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Serum amyloid P component:a new biomarker for low sperm concentration?

Asian Journal of Andrology 2021年第5期23卷 450-455页

作者： Annika Sonesson Johan Malm lars rylander Aleksander Giwercman Andreas Hillarp Department of Translational Medicine Lund UniversityMalmo 20502Sweden University and Regional Laboratories Region Skane Department of Clinical Chemistry and PharmacologyMalmo 20502Sweden Department of Laboratory Medicine Division of Occupational and Environmental MedicineLund UniversityLund 22381Sweden

Serum amyloid P component(SAP)is present in seminal plasma,on spermatozoa,and in different tissues of the male reproductive tract,but its function is not *** aims of this study were to determine if the concentration of SAP in seminal plasma is associated with commonly assessed semen parameters and to investigate if SAP could be a new,indirect biomarker for these *** a cross-sectional study of 203 young volunteers,the concentration of SAP in seminal plasma was measured with a in-house developed enzyme-linked immunosorbent *** plots,Pearson’s correlation coefficients(r),and linear regression models were produced,and SAP showed a statistically significant correlation with sperm concentration(r=0.75),sperm number(r=0.68),semen volume(r=-0.19),progressive sperm motility(r=0.24),and sperm immotility(r=-0.20).When the study group was dichotomized,SAP could be used to discriminate samples with a sperm concentration

关键词： fertility reproduction seminal plasma serum amyloid P component sperm

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Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage

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Asian Journal of Andrology