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A short P-wave duration is associated with incident heart failure in the elderly: a 15 years follow-up cohort study

Journal of Geriatric Cardiology 2022年第9期19卷 643-650页

作者： Bozena Ostrowska lars lind Elena Sciaraffia Carina Blomström-Lundqvist Department of Medical Sciences Uppsala UniversityUppsalaSweden School of Medical Science Faculty of Medi-cine and HealthÖrebro UniversityÖrebroSweden

BACKGROUND Early identification of patients at risk of congestive heart failure(HF)may alter their poor prognosis.The aim was therefore to test whether simple electrocardiographic variables,the P-wave and PR-interval,could predict incident HF.METHODS The PIVUS(Prospective Investigation of the Vasculature in Uppsala Seniors)study(1016 individuals all aged 70 years,50%women)was used to identify predictors of HF.Subjects with prevalent HF,QRS duration≥130 ms,atrial tachyar-rhythmias,implanted pacemaker/defibrillator,second-and third-degree atrioventricular block or delta waves at baseline were excluded.Cox proportional hazard analysis was used to relate the PR interval,P-wave duration(Pdur)and amplitude(Pamp),measured in lead V1,to incident HF.Adjustment was performed for gender,RR-interval,beta-blocking agents,systolic blood pressure,body mass index and smoking.RESULTS Out of 836 subjects at risk,107 subjects were diagnosed with HF during a follow-up of 15 years.In the multivariate analysis,there was a strong U-shaped correlation between Pdur in lead V1 and incident HF(P=0.0001)which was significant for a Pdur<60 ms[HR=2.75;95%CI:1.87-4.06,at Pdur 40 ms]but not for prolonged Pdur.There was no significant relationship between incident HF and the PR-interval or the Pamp.A Pdur<60 ms improved discrimination by 3.7%when added to the tradi-tional risk factors including sex,RR-interval,beta-blocking agents,systolic blood pressure,BMI and smoking(P=0.048).CONCLUSIONS A short Pdur,an easily measured parameter on the ECG,may potentially be a useful marker of future HF,enabling its early detection and prevention,thus improving outcomes.

关键词： prevention incident wave

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Comparison of four non-alcoholic fatty liver disease detection scores in a Caucasian population

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World Journal of Hepatology 2020年第4期12卷 149-159页

作者： lars lind lars Johansson Hakan Ahlstrom Jan W Eriksson Anders larsson Ulf Risérus Joel Kullberg Jan Oscarsson Department of Medical Sciences UppsalaUniversityUppsala 75185Sweden Antaros Medical AB BioVenture HubMolndal 43153Sweden Department of Surgical Sciences Uppsala UniversityUppsala 75185Sweden Department of Public Health and Caring Sciences Clinical Nutrition and Metabolism Uppsala UniversityUppsala 75122Sweden Global Medicines Development AstraZenecaMoIndal 43150Sweden

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a common disorder,with an estimated prevalence ranging from 20%to 35%in the general population.Several scores based on easily measurable biochemical and clinical parameters,including the fatty liver index(FLI),hepatic steatosis index(HSI),lipid accumulation product(LAP),and NAFLD liver fat score(LFS),have been developed for the detection of NAFLD.However,comparative information regarding the efficacy of these scores for predicting NAFLD in population-based samples comprising normal and high-risk individuals is lacking.AIM To evaluate four NAFLD detection scores in two samples with different NAFLD risks.METHODS NAFLD screening was performed in a population-based sample of 50-year-old individuals in Uppsala,Sweden[n=310;Prospective investigation of obesity,energy and metabolism(POEM)study]and a high-risk population comprising patients with a body mass index>25 kg/m2 and either high plasma triglycerides(≥1.7 mmol/L)or type 2 diabetes(n=310;EFFECT studies).NAFLD was defined as liver fat>5.5%using magnetic resonance imaging-proton density fat fraction.FLI,HSI,LAP,and NAFLD LFS were assessed.A logistic regression model was used to evaluate the effectiveness of the different scores.RESULTS The prevalence of NAFLD was 23%in POEM.FLI showed the highest receiver operating characteristic area under the curve(ROC AUC;0.82)and was significantly better than the LAP score(P=0.005 vs LAP,P=0.08 vs LFS,P=0.12 vs HSI)for detection of NAFLD.The other three indices performed equally in POEM(0.77-0.78).The prevalence of NAFLD was 74%in EFFECT;LFS performed best(ROC AUC 0.80)in this sample.The ROC AUC for LFS(0.80)was significantly higher than that for FLI(P=0.0019)and LAP(P=0.0022),but not HSI(P=0.11).We performed a sensitivity analysis with stratification for the two high-risk subgroups(patients with diabetes or hypertriglyceridemia)from the EFFECT studies.LAP performed best in patients with hypertriglyceridemia.No major differences were observed between the other scores.CONCLUSI

