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Non-pancreatic hyperlipasemia:A puzzling clinical entity

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World Journal of Gastroenterology 2024年第19期30卷 2538-2552页

作者： Krisztina Eszter Feher David Tornai Zsuzsanna Vitalis laszlo Davida Nora Sipeki Maria Papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hajdu-BiharHungary Kalman Laki Doctoral School of Biomedical and Clinical Sciences Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary

BACKGROUND Increased lipase level is a serological hallmark of the diagnosis of acute pancreatitis(AP)but can be detected in various other diseases associated with lipase leakage due to inflammation of organs surrounding the pancreas or reduced renal clearance and/or hepatic *** non-pancreatic hyperlipasemia(NPHL)is puzzling for attending physicians during the diagnostic procedure for *** would be clinically beneficial to identify the clinical and laboratory variables that hinder the accuracy of lipase diagnosis with the aim of improve it.A more precise description of the NPHL condition could potentially provide prognostic factors for adverse outcomes which is currently *** To perform a detailed clinical and laboratory characterization of NPHL in a large prospective patient cohort with an assessment of parameters determining disease *** A Hungarian patient cohort with serum lipase levels at least three times higher than the upper limit of normal(ULN)was prospectively evaluated over 31 *** were identified using daily electronic laboratory reports developed to support an ongoing observational,multicenter,prospective cohort study called the EASY trial(ISRCTN10525246)to establish a simple,easy,and accurate clinical scoring system for early prognostication of *** of NPHL was established based on≥3×ULN serum lipase level in the absence of abdominal pain or abdominal imaging results characteristic of *** A total of 808 patients[male,n=420(52%);median age(IQR):65(51-75)years]were diagnosed with≥3×ULN serum lipase levels.A total of 392 patients had AP,whereas 401 had NPHL with more than 20 different *** and acute kidney injury(AKI)were the most prevalent etiologies of NPHL(27.7%and 33.2%,respectively).The best discriminative cut-off value for lipase was≥666 U/L(sensitivity,71.4%;specificity,88.8%).The presence of AKI or sepsis negatively affected the diagnostic performance of *** w

关键词： Non-pancreatic hyperlipasemia Acute pancreatitis Glycoprotein 2 Acute kidney injury Sepsis Mortality

Carbon Monoxide as C1 Building Block in Fine Chemical Synthesis

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Chinese Journal of Chemistry 2024年第2期42卷 199-221页

作者： Rui M.B.Carrilho Mario J.F.Calvete Gabor Mikle laszlo Kollar Mariette M.Pereira University of Coimbra Coimbra Chemistry CentreDepartment of ChemistryRua Larga3004-535 CoimbraPortugal Department of General and Inorganic Chemistry and ELKH-PTE Research Groupfor Selective Chemical Syntheses University of PecsIfjusag utja 6H-7624 PecsHungary

Carbon monoxide(CO)has become one of the most relevant and versatile renewable C1 building blocks for chemical synthesis,especially in the fine chemicals industry,due to the development of efficient and selective catalysts for its *** this review,we present a comprehensive critical analysis of the last 10 years literature on the use of CO as a renewable feedstock for fine chemicals *** review is organized by type of catalytic reaction,namely alkene and alkyne carbonylation,hydroformylation,carbonylation of aryl halides,carbonylative cross-coupling and C-H *** examples of the synthesis of relevant building blocks and/or known pharmaceuticals are *** is placed on examples of utilizing CO as the C1 building block in one or more catalytic *** catalyst used and the reaction conditions are consistently presented throughout all of the examples.

关键词： Carbon monoxide Fine chemicals Carbonylation Hydroformylation C-H functionalization

Serological biomarkers for management of primary sclerosing cholangitis

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World Journal of Gastroenterology 2022年第21期28卷 2291-2301页

作者： David Tornai Peter laszlo Ven Peter laszlo Lakatos Maria Papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hajdu-BiharHungary European Reference Network on Hepatological Diseases ERN RARE-LIVERDebrecen H-4032Hajdu-BiharHungary The First Department of Medicine Division of GastroenterologyUniversity of PécsPécs H-7624BaranyaHungary Kálmán Laki Doctoral School of Biomedical and Clinical Sciences Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hajdu-BiharHungary Division of Gastroenterology McGill University Health CentreMontreal QC H4A 3J1QuebecCanada The First Department of Medicine Semmelweis UniversityBudapest H-1083PestHungary

