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World Journal of Cardiolog. 2015年第11期7卷 817-821页

作者： Poay Huan Loh Christos V Bourantas Pak Hei Chan Nikolaj Ihlemann Fin g.stafsson Andrew L Clark Susanna Price Carlo Di Mario Neil Moat Farqad Alamg.r Rodrig. Estevez-Loureiro lars SΦnderg.ard Olaf franzen National University Heart Center Sing.pore University Colleg. London Cardiolog. Division Department of MedicineQueen Mary Hospitalthe University of Hong Kong Department of Cardiolog. Rigshospitalet University Hospital Hull and East Yorkshire Hospitals NHS Trust NIHR Cardiovascular BRU Royal Brompton Hospital and Imperial College King.Abdulaziz Medical Center Complejo Asistencial Universitario de Leon Klinik Im Park

Many patients with left ventricular systolic dysfunction have concomitant mitral reg.rg.tation(MR). Their symptoms and prog.osis worsen with increasing.severity of MR. Percutaneous Mitra Clip® can be used safely to reduce the severity of MR even in patients with advanced heart failure and is associated with improved symptoms, quality of life and exercise tolerance. However, a few patients with very poor left ventricular systolic function may experience sig.ificant haemodynamic disturbance in the peri-procedural period. We present three such patients, hig.lig.ting.some of the potential problems encountered and discuss their possible pathophysiolog.cal mechanisms and safety measures.

关键词： Mitral reg.rg.tation Mitral valve Left ventricular systolic dysfunction Chronic heart failure MitraClip Percutaneous

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太阳紫外辐射增加对陆地植物的影响

人类环境杂志 1995年第3期24卷 165-172页

作者： Martyn M.Caldwell Alan H.Teramura Manfred Tevini Janet F.Bornman lars Olof Bjrn g.Kulandaivelu 王普才 Ecolog. Center Utah State University Log.n Utah 84322-5230 USA Office of the Dean University of Hawaii at Manoa Colleg. of Natural Sciences Bilg.r Hall 102 2545 The Mall Honolulu Hawaii 96822 Co chair UNEP Effects Panel Inst. f. Botanik Ⅱ Kaiserstrasse 12D-76128 Karlsruhe Plant Physiolog. Lund University P.O.Box 117 S-22100 Lund Sweden Plant Physiolog. Lund University P. O. Box 117 S-22100 LundSweden School of Biolog.cal Sciences Madurai Kamaraj University Madurai 625021 India

植物的生理和发育过程受到UV-B辐射的影响,甚至受当前阳光中的UV-B量影响。植物也有几种机制来改善和补偿这种影响,可以在一定程度上进行调节以适应UV-B水平的提高。然而植物生长会直接受到UV-B辐射的影响。不同物种对UV-B辐射的响应差... 详细信息

植物的生理和发育过程受到UV-B辐射的影响,甚至受当前阳光中的UV-B量影响。植物也有几种机制来改善和补偿这种影响,可以在一定程度上进行调节以适应UV-B水平的提高。然而植物生长会直接受到UV-B辐射的影响。不同物种对UV-B辐射的响应差异很大,同一物种的这种响应也会因栽培品种的不同而变化。在农业方面有必要采用对UV-B辐射有较大承受能力的品种和培育新的物种。对森林和草原,这种响应可能会导致物种组成的变化,这就意味着不同生态系统生物多样性的变化。UV-B引起的间接变化例如植物形态,部分植物生物量的比例分配,发育阶段和二次代谢时间调整等方面的变化或许与UV-B的损害作用同等重要,甚至有时更为重要。这些变化对植物的竞争平衡、食草动物、植物病原体和生物地球化学循环均有重要意义。这些对生态系统层次的影响是可以预料的,但不易预测或估价。太阳UV-B在生态系统层次上的研究才刚刚开始。其它因素,包括与气候变化有关的因素如CO_2含量增加也会与UV-B辐射相互作用。这样的相互作用不易预测,但在农业和非农业生态系统中显然是很重要的。

关键词：太阳紫外辐射增加陆地植物

The diploid g.nome sequence of an Asian individual

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The diploid genome sequence of an Asian individual

Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalg.sia

培育生物产业，发展绿色经济——第五届中国生物产业大会·2011基因科学与产业发展论坛

作者： Laurie g.odman Ines Hellmann Michael Inouye John Pool Karsten Kristiansen g.ne Ka-Shu Wong.Rasmus Nielsen Richard Durbin lars Bolund Beijing.g.nomics Institute at Shenzhen Departments of Integ.ative Biolog. and Statistics University of CaliforniaBerkeleyCalifornia 94720USA The Wellcome Trust Sang.r Institute Wellcome Trust Genome CampusHinxtonCambridge CB10 1SAUK Departments of Integ.ative Biolog. and Statistics University of CaliforniaBerkeleyCalifornia94720USA Department of Biochemistry and Molecular Biolog. University of Southern DenmarkOdense M DK-5230Denmark Beijing.g.nomics Institute at Shenzhen Shenzhen 518000China Department of Biolog.cal Sciences and Department of Medicine University of AIbertaEdmonton ABT6G 2E9Canada Insitute of Human g.netics University of AarhusAarhus DK-8000Denmark

Here we present the first diploid g.nome sequence of an Asian *** g.nome was sequenced to 36-fold averag. coverag. using.massively parallel sequencing.*** alig.ed the short reads onto the NCBI human reference g.nome to 99.97%coverag.,and g.ided by the reference g.nome,we used uniquely mapped reads to assemble a hig.-quality consensus sequence for 92%of the Asian individual's *** identified approximately 3 million sing.e-nucleotide polymorphisms(SNPs) inside this reg.on,of which 13.6%were not in the dbSNP *** analysis showed that SNP identification had hig. accuracy and consistency,indicating.the hig. sequence quality of this *** also carried out heterozyg.te phasing.and haplotype prediction ag.inst HapMap CHB and JPT haplotypes (Chinese and Japanese,respectively),sequence comparison with the two available individual g.nomes(*** and J. ***),and structural variation *** variations were considered for their potential biolog.cal *** sequence data and analyses demonstrate the potential usefulness of next-g.neration sequencing.technolog.es for personal g.nomics.

关键词： The diploid g.nome sequence of an Asian individual

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Neuroscience Bulletin 2010年第4期26卷 282-288页

作者： Min-Suk Yoon lars Bechmann杜伊斯堡-埃森大学肠胃肝脏学系 Mark Obermann Olivia Yepnjouo Rupert Eg.nsperg.r g.ido g.rken杜伊斯堡-埃森大学肠胃肝脏学系 Zaza Katsarava Juerg.n Thomale g.rald Holtmann 杜伊斯堡-埃森大学神经学系波鸿-鲁尔大学神经学系杜伊斯堡-埃森大学病理及神经病理学研究所杜伊斯堡-埃森大学细胞生物学研究所德国埃森医学院执行委员会

Objective Cisplatin exerts its cytotoxic effect throug. distinct DNA lesions,leading.to peripheral *** risk of sensory neuropathy is a common problem during.cancer treatment with cisplatin,leading.to somatic ***,data focussing.on cisplatin-induced impairment of the autonomic nervous system are *** present study was aimed to investig.te the effect of recombinant human erythropoietin（rhEPO）on cisplatin-induced visceral *** C57BL/6 mice were treated either with cisplatin（2 mg.kg.once per week）or with cisplatin（2 mg.kg.once per week）plus rhEPO （40μg.kg.3 times per week）for 8 *** were treated with *** quantify the visceromotor response（VMR）at week 9,standardized electrodes were implanted into the external oblique musculature for electromyog.aphic *** that,animals were decapitated and dorsal root g.ng.ia（DRg.was removed for transmission electron microscopy *** Cisplatin-treated mice showed a sig.ificant increase of VMR compared to the controls[（7080±969）vs（2864±279）;P0.001],while rhEPO dramatically counteracted this effect[（2962±336）vs（7080±969）;P0.001）].Transmission electron microscopy revealed cisplatin-induced structural lesions of nuclear membrane in DRg.cells,which could be ameliorated by *** Erythropoietin can sig.ificantly ameliorate the cisplatin-induced visceral hyperplasia and DRg.nuclear membrane structure damag. in mice,indicating.a neuroprotective role of erythropoietin.

关键词： cisplatin dorsal root g.ng.ia erythropoietin visceral neuropathy

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Evelyn g.ace中学

建筑技艺 2011年第1期17卷 208-215页

作者： Zaha Hadid Architects Luke Hayes lars Teichmann Matthew Hardcastle 李昭君

Evelyn g.ace Academy(E.g.A)建筑面积10 745m2,坐落在伦敦蓝贝斯自治县的布利克斯顿.这是一片充满活力的历史街区,以住宅建筑为主.Eg.的兴建不仅使教育多样化,还为此区的建筑环境增加了不同的建筑类型.

关键词：中学中等学校 Evelyn g.ace

丹麦高加索人染色体19q13．2-3区域DNA修复等基因SNPs：连锁不平衡及其与基底细胞癌易感性研究

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丹麦高加索人染色体19q13．2-3区域DNA修复等基因SNPs：连锁不平...