关键词： Comparison EFFECT studies Fatty liver Non-alcoholic fatty liver disease Non-invasive indices Screening

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降压治疗过程中血糖水平升高是心肌梗死的预测因素:以人群为基础的队列研究

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英国医学杂志中文版 2003年第4期6卷 254-254页

作者： Kristina Dunder lars lind Bjorn Zethelius lars Berglund Hans Lithell 杜昕

研究目的:研究血糖水平升高对发生心肌梗死危险的影响,尤其是对服用降压药物的患者。设计:以人群为基础的前瞻性队列研究研究地点:瑞典乌普萨拉参与者:1860名男性,在1970～1973年间参加了一项旨在确定心血管疾病危险因素的健康调查。

关键词：降压治疗血糖心肌梗死心血管疾病

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Controlling Osteogenic Differentiation through Nanoporous Alumina

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Journal of Biomaterials and Nanobiotechnology 2014年第2期5卷 98-104页

作者： Shiuli Pujari-Palmer Thomas lind Wei Xia Liping Tang Marjam Karlsson Ott Applied Material Science Department of Engineering SciencesThe Angstrom LaboratoryUppsala UniversityUppsalaSweden Department of Medical Sciences Uppsala UniversityUppsalaSweden Bioengineering Department University of Texas at ArlingtonArlingtonUSA

Nanotopographical features are found to have significant effects on bone behavior. In the present study, nanoporous aluminas with different pore sizes (20, 100 and 200 nm in diameter), were evaluated for their osteoinductive and drug eluting properties. W20-17 marrow stromal cells were seeded on nanoporous alumina with and without the addition of BMP-2. Although cell proliferation was not affected by pore size, osteogenic differentiation was 200 nm as compared to 20 and 100 nm pores induced higher alkaline phosphatase activity (ALP) and osteocalcin expression levels, thus indicating osteoblastic differentiation. Cell morphology revealed that cells cultured on 20 nm pores adopted a rounded shape, while larger pores (200 nm) elicited an elongated morphology. Furthermore, ALP expression levels were consistently higher on BMP-2 loaded nanoporous alumina surfaces compared to unloaded surfaces, indicating that not only is nanoporous alumina osteoinductive, but also has the potential to be used as a drug eluting bone-implant coating.

关键词： Nanotopography Nanoporous Alumina Osteogenic Differentiation Marrow Stromal Cells

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绝经早期使用激素补充治疗对心血管事件的影响：随机临床试验

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英国医学杂志中文版 2013年第4期16卷 229-235页

作者： Louise lind Schierbeckregistrar lars Reociate professor,consultant Charlotte LandboToftengstaff specialist Lis Stilgrenconsultartt Pia Eikenconsultant, seniorerwlocrinologist Leif Mosekildeprofessor, seniorconsultant Iars Kber professor, consultant Jens-Frik Beck Jensenassociate professorconsultant 姬萌霞(译) 陈蓉郁琦(校) Department ofEndocrinology Hvidovre HospitalKettegfird 'die 302650 HvidovDenmark Department ofMedicine andDepartment ofEndocrinology andInternal Medicine tu'hus UniversityHspital lar' busDenmk Department ofEndocrinology Svendborg HospitalSvetdborg Dermark Department ofCardiology Nephrologyand EndocrinologyHilletCd HospitalHillercd Demam-k Departmem ofCardiology RigshospitaletCopenhagen Delnnark 北京协和医院妇产科

目的探讨在绝经早期妇女中使用激素补充治疗（HRT）对心血管结局的长期影响。研究设计开放标签，随机对照研究研究地点与开始时间丹麦，1990--1993。试验对象1006名健康妇女，年龄45～58岁，绝经早期或有围绝经期症状并且记录绝经后血... 详细信息

目的探讨在绝经早期妇女中使用激素补充治疗（HRT）对心血管结局的长期影响。研究设计开放标签，随机对照研究研究地点与开始时间丹麦，1990--1993。试验对象1006名健康妇女，年龄45～58岁，绝经早期或有围绝经期症状并且记录绝经后血清卯泡刺激素（FSH）值。经随机分配，其中502例为接受激素补充治疗组，504例为不接受治疗的对照组。曾行子宫切除术的年龄45～52岁且记录绝经期后血清FSH值的妇女也纳入研究。

关键词：激素补充治疗随机临床试验心血管事件绝经早期早期使用围绝经期症状随机对照研究健康妇女

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