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Long-term effects of gestational diabetes mellitus on the pancreas of female mouse offspring

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World Journal of Diabetes 2024年第4期15卷 758-768页

作者： Enriqueta muñoz-Islas Edgar David Santiago-Sanmartin Eduardo mendoza-Sánchez Héctor Fabián Torres-Rodríguez laura Yanneth Ramírez-Quintanilla Christopher michael Peters Juan miguel Jiménez-andrade Unidad Académica multidisciplinaria Reynosa-Aztlán Universidad Autónoma de TamaulipasReynosa 88740TamaulipasMexico department of Anesthesiology Wake Forest University School of MedicineWinston SalemNC 27101United States

BACKGROUND Prolonged fetal exposure to hyperglycemia may increase the risk of developing abnormal glucose metabolism and type-2 diabetes during childhood,adolescence,and adulthood;however,the mechanisms by which gestational diabetes mellitus(GDm)predisposes offspring to metabolic disorders remain *** To quantify the nerve axons,macrophages,and vasculature in the pancreas from adult offspring born from mouse dams with *** GDm was induced by *** of streptozotocin(STZ)in ICR mouse *** 12 wk old,fasting blood glucose levels were determined in *** 15 wk old,female offspring born from dams with and without GDm were sacrificed and pancreata were processed for *** quantified the density of sensory[calcitonin gene-related peptide(CGRP)]and tyrosine hydroxylase(TH)axons,blood vessels(endomucin),and macro-phages(CD68)in the splenic pancreas using confocal *** Offspring mice born from STZ-treated dams had similar body weight and blood glucose values compared to offspring born from vehicle-treated ***,the density of CGRP+and TH+axons,endomucin+blood vessels,and CD68+macrophages in the exocrine pancreas was significantly greater in offspring from mothers with GDm vs control ***,the microvasculature in the islets was significantly greater,but not the number of macrophages within the islets of offspring born from dams with GDm compared to control *** GDm induces neuronal,vascular,and inflammatory changes in the pancreas of adult progeny,which may partially explain the higher propensity for offspring of mothers with GDm to develop metabolic diseases.

关键词： Gestational diabetes mellitus Immunohistochemistry Confocal microscopy Pancreas Offspring

Effect of Turbidity on Semi-Automatic Analysis of Copepod Size and Abundance Distribution in the Water Column

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3′-UTR of the SARS-CoV-2 genome as a possible source of piRNAs

Advances in Bioscience and Biotechnology（生命科学与技术进展） 2024年第6期 380页

作者： Thiago da Silva matos Carolina Siqueira dos Reis laura de andrade m.ura márcio Abreu Ricardo Coutinho Lohengrin Fernandes

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Genes & Diseases 2023年第3期10卷 668-670页

作者： maría Teresa Hernández-Huerta laura Pérez-Campos mayoral Carlos Alberto matias-Cervantes Carlos Romero Díaz Eli Cruz Parada Eduardo Pérez-Campos mayoral Rafael Baltiérrez-Hoyos margarito martínez Cruz Gabriel mayoral andrade Eduardo Pérez-Campos CONACyT Faculty of Medicine and SurgeryAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico Research Center Faculty of Medicine UNAM-UABJOAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 8020Mexico National Technology of mexico/IT Oaxaca Oaxaca de JuárezOaxaca 68030Mexico

SARS-CoV-2 is the causal agent of the COVID-19 pandemic. This is a single-stranded RNA beta-coronavirus that is comprised of a 5′ and 3′-untranslated region (UTR) in its non-coding RNA (ncRNA) region. The P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are ncRNA sequences that bind to transposons and interfere with the translation of new genes. Here, we search for short sequences in the non-coding regions, corresponding to 28 nucleotides (nt). These start from a uracil and have a conserved region of at least 10 nt of homology with the previously reported piRNAs. The aim of this work was to identify piRNA-like sequences in the 3′-UTR of SARS-CoV-2 from the reported Wuhan Patient's genome sequence (GenBank: mN908947.3).

