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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural Regeneration Research 2025年第3期20卷 803-804页

作者： Glenn A.Harris lauren R.Hirschfeld Rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3R) or 4-repeat(4R) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Social learning in nest-building birds watching live-streaming video demonstrators

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Integrative Zoology 2019年第2期14卷 204-213页

作者： lauren M.GUILLETTE Susan d.HEALY School of Biology University of St AndrewsSt AndrewsFifeUK

determining the role that social learning plays in construction behaviors,such as nest building or tool manufacture,could be improved if more experimental control could be gained over the exact public information that is provided by the demonstrator,to the observing *** video playback allows the experimenter to choose what information is provided but will only be useful in determining the role of social learning if observers attend to,and learn from,videos in a manner that is similar to live *** goal of the current experiment was to test whether live-streamed video presentations of nest building by zebra finches Taeniopygia guttata would lead observers to copy the material choice demonstrated to ***,males that had not previously built a nest were given an initial preference test between materials of 2 *** observers then watched live-stream footage of a familiar demonstrator building a nest with material of the color that the observer did not *** this experience,observers were given the chance to build a nest with materials of the 2 *** two-thirds of the observer males preferred material of the demonstrated color after viewing the demonstrator build a nest with material of that color more than they had previously,their preference for the demonstrated material was not as strong as that of observers that had viewed live demonstrator builders in a previous *** results suggest researchers should proceed with caution before using video demonstration in tests of social learning.

关键词： construction behavior copying nest social learning video playback zebra finch

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巧吃零食

新东方英语（中学版） 2007年第4期 47-49页

作者： Mary L.Gavin Jessica d.black 赵娜

是不是喜欢吃零食,却被告知吃零食有种种弊端?其实吃零食并不全无好处,关键要看你怎么吃!即使你一天吃三顿正餐,有时也可能感到饿——比如上了整整一下午的课,之后还要参加游泳比赛,这期间就会饿。该怎么办?健康的零食。富含营养的加餐... 详细信息

是不是喜欢吃零食,却被告知吃零食有种种弊端?其实吃零食并不全无好处,关键要看你怎么吃!即使你一天吃三顿正餐,有时也可能感到饿——比如上了整整一下午的课,之后还要参加游泳比赛,这期间就会饿。该怎么办?健康的零食。富含营养的加餐可以将你的能量维持在高水平状态,使你头脑清醒,又不会占用你太多的时间。事实上,如果你的日程安排十分繁忙,吃健康食品就更加重要。

关键词：零食健康食品碳水化合物营养游泳比赛能量维水平状态日程安排青春期酸奶

Atrial Septal defect(ASd)associated long non-coding RNA STX18-AS1 maintains time-course of in vitro cardiomyocyte differentiation

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Genes & diseases 2023年第4期10卷 1150-1153页

作者： Yingjuan Liu Mun-kit Choy Sabu Abraham Gennadiy Tenin Graeme C.black Bernard d.Keavney division of Cardiovascular Sciences University of ManchesterManchester M139PLUK Manchester University NHS Foundation Trust Manchester Academic Health Science CentreManchester M139NQUK division of Evolution&Genomic Sciences University of ManchesterManchester M139WLUK

Congenital heart disease(CHd)is the commonest birth defect,affecting approximately 9.4/1000 live births.^(1)Atrial Septal defect(ASd)is one of the commonest CHd clinical phenotypes,which frequently requires treatment either in childhood or adulthood,and can lead to severe complications such as right heart failure and cardiac *** genome-wide association studies(GWAS)have identified a region of chromosome 4p16(Ch4p16)associated with the risk of ASd.

