Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesia

作     者：Min-Suk Yoon Lars Bechmann杜伊斯堡-埃森大学肠胃肝脏学系 Mark Obermann Olivia Yepnjouo Rupert Egensperger Guido Gerken杜伊斯堡-埃森大学肠胃肝脏学系 Zaza Katsarava Juergen Thomale Gerald Holtmann 

作者机构：杜伊斯堡-埃森大学神经学系 波鸿-鲁尔大学神经学系 杜伊斯堡-埃森大学病理及神经病理学研究所 杜伊斯堡-埃森大学细胞生物学研究所 德国埃森医学院执行委员会 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2010年第26卷第4期

页      面：282-288页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：cisplatin dorsal root ganglia erythropoietin visceral neuropathy 

摘      要：Objective Cisplatin exerts its cytotoxic effect through distinct DNA lesions,leading to peripheral *** risk of sensory neuropathy is a common problem during cancer treatment with cisplatin,leading to somatic ***,data focussing on cisplatin-induced impairment of the autonomic nervous system are *** present study was aimed to investigate the effect of recombinant human erythropoietin（rhEPO）on cisplatin-induced visceral *** C57BL/6 mice were treated either with cisplatin（2 mg/kg,once per week）or with cisplatin（2 mg/kg,once per week）plus rhEPO （40μg/kg,3 times per week）for 8 *** were treated with *** quantify the visceromotor response（VMR）at week 9,standardized electrodes were implanted into the external oblique musculature for electromyographic *** that,animals were decapitated and dorsal root ganglia（DRG）was removed for transmission electron microscopy *** Cisplatin-treated mice showed a significant increase of VMR compared to the controls[（7080±969）vs（2864±279）;P0.001],while rhEPO dramatically counteracted this effect[（2962±336）vs（7080±969）;P0.001）].Transmission electron microscopy revealed cisplatin-induced structural lesions of nuclear membrane in DRG cells,which could be ameliorated by *** Erythropoietin can significantly ameliorate the cisplatin-induced visceral hyperplasia and DRG nuclear membrane structure damage in mice,indicating a neuroprotective role of erythropoietin.