pure Fe when controlled by dislocation *** data from these simulations is used to develop a revised static recovery law,and provides the parameters appropriate for predictive microstructure models in *** law differs from previous analytical derivations invoking climb of dislocations,following the logarithmic trends typical of experimental observations where prior work did *** comparison between the recovery law derived from DDD to experimental recovery data in alpha Fe shows strong agreement across a range of temperatures,and suggests that climb is the controlling mechanism for static recovery in pure metals.

关键词： dislocation law treatment

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