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Gastroenterology Report 2022年第1期10卷 683-684页

作者： thomas j.Hurr South Australian Reflux Research Unit AdelaideSouth AustraliaAustralia

The aim of this commentary is to demonstrate,using two examples,that the six-question Gastroesophageal Reflux Disease Questionnaire(GerdQ)cannot accurately quantify reflux and reflux-associated symptoms(RRAS)frequency... 详细信息

关键词： symptoms oesophageal Gerd

Modeling the Kinetics of Moisture Desorption from Safou Pulp [Dacryodes edulis (G. Don) ***] before the Oil Extraction Step

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Open journal of Applied Sciences 2024年第8期14卷 2050-2064页

作者： Anicet Frédéric Binaki Feueltgaldah Christian Bopoundza Bob Wilfrid Loumouamou Gueko Séraphin Nguié Eliane Thérèse Biassala thomas Silou Multidisciplinary Food and Nutrition Research Team Regional Center of Excellence in Food and Nutrition Faculty of Science and Technology Marien Ngouabi University Brazzaville Congo Process Engineering Laboratory UNESCO-ENSP Chair Marien Ngouabi University Brazzaville Congo CR2IE Chemistry and Technology Platform Higher School of Cataract Technology (EPrES) Brazzaville Congo

The aim of this work is to model the drying kinetics of Safou pulp with or without endocarp using a phenomenological approach. Oven-drying kinetics at 70˚C, 90˚C and 105˚C were monitored using the curves given by the reduced mass as a function of time, which are modeled according to the Avrami/page, Fick and Peleg models using OringinPro 2018 software. The results showed that parameters k and n of the Avrami/Page model vary very little with fruit size and drying temperature (0.0018 ± 0.0002 k n k (Avrami model/page) were virtually identical, while b (Fick model) and n (Avrami model/page) were virtually identical for the same sample. For the Peleg model, the parameter a, varies from 0.0018 ± 0.0002 to 0.03328 ± 0.0079, with a ratio of 18.6 for all experimental conditions studied. However, with 0.977 R2 χ2 < 0.00002, we have a good fit of the model to the experimental data. The same applies to parameter b, which ranges from 0.82 ± 0.05 to 1.21 ± 0.02. Thus, drying modeling by these three models can be used to describe and predict the progress of oven-drying of safou pulp.

关键词： Drying Modeling Empirical Models Dacryodes edulis Congo Basin

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病人家庭安全用氧指南

国际护理学杂志 1982年第6期03卷 8-9页

作者： Patricia Ellmyer ,Nancy j.thomas ,李建生

由于家庭输氧设备易于掌握,使病人在家中可得到氧疗,从而缩短了他的住院时间,不过,随着家庭治疗在经济上和心理上的益处也带来了氧疗的危险。氧疗有引起“爆”和“燃”危险,如果使用不当,任何点燃的火源,在氧气存在下火灾将迅猛而激烈。作

关键词：病人指导衣服家属压力容器氧气瓶氧疗酒精擦浴

Superchiral near fields detect virus structure

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Light(Science & Applications) 2020年第1期9卷 103-112页

作者： Tarun Kakkar Chantal Keijzer Marion Rodier Tatyana Bukharova Michael Taliansky Andrew j.Love joel j.Milner Affar S.Karimullah laurence D.Barron Nikolaj Gadegaard Adrian j.Lapthorn Malcolm Kadodwala School of Chemistry Joseph Black BuildingUniversity of GlasgowGlasgow G128QQUK Institute of Molecular Cell and Systems Biology and School of Life SciencesUniversity of GlasgowG128QQ GlasgowUK james Hutton Inst Cell&Mol SciDundee DD25DAUK Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS Moscow 117997Russia School of Engineering Rankine BuildingUniversity of GlasgowGlasgow G128LTUK

Optical spectroscopy can be used to quickly characterise the structural properties of individual ***,it cannot be applied to biological assemblies because light is generally blind to the spatial distribution of the component *** insensitivity arises from the mismatch in length scales between the assemblies(a few tens of nm)and the wavelength of light required to excite chromophores(≥150 nm).Consequently,with conventional spectroscopy,ordered assemblies,such as the icosahedral capsids of viruses,appear to be indistinguishable isotropic spherical *** limits potential routes to rapid high-throughput portable detection appropriate for point-of-care ***,we demonstrate that chiral electromagnetic(EM)near fields,which have both enhanced chiral asymmetry(referred to as superchirality)and subwavelength spatial localisation(∼10 nm),can detect the icosahedral structure of virus ***,they can detect both the presence and relative orientation of a bound virus *** illustrate the potential uses of the exquisite structural sensitivity of subwavelength superchiral fields,we have used them to successfully detect virus particles in the complex milieu of blood serum.