关键词： clinical maintain cardiac

P recision L ivestock F arming: A n international review of scientific and commercial aspects

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International Journal of Agricultural and Biological Engineering 2012年第3期5卷 1-9页

作者： T M Banhazi H Lehr J L black H Crabtree P Schofield M Tscharke d Berckmans National Centre for Engineering in Agriculture University of Southern QueenslandToowoomba CampusQLDAustralia Syntesa(Ltd.) BarcelonaSpain John L black Consulting PO Box 4021Warrimoo NSWAustralia Farmex Ltd Wyvols Court FarmBasingstoke RoadSwallowfieldReadingUK Silsoe Livest ock Systems Ltd Wrest ParkSilsoeBedsUK M3-BIORES Katholieke Universiteit LeuvenKasteelpark ArenbergLeuvenBelgium

Precision Livestock Farming(PLF)is potentially one of the most powerful developments amongst a number of interesting new and upcoming technologies that have the potential to revolutionise the livestock farming *** properly implemented,PLF or Smart Farming could(1)improve or at least objectively document animal welfare on farms;(2)reduce greenhouse gas(GHG)emission and improve environmental performance of farms;(3)facilitate product segmentation and better marketing of livestock products;(4)reduce illegal trading of livestock products;and(5)improve the economic stability of rural ***,there are only a few examples of successful commercialisation of PLF technologies introduced by a small number of commercial companies which are actively involved in the PLF commercialisation *** ensure that the potential of PLF is taken to the industry,it is recommended to:(1)establish a new service industry;(2)verify,demonstrate and publicise the benefits of PLF;(3)better coordinate the efforts of different industry and academic organisations interested in the development and implementation of PLF technologies on farms;and(4)encourage the commercial sectors to assist with professionally managed product development.

关键词： Precision Livestock Farming(PLF) smart farming commercialisation scientific issue animal welfare efficiency

Challenges in the implementation of food safety and quality assurance systems in small-scale fisheries

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Food Quality and Safety 2023年第1期7卷 178-186页

作者： Esther GarridoGamarro Cecilie Smith Svanevik Anne-Katrine Lundebye Monica Sanden Enrica d'Agostino Marian Kjellevold lauren Pincus Johannes Pucher Fisheries and Aquaculture division Food and Agriculture Organization of the United NationsViale delle Terme di CaracallaRomeItaly Institute of Marine Research BergenNorway WorldFish Jalan Batu MaungBatu MaungPenangMalaysia German Federal Institute for Risk Assessment Department Experimental Toxicology and ZEBETBerlinGermany Shared first authorship

Ninety percent of the world’s fishers are directly involved in small-scale fisheries(SSFs),and many food safety and quality issues along the food value chains may be both irreversible and *** safe,high-quality aquatic products are key to sustaining life,promoting good health,and avoiding adverse health *** This paper aimed to highlight factors preventing the implementation of safety and quality assurance systems in SSFs by analysing the results from surveys on the implementation of Article 11 of the Food and Agriculture Organization of the United Nations(FAO)Code of Conduct for Responsible Fisheries(2017,2019,and 2022).Materials and methods The analysis considered responses to 15 closed-ended questions on food safety and quality obtained from 143 FAO Members and the European Union,and 87 open-ended replies addressing challenges in *** The major factors preventing the implementation of the Code’s food safety and quality provisions were lack of sanitation and monitoring programmes,lack of infrastructure(particularly refrigeration facilities)lack of technical capacities and limited management of food safety risks along the value *** and quality assurance efforts were focused on international markets,resulting in less attention being paid to domestic markets where a high degree of informality was *** Improved implementation of safety and quality assurance systems will lead to safer food with higher nutritional quality,extended shelf-life and reduced post-harvest *** awareness of food safety issues in SSFs is a prerequisite for achieving several of the UN Sustainable development Goals.

关键词： Food security policy monitoring legislation value chain domestic market international trade

Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?

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World Journal of Gastroenterology 2021年第18期27卷 2054-2072页

作者： Steve M d'Souza Kevin Houston lauren Keenan Byung Soo Yoo Parth J Parekh david A Johnson department of Internal Medicine Division of GastroenterologyEastern Virginia Medical SchoolNorfolkVA 23502United States

Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and *** interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the *** relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the *** changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other *** effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease *** has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory ***,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression).

