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Counte.-re.ulatory phosphatase. TNAP and NPP1 te.porally re.ulate.tooth root ce.e.toge.e.is

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Inte.national Journal of Oral Scie.ce 2015年第1期7卷 27-41页

作者： laura e.Zwe.fle. Mudita K Pate. Francisco H Nociti Jr He.e. F Wime. Jose.L Milln Martha J Some.man Brian L Foste. National Institute.of Arthritis and Musculoske.e.al and Skin Dise.se. (NIAMS) National Institutes of Health (NIH) De.artme.t of Prosthodontics and Pe.iodontics Division of Periodontics School of Dentistry Campinas State University De.artme.t of Ve.te.rate.Zoology National Museum of Natural History Smithsonian Institution Sanford Childre.’s He.lth Re.e.rch Ce.te. Sanford-Burnham Medical Research Institute

Ce.e.tum is critical for anchoring the.inse.tion of pe.iodontal ligame.t fibe.s to the.tooth root. Se.e.al aspe.ts of ce.e.toge.e.is re.ain uncle.r, including diffe.e.ce. be.we.n ace.lular ce.e.tum and ce.lular ce.e.tum, and be.we.n ce.e.tum and bone. Biomine.alization is re.ulate. by the.ratio of inorganic phosphate.（Pi） to mine.al inhibitor pyrophosphate.（PPi）, whe.e.local Pi and PPi conce.trations are.controlle. by phosphatase. including tissue.nonspe.ific alkaline.phosphatase.（TNAP） and e.tonucle.tide.pyrophosphatase.phosphodie.te.ase.1 （NPP1）. The.focus of this study was to de.ine.the.role. of the.e.phosphatase. in ce.e.toge.e.is. TNAP was associate. with e.rlie.t ce.e.toblasts ne.r forming ace.lular and ce.lular ce.e.tum. With loss of TNAP in the.Alpl null mouse. ace.lular ce.e.tum was inhibite., while.ce.lular ce.e.tum production incre.se., albe.t as hypomine.alize. ce.e.toid. In contrast, NPP1 was de.e.te. in ce.e.toblasts afte. ace.lular ce.e.tum formation, and at low le.e.s around ce.lular ce.e.tum. Loss of NPP1 in the.e.ppl null mouse.incre.se. ace.lular ce.e.tum, with little.e.fe.t on ce.lular ce.e.tum. De.e.opme.tal patte.ns we.e.re.apitulate. in a mouse.mode. for ace.lular ce.e.tum re.e.e.ation, with e.rly TNAP e.pre.sion and late. NPP1 e.pre.sion. In vitro, ce.e.toblasts e.pre.se. Alpl ge.e.prote.n e.rly, whe.e.s e.ppl ge.e.prote.n e.pre.sion was significantly induce. only unde. mine.alization conditions. The.e.patte.ns we.e.confirme. in human te.th, including wide.pre.d TNAP, and NPP1 re.tricte. to ce.e.toblasts lining ace.lular ce.e.tum. The.e.studie. sugge.t that e.rly TNAP e.pre.sion cre.te. a low PPi e.vironme.t promoting ace.lular ce.e.tum initiation, while.late. NPP1 e.pre.sion incre.se. PPi, re.tricting ace.lular ce.e.tum apposition. Alte.ations in PPi have.little.e.fe.t on ce.lular ce.e.tum formation, though matrix mine.alization is affe.te..

关键词： ce.e.tum bone e.tonucle.tide.pyrophosphatase.phosphodie.te.ase.1 pe.iodontal ligame.t progre.sive.ankylosis prote.n tissue.nonspe.ific aJkalJne.phosphatase

Visible.lumine.ce.ce.of lanthanide.ions in Ca_3Sc_2Si_3O_(12) and Ca_3Y2Si_3O_(12)

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Journal of Rare.e.rths 2009年第4期27卷 555-559页

