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Neural Regeneration Research 2024年第9期19卷 1861-1862页

作者： Robert Galinsky laura Bennet Alistair J.Gunn The Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Department of Obstetrics and Gynaecology Monash UniversityMelbourneVICAustralia Department of Physiology The University of AucklandAucklandNew Zealand

Mitigating preterm encephalopathy continues to be one of the greatest challenges in perinatal *** encephalopathy is associated with high mortality,serious morbidity,and significant socio-economic impacts on the individuals,their families,and public health sectors and welfare systems that last a *** cost of disability associated with preterm brain injury continues to *** of this injury,and disability,would significantly reduce this socioeconomic burden.

关键词： encephalopathy mortality hypoxic

DNA-directed assembly of copper nanoblocks with inbuilt fluorescent and electrochemical properties： Application in simultaneous amplification-free analysis of multiple RNA species

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Nano Research 2018年第2期11卷 940-952页

作者： Kevin M. Koo laura G. Carrascosa Matt Trau Centre for Personalized Nanomedicine Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensland Brisbane Australia School of Chemistry and Molecular Biosciences The University of Queensland Brisbane Australia

The intrinsic affinity of DNA molecules toward metallic ions can drive the specific formation of copper nanostructures within the nucleic acid helix structure in a sequence-dependent manner. The resultant nanostructures have interesting fluorescent and electrochemical properties, which are attractive for novel biosensing applications. However, the potential of using DNA-templated nano- structures for precision disease diagnosis remains unexplored. Particularly, DNA- templated nanostructures show high potential for the universal amplification-free detection of different RNA biomarker species. Because of their low cellular levels and differing species-dependent length and sequence features, simultaneous detection of different messenger RNAs, microRNAs, and long non-coding RNAs species with a single technique is challenging. Here, we report a contemporary technique for facile in situ assembly of DNA-templated copper nanoblocks （CuNBs） on various RNA species targets after hybridization-based magnetic isolation. Our approach circumvents the typical limitations associated with amplification and labeling procedures of current RNA assays. The synthesized CuNBs enabled amplification-free fM-level RNA detection with flexible fluorescence or electrochemical readouts. Furthermore, our nanosensing technique displays potential for clinical application, as demonstrated by non-invasive analysis of three diagnostic RNA biomarkers from a cohort of 10 prostate cancer patient urinary samples with 100%-concordance （quantitative reverse transcription- polymerase chain reaction （PCR） validation）. The good analytical performance and versatility of our method may be useful in both diagnostics and research fields.

关键词： prostate cancer RNA detection DNA-templated coppernanostTuctures amplification-free fluorescence detection electrochemical detection

Mature versus emerging technologies for CO2 capture in power plants： Key open issues in post-combustion amine scrubbing and in chemical looping combustion

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Frontiers of Chemical Science and Engineering 2018年第2期12卷 315-325页

作者： Giorgia De Guido Matteo Compagnoni laura A. Pellegrini Ilenia Rossetti Department of Chemistry Materials and Chemical Engineering "Giulio Natta" Politecnico di Milano Piazza Leonardo da Vinci 32 20133 MilanItaly Department of Chemistry Universita degli Studi di Milano INSTM Unit Milano-Universita and CNR-ISTM Via Camillo Golgi 19 20133 Milan Italy

Carbon capture and storage （CCS） have acquired an increasing importance in the debate on global wanning as a mean to decrease the environmental impact of energy conversion technologies, by capturing the CO2 produced from the use of fossil fuels in electricity generation and industrial processes. In this respect, post-combustion systems have received great attention as a possible near-term CO2 capture technology that can be retrofitted to existing power plants. This capture technology is, however, energy-intensive and results in large equipment sizes because of the large volumes of the flue gas to be treated. To cope with the demerits of other CCS technologies, the chemical looping combustion （CLC） process has been recently considered as a solution for CO2 separation. It is typically referred to as a technology without energy penalty. Indeed, in CLC the fuel and the combustion air are never mixed and the gases from the oxidation of the fuel （i.e., CO2 and H2O） leave the system as a separate stream and can be separated by condensation of H2O without any loss of energy. The key issue for the CLC process is to find a suitable oxygen carrier, which provides the fuel with the activated oxygen needed for combustion. The aim of this work is to explore the feasibility of using perovskites as oxygen carriers in CLC and to consider the possible advantages with respect to the scrubbing process with amines, a mature post-combustion technology for CO2 separation.

