Microwave Application and Anhydrous Cu(OAc)<sub>2</sub> Mediated O-Arylation of Aliphatic Amino Alcohols
Microwave Application and Anhydrous Cu(OAc)<sub>2</sub> Mediated O-Arylation of Aliphatic Amino Alcohols作者机构：Department of Chemistry Tennessee State University Nashville TN USA
出 版 物：《International Journal of Organic Chemistry》 (有机化学国际期刊（英文）)
年 卷 期：2016年第6卷第2期
页 面：100-106页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
主 题：Hydroxylamine Amino Ether O-Arylation O-Styrylation Microwave
摘 要：Anhydrous Cu(OAc)2 mediated efficient protocol has been developed in the area of C-O coupling from potassium aryltrifluoroborates and aliphatic amino alcohols such as β-hydroxy, γ-hydroxy, and δ-hydroxy amines. The scope of this transformation focuses on direct O-arylation and O-styrylation. The reaction vial loaded with reactants under argon atmosphere is microwaved at 140°C for 30 min to furnish the corresponding cross-coupling product, amino ethers, in good yields.
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