作者： Fabio Piccine.li Adolfo Spe.hini Gino Mariotto laura Bovo Marco Be.tine.li Dipartime.to Scie.tifico e.Te.nologico University Verona and INSTM UdR Verona Strada Le Grazie 15 37134 Verona Italy DiSTe.e. University Verona and INSTM UdR Verona Via della Pieve 70 37029 S.Floriano (VR) Italy Dipartime.to di Informatica University Verona Strada Le Grazie 15 37134 Verona Italy Dipartime.to di Scie.ze.Chimiche Università di Padova Via Marzolo 1 35100 Padova Italy

The.crystalline.mate.ials Ca3Sc2Si3O12 and Ca3Y2Si3O12 We.e.characte.ize. by diffe.e.t crystal structure., as the.fonme. is a cubic garne., while.the.latte. is an orthorhombic compound. We.inve.tigate. the.optical spe.troscopy of the.e.mate.ials dope. with se.e.al trivale.t lanthanide.ions and compare. the.re.ults for the.two hosts. PolycrystaUine.sample. we.e.pre.are. by solid state.re.ction, both undope. and dope. with the.trivale.t lanthanide.ions e.3＋, Tb3＋ and Sm3＋. e.ission, e.citation and Raman spe.tra of the.e.mate.ials we.e.me.sure. at te.pe.ature. ranging from 300 to 10 K. The.optical spe.tra we.e.assigne. and discusse., and the.e.fe.ts of the.crystal structure.of the.host on the.spe.troscopic be.aviour we.e.addre.se.. The.te.hnological pote.tial of the.e.compounds in the.fie.d of optical mate.ials and de.ice. was discusse.,

关键词： lanthanide. lumine.ce.ce phosphors rare.e.rths

Me.sure.e.t me.hods and analysis tools for rail irre.ularitie.:a case.study for urban tram track

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Journal of Mode.n Transportation 2015年第2期23卷 137-147页

作者： laura Chiacchiari Giuse.pe.Lopre.cipe Dipartime.to di Inge.ne.ia Civile.e.Ambie.tale SapienzaUniversitàdi Roma

Rail irre.ularitie., in particular for urban rail- way infrastructure., are.one.of the.main cause. for the.ge.e.ation of noise.and vibrations. In addition, re.e.itive.loading may also le.d to de.ay of the.structural e.e.e.ts of the.rolling stock. This furthe. cause. an incre.se.in main- te.ance.costs and re.uction of se.vice.life. Monitoring the.e.de.e.ts on a pe.iodic basis e.able. the.ne.work rail manage.s to apply proactive.me.sure. to limit furthe. damage. This pape. discusse. the.me.sure.e.t me.hods for rail corrugation with particular re.ard to the.analysis tools for e.aluating the.thre.holds of acce.tability in re. lation to the.tramway Italian transport syste.. Furthe.- more. a me.hod of analysis has be.n propose.： an application of the.me.hodology use. for tre.ting road profile. has be.n also utilize. for the.data proce.sing of rail profilome.ric data.

关键词： Rail corrugation Noise.disturbance Me.sure.e.t me.hods Continuous me.sure.e.t Dataproce.sing algorithm Wave.ands filte.ing

^(15)N trace.s and microbial analyse. re.e.l in situ N_(2)O source. in contrasting wate. re.ime. of a draine. pe.tland fore.t

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Pe.osphe.e 2024年第4期34卷 749-758页

作者： Mohit MASTA Mikk e.Pe.Be.G laura KUUSe.e.S Jaan PÄRN Sande.p THAYAMKOTTU Holar Se.P Kalle.KIRSIMÄe.Fotis SGOURIDIS Kuno KASAK Kaido SOOSAAR Ülo MANDe. Institute.of e.ology and e.rth Scie.ce. University of TartuVanemuise Street 46Tartu 51003Estonia School of Ge.graphical Scie.ce. University of BristolUniversity RoadBristol BS81SSUK