关键词： CO2 capture monoethanolamine chemical looping combustion oxygen carder perovskites

Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury

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Neural Regeneration Research 2023年第6期18卷 1257-1258页

作者： Alexandra Chovsepian laura Empl Florence M.Bareyre Institute of Clinical Neuroimmunology Biomedical Building and Clinic of the Ludwig-Maximilians Universität MünchenMunichGermany

Traumatic brain injury(TBI) represents a significant cause of disability *** creates a vast array of damaging macro-and microscopic changes in the affected brain area(s),ranging from neuronal cell death,changes in structural spine integrity and dynamics to axonal injury and ove rall neuronal circuit disruption,ultimately leading to functional and cognitive deficits in both humans and animal models(N udo,2013).

关键词： injury traumatic cortex

Interaction of silver nanoparticles with mediterranean agricultural soils: Lab-controlled adsorption and desorption studies

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Journal of Environmental Sciences 2019年第9期31卷 205-216页

作者： laura Torrent Eva Margui Ignasi Queralt Manuela Hidalgo Monica Iglesias Department of Chemistry University of Girona C/M. Aurelia Capmany 69 17003 Girona Spain Institute of Environmental Assessment and Water Research (IDAEA-CSIC) C. Jordi Girona 28-26 08034 Barcelona Spain

The production of silver nanoparticles(AgNPs) has increased tremendously during recent years due to their antibacterial and physicochemical properties. As a consequence, these particles are released inevitably into the environment, with soil being the main sink of disposal. Soil interactions have an effect on AgNP mobility, transport and bioavailability. To understand AgNP adsorption processes, lab-controlled kinetic studies were *** tests performed with five different Mediterranean agricultural soils showed that cation exchange capacity and electrical conductivity are the main parameters controlling the adsorption processes. The adsorption kinetics of different sized(40, 75, 100 and 200 nm)and coated(citrate, polyvinylpyrrolidone and polyethyleneglycol(PEG)) AgNPs indicated that these nanoparticle properties have also an effect on the adsorption *** assess the mobility and bioavailability of AgNPs and to determine if their form is maintained during adsorption/desorption processes, loaded soils were submitted to leaching tests three weeks after batch adsorption studies. The DIN 38414-S4 extraction method indicated that AgNPs were strongly retained on soils, and single-particle inductively coupled plasma mass spectrometry confirmed that silver particles maintained their nanoform, except for 100 nm PEG-AgNPs and 40 nm citrate-coated AgNPs. The DTPA(diethylenetriaminepentaacetic acid) leaching test was more effective in extracting silver,but there was no presence of AgNPs in almost all of these leachates.

关键词： Silver nanoparticles Agricultural soils Sorption kinetics Leaching tests Single-particle inductively coupled plasma mass spectrometry

Molecular dynamics of pre-germinative metabolism in primed eggplant(Solanum melongena L.)seeds

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Horticulture Research 2020年第1期7卷 1599-1610页

作者： Chiara Forti Valentino Ottobrino laura Bassolino laura Toppino Giuseppe Leonardo Rotino Andrea Pagano Anca Macovei Alma Balestrazzi Department of Biology and Biotechnology‘Lazzaro Spallanzani’ University of PaviaPaviaItaly CREA-Research Centre for Genomics and Bioinformatics Montanaso LombardoLOItaly CREA-Research Centre for Cereal and Industrial Crops BolognaItaly Institute of Plant Genetics Polish Academy of SciencesPoznanPoland