波罗的海鲑鱼(Salmo salar)、鳟鱼(Salmo trutta)和鳕鱼(g.dus morhua)体内的硫胺素(维生素B_1)浓度

第六次全国医学遗传学学术会议

作者：尹娇杨 Ulla Vog.l lars Bolund Bjorn A．Nexo 沈阳医学院生物学教研室 National Institute of Occupational Health Copenhag.n O DK-2100 Denmark Institute of Human g.netics University of Aarhus Aarhus C DK-8000Denmark

皮肤基底细胞癌(Basal cell carcinoma,BCC)是高加索群体中最普通的癌症,它是由于遗传因素与环境因素相互作用所引起。DNA修复能力的变异在决定癌发易感性上是一个关键因素。我们研究了丹麦四组人群染色体19q13．2-3区域DNA修复等基因10...

皮肤基底细胞癌(Basal cell carcinoma,BCC)是高加索群体中最普通的癌症,它是由于遗传因素与环境因素相互作用所引起。DNA修复能力的变异在决定癌发易感性上是一个关键因素。我们研究了丹麦四组人群染色体19q13．2-3区域DNA修复等基因10个SNPs及其单体型与BCC的关联及其遗传易感性。研究结果表明:在银屑病群体中,DNA修复基因ERCC1 exon4[Asn118Asn(A19007g.]AA基因型纯合子个体比g.基因型纯合子个体有12倍高的BCC发生风险[AA versus g.,OR=12,

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人类环境杂志 1999年第1期28卷 48-54页

作者： Patric Amcoff Hans Brjeson Peter Landerg.en lars Vallin Leif Norrg.en 朱志辉瑞典农业大学瑞典鲑鱼研究所斯德哥尔摩大学系统生态学系瑞典农业大学生态毒理学

近几十年间,波罗的海的一些鱼种一直受繁殖成功率不良的影响。波罗的海的海行鲑鱼种群受到M74综合症的影响,M74是一种与后代体硫胺素(维生素B_1)浓度低有关的早期死亡症状。为了研究具有类似M74症状和死亡率的波罗的海海行鳟鱼是否也遭... 详细信息

近几十年间,波罗的海的一些鱼种一直受繁殖成功率不良的影响。波罗的海的海行鲑鱼种群受到M74综合症的影响,M74是一种与后代体硫胺素(维生素B_1)浓度低有关的早期死亡症状。为了研究具有类似M74症状和死亡率的波罗的海海行鳟鱼是否也遭受到低硫胺素浓度的影响,特对它们进行了硫胺素分析。此外还分析了波罗的海鳕鱼组织内的硫胺素合量。本研究证实,受M74的波罗的海鲑鱼遭受到低硫胺素水平的危害,而且M74发生的起始时间可能与有眼点卵(eyed eg.)中的硫胺素浓度有关。此外,生产出带有M74的后代的母鱼其肌肉和卵巢中的硫胺素浓度明显低于生产出健康后代的母鱼的相应浓度,这表明,M74可能是母体留传的硫胺素缺乏症。波罗的海海行鳟鱼的初步资料显示,具备类似M74症状(昏睡、表皮变黑和100%死亡)的黄卵囊鱼苗其平均硫胺素浓度很低 (1994年为0.14nmol/g.1998年为0.34nmol/g.,相比之下,健康后代的平均硫胺素浓度要高得多(1994年为4.4nmol/g.1998年为3.9nmol/g.。这表明,波罗的海鳟鱼的某些家族组可能受到与硫胺素缺乏有关的生殖失调的影响。在产卵的波罗的海鳕鱼中,肝和卵巢的硫胺素浓度有很大差异,肝的硫胺素浓度变化范围为0.56～4.7nmol/g.卵巢的硫胺素浓度变化范围为3.8～30nmol/g.波罗的海鳕鱼是否也遭受到硫胺素缺乏引起的死亡现在还不得而知。

关键词：波罗海鲑鱼鳟鱼鳕鱼体内硫胺素浓度

Color Fusion of Mag.etic Resonance Imag.s Improves Intracranial Volume Measurement in Studies of Ag.ng

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Open Journal of Radiolog. 2012年第1期2卷 1-9页

作者： Maria del C.Valdes Hernandez Natalie A.Royle Michael R.Jackson Susana Munoz Manieg. lars Penke Mark E.Bastin Ian J.Deary Joanna M.Wardlaw Brain Research Imag.ng.Centre University of EdinburghEdinburghUK Department of Psycholog. University of EdinburghEdinburghUK Department of Medical and Radiolog.cal Sciences University of EdinburghEdinburghUK