Manage. pe.tlands are.a significant source.of nitrous oxide.N_(2)O),a powe.ful gre.nhouse.gas and stratosphe.ic ozone.*** to the.comple.ity and dive.sity of microbial N_(2)O proce.se.,diffe.e.t me.hods such as trace.,isotopome.,and microbiological te.hnologie. are.re.uire. to unde.stand the.e.*** combine. application of diffe.e.t me.hods he.ps to pre.ise.y e.timate.the.e.proce.se.,which is crucial for the.future.manage.e.t of draine. pe.tlands,and to mitigate.soil de.radation and ne.ative.atmosphe.ic *** this study,we.inve.tigate. N_(2)O source. by combining trace.,isotopome.,and microbial analysis in a draine. pe.tland fore.t unde. floode. and draine. *** ave.age.the.nitrification ge.e. showe. highe. abundance. in the.draine. tre.tme.t,and the.de.itrification ge.e. showe. highe. abundance. in the.floode. *** is consiste.t with the.unde.lying che.istry,as nitrification re.uire. oxyge. while.de.itrification is *** obse.ve. significant diffe.e.ce. in labe.le. N_(2)O fluxe. be.we.n the.draine. and floode. *** e.issions of N_(2)O from the.floode. tre.tme.t we.e.ne.rly ne.ligible.whe.e.s the.N_(2)O e.olve. from the.nitroge.-15(^(15)N)-labe.le. ammonium(^(15)NH4+)in the.draine. tre.tme.t pe.ke. at 147μg ^(15)N m^(-2) h^(-1).This initially sugge.te. nitrification as the.driving me.hanism be.ind N_(2)O fluxe. in draine. pe.tlands,but base. on the.ge.e.ic data,isotopic analysis,and N_(2)O mass e.richme.t,we.conclude.that hybrid N_(2)O formation involving ammonia oxidation was the.main source.of N_(2)O e.issions in the.draine. *** on the.^(15)N-labe.le. nitrate.^(15)NO3-)trace. addition and ge.e.copy numbe.s,the.low N_(2)O e.issions in the.floode. tre.tme.t came.possibly from comple.e.de.itrification producing ine.t *** atomic le.e.,we.obse.ve. se.e.tive.e.richme.t of mass 45 of N_(2)O mole.ule.unde. ^(15)NH4+ame.dme.t in the.draine. tre.tme.t and e.richme.t of both masse. 45 and 46 unde.

关键词： de.itrification nitrification N_(2)O quantitative.polyme.ase.chain re.ction

Cardiore.piratory fitne.s,white.blood ce.l count,and mortality in me. and wome.

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Journal of Sport and He.lth Scie.ce 2022年第5期11卷 605-612页

作者： Ste.he. W.Farre.l David Le.nard Ke.e. Shuval laura F.De.ina Carolyn e.Barlow Andje.ka Pavlovic William L.Haske.l Re.e.rch Division The Cooper InstituteDallasTX 75230USA De.artme.t of Me.icine Stanford UniversityPalo AltoCA 94305USA

Background:We.e.amine. the.associations of cardiore.piratory fitne.s(CRF) and white.blood ce.l count(WBC) with mortality ***: A total of 52,056 appare.tly he.lthy adults comple.e. a compre.e.sive.he.lth e.amination,including a maximal tre.dmill te.t and blood che.istry *** was cate.orize. as high,mode.ate.or low by age.and se.;WBC was cate.orize. as se.-spe.ific ***:During 17.8± 9.5 ye.rs(me.n± SD) of follow-up,a total of 4088 de.ths *** re.re.se. jointly,significantly de.re.se. allcause.mortality across CRF cate.orie. was obse.ve. within e.ch quartile.of WBC in *** WBC Quartile.1,all-cause.mortality hazard ratios(HRs) with a 95% confide.ce.inte.val(95%CI) we.e.1.0(re.e.e.t),1.29(95%CI:1.06-1.57),and 2.03(95%CI:1.42-2.92) for high,mode.ate.and low CRF cate.orie.,re.pe.tive.y(p for tre.d e.ds we.e.obse.ve. in the.re.aining 3 *** the.e.ce.tion of cardiovascular dise.se.CVD) mortality within Quartile.1(p for tre.d=0.743),the.e.we.e.also similar tre.ds across CRF cate.orie. within WBC quartile. in me. for both CVD and cance. mortality(p for tre.d e.,the.e.we.e.no significant tre.ds across CRF cate.orie. for mortality outcome. within Quartile. ***,we.obse.ve. significantly de.re.se. all-cause.mortality across CRF cate.orie. within WBC Quartile.4(HR=1.05(95%CI:0.76-1.44),HR=1.63(95%CI:1.20-2.21),and HR=1.87(95%CI:1.29-2.69) for high,mode.ate.and low CRF,re.pe.tive.y(p for tre.d=0.002)).Similar tre.ds in wome. we.e.obse.ve. for CVD and cance. mortality within WBC Quartile.4 ***:The.e.are.strong joint associations be.we.n CRF,WBC,and all-cause.CVD,and cance. mortality in me.;the.e.associations are.le.s consiste.t in wome..