关键词： piRNA sequences piRNAs

Rhino-Orbito-Cerebral mucormycosis in a Diabetic Patient with Idiopathic CD4+Lymphocytopenia

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Advances in Infectious Diseases 2013年第4期3卷 248-252页

作者： Nuno Rocha Pereira Paulo andrade laura Sa Candida Abreu Rita Figueiredo Roberto Silva Antonio Sarmento Infectious Diseases department Centro Hospitalar Sao Joao and Faculty of Medicine of Porto UniversityPortoPortugal Neuroradiology department Centro Hospitalar Sao JoaoPortoPortugal Pathology department Centro Hospitalar Sao Joao and Faculty of Medicine of Porto UniversityPortoPortugal

A 54-year-old diabetic male, with idiopathic CD4 + lymphocytopenia, was presented with a two-month history of headache and periocular pain followed by vertigo, left hypoacusia and left peripheral facial palsy and hypoesthesia. more than a month after admission, a palate ulcer appeared and Infectious Diseases consultation was required. mucormycosis was suspected and the diagnosis was confirmed by histologic examination. despite early surgery and combination antifungal therapy, the patient did not survive. This case report illustrates the difficulty in diagnosing a rare condition with non-specific clinical manifestations and underlines the importance of a timely multidisciplinary approach in order to recognise this highly fatal disease earlier. It also describes a previously non-reported situation of mucormycosis in a patient with idiopathic CD4 + lymphocytopenia.

关键词： mucormycosis Idiopathic CD4+Lymphocytopenia Diabetes Amphotericin B

Photodynamic Therapy as Palliative Therapy for Invasive Syringoid Eccrine Carcinoma of the Auricle: A Case Report

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Journal of Cancer Therapy 2013年第6期4卷 1091-1094页

作者： Claudia Gutiérrez Gómez Anail Alvarez Ana Lilia Ruelas Ixchel Landgrave Alfonso Vallarta laura andrade department of Plastic and Reconstructive Surgery Medica Sur Hospital México City México dermatology department Medica Sur Hospital México City México Plastic Surgery department Medica Sur Hospital México City México

Recurrent eccrine syringomatous carcinoma is an extremely rare adnexal tumor predominantly found in the head and neck region. We present a case of a 75-year-old woman with a 7-year history of recurrent syringoid eccrine carcinoma in the scalp and auricle. She had undergone five previous oncologic resections and declined further oncologic ablation of the auricle, including temporal bone and external ear canal resection. We performed five sessions of palliative photodynamic therapy using topical aminolevulinic acid HCL 20% (ALA) and between 25 and 33 pulses of Intense Pulsed Light (Quantum) with an intensity of 30 Joules. The ALA incubation time was 3 hours, while the time between each session was 4 weeks. This treatment helped to control ulceration, pain, and swelling. We saw the patient 1 month after the last treatment, by that time she moved and we lost contact.

关键词： Syringoid Eccrine Carcinoma Photodynamic Therapy

Environmental Data Observation System—Solam for Analysis and Interpretation of Soil moisture Variation and Precipitation Indexes

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International Journal of Geosciences 2018年第11期9卷 658-667页

作者： laura Vanessa Araque Lavalle Rodrigo A.Stabile Cassiano A.Bortolozo Rodolfo m.mendes Joao V.C.Garcia mariana F.B.motta marcio R.m.andrade Tehrrie Konig Daniel metodiev National Center for monitoring and Early Warning of Natural Disasters(CEmAdeN/mCTIC) Sao Jose dos CamposBrazil

The monitoring of urban slopes employing in-situ equipment seeks to avoid the loss of human lives midst emergency events like landslides. Cemaden (Brazilian National Centre for monitoring and Early Warnings of Natural Disasters) has a pilot network of soil moisture and rain gauge stations located in urban slopes to understand, prevent, and mitigate landslides. Due to the large volume of data produced by this system there was a need for tools for data retrieval and visualization. This paper describes the Solam (Environmental Data Observation System) software which generates automated graphs that enable researchers to analyze and comprise data from soil moisture sensors and rain gauge stations. Those results allow to research moisture variations in six different sensor levels (from 0.5 m to 3 m deep) and precipitation indexes (hourly and accumulated rainfall) for the established period. This analysis will provide information to set critical environmental thresholds on base recorded landslides.

关键词： Slope Stability Geotechnical monitoring Environmental Thresholds Urban Slopes Software Warning System