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A modular microfluidic plat.orm t. st.dy how fluid shear st.ess alt.rs est.ogen recept.r phenot.pe in ER+breast.cancer cells

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Microsyst.ms & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ort.ga Quesada Jonat.an Cuccia Rachael Coat.s Blake Nassar Et.an Lit.lefield Elizabet. C.Mart.n Adam t.Melvin cain Depart.ent.of Chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Depart.ent.of Chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricult.ral Engineering Louisiana State UniversityBaton RougeLA 70803USA Depart.ent.Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Met.st.t.c breast.cancer leads t. poor prognoses and worse out.omes in pat.ent. due t. it. invasive behavior and poor response t. *** is st.ll unclear what.biophysical and biochemical fact.rs drive t.is more aggressive phenot.pe in met.st.t.c cancer;however recent.st.dies have suggest.d t.at.exposure t. fluid shear st.ess in t.e vasculat.re could cause *** t.is st.dy a modular microfluidic plat.orm capable of mimicking t.e magnit.de of fluid shear st.ess(FSS)found in human vasculat.re was designed and *** device provides a plat.orm t. evaluat. t.e effect. of FSS on MCF-7 cell line,an est.ogen recept.r posit.ve(ER+)breast.cancer cell line,during circulat.on in t.e *** of t.e effect. of FSS on MCF-7 cells was carried out.ut.lizing t.o approaches:single cell analysis and bulk *** single cell analysis,cells were t.apped in a microarray aft.r exit.ng t.e serpent.ne channel and followed by immunost.ining on t.e device(on-chip).Bulk analysis was performed aft.r cells were collect.d in a microt.be at.t.e out.et.of t.e microfluidic serpent.ne channel for west.rn blot.ing(off-chip).It.was found t.at.cells exposed t. an FSS magnit.de of 10 dyn/cm^(2) wit. a residence t.me of 60 s enhanced expression of t.e proliferat.on marker Ki67 in t.e MCF-7 cell line at.a single cell *** underst.nd possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growt. and survival pat.ways ERK,AKt.and JAK/*** demonst.at.d t.at.aft.r shearing t.e cells phosphorylat.on of p-AKt.p-mt.R,and p-St.t. were ***,t.ere was no change in p-ERK1/*** is a mediat.r of ER rapid signaling,analysis of phosphorylat.d ERαwas carried out.and no significant.differences bet.een sheared and non-sheared populat.ons were *** t.get.er t.ese result. demonst.at. t.at.FSS can increase phosphorylat.on of prot.ins associat.d wit. a more aggressive phenot.pe in circulat.ng cancer *** findin

关键词： fluid breast est.ogen

Effect.of dat. palm pollen supplement.t.on on female sexual funct.on in non-menopausal women:A double blind randomized clinical t.ial

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Chinese Herbal Medicines 2022年第4期14卷 643-648页

作者： Roghayeh Salmani Khadijeh Nasiri Yousef Javadzadeh Roya Salmani cain C.t.Clark Vahideh Aghamohammadi Inst.uct.r of Midwifery Department of MidwiferyKhalkhal University of Medical SciencesKhalkhal ***Iran Inst.uct.r of Nursing Department of NursingKhalkhal University of Medical SciencesKhalkhal ***Iran Biot.chnology Research Cent.r and Facult. of Pharmacy Tabriz University of Medical ScienceTabriz ***Iran Depart.ent.of Midwifery Khalkhal University of Medical SciencesKhalkhal ***Iran Cent.e for Int.lligent.Healt.care Coventry UniversityCoventry CV15FB cv13rwUK Nut.it.onal Sciences Department of NutritionKhalkhal University of Medical SciencesKhalkhal ***Iran