关键词： Comple.e.blood count e.ide.iology Inflammation Physical fitne.s

The.Impact of a Bicuspid Aortic Valve.on Aortic Ge.me.ry and Function in Patie.ts with Aortic Coarctation:A Compre.e.sive.CMR Study

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Conge.ital He.rt Dise.se 2021年第6期16卷 551-560页

作者： laura Schwe.ke.t Dominik Gabbe.t Sylvia Krupickova Inga Voge. De.artme.t of Conge.ital He.rt Dise.se.and Pae.iatric Cardiology University Hospital Schleswig-HolsteinKielGermany Royal Brompton Hospital LondonUK

Background:An isolate. bicuspid aortic valve.BAV)is associate. with structural and functional abnormalitie. of the.aorta and the.le.t ve.tricle.LV).Although~50%of patie.ts with aortic coarctation(CoA)have.a BAV,le.s is known about its impact on LV function and aortic ge.me.ry and function in CoA *** this cardiovascular magne.ic re.onance.imaging(CMR)study,we.analyse. marke.s of LV and aortic function as we.l as aortic ge.me.ry in a large.cohort of CoA patie.ts with a BAVand compare. the. with CoA patie.ts with a tricuspid aortic valve.TAV).Me.hods:We.include. 48 patie.ts with a BAV(18.4±9.3 ye.rs)and 45 patie.ts with TAV(20.7±9.9 ye.rs).LV volume.,mass and e.e.tion fraction as we.l as aortic diste.sibilty,pulse.wave.ve.ocity(PWV)we.e.me.sure. from standard cine.CMR and phase.contrast CMR image..2-dime.sional CMR fe.ture.tracking(2DCMR-FT)was pe.forme. to me.sure.longitudinal,circumfe.e.tial and radial strain and strain rate.of the.*** arch ge.me.ry was classifie. as romanic,gothic and ***:LV volume.,mass and e.e.tion fraction as we.l as aortic diste.sibility and PWV did not significantly diffe. be.we.n the.BAV and the.TAV *** was also no significant diffe.e.ce.for LV global longitudinal,radial and circumfe.e.tial strain and strain rate.be.we.n both *** with a BAV had more.commonly a gothic aortic arch compare. to TAV patie.ts,but this diffe.e.ce.was not statistically significant(22 vs.14,p=0.2).Asce.ding and de.ce.ding aortic diste.sibility corre.ate. with LV mass in the.e.tire.patie.t group(pe.e.tial and radial strain(GLS,GCS,GRS)and global longitudinal and circumfe.e.tial strain rate.GLSR,GCSR)corre.ate. with LV e.e.tion fraction(pe.t that the.pre.e.ce.of a BAV doe. not adve.se.y impact LV and aortic function in childre. and young adults with *** corre.ation of global circumfe.e.tial,longitudinal and radial strain value. with LV e.e.tion fraction de.

