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腹股沟假瘤:天疱疮15年缓解后复发

世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 52-53页

作者： esteve e. Kerdraon R. Martin L. 田中伟 Service de Dermatologie H.opi tal Porte Madeleine BP 2439 45032 Orl'Cedex France

Introduction. Pemphigus vegetans (PV) is a rare type of pemphigus vulgaris. We report a patient with pemphigus vulgaris relapsing as an isolated vegetative tu mour. Case report. A 59year-old man was seen in February 2001 for a tumour on t he right groin. He had received systemic corticosteroids and cyclophosphamide fo r pemphigus vulgaris from 1974 to 1985, and he had been in complete remission si nce 1985. At the time of evaluation,a10 ×5 ×5cm,smooth vegetative tumour was s een on the right groin. Biopsies showed spongiosis, acanthosis and some acanthol ysis. Direct immunofluorescence showed strong deposition of immunoglobulin C wit hin the intercellular substance of the epidermis. Indirect immunofluorescence re vealed anti-intercellular antibodies at a titer of 1/800. Immunoblot analysis s howed reactivity with the 130 kD pemphigus vulgaris antigen. PVg was diagnosed. Local corticosteroid treatment was initiated. The patient was disease-free at f ollow-up three years later. Discussion. Localised forms of pemphigus are very r are. Twenty four other cases have been reported among them just one case of loca lised PV. Our case report is very unusual because of the variability of the expr ession of the disease, the high antibody level, the absence of trigger factors, and the efficacy of the local corticosteroid treatment.

关键词：假瘤棘层松解棘细胞层右侧腹股沟直接免疫荧光间接免疫荧光增殖型糖皮质激素表皮细胞增殖性

非ST段抬高型急性冠状动脉综合征患者中促炎细胞因子与抗炎细胞因子比值和长期预后的关系

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 39-40页

作者： Kilic T. Ural D. Ural e. 徐永城 Cardiology Department Kocaeli University Medical Faculty Cumhuriyet Mah Blok Kat: 1 Daire 4 Izmit/Kocaeli Kocaeli 41100 Turkey Dr.

Objective: To investigate the relation between serum high sensitivity(hs) C reactive protein(CRP), proinflammatory cytokine concentrations, proinflammatory to anti-inflammatory cytokine ratios and long-term prognosis in patients with non-ST elevation acute coronary syndrome(NSTeACS). Design: Prospective follow-up study for the first six months and then for the first year after admission to hospital. Setting: Tertiary referral centre. Patients: 80 patients(60 men, 20 women, mean age 60(SD 10) years) with NSTeACS and moderate to high TIMI(Thrombolysis In Myocardial Infarction) risk scores. Interventions: Blood samples from patients with NSTeACS were obtained at the time of admission. Serum concentrations of hs-CRP,(hs)-pro-inflammatory(interleukin(IL)-1β, IL-6, tumour necrosis factor α) and(hs) anti-inflammatory(IL-10) cytokines were analysed and proinflammatory to anti-inflammatory cytokine ratios were calculated by dividing proinflammatory cytokine concentrations by anti-inflammatory cytokine IL-10. Main outcome measure: The primary end point of the study was new coronary events(nce) defined as the combination of cardiac death, non-fatal myocardial infarction and recurrent rest angina that required hospitalisation within 12 months of follow up. Results: During the one-year follow-up period, 23 patients(29%) met the nce criteria. Concentrations of hs-CRP, IL-1βand IL-6 and ratios of IL-1β∶IL-10 and IL-6 ∶IL-10 were significantly higher in patients with nce than in patients without nce. In the logistic regression analysis, IL-6 ∶IL-10 ratio was the most important predictor for nce(p=0.006) with an odds ratio of 2.24(95%CI 1.26 to 3.97). Conclusions: Cytokine concentrations and proinflammatory to anti-inflammatory cytokine ratios may be useful markers for predicting vascular risk in patients with NSTeACS.

关键词：急性冠状动脉综合征长期预后炎细胞抗炎细胞因子患者 ST

一种GPS差分计算机故障检测仪的设计及实现

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计算机工程与应用 2003年第2期39卷 142-143,162页

作者：宋煜炜张继伟北京理工大学自动控制系北京100081

论文探讨了一种GPS差分计算机故障检测仪的设计及实现。该系统采用嵌入式计算机PC/104及其外围扩展芯片实现了对GPS差分计算机通信接口及GPS接收机的检测,并引入了故障诊断专家系统的设计。

关键词： GPS 差分计算机故障检测仪设计专家系统知识库推理机制人工智能

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从盐池县谈农牧交错地带草场资源的管护问题

干旱地区农业研究 1985年第4期 64-70页

作者：陈一鹗中国科学院西北植物研究所

在我国半干旱的草原分布区内,从东北到西南有一条过渡特征明显的农牧交错地带,地辖81个县(旗、市),面积约26.7万平方公里。这个地带作为为半农半牧的一种类型,它在历史、社会、经济和资源等方面具有自己特有的既不同于农区,又有别于牧... 详细信息