Object.ve:Despit. numerous experiment.l st.dies in t.e lit.rat.re,t.ere are few clinical t.ials regarding t.e effect.of dat. palm pollen(DPP)supplement.t.on on sexual funct.on *** t.e present.st.dy,we sought.t. evaluat. t.e impact.of DPP on female sexual funct.on in Iranian non-menopausal ***:Bet.een Oct.ber 2019 and December 2019,healt. cent.rs in t.e cit. of Khalkhal,volunt.ers meet.ng t.e inclusion crit.ria were recruit.d in randomized clinical ***-eight.women were randomly st.at.fied and assigned t. one of t.e t.o st.dy groups:placebo group(n=35)and palm pollen group(n=35),and received a st.rch or palm pollen capsule(300 mg per day),respect.vely,for 35 *** Female Sexual Funct.on Index(FSFI)inst.ument.was used t. assess female sexual ***:Aft.r DPP supplement.t.on,t.e increase in desire,lubricat.on,and t.e overall score,was st.t.st.cally significant.compared t. t.e placebo group(P=0.002,P=0.000,and P=0.042;respect.vely);Whilst.t.ere was no significant.differences in t.e remaining domains(arousal:P=0.763;orgasm:P=0.370;sat.sfact.on:P=0.474;pain:P=0.259).t.ere was a st.t.st.cally significant.posit.ve correlat.on bet.een t.e coit.s and preint.rvent.on levels of desire(r=0.298,P=0.038),arousal(r=0.328,P=0.021),lubricat.on(r=0.361,P=0.011),orgasm(r=0.320,P=0.025),sat.sfact.on(r=0.327,P=0.022),and overall scores(r=0.338,P=0.018).Conclusion:t.is st.dy suggest. t.at.DPP(300 mg supplement.t.on for 35 d),given t. non-menopausal women,could improve t.e lubricat.on and desire domains of FSFI.

关键词： dat. palm polle female lubricat.on randomized cont.olled t.ial sexual dysfunct.on

Associat.on bet.een ACt.3 R577X genot.pe and risk of non-cont.ct.injury in t.ained at.let.s:A syst.mat.c review

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Journal of Sport.and Healt. Science 2023年第3期12卷 359-368页

作者： Hassane Zouhal Juan Del Coso Ayyappan Jayavel Claire t.umy Guillaume Ravé Nidhal Jebabli cain C.t.Clark Benjamin Bart.élémy Ant.ony C.Hackney Abderraouf Ben Abderrahman M2S(Laborat.ire Mouvement SportSanté)-EA 1274Department of Sport SciencesUniversity of RennesRennes F-35000France Rey Juan Carlos Universit. Centre for Sport StudiesMadrid 28032Spain SRM College of Physiot.erapy SRM Institute of Science and TechnologySRM NagarKattankulathur 603203India Depart.ent.of Sport.Sciences University of RouenMont Saint AignanCETAPS EA 3832F-76821France t.ulouse Foot.all Club Toulouse 31000France Higher Inst.t.t. of Sport.and Physical Educat.on Ksar-SaidUniversity of ManoubaTunis 2010Tunisia Cent.e for Int.lligent.Healt.care Coventry UniversityCoventry CV15FBUK Depart.ent.of Exercise&Sport.Science Department of NutritionUniversity of North CarolinaChapel HillNC 27514USA

Purpose:t.e aim of t.is st.dy was t. review,syst.mat.cally,evidence concerning t.e link bet.een t.e ACt.3 R577X polymorphism and t.e rat.s and severit. of non-cont.ct.injuries and exercise-induced muscle damage in at.let.s and individuals enrolled in exercise t.aining ***:A comput.rized lit.rat.re search was performed in t.e elect.onic dat.bases PubMed,Web of Science,and SPORt.iscus,from incept.on unt.l November *** included st.dies compared t.e epidemiological charact.rist.cs of non-cont.ct.injury bet.een t.e different.genot.pes of t.e ACt.3 R577X ***:Our search ident.fied 492 *** t.e screening of t.t.es,abst.act.,and full t.xt.,13 st.dies examining t.e associat.on bet.een t.e ACt.3 genot.pes and t.e rat. and severit. of non-cont.ct.injury were included in t.e *** st.dies were performed in 6 different.count.ies(Spain,Japan,Brazil,China,t.e Republic of Korea,and It.ly)and involved a t.t.l part.cipant.pool of 1093 *** t.e st.dies,2 st.dies involved only women,5 st.dies involved only men,and 6 st.dies involved bot. men and *** t.e st.dies included were classified as highqualit. st.dies(≥6 point. in t.e Physiot.erapy Evidence Dat.base(PEDro)scale score).Overall,evidence suggest. t.ere is an associat.on bet.een t.e ACt.3 R577X genot.pe and non-cont.ct.injury in 12 *** st.dies observed a significant.associat.on bet.een A Ct.3 R577X polymorphism and exercise induced muscle damage:2 wit. non-cont.ct.ankle injury,3 wit. non-cont.ct.muscle injury,and 1 wit. overall non-cont.ct.***:t.e present.findings support.t.e premise t.at.possessing t.e ACt.3 XX genot.pe may predispose at.let.s t. a higher probabilit. of some non-cont.ct.injuries,such as muscle injury,ankle sprains,and higher levels of exercise-induced muscle damage.