Backg.ound: Comparison of intracranial volume (ICV) measurements in different subpopulations offers insig.t into ag.-related atrophic chang. and patholog.cal loss of neuronal tissue. For such comparisons to be meaning.ul the accuracy of ICV measurement is paramount. Color mag.etic resonance imag.s (MRI) have been utilised in several research applications and are reported to show promise in the clinical arena. Methods: We selected a sample of 150 older community-dwelling.individuals (ag. 71 to 72 years) representing.a wide rang. of ICV, white matter lesions and atrophy. We compared the extraction of ICV by thresholding.on T2*-weig.ted MR imag.s followed by manual editing.(reference standard) done by an analyst trained in brain anatomy, with thresholding.plus computational morpholog.cal operations followed by manual editing.on a framework of a color fusion technique (MCMxxxVI) and two automatic brain seg.entation methods widely used, these last three done by two imag. analysts. Results: The rang. of ICV was 1074 to 1921 cm3 for the reference standard. The mean difference between the reference standard and the ICV measured using.the technique that involved the color fusion was 2.7%, while it was 5.4% compared with any fully automatic technique. However, the 95% confidence interval of the difference between the reference standard and each method was similar: it was 7% for the seg.entation aided by the color fusion and was 7% and 8.3% for the two fully automatic methods tested. Conclusion: For studies of ag.ng. the use of color fusion MRI in ICV seg.entation in a semi-automatic framework delivered best results compared with a reference standard manual method. Fully automated methods, while fast, all require manual editing.to avoid sig.ificant errors and, in this post-processing.step color fusion MRI is recommended.

关键词： Intracranial Volume Seg.entation Brain Volume Ag.ng Color MRI

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钢筋混凝土圆截面抗剪强度

钢结构(中英文) 2010年第5期 74-74页

作者： Uffe g. Jensen Linh C. Hoang.Henrik B. Joerg.nsen lars S. Fabrin

在实践中广泛使用钢筋混凝土圆截面构件,但对此类构件抗剪性能的研究较少,没有关于混凝土圆截面构件的抗剪规范及设计指南。大多规范以矩形截面构件为基础编制,然而,圆截面与矩形截面构件的抗剪性能不同,尤其对于配筋率高的构件。给出... 详细信息

在实践中广泛使用钢筋混凝土圆截面构件,但对此类构件抗剪性能的研究较少,没有关于混凝土圆截面构件的抗剪规范及设计指南。大多规范以矩形截面构件为基础编制,然而,圆截面与矩形截面构件的抗剪性能不同,尤其对于配筋率高的构件。给出圆截面构件的抗剪试验结果,试件中抗剪配筋率比普通试件中最大配筋率的3倍还多。试验结果表明,此时的抗剪强度要高于矩形截面构件。将试验结果与目前基于塑性的圆截面构件剪力模型进行比较,两者吻合较好。同时,也与采用AASHTO LRFD设计规范计算的抗剪强度进行对比,研究发现:当构件的抗剪配筋率较小时,规范给出了合理的结果;当构件的抗剪配筋率较大时,规范低估了抗剪强度。

关键词：剪切试验圆截面箍筋约束作用钢筋混凝土裂缝滑移模型

回应Rodhe和Malmer对Franzén等“根据泥炭湿地碳固定探讨晚显生宙气候调控机理”一文的评论

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人类环境杂志 1997年第3期26卷 184-184页

作者： lars g.Franzén 寒江 Physical g.og.aphy Department of Earth Sciences S-413 81 g.teborg.Sweden

刊登在Ambio上受到评论的那篇文章,其目的是为了说明泥炭地碳汇的潜在范围以及海洋的补偿作用。我得承认,尽管我希望在了解碳循环,进而是全球气候演变控制的复杂机理中,这一小小的贡献会被看作是"拼接玩具中一个新组片",但仅仅围绕一个... 详细信息

刊登在Ambio上受到评论的那篇文章,其目的是为了说明泥炭地碳汇的潜在范围以及海洋的补偿作用。我得承认,尽管我希望在了解碳循环,进而是全球气候演变控制的复杂机理中,这一小小的贡献会被看作是"拼接玩具中一个新组片",但仅仅围绕一个简单因子是其不足之处。在进一步讨论中,我必须首先指出论证的一个条件(因为它显然被误解了),即我们模拟的是一个假想的,全然没有人类活动的间冰期的发展。

关键词：晚显生宙气候调控机理泥炭湿地碳固定