在我国半干旱的草原分布区内,从东北到西南有一条过渡特征明显的农牧交错地带,地辖81个县(旗、市),面积约26.7万平方公里。这个地带作为为半农半牧的一种类型,它在历史、社会、经济和资源等方面具有自己特有的既不同于农区,又有别于牧区的特点。长期以来由于经营方针多变,技术管理落后,加上人口压力的增加和自然灾害频繁,使得那里的土地和植被资源遭到了严重的破坏;土地的沙化、碱化或贫瘠化和草场的退化十分突出。从生态学观点来看,这一地区的农业生态系统受自然条件的限制,在人为不恰当经济活动的干扰下,似乎更为脆弱和更不稳定。很多地方由于生态平

关键词：盐池县农牧交错地带草场面积草场资源草地资源草原资源饲养业

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对结肠直肠癌高危患者的筛查行为

世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 20-21页

作者： Bleiker e.M.A Menko F.H Taal B.G 樊菁 Div. Psychosoci al Res. epidemiol. Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amste rdamNetherlands.Dr

Background &Aims: Periodic colonoscopy is an effective means of reducing the incidence and mortality of colorectal cancer in individuals with a family histor y of the disease. The aims of this study were to determine the degree of complia nce and to identify the factors related significantly to noncompliance with peri odic screening in this high-risk population. Methods:A total of 178 individuals who had undergone genetic couns eling for colorectal cancer between 1986 and 1998 and who had been advised to un dergo periodic screening because of familial colorectal cancer (FCRC) or heredit ary nonpolyposis colorectal cancer (HNPCC) were invited to complete a self-repo rt questionnaire on psychosocial issues and screening *** dat a were derived from medical records and via self-report. Results: A total of 14 9 individuals (84%) participated in the study. Noncompliance with screening adv icewas rare (in 3%of cases), but significant delays (more than 1 year) in under going screening were observed in approximately 25%of the cases. The number of p erceived barriers to screening (eg, discomfort, embarrassment) was the only vari able related significantly to noncompliance/screening delay (odds ratio, 1.2;95 %confidence interval, 1.1-1.3). Use of sedatives during the procedure and rece ipt of a reminder letter seemed to facilitate better compliance. Conclusions: Al though few high-risk individualsabstain from screening entirely, approximately one in 4 deviates significantly from the recommended frequency of screening. Inc reased compliance may be achieved by reducing the discomfort and embarrassment a ssociated with the procedure and by the use of reminder letters.

关键词：结肠直肠癌依从性结肠镜检认知障碍高危人群族性社会心理问题问卷表本项自我报告

1983—1999年洛林地区儿童癌症的发病率及存活率记录

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世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 18-19页

作者： Lacour B. Desandes e. Mallol N. Sommelet D. 朱新菊 Registre Lorrain des Cancers de l'enfant CHU Vandoeuvre-lè s-Nancy France

Background. - Cancer in childhood account for less than 1% of all cancers and for the second most important cause of death for children aged less than 15 years in France, injuries being the leading cause. Compared to adult cancers, childhood cancers’ particularities justify to create pediatric registries. The first French population-based registry was created in Lorraine in 1983. The incidence and survival results from a 17 year-period are presented. Methods. - In Lorraine region, all children (0- 14 years) with cancer diagnosed between 1983 and 1999 were included. Crude, age-standardized (world population) and cumulative incidence rates were calculated just as overall, specific- disease and event-free survival rates, using Kaplan-Meier methods. Results. - With 1086 registered cases, the crude incidence rate per million children is 132.4, the age-standardized incidence rate per million is 137.5; 1 out of every 500 children will develop cancer before the age of 15 years. The incidence of all cancers combined is slightly higher in males than in females with a M/F ratio of 1.13. For this 17 years-period, no trend in childhood cancer incidence is observed. The main cancer groups are leukemia (30.7% ), brain and spinal tumors (23.2% )- and lymphomas (12.9% ), sympathetic nervous system tumors (7.4% ), soft-tissue sarcomas (6.1% ), renal tumors (5.2% ), and bone tumors (5.0% ). Five-year specific survival rates for all cancers combined is 71.4% [95% CI: 68.5- 74.3]. The prognosis is significatively worse for theear age group (55% ) and for some histologic types: brain stem gliomas (27% ), hepatic tumors (43% ), osteosarcomas (57% ), neuroblastomas (65% ), rhabdomyosarcomas (55% ). Discussion. - Relative distribution of histologic groups, incidence and survival rates observed in Lorraine registry are compatible with the general pattern in the european Union cancer registries. The lack of significative trend in incidence unlike others country may be explained by too sm

