Good and bad dispositions between archaea and bacteria in the human gut:New insights from metagenomic survey and co-occurrence analysis
作者机构：Department of Life SciencesUniversity of Modena and Reggio Emilia41125 ModenaItaly Biogest-SiteiaUniversity of Modena and Reggio Emilia41125 ModenaItaly
出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)
年 卷 期：2024年第9卷第1期
页 面：88-98页
核心收录：
学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 071005[理学-微生物学] 10[医学]
基 金：partially funded by PIANO NAZIONALE DI RIPRESA E RESILIENZA(PNRR)-MISSIONE 4 COMPONENTE 2 “Dalla ricerca all’impresa”INVESTIMENTO 1.3 Creazione di“Partenariati estesi alle universita ai centri di ricerca alle aziende per il finanziamento di progetti di ricerca di base” finanziato dall’Unione europea-NextGenerationEU”-Progetto identificato con codice PE00000019 Titolo“HEAL ITALIA”-Spoke 5-CUP E93C22001860006 Avviso MUR DD.341 del 15.03.2022
主 题：Gut microbiota Archaea Metagenome Co-occurrence Methanomassiliicoccus Methanobrevibacter smithii
摘 要：Archaea are an understudied component of the human *** this study,the gut archaeome and bacteriome of 60 healthy adults from different region were analyzed by whole-genome shotgun *** were ubiquitously found in a wide range of abundances,reaching up to 7.2%.The dominant archaeal phylum was Methanobacteriota,specifically the family Methanobacteriaceae,encompassing more than 50%of Archaea in 50 *** previously underestimated Thermoplasmatota,mostly composed of Methanomassiliicoccaceae,dominated in 10 subjects(50%)and was present in all others except ***,the sole other archaeal phylum,occurred in negligible concentration,except for two samples(4.6-4.8%).This finding confirmed that the human gut archaeome is primarily composed of methanogenic organisms and among the known methanogenic pathway:i)hydrogenotrophic reduction of CO_(2) is the predominant,being the genus Methanobrevibacter and the species Methanobrevibacter smithii the most abundant in the majority of the samples;ii)the second pathway,that involved Methanomassiliicoccales,was the hydrogenotrophic reduction of methyl-compounds;iii)dismutation of acetate or methyl-compounds seemed to be ***-occurrence analysis allowed to unravel correlations between Archaea and Bacteria that shapes the overall structure of the microbial community,allowing to depict a clearer picture of the human gut archaeome.
维普期刊数据库