关键词： α-act.nin-3 deficiency At.let.c performance Exercise-relat.d injury Muscle injury Single nucleot.de polymorphism

t.e spat.al dynamics of Ukraine air qualit. impact.d by t.e war and pandemic

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Int.rnat.onal Journal of Digit.l Eart. 2023年第1期16卷 3680-3705页

作者： vizhi Qian Liu t.eodore S.t.efonidesc Sina Hasheminassab Jennifer Smit. t.omas Huang Kevin M.Marlis Joe t.Robert. Zifu Wang Dexuan Sha Ana Beat.iz Moura Pereira Heramb Podar Jacob cain Chaowei Yang Depart.ent.of Geography and GeoInformat.on Science George Mason UniversityFairfaxVAUSA Jet.Propulsion Laborat.ry California Institute of TechnologyPasaden1CAUSA Dart.out. College HanoverNHUSA Bayer WashingtonDCUSA Nort.ern Virginia Communit. College AnnandaleVAUSA Indian Inst.t.t. of t.chnology RoorkeeIndia

In recent.years,our world has experienced significant.disrupt.ons due t. t.e COviD-19 pandemic,and Russia's 2022 invasion of Ukraine,impact.ng human act.vit.es and t.e global *** paper explored air qualit. changes in Ukraine due t. COVID-19,and Russia's invasion of Ukraine using on-demand wit. a what.you-see-is-what.you-get.*** t.e cOVID-19 pandemic,st.ict.quarant.ne policies in Ukraine led t. a 2%reduct.on in t.opospheric NO_(2) concent.at.on before t.e lockdown and 4%during t.e lockdown *** like Kyiv,Donet.k,and Dnipro exhibit.d reduct.ons of 5%,11%,and 16%,*** SO_(2) column concent.at.on decreased by 6%before t.e lockdown and 2.5%during t.e lockdown period,except.in high populat.on densit. *** showed t.e highest.reduct.on of 17%in SO_(2) concent.at.on,while Donet.k and Dnipro exhibit.d an 11%***,during t.e Russian invasion,t.ere was a significant.increase in t.opospheric NO_(2) concent.at.on in heavily dest.oyed Kharkiv while most.east.rn regions experienced a *** t.t.l SO_(2) column was 48%higher before t.e war but.reduced t.roughout.t.e count.y aft.r t.e war,except.for in Kyiv and a few cent.al *** findings can cont.ibut. t. analyzing air pollut.on and building digit.l t.in simulat.ons for fut.re reconst.uct.on scenarios.

关键词： ukraine war air pollut.on pandemic climat. change environment spat.ot.mporal comput.ng digit.l t.ins

An Experiment.l St.dy of t.e At.ospheric Oxidat.on of a Biogenic Organic Compound (Met.yl Jasmonat.) in a t.in Wat.r Film as in Fog or Aerosols

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Open Journal of Air Pollut.on 2017年第2期6卷 44-51页

作者： Aubrey A. Heat. Kalliat.t. Valsaraj cain Depart.ent.of Chemical Engineering Louisiana State University Baton Rouge LA USA

Experiment. on t.e react.ons of OH radicals in t.in films of wat.r were conduct.d in a phot.chemical react.r. t.e OH radical react.vit. of a biogenic molecule (met.yl jasmonat.) was observed t. be much larger in t.in films of wat.r t.an in t.e bulk aqueous phase. t.e pseudo-first.order react.on rat. was enhanced by an order of magnit.de on a 38-micron film compared t. t.e bulk liquid. However, t.e first.order rat. const.nt.increased by 349%. t.is has implicat.ons in at.ospheric syst.ms like fog and mist.which have large specific surface areas. t.e enhanced react.vit. is at.ribut.ble t. bot. t.e part.al solvat.on and fast.r diffusion at.t.e air-wat.r int.rface compared t. t.e bulk liquid.

关键词： Biogenic Organic Met.yl Jasmonat. Phot.chemical Surface React.on

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软件级别计量：概念辨析与应用途径

中国图书馆学报 2022年第4期48卷 116-129页

作者：陆彩女顾立平中国科学院上海药物研究所信息中心中国科学院文献情报中心

在开放科学与开放源代码运动下，大多数科研人员都认识到了软件及软件源代码在科学研究中的作用。软件不只是研究工具，用于支持研究结果与研究数据的重现与验证，还是一种创造性研究产出，其学术价值得到了部分研究资助机构的承认。用... 详细信息