Clinical manifestations and progression of primary sclerosing cholangitis(PSC)are heterogeneous,and its pathogenesis is poorly *** importance of gut-liver interactions in the pathogenesis has been clinically confirmed and highlighted in different *** advances regarding biomarkers of biliarygut crosstalk may help to identify clinically relevant PSC subgroups assisting everyday clinical work-up(e.g.,diagnosis,disease stratification,or surveillance)and the exploration of potential therapeutic *** phosphatase produced by the biliary epithelium is consistently associated with ***,its level shows natural fluctuation limiting its use in individual ***,cell activation,and tissue remodeling markers have been reported to predict clinical *** immunoglobulin(Ig)G4 level is associated with a shorter transplantation-free *** type atypical perinuclear anti-neutrophil cytoplasmic antibodies(P-ANCAs)are non-specific markers of various autoimmune liver diseases and may reflect an abnormal B-cell response to gut microbial *** type atypical P-ANCA identifies PSC patients with particular clinical and genetic(for human leukocyte antigens)*** presence of IgA type anti-F-actin antibody(AAA)may predict a progressive disease course,and it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte *** type anti-glycoprotein 2(GP2)antibodies identify patients with a severe disease phenotype and poor survival due to enhanced fibrogenesis or development of *** soluble vascular adhesion protein-1(sVAP-1)level is associated with adverse disease outcomes in *** sVAP-1 levels correlate with mucosal addressin cell adhesion molecule-1(MAdCAM-1)expression in the liver that contributes to gut activated T-cell homing to the hepatobiliary *** the present paper,we review the evidence on these possible serological ma

关键词： Primary sclerosing cholangitis Hepatobiliary Serological biomarker Immunoglobulin Inflammatory Tissue remodeling

Mortality and Long-Term Outcome of Neonates with Congenital Heart Disease and Acute Perinatal Stroke:A Population-Based Case-Control Study

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Congenital Heart Disease 2022年第4期17卷 447-461页

作者： Eszter Vojcek VAnna Gyarmathy Rozsa Graf Anna M.laszlo laszlo Ablonczy Zsolt Prodan Istvan Seri First Department of Pediatrics Semmelweis UniversityMTA Centre of ExcellenceBudapestHungary Department of Pediatrics Saint John Hospital and North-Buda Unified HospitalsBudapestHungary Epiconsult BioMedical Consulting and Medical Communications Agency DoverUSA Department of Epidemiology Johns Hopkins UniversityBaltimoreUSA Department of Rehabilitation Saint John Hospital and North-Buda Unified HospitalsBudapestHungary Institute of Mathematics and Base Sciences Hungarian University of Agriculture and Life SciencesGödöllőHungary Gottsegen National Cardiovascular Center BudapestHungary Children’s Hospital Los Angeles University of Southern CaliforniaLos AngelesUSA

Objective:Neonates with congenital heart disease(CHD)and perinatal stroke have high mortality and survivors are at risk for poor long-term neurodevelopmental *** aim of this study was to assess the risk factors and outcome of neonates with both CHD and MRI-confirmed perinatal stroke(Study Group)and compare those to the risk factors and outcome of infants matched for CHD without stroke(Control-1)and of infants matched for MRI-confirmed stroke without CHD(Control-2).Methods:We conducted a population-based case-control study enrolling 28 term neonates with CHD and MRI-confirmed acute perinatal stroke born between 2007–2017 in the Central-Hungarian *** of the control groups included 56 *** Bayley Scales of Infant Development-II,the Brunet-Lézine test and the Binet Intelligence scales-V were used for neurodevelopmental follow-up at a median age of 61 ***:Mortality was highest in the Study Group(25%compared to 5%and 2%,respectively,p=0.001).Adverse neurodevelopmental outcome was prevalent in the Study(53%)and Control-2 Groups(52%,p=0.03).Significantly different parameters among the three groups included Apgar scores,mode of delivery,gestational age at birth,cardiac interventions and twin *** a multivariable regression analysis adjusted for clinically relevant parameters,patients in the Study Group had significantly higher odds for mortality compared to patients in the Control-1 Group(OR:6.595%CI:1.1–39.4).Conclusions:Neonates with perinatal stroke and CHD are at a higher risk for dying compared to neonates with CHD without *** addition,the stroke-associated direct insult to the brain likely plays an important role in the development of neurodevelopmental morbidity in these patients.

关键词： Congenital heart disease perinatal stroke neurodevelopmental outcome mortality

A thermal activation based constitutive model for the dynamic deformation of AA5083 processed by large-scale equal-channel angular pressing

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Chinese Journal of Aeronautics 2023年第5期36卷 499-507页

作者： Yunfei WANG Minjie WANG Biao CHEN Huijie SUN Katsuyoshi KONDOH laszlo JKECSKES Jianghua SHEN School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China Joining and Welding Research Institute Osaka University11-1 MihogaokaOsaka 567-0047Japan Hopkins Extreme Materials Institute Johns Hopkins UniversityBaltimore 21218USA Shaanxi Key Laboratory of Impact Dynamic and Its Engineering Application Xi’an 710072China

Aluminum alloy 5083(AA5083)processed by large-scale Equal-channel angular pressing(ECAP)is an excellent engineering material with great prospects for industrial *** accurate assessment of the underlying constitutive relationships with easily determined material constants is critical for the predictive design and informed processing of such structural *** develop such a design framework,uniaxial dynamic compressive tests over a wide range of temperatures(293-573 K)were carried out for an ECAP-processed AA5083 ***,the microstructure before and after dynamic loading was characterized by SEM and *** on the experimental results,a new dynamic constitutive model,based on thermal activation theory,was established to describe the plastic flow behavior of the AA5083 alloy that incorporates the effects of plastic strain,temperature,and strain *** input parameters of the new model were determined using a particle swarm optimization(PSO)*** model predictions show excellent agreement with experimental results,which suggests that the current predictive constitutive model is highly effective in reproducing the dynamic deformation behavior of the large-scale ECAP-processed AA5083.