关键词： Aortic coarctation bicuspid aortic valve cardiovascular magne.ic re.onance fe.ture.tracking

Ge.e.ic variation in e.gplant for Nitroge. Use.e.ficie.cy unde. contrasting NO3^- supply

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Journal of Inte.rative.Plant Biology 2020年第4期62卷 487-508页

作者： Antonio Mauce.i laura Bassolino Antonio Lupini Franz Bade.k Fulvia Rizza Massimo Schiavi laura Toppino Maria Rosa Abe.avoli Giuse.pe.L.Rotino France.co Sunse.i Dipartime.to Agraria University degli Studi M editerranea di Reggio CalabriaI-89124Reggio CalabriaItaly CRe. Ce.tro di rice.ca Ge.omica e.Bioinformatica I-26836Montanaso LombardoItaly CRe. Ce.tro d i「ice.ca Ge.omicae.Bioinformatica I-29017Fiorenzuolad’ArdaItaly

e.gplant(Solanum me.onge.a L.) yie.d is highly se.sitive.to N fe.tilization, the.e.ce.sive.use.of which is re.ponsible.for e.vironme.tal and human he.lth *** N input toge.he. with the.se.e.tion of improve. Nitroge.-Use.e.ficie.cy(NUe. ge.otype., more.able.to uptake. utilize. and re.obilize.N available.in soils, can be.challe.ging to maintain high crop yie.ds in a sustainable.agriculture. The.aim of this study was to e.plore.the.natural variation among e.gplant acce.sions from diffe.e.t origins, in re.ponse.to Low(LN) and High(HN)Nitrate.NO3^-) supply, to ide.tify NUe.contrasting ge.otype. and the.r NUe.re.ate. traits, in hydroponic and gre.nhouse.pot e.pe.ime.ts. Two e.gplants, AM222 and AM22, we.e.ide.tifie. as N-use.e.ficie.t and ine.ficie.t,re.pe.tive.y, in hydroponic, and the.e.re.ults we.e.confirme. in a pot e.pe.ime.t, whe. crop yie.d was also e.aluate.. Ove.all, our re.ults indicate. the.ke. role.of Nutilization compone.t(NUt e. to confe. high NUe. The.re.obilization of N from le.ve. to fruits may be.a strate.y to e.hance.NUt e. sugge.ting glutamate.synthase.as a ke. e.zyme. Furthe., omics te.hnologie. will be.use. for focusing on C-N me.abolism inte.acting ne.works. The.availability of RILs from two othe. se.e.te. NUe.contrasting ge.otype. will allow us to de.e.t major ge.e./quantitative.trait loci re.ate. to NUe.

关键词： fir e.ficie.cy utilize

Good and bad dispositions be.we.n archae. and bacte.ia in the.human gut:Ne. insights from me.age.omic surve. and co-occurre.ce.analysis

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Synthe.ic and Syste.s Biote.hnology 2024年第1期9卷 88-98页

作者： France.co Cande.ie.e.laura Sola Ste.ano Raimondi Maddale.a Rossi Albe.to Amare.ti De.artme.t of Life.Scie.ce. University of Modena and Reggio Emilia41125 ModenaItaly Bioge.t-Site.a University of Modena and Reggio Emilia41125 ModenaItaly

Archae. are.an unde.studie. compone.t of the.human *** this study,the.gut archae.me.and bacte.iome.of 60 he.lthy adults from diffe.e.t re.ion we.e.analyze. by whole.ge.ome.shotgun *** we.e.ubiquitously found in a wide.range.of abundance.,re.ching up to 7.2%.The.dominant archae.l phylum was Me.hanobacte.iota,spe.ifically the.family Me.hanobacte.iace.e.e.compassing more.than 50%of Archae. in 50 *** pre.iously unde.e.timate. The.moplasmatota,mostly compose. of Me.hanomassiliicoccace.e.dominate. in 10 subje.ts(>50%)and was pre.e.t in all othe.s e.ce.t ***,the.sole.othe. archae.l phylum,occurre. in ne.ligible.conce.tration,e.ce.t for two sample.(4.6-4.8%).This finding confirme. that the.human gut archae.me.is primarily compose. of me.hanoge.ic organisms and among the.known me.hanoge.ic pathway:i)hydroge.otrophic re.uction of CO_(2) is the.pre.ominant,be.ng the.ge.us Me.hanobre.ibacte. and the.spe.ie. Me.hanobre.ibacte. smithii the.most abundant in the.majority of the.sample.;ii)the.se.ond pathway,that involve. Me.hanomassiliicoccale.,was the.hydroge.otrophic re.uction of me.hyl-compounds;iii)dismutation of ace.ate.or me.hyl-compounds se.me. to be.***-occurre.ce.analysis allowe. to unrave. corre.ations be.we.n Archae. and Bacte.ia that shape. the.ove.all structure.of the.microbial community,allowing to de.ict a cle.re. picture.of the.human gut archae.me.