Seed priming,a pre-sowing technique that enhances the antioxidant/DNA repair activities during the pre-germinative metabolism,still retains empirical *** explore for the first time the molecular dynamics of pre-germinative metabolism in primed eggplant(Solanum melongena L.)seeds in order to identify hallmarks(expression patterns of antioxidant/DNA repair genes combined with free radical profiles)useful to discriminate between high-and lowquality *** hydropriming protocol hereby developed anticipated(or even rescued)germination,when applied to lots with variable ***(reactive oxygen species)raised during hydropriming and dropped after *** of antioxidant/DNA repair genes was observed during hydropriming and the subsequent *** of SmOGG1(8-oxoguanine glycosylase/lyase)gene detected in primed seeds at 2 h of imbibition appeared as a promising *** the basis of these results,the investigation was restricted within the first 2 h of imbibition,to verify whether the molecular landscape was reproducible in different lots.A complex pattern of antioxidant/DNA repair gene expression emerged,reflecting the preponderance of seed lot-specific *** the low-quality eggplant seeds subjected to hydropriming showed enhanced ROS levels,both in the dry and imbibed state,and this might be a useful signature to discriminate among *** plasticity of eggplant pre-germinative metabolism stimulated by priming imposes a plethora of heterogeneous molecular responses that might delay the search for quality ***,the information hereby gained could be translated to eggplant wild relatives to speed-up their use in breeding programs or other agronomical applications.

关键词： metabolism dynamics gained

Conversion of CO_(2)to added value products via rWGS using Fe-promoted catalysts:Carbide,metallic Fe or a mixture?

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Journal of Energy Chemistry 2022年第3期31卷 635-646,I0017页

作者： Q iZhang laura Pastor-Pérez Qiang Wang Tomas Ramirez Reina Department of Chemical and Process Engineering University of SurreyGuildford GU27XHUnited Kingdom College of Environmental Science and Engineering Beijing Forestry UniversityBeijing 100083China

Fe-based catalysts are efficient systems for CO_(2)conversion via reverse water-gas shift(rWGS)***,the nature of the active phase,namely metallic iron,iron oxide or iron carbide remains a subject of debate which our paper is meant to ***0 is a much better catalyst for the rWGS than Fe_(3)*** activity of Fe0 can be promoted by the addition of Cs and Cu whose presence hinders iron carburisation while favouring both higher conversion and enhanced *** the samples are aged in the rWGS reaction mixture during stability test a new phase appear:Fe_(5)C_(2),resulting in a more active but less selective catalysts than Fe0 for the rWGS *** our results indicate that we could potentially achieve an optimal activity/selective balance upon finely tuning the proportion Fe/Fe_(5)C_(2).Beyond the fundamental information concerning active phase we have observed the presence of advanced Fischer-Tropsch-like products at ambient pressure opening new opportunities for the design of hybrid rWGS/Fischer-Tropsch systems.

关键词： CO_(2)conversion rWGS Fe carbide Fe catalysts Hybrid catalysts

How to optimize the treatment of early stage Parkinson’s disease

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Translational Neurodegeneration 2015年第1期4卷 26-32页

作者： Fabrizio Stocchi laura Vacca Fabiana G Radicati Department of Neurology Institute for Research and Medical CareIRCCS San Raffaelevia della Pisana 23500163 RomeItaly

The approach to early Parkinson’s disease denotes the communication of the diagnosis and important decisions,such as when and how to start *** based medicine and guidelines indicate which drugs have robust evidence of efficacy and tolerability in this specific ***,de-novo patients may show different characteristics and they may be in a different phase of their *** this review,we will give an insight into the appropriate time therapy should be started and the actual knowledge about disease modification ***,the drugs indicated for early treatment will be considered and an indication for the use of these drugs will be given with the support of the actual knowledge.