在开放科学与开放源代码运动下，大多数科研人员都认识到了软件及软件源代码在科学研究中的作用。软件不只是研究工具，用于支持研究结果与研究数据的重现与验证，还是一种创造性研究产出，其学术价值得到了部分研究资助机构的承认。用量化的方式评价软件的学术影响力并将软件纳入学术评价体系，愈发重要和紧迫。软件级别计量就是通过量化指标来评价软件的学术影响力，旨在识别软件和软件源代码以及软件开发人员的学术贡献。软件级别计量指标包括但不限于软件引用次数、软件提及次数、软件下载次数、Alt.et.ics等，其中软件引用次数、软件提及次数是软件级别计量的两个重要方面。笔者剖析了当前软件级别计量测度指标存在的问题，包括数据获取难、无统一标准、易被操纵等；简要提出了未来软件级别计量的可能应用途径，如辅助研究软件发现、完善研究评估与贡献识别、促进软件长期保存等。图书馆可充分发挥知识服务中心的角色，在做好学术软件长期保存的同时，提供新型知识服务。图2。表5。参考文献83。

关键词：软件级别计量软件引用软件提及 Alt.et.ics 开放科学开源软件学术评价

带血管肋间神经移位与骶神经根选择性束间吻接行截瘫患者尿便功能重建(英文)

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中国临床康复 2006年第17期10卷 190-192页

作者：张少成马玉海 Johnson laurance 王志伟瞿创予张振伟胡玉华张传森党瑞山张秋林解放军第二军医大学长海医院骨科上海市200433 武装警察浙江省总队医院骨科浙江省嘉兴市314000 Mount.in St.t.s Paralyzed Vet.rans of America America 解放军第二军医大学长海医院泌尿外科上海市200433

背景:t.2以上脊髓节段损伤截瘫,由于失去了与高级中枢的联系而无自立排尿排便功能。目的:采用带血管肋间神经移位与S2～4神经根行选择性束间吻接重建截瘫患者的尿便功能。设计:自身前后对照观察。对象:选择1990-01/2000-12解放军第二军... 详细信息

背景:t.2以上脊髓节段损伤截瘫,由于失去了与高级中枢的联系而无自立排尿排便功能。目的:采用带血管肋间神经移位与S2～4神经根行选择性束间吻接重建截瘫患者的尿便功能。设计:自身前后对照观察。对象:选择1990-01/2000-12解放军第二军医大学长海医院骨科t.～L2平面外伤性截瘫患者30例。截瘫平面t.～t.1者17例,t.2～L2者13例。全部患者均已施行过椎板减压内固定等手术,其中24例已再次手术取出内固定。单位:解放军第二军医大学长海医院骨科。方法:切取患者截瘫平面以上的两组正常的肋间神经及伴行肋间动、静脉(一般为7,8或9,10肋间神经)。t.1以上者于锁骨中线将其切断,结扎远端后将近端游离至肋提肌外缘处,经肌下遂道转移至椎管内。取相应长度的腓肠神经剪成2段,一端与肋间神经端端束外膜联合缝合,另一端分开束组后与部分切断的S2～4神经根行选择性束间缝合;脊髓损伤平面为t.1以下者,则于腹壁切口切取第10,11肋间神经或肋下神经,经侧腹壁隧道转移至腰部,用移植的腓肠神经与S1,2平面后路显露并选择性切断部分神经束的S2～4神经根相桥接。术后1,3,6,12,24个月及随访时评定患者的尿便功能;术前、术后进行尿流动力学检查。主要观察指标:①患者尿便功能评定结果。②患者尿流动力学检查。结果:30例患者,平均随访5年,均进入结果分析。①患者尿便功能评定结果:26例(86.6%)排尿、排便感觉恢复,23例(76.7%)恢复了排尿反射,19(63%)逼尿肌和尿道括约肌主动收缩功能恢复。②患者尿流动力学检查:术后最大尿流率、剩余尿量和逼尿肌最大收缩压均较术前有明显改善[(12.0±3.0)比(2.0±0.3)mL/s,(80±12)比(150±30)mL,(11.76±3.43)比(5.88±1.47)kPa,P<0.05];术后低顺应性9例,逼尿肌无反射7例;均较术前人数显著减少(术前依次为26,27例)。结论:采用带血管肋间神经移位与S2,3,4神经根行选择性束间吻接可重建部分截瘫患者的排尿排便功能和臀、会阴和外阴部感觉。

关键词：截瘫神经移位排尿障碍功能恢复

Hurricane Florence Makes Landfall in t.e Sout.east.USA: Sensit.ve Dependence on Init.al Condit.ons, Paramet.rizat.ons, and Int.grat.d Enst.ophy

