Atrial Septal Defect(ASD)associated long non-coding RNA STX18-AS1 maintains time-course of in vitro cardiomyocyte differentiation

作     者：Yingjuan Liu Mun-kit Choy Sabu Abraham Gennadiy Tenin Graeme C.Black Bernard D.Keavney Yingjuan Liu;Mun-kit Choy;Sabu Abraham;Gennadiy Tenin;Graeme C.Black;Bernard D.Keavney

作者机构：Division of Cardiovascular SciencesUniversity of ManchesterManchester M139PLUK Manchester University NHS Foundation TrustManchester Academic Health Science CentreManchester M139NQUK Division of Evolution&Genomic SciencesUniversity of ManchesterManchester M139WLUK 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第4期

页      面：1150-1153页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by The University of Manchester-Peking University Health Science Centre Alliance the China Scholarships Council and British Heart Foundation Programme Grant RG/15/12/31616 

主　　题：clinical maintain cardiac 

摘      要：Congenital heart disease(CHD)is the commonest birth defect,affecting approximately 9.4/1000 live births.^(1)Atrial Septal Defect(ASD)is one of the commonest CHD clinical phenotypes,which frequently requires treatment either in childhood or adulthood,and can lead to severe complications such as right heart failure and cardiac *** genome-wide association studies(GWAS)have identified a region of chromosome 4p16(Ch4p16)associated with the risk of ASD.