关键词： drugs diagnosis treatment

Diet and microbiome in the beginning of the sequence of gut inflammation

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World Journal of Clinical Cases 2021年第36期9卷 11122-11147页

作者： Daniel Ceballos A Hernández-Camba laura Ramos Department of Gastroenterology Hospital Universitario de Gran Canaria Doctor NegrinLas Palmas 35019CanariasSpain Department of Gastroenterology Hospital Universitario Nuestra Señora de La CandelariaSanta Cruz de Tenerife 38010CanariasSpain Department of Gastroenterology Hospital Universitario de CanariasSan Cristóbal de La Laguna 38320CanariasSpain

Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract due,at least partially,to an aberrant and excessive mucosal immune response to gut bacteria in genetically-predisposed individuals under certain environmental *** incidence of IBD is rising in western and newly industrialized countries,paralleling the increase of westernized dietary patterns,through new antigens,epithelial function and permeability,epigenetic mechanisms(e.g.,DNA methylation),and alteration of the gut *** in the composition and functionality of the gut microbiome(including bacteria,viruses and fungi)seems to be a nuclear pathogenic *** microbiome itself is dynamic,and the changes in food quality,dietary habits,living conditions and hygiene of these western societies,could interact in a complex manner as modulators of dysbiosis,thereby influencing the activation of immune cells’promoting *** microbiome produces diverse small molecules via several metabolic ways,with the fiber-derived short-chain fatty acids(i.e.,butyrate)as main elements and having anti-inflammatory *** metabolites and some micronutrients of the diet(i.e.,vitamins,folic acid,beta carotene and trace elements)are regulators of innate and adaptive intestinal immune *** excessive and unhealthy consumption of sugar,animal fat and a low-vegetable and-fiber diet are risk factors for IBD ***,metabolism of nutrients in intestinal epithelium and in gut microbiota is altered by inflammation,changing the demand for nutrients needed for *** role of food and a reduced gut microbial diversity in causing IBD might also have a prophylactic or therapeutic role for *** relationship between dietary intake,symptoms,and bowel inflammation could lead to dietary and lifestyle recommendations,including diets with abundant fruits,vegetables,olive oil and oily fish,which have anti-inflammatory effects and could pre

关键词： Diet Microbiome Inflammatory bowel disease Pathogenia

Acute pancreatitis:The stress factor

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World Journal of Gastroenterology 2014年第19期20卷 5801-5807页

作者： Marcelo G Binker laura I Cosen-Binker CBRHC Research Center 1053 Ciudad Autónoma de Buenos AiresBuenos Aires 1426Argentina Department of Molecular and Cell Biology Henry M Goldman School of Dental MedicineBoston UniversityBostonMA 02118United States

Acute pancreatitis is an inflammatory disorder of the pancreas that may cause life-threatening *** of pancreatitis vary,with gallstones accounting for the majority of all cases,followed by *** causes of pancreatitis include trauma,ischemia,mechanical obstruction,infections,autoimmune,hereditary,and *** main events occurring in the pancreatic acinar cell that initiate and propagate acute pancreatitis include inhibition of secretion,intracellular activation of proteases,and generation of inflammatory *** cytokines known as chemokines are released from damaged pancreatic cells and attract inflammatory cells,whose systemic action ultimately determined the severity of the ***,severe forms of pancreatitis may result in systemic inflammatory response syndrome and multiorgan dysfunction syndrome,characterized by a progressive physiologic failure of several interdependent organ *** occurs when homeostasis is threatened,and stressors can include physical or mental forces,or combinations of *** on the timing and duration,stress can result in beneficial or harmful *** it is well established that a previous acute-short-term stress decreases the severity of experimentally-induced pancreatitis,the worsening effects of chronic stress on the exocrine pancreas have received relatively little *** review will focus on the influence of both prior acute-short-term and chronic stress in acute pancreatitis.

关键词： Pancreatitis Acute stress Chronic stress Heat shock proteins Tumor necrosis factor alpha