关键词： chiral detect fields

High Oxygen Nanocomposite Barrier Films Based on Xylan and Nanocrystalline Cellulose

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Nano-Micro Letters 2010年第4期2卷 235-241页

作者： Amit Saxena thomas j.Elder jeffrey Kenvin Arthur j.Ragauskas School of Chemistry and Biochemistry Georgia Institute of Technology USDA-Forest Service Southern Research Station Micromeritics Instrument Corporation

The goal of this work is to produce nanocomposite film with low oxygen permeability by casting an aqueous solution containing xylan,sorbitol and nanocrystalline *** morphology of the resulting nanocomposite films was examined by scanning electron microscopy and atomic force microscopy which showed that control films containing xylan and sorbitol had a more open structure as compared to xylan-sorbitol films containing sulfonated nanocrystalline *** average pore diameter,bulk density,porosity and tortuosity factor measurements of control xylan films and nanocomposite xylan films were examined by mercury intrusion porosimetry *** films reinforced with nanocrystalline cellulose were denser and exhibited higher tortuosity factor than the control xylan *** xylan films had average pore diameter,bulk density,porosity and tortuosity factor of 0.1730 μm,0.6165 g/ml,53.0161% and 1.258,respectively as compared to xylan films reinforced with 50% nanocrystalline cellulose with average pore diameter of 0.0581 μm,bulk density of 1.1513 g/ml,porosity of 22.8906% and tortuosity factor of *** transmission rate tests demonstrated that films prepared with xylan,sorbitol and 5%,10%,25% and 50% sulfonated nanocrystalline cellulose exhibited a significantly reduced oxygen permeability of 1.1387,1.0933,0.8986 and 0.1799 cm^3×μm/m^2×d×k Pa respectively with respect to films prepared solely from xylan and sorbitol with a oxygen permeability of 189.1665 cm^3×μm/m^2×d×k *** properties suggested these nanocomposite films have promising barrier properties.

关键词： Nanocomposites Xylan Nanocrystalline cellulose Oxygen barrier

Isotretinoin for the treatment of nonobstructive azoospermia: a pilot study

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Asian journal of Andrology 2021年第5期23卷 537-540页

作者： john K Amory Charles H Muller thomas j Walsh Department of Medicine University of WashingtonSeattleWA 98195USA Department of Urology University of WashingtonSeattleWA 98195USA

The treatment of men with infertility from azoospermia is *** some men with severe oligozoospermia improve sperm output during treatment with isotretinoin,we treated nine men with azoospermia with isotretinoin to determine if azoospermic men would also respond to isotretinoin *** of these men who had a previous negative testicular sperm extraction(TESE)was found to have an area of sperm production on a postisotretinoin testicular *** man achieved a pregnancy and a live birth of a healthy,term daughter after in vitro fertilization coupled with intracytoplasmic sperm injection(IVF/ICSI).A second subject had a positive TESE after treatment as *** study of isotretinoin therapy in men with azoospermia undergoing testicular sperm harvesting procedures is warranted.

关键词： treatment injection pregnancy

Can inhibition of telomerase increase pancreatic cancer cell's susceptibility to chemotherapeutic reagents?

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Hepatobiliary & Pancreatic Diseases International 2002年第1期1卷 155-160页

作者： thomas j.Ⅲ Fahey Department of Surgery Cornell University Medical College New York NY USA