关键词： Aluminum alloy 5083(AA5083) Constitutive models Dynamic response Equal channel angular pressing(ECAP) Thermal activation

Role of biliary complications in chronic graft rejection after living donor liver transplantation

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World Journal of Hepatology 2022年第5期14卷 1050-1052页

作者： Aiman Obed Abdalla Bashir Anwar Jarrad laszlo Fuzesi Hepatobiliary and Liver Transplant Unit Jordan HospitalAmman 52112Jordan Department of General Surgery Jordan HospitalAmman 52112Jordan Department of Hepatology Jordan HospitalAmman 52112Jordan Department of Pathology Faculty of MedicineUniversity AugsburgAugsburg 86156Germany

Postoperative biliary complications remain a substantial challenge after living donor liver transplantation,especially due to its heterogeneous clinical presentation.

关键词： Chronic graft rejection Biliary complications Living donor liver transplantation Graft survival Cholangiopathy

Influence of entrainer recycle for batch heteroazeotropic distillation

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Frontiers of Chemical Science and Engineering 2018年第4期12卷 643-659页

作者： laszlo Hegely Peter Lang Department of Building Service and Process Engineering Faculty of Mechanical Engineering Budapest University of Technology and EconomicsMuegyetem rkp.3-9Hungary

Dehydration of isopropanol applying batch heteroazeotropic distillation with toluene as entrainer (E) is investigated. The composition of the feed is near to that of the isopropanol (A)-water (B) azeotrope. The effects of recycling the entrainer and the off-cut are studied by dynamic simulation with a professional flow-sheet simulator. Three consecutive batches (one production cycle) is studied. Both operational modes (Mode I: decantation after distillation and Mode II: decantation during distillation) are simulated. For Mode II, calculations are performed both for Strategy A (distillate from the aqueous (E-lean) phase only) and Strategy B (partial withdrawal of the organic (E-rich phase), as well). The E-rich phase, the final column hold-up and the off-cut (Mode II only) are recycled to the next batch. The influence of the following parameters are determined: quantity of entrainer, reflux ratios of the steps. The variations caused by the recycling in the 2nd and 3rd batches are also shown. The best results (lowest specific energy demand and highest recovery of A) are obtained by Mode II, Strategy A. Recycling increases the recovery, and drastically diminishes the entrainer consumption. However, it makes the production slower and decreases the quantity of fresh feed that can be processed.

关键词： batch distillation heteroazeotropic distillation operational policies off-cut recycle entrainer

Prevalence,predictors,and clinical consequences of medical adherence in IBD:How to improve it?

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World Journal of Gastroenterology 2009年第34期15卷 4234-4239页

作者： Peter laszlo Lakatos 1st Department of Medicine Semmelweis University

Inflammatory bowel diseases(IBD)are chronic diseases with a relapsing-remitting disease course necessitating lifelong ***,non-adherence has been reported in over 40%of patients,especially those in remission taking maintenance therapies for IBD. The economical impact of non-adherence to medical therapy including absenteeism,hospitalization risk, and the health care costs in chronic conditions,is *** causes of medication non-adherence are complex,where the patient-doctor relationship, treatment regimen,and other disease-related factors play key ***,subjective assessment might underestimate *** adherence may result in more frequent relapses,a disabling disease course, in ulcerative colitis,and an increased risk for colorectal *** medication adherence in patients is an important challenge for *** the different patient types,the reasons given by patients for non-adherence,simpler and more convenient dosage regimens,dynamic communication within the health care team,a self-management package incorporating enhanced patient education and physician-patient interaction,and identifying the predictors of nonadherence will help devise suitable plans to optimize patient *** editorial summarizes the available literature on frequency,predictors,clinical consequences,and strategies for improving medical adherence in patients with IBD.

关键词：传染性法氏囊病医疗费用预测临床患病率溃疡性结肠炎药物治疗慢性疾病

Prediction of disease course in inflammatory bowel diseases

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World Journal of Gastroenterology 2010年第21期16卷 2589-2590页

作者： Peter laszlo Lakatos 1st Department of Medicine Semmelweis UniversityH-1083 BudapestKoranyi S 2AHungary

Clinical presentation at diagnosis and disease course of both Crohn's disease(CD) and ulcerative colitis are heterogeneous and variable over *** most patients have a relapsing course and most CD patients develop complications(*** and/or perforation),much emphasis has been placed in the recent years on the determination of important predictive *** identification of these factors may eventually lead to a more personalized,tailored *** this TOPIC HIGHLIGHT series,we provide an update on the available literature regarding important clinical,endoscopic,fecal,serological/routine laboratory and genetic *** aim is to assist clinicians in the everyday practical decisionmaking when choosing the treatment strategy for their patients suffering from inflammatory bowel diseases.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Disease course Predictive markers Clinical Serology Genetics