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Hepatitis C virus-related mixed cryoglobulinemia: Is genetics to blame?

World Journal of Gastroenterology 2013年第47期19卷 8910-8915页

作者： laura gragnani Elisa Fognani Alessia Piluso Anna Linda Zignego Center for Systemic Manifestations of Hepatitis Viruses Department of Experimental and Clinical MedicineUniversity of Florence50134 FlorenceItaly

Mixed cryoglobulinemia(MC)is the extrahepatic manifestation most strictly correlated with hepatitis C virus(HCV)infection;it is a benign autoimmune and lymphoproliferative disorder that evolves to lymphoma in5%-10%of *** is reputed to be a multistep and multifactorial process whose pathogenicity is still poorly *** is still unknown why only some chronically infected HCV patients develop MC and only some of these exhibit systemic symptoms(MC syndrome).Several studies have investigated the pathogenetic basis of MC and the most recent ones suggest that the virus is able to trigger such a disorder only in the presence of genetic factors that are still ***,we try to clarify the complex relationship between HCVrelated MC and the host’s genetic *** data that we report are heterogeneous and sometimes even ***,large,multicenter studies are clearly *** identification of a characteristic genetic signature of cryoglobulinemic patients would be an important step toward a personalized approach in their clinical *** new wide-ranging genomics technologies will hopefully help to resolve these complex issues.

关键词： Hepatitis C virus Mixed cryoglobulinemia Genetics Viral pathogenetic factors Host pathogenetic factors

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Micro RNA expression in hepatitis C virus-related malignancies: A brief review

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World Journal of Gastroenterology 2015年第28期21卷 8562-8568页

作者： laura gragnani Alessia Piluso Elisa Fognani Anna Linda Zignego Center for Systemic Manifestations of Hepatitis Viruses Department of Experimental and Clinical Medicine University of Florence

Not only is chronic hepatitis C virus(HCV) infection a major public health problem,but also it can cause hepatocellular carcinoma and,more rarely,nonHodgkin's *** characteristics mean that HCV is the only virus infecting humans that is able to cause two different *** fine pathogenetic and molecular mechanisms by which HCV induces these two malignancies are not completely *** the last decade,it has been shown that microRNAs(miRNAs),a class of 21-23-nucleotide molecules modulating posttranscriptional gene expression,make an important contribution to the pathogenesis of several cancers and are also considered highly promising ***,we briefly describe the current knowledge about microRNAs' involvement in HCV-related molecular *** decided to focus our attention on studies fully conducted on ex vivo samples with this specific etiology,and on cultured cell lines partially or completely expressing the HCV *** of the results reported in this review are controversial,possibly because of methodological issues,differences in sampling size and features,and ethnicity of *** is certain is that miRNAs play a remarkable role in regulating gene expression during oncogenetic processes and in viral infection.A clear understanding of their effects is fundamental to elucidating the mechanisms underlying virus-induced malignancies.

关键词： MicroRNA Hepatitis C virus Hepatocellularcarcinoma Lymphoma

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