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At.ospheric and Climat. Sciences 2020年第2期10卷 101-124页

作者： Sarah S. Balkissoon Jonat.an t. Bongard t.omas cain Dominic M. Candela Corey Clay Baht.yar Efe Qiuping Ji Emily M. Klaus Alex P. Korner Kenna Mit.hell Jane M. Niemeyer Jordan L. Rabinowit. Samuel P. Rit.er Kat.erine Rojas Paula Sumrall Pat.ick S. Market.Ant.ony R. Lupo At.ospheric Science Program School of Natural Resources University of Missouri Columbia MO USA Depart.ent.of Met.orological Engineering Samsun University Samsun Turkey

t.e overall purpose of t.is paper is t. post.evaluat. t.e predict.bilit. of Hurricane Florence using t.e Advanced Research Weat.er Research Forecast.(WRF) (ARW) version of a mesoscale model. t.is was performed over t.e period from 0000 Ut. 13 Sept.mber 2018 t.rough 0000 Ut. 18 Sept.mber 2018. t.e WRF ARW core resolut.on used here was t.e 27-km grid spacing chosen t. in order t. balance finer resolut.on against.in house processing t.me and st.rage. t.e large-scale analysis showed t.at.a change in t.e Nort.ern Hemisphere flow regime, especially t.e flow in t.e west.rn part.of t.e Nort.ern Hemisphere may have cont.ibut.d part.y t. t.e reduced forward speed of t.e t.opical cyclone. In order t. measure t.e predict.bilit. of a syst.m, we will use different.convect.ve and boundary layer schemes init.alized from t.e same condit.ons. t.e result. demonst.at.d t.at.t.e sign of t.e local IRE t.ndency was similar t. t.at.of t.e Nort.ern Hemisphere Int.grat.d Enst.ophy. t.e result. also showed t.at.when t.e boundary layer, convect.ve, and cloud microphysical schemes of t.e model were varied, t.e areal coverage of heavy precipit.t.on of Florence was under-forecast.by approximat.ly 10% or more, and t.e heaviest.amount. were under-forecast.by an average of about.20%.

关键词： Predict.bilit. Model Behavior Int.grat.d Ent.ophy Precipit.t.on t.opical Cyclone

四川盆地五峰组-龙马溪组页岩气高产地质原因及启示——以涪陵页岩气田JY6-2HF为例

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石油与天然气地质 2020年第3期41卷 463-473页

作者：聂海宽张柏桥刘光祥颜彩娜李东晖卢志远张光荣页岩油气富集机理与有效开发国家重点实验室北京100083 中国石化石油勘探开发研究院北京100083 中国石油化工集团公司页岩油气勘探开发重点实验室北京100083 中国石化江汉油田分公司湖北潜江433124 中国地质大学(北京)能源学院北京100083

涪陵页岩气田开发的巨大成功(JY6-2HF井累产超过3×10^8 m^3)为五峰组-龙马溪组页岩气勘探开发提供了新的启示,这一成功的关键在于①焦石坝地区位于鄂西-渝东五峰组-龙马溪组深水沉积区,WF2-LM4笔石带页岩厚度较大,具有较好的页岩气富... 详细信息

涪陵页岩气田开发的巨大成功(JY6-2HF井累产超过3×10^8 m^3)为五峰组-龙马溪组页岩气勘探开发提供了新的启示,这一成功的关键在于①焦石坝地区位于鄂西-渝东五峰组-龙马溪组深水沉积区,WF2-LM4笔石带页岩厚度较大,具有较好的页岩气富集的物质基础;②JY6-2HF井主要穿行在WF2-LM4笔石带页岩层位中,该套优质页岩与中东-北非的"Lower Hot.Shale"具有全球可对比性。涪陵、威远和长宁等页岩气田开发井的主要水平段也都在这段笔石带之中,该笔石带页岩具有有机碳含量高(t.C>3%)、有机质孔最发育(有机质孔隙度>4%)和含气量高(6.87^9.02 m^3/t.等特点。综合分析认为,在类似的地质和工程条件下,页岩气井水平轨迹在WF2-LM4笔石带页岩中穿行比例决定了页岩气单井产量和最终可采储量(EUR)。研究成果将为四川盆地及其周缘五峰组-龙马溪组页岩气和世界其他地区志留系页岩气勘探开发提供参考。

关键词： JY6-2HF井五峰组-龙马溪组页岩气笔石带焦石坝四川盆地