Objectives: To clarify the inhibition of pancreatic can-cer cells by interference with the hTR component of thetelomerase reverse transcriptase enzymatic complexand evaluate susceptibility of antisense hTR pancreaticcancer cells to chemotherapeutic ***: A 593 bp of full length hTR cDNA was sub-cloned into a mammalian expression vector pcDNA3.1(-) in antisense orientation to construct an antisensehTR expression plasmid. The plasmids were introducedinto Pancl cells, a human pancreatic carcinoma cellline, by lipofectin, and G418-resistant stable trans-formants were expanded. Resulting stable clones werescreened for the presence of hTR insert by PCR withT7 and BGH reverse primers located on the flanks ofthe multiclonal site of pcDNA3.1 vector. Cell growth rate,hTR expression, telomerase activity, and anchorage-in-dependent growth property were analyzed. Finally, sus-ceptibility of antisense hTR cells to chemotherapeuticreagents was ***: Significant downregulation of endogenous hTRwas evident in the antisense-hTR transformed cells,and telomerase activity was markedly decreased com-pared to control cells in standard TRAP assays. Fur-thermore, the proliferation and the anchorage-inde-pendent growth ability in antisense-hTR expressingcells were significantly decreased compared with thecontrol parental cells. However, no crisis or senescencephenomena was observed. Antisense hTR appears toincrease Pancl cell's susceptibility to chemotherapeuticreagent cDDP, but not to differentiation reagent DM-SO, COX2 inhibitor sulinbac, NS-398, curcumin, andchemotherapeutic reagent adriamycin(ADM).Conclusions: These data indicate that hTR is probablya critical component of human telomerase activity andthat downregulation of the RNA component of humantelomerase is an effective target for anticancer strategyand antisense hTR can increase Pancl cell's susceptibilityto cDDP.

关键词： Telomerase hTR Antisense Pancreatic carcinoma cellline chemotherapeutic reagents

The impact of vitamin D deficiency on neurogenesis in the adult brain

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Neural Regeneration Research 2017年第3期12卷 393-394页

作者： Natalie j.Groves thomas H.j.Burne Queensland Brain Institute The University of QueenslandSt.LuciaAustralia Queensland Centre for Mental Health Research The Park Centrefor Mental HealthWacolAustralia

There is increasing evidence from epidemiological studies indicating that vitamin D deficiency during adulthood is associated with adverse brain outcomes in humans（Ginde et al.,2009）and rodents（Groves et al.,2014）... 详细信息

关键词： The impact of vitamin D deficiency on neurogenesis in the adult brain GAD

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一九八一年核燃料概况

地球与环境 1983年第3期 17-18页

作者： j.thomas Nash ,姚振凯 ,刘艳平

1981年总的形势是铀、钍供应过剩。情况比较简单,但引起的原因却颇为复杂,是几年来所累积的社会、政治、经济等因素交织在一起的结果。后果要比预料的严重得多。在过去的两年里,铀的价格下跌到每磅23美元—实际美元值下跌了60％。美国约... 详细信息

1981年总的形势是铀、钍供应过剩。情况比较简单,但引起的原因却颇为复杂,是几年来所累积的社会、政治、经济等因素交织在一起的结果。后果要比预料的严重得多。在过去的两年里,铀的价格下跌到每磅23美元—实际美元值下跌了60％。美国约有60个(总共240个)铀矿山和16家铀工厂关闭,约三分

关键词：铀矿床铀矿资源矿床品位核燃料

Multiscale Domain Decomposition Methods for Elliptic Problems with High Aspect Ratios

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Acta Mathematicae Applicatae Sinica 2002年第1期18卷 63-76页

作者： jφrgAarnes thomas Y.Hou Department of Mathematics University of BergenJohs.Brunsgt.125008 BergenNorwayApplied Mathematics217-50CaltechPasadenaCA 91125

In this paper we study some nonoverlapping domain decomposition methods for solving a class of elliptic problems arising from composite materials and flows in porous media which contain many spatial scales. Our preconditioner differs from traditional domain decomposition preconditioners by using a coarse solver which is adaptive to small scale heterogeneous features. While the convergence rate of traditional domain decomposition algorithms using coarse solvers based on linear or polynomial interpolations may deteriorate in the presence of rapid small scale oscillations or high aspect ratios, our preconditioner is applicable to multiple-scale problems without restrictive assumptions and seems to have a convergence rate nearly independent of the aspect ratio within the substructures. A rigorous convergence analysis based on the Schwarz framework is carried out, and we demonstrate the efficiency and robustness of the proposed preconditioner through numerical experiments which include problems with multiple-scale coefficients, as well problems with continuous scales.

关键词： Multiscale elliptic problems Domain decomposition Schwarz methods Porous media