关键词：儿童癌症洛林儿童期癌症肿瘤类型累积发病率神经母细胞瘤肿瘤组织学儿童实体肿瘤肾肿瘤软

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信息论与体育理论课教学的探析

新乡师范高等专科学校学报 2000年第4期14卷 76-78页

作者：赵静生河南城建高等专科学校体育教学部，平顶山467001

在文献研究的基础上，阐述了信息论与体育理论课的关系；体育理论课在学校体育教学中的作用及重要性。根据信息论的原理分析了体育理论课应遵循的规律，以及体育教师在实践中运用这一规律，掌握解决问题的方法，旨在提高体育教学质量。

关键词：信息信息论学校体育体育理论课教学教学信息传递

通过单一压力和多普勒血量测定得出肺动脉高压儿童的肺血管顺应性、肺血管阻力及右心室的工作状态:一种在体外和临床研究中评价反应性的新方法

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 39-40页

作者： Weinberg C. e. Hertzberg J. R. Ivy D. D. R. Shandas 腾增辉 Cardiovasc. Flow Research Laboratory Children's Hospital UC Health Sciences Center 1056 E 19th Ave Denver CO 80218 United States Dr.

Background-Current evaluation of pulmonary hypertension (PH) in children invo lves measurement of pulmonary vascular resistance(PVR); however, PVR neglects im portant pulsatile components. Pulmonary artery(PA) input impedance and ventricul ar power(VP) includemean and pulsatile effects and have shown promise as alterna tive measures of vascular function. Here we report the utility of pulsed-wave(P W) Dopplermeasured instantaneous flow and pressure measurements for estimation o f input impedance and VP and use this method to develop a novel parameter: react ivity in complia nce. Methods and Results-An in vitro model of the general pulmonary vasculature was used to obtain impedance and VP, measured by PW Doppler and a reference flo wmeter. Themethodwas then tested in a preliminary clinical study in subjects wit h normal PA hemodynamics(n=4) and patients with PH undergoing reactivity evaluat ion(8 patients; 23 data points). In vitro results showed good agreement between the impedance spectra computed from both flow-measurement methods. excellent co rrelation was seen in vitro between actual resistance and the zero-frequency(Z0 ) impedance value(r2=0.984). excellent agreement was also found between Z 0 and PVR in the clinical measurements(j=1.075x+0.73; r=0.993). Furthermore, total VP and VP/cardiac output increased significantly with hypertension(128.73 to 365.9 1 mW and 2.42 to 6.69 mW·mL-1·s-1, respectively). The first-harmonic value of impedance(Z1) was used as a measure of compliance reactivity; older patients exhibited markedly less compliance reactivity than did younger patients. Conclus ions-Input impedance and VP calculated from Doppler measurements and a single- catheter pressure measurement provide comprehensive characterization of PH and r eactivity.

关键词：肺动脉高压肺血管阻力血管顺应性右心室多普勒测量血管功能临床前期工作状态血流动力学肺动脉血管

石菖蒲超临界萃取物对抑郁模型大鼠行为学的影响

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医学综述 2019年第10期25卷 2064-2068页

作者：王小萌吴全娥石鑫韩云鹏黑龙江中医药大学基础医学院哈尔滨150036 河北中医学院基础医学院石家庄050200 河北中医学院国医堂石家庄050200

目的探讨石菖蒲超临界萃取物对抑郁模型大鼠行为学的影响。方法 80只造模成功大鼠根据实验处理方法不同分为模型组、低剂量组、中剂量组和高剂量组,每组20只,分别按0.05g/100g、0.10g/100g和0.15g/100g的剂量对抑郁型大鼠进行药液灌胃... 详细信息

目的探讨石菖蒲超临界萃取物对抑郁模型大鼠行为学的影响。方法 80只造模成功大鼠根据实验处理方法不同分为模型组、低剂量组、中剂量组和高剂量组,每组20只,分别按0.05g/100g、0.10g/100g和0.15g/100g的剂量对抑郁型大鼠进行药液灌胃治疗,以20只正常大鼠为空白组,对各组糖水偏爱度、强迫游泳不动时间和旷场运动得分进行观察和评分。结果实验第1天,模型组和低、中、高剂量组大鼠糖水偏爱度显著低于空白组[(55.1±3.6)%、(54.7±2.5)%、(55.8±3.4)%、(54.9±2.8)%比(80.1±2.6)%](P<0.05),在实验第28天,低、中、高剂量组抑郁大鼠糖水偏爱度高于模型组[(62.0±4.5)%、(72.5±4.9)%、(77.8±3.8)%比(54.8±3.2)%](P<0.05),中剂量组高于低剂量组(P<0.05)。实验第28天,低、中、高剂量组游泳不动时间少于模型组[(112.0±5.4)s、(91.8±3.6)s、(78.4±4.9)s比(142.2±4.8)s](P<0.05),且低、中、高剂量组逐渐降低;低、中、高剂量组水平和垂直得分均高于模型组(P<0.05)。结论石菖蒲超临界萃取物可以有效改善抑郁型大鼠的行为学的病征。

关键词：石菖蒲超临界萃取抑郁大鼠行为学