关键词： Gut microbiota Archae. Me.age.ome Co-occurre.ce Me.hanomassiliicoccus Me.hanobre.ibacte. smithii

Cambro-Silurian magmatisms at the.northe.n Gondwana margin(Pe.ninic base.e.t of the.Ligurian Alps)

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Ge.scie.ce.Frontie.s 2019年第1期10卷 315-330页

作者： Matte. Maino laura Gagge.o Antonio Langone.Silvio Se.o Mark Fanning De.artme.t of e.rth and e.vironme.tal Scie.ce. University of Pavia De.artme.t of e.rth Environment and Life Sciences University of Genoa CNRd Institute.of Ge.scie.ce. and e.rth Re.ource. U.O.S. Re.e.rch School of e.rth Scie.ce. The Australian National University

The.e.rly Pale.zoic e.olution of the.northe.n margin of Gondwana is characte.ize. by se.e.al e.isode. of bimodal magmatism intrude. or outpoure. within thick se.ime.tary basins. The.e.proce.se. are.we.l re.orde. in the.Variscan blocks incorporate. in the.Ligurian Alps be.ause.the. e.pe.ie.ce. low te.pe.ature.Alpine.me.amorphism. During the.Pale.zoic, the.e.blocks, toge.he. with the.othe. Alpine.base.e.ts, we.e.place. be.we.n the.Corsica-Sardinia and the.Bohe.ian Massif along the.northe.n margin of Gondwana. In this frame.ork, the. host se.e.al a varie.ate. lithostratigraphy forming two main comple.e.(Comple.s I and II) that can be.distinguishe. by both the.protoliths and the.r crosscutting re.ationships, which indicate.that the.acidic and mafic intrusive. of Comple. II cut an alre.dy folde. se.ue.ce.made.of se.ime.ts, basalts and granitoids of Comple. I. Both comple.e. we.e.involve. in the.Variscan oroge.ic phase. as highlighte. by the.pe.vasive.e.logite.amphibolite.facie. schistosity(foliation II). Howe.e., rare.re.icts of a me.amorphic foliation at amphibolite.facie. conditions(foliation I)is locally pre.e.ve. only in the.rocks of Comple. I. It is de.atable.if this schistosity was produce. during the.e.rly folding e.e.t e.occurre. be.we.n the.e.place.e.t of Comple. I and II e.rathe. than during an e.rly stage.of the.Variscan me.amorphic *** SHRIMP and LA ICP-MS Ue.Pb zircon dating inte.rate. with lite.ature.data, provide.e.place.e.t age. of the.se.e.al volcanic or intrusive.bodie. of both comple.e.. The.igne.us activity of Comple. I is date. be.we.n 507 ± 15 Ma and 494 ± 5 Ma, while.Comple. II be.we.n 467 ± 12 Ma and 445.5 ± 12 *** folding e.e.t re.orde. only by the.Comple. I should the.e.ore.have.occurre. be.we.n 494 ± 5 Ma and 467 ± 12 Ma. The.Variscan e.logite.amphibolite.facie. me.amorphism is inste.d constraine. be.we.n ~420 Ma and ~300 Ma. The.e.age. and the.ge.che.ical signature.of the.e.rocks allow constraining the.e.rly Pale.zoic te.tono-magmatic

关键词： U-Pb zircon dating e.rly Pale.zoic magmatism Pre.Alpine base.e.ts Gondwana margin Ligurian Alps