关键词： Microbiome Gastroesophageal reflux disease Probiotics Prebiotics Bacteriocins dysbiosis Barrett’s esophagus Esophageal cancer Esophagitis Eosinophilic esophagitis

Gene expression profiling as a prognostic tool in multiple myeloma

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Cancer drug Resistance 2021年第4期4卷 1008-1018页

作者： Harmony black Siobhan Glavey department of Haematology Beaumont HospitalDublin D09 V2N0Ireland department of Pathology Royal College of Surgeons in IrelandDublin D02 YN77Ireland

Multiple myeloma(MM)is an aggressive plasma cell malignancy with high degrees of variability in outcome,some patients experience long remissions,whilst others survive less than two years from *** refractoriness and relapse remain challenges in MM management,and there is a need for improved prognostication and targeted therapies to improve overall survival(OS).The past decade has seen a surge in gene expression profiling(GEP)studies which have elucidated the molecular landscape of MM and led to the identification of novel gene signatures that predict OS and outperform current clinical *** this review,we discuss the limitations of current prognostic tools and the emerging role of GEP in diagnostics and in the development of personalised medicine approaches to combat drug resistance.

关键词： Multiple myeloma gene expression profiling prognostication risk stratification risk-adapted therapies SKY92 drug resistance

Characterization of gut microbiome and metabolome in Helicobacter pylori patients in an underprivileged community in the United States

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World Journal of Gastroenterology 2021年第33期27卷 5575-5594页

作者： Brian White John d Sterrett Zoya Grigoryan lauren Lally Jared d Heinze Hyder Alikhan Christopher A Lowry Lark J Perez Joshua deSipio Sangita Phadtare department of Biomedical Sciences Cooper Medical School of Rowan UniversityCamdenNJ 08103United States department of Integrative Physiology University of Colorado BoulderBoulderCO 80309United States department of Internal Medicine Lenox Hill HospitalNYCNY 10075United States department of Internal Medicine Thomas Jefferson University HospitalPhiladelphiaPA 19107United States department of Biological Sciences Rowan UniversityGlassboroNJ 08028United States department of Chemistry and Biochemistry Rowan UniversityGlassboroNJ 08028United States department of Gastroenterology Cooper University HospitalCamdenNJ 08103United States

BACKGROUNd Helicobacter pylori(***),a bacterium that infects approximately half of the world’s population,is associated with various gastrointestinal diseases,including peptic ulcers,non-ulcer dyspepsia,gastric adenocarcinoma,and gastric *** the burden of antibiotic resistance increases,the need for new adjunct therapies designed to facilitate *** eradication and reduce negative distal outcomes associated with infection has become more *** of the interactions between ***,the fecal microbiome,and fecal fatty acid metabolism,as well as the mechanisms underlying these interactions,may offer new therapeutic *** To characterize the gut microbiome and metabolome in *** patients in a socioeconomically challenged and underprivileged inner-city *** Stool samples from 19 *** patients and 16 control subjects were analyzed.16S rRNA gene sequencing was performed on normalized pooled amplicons using the Illumina MiSeq System using a MiSeq reagent kit *** and beta diversity analyses were performed in QIIME ***-targeted fatty acid analysis of the samples was carried out using gas chromatography-mass spectrometry,which measures the total content of 30 fatty acids in stool after conversion into their corresponding fatty acid methyl ***-dimensional scaling(MdS)was performed on Bray-Curtis distance matrices created from both the metabolomics and microbiome datasets and a Procrustes test was performed on the metabolomics and microbiome MdS *** Fecal microbiome analysis showed that alpha diversity was lowest in *** patients over 40 years of age compared to control subjects of similar age *** diversity analysis of the samples revealed significant differences in microbial community structure between *** patients and control subjects across all ***-eight and six taxa had lower and higher relative abundance in *** patients,*** that were e

关键词： Gut microbiome Metabolome Helicobacter pylori Antibiotic resistance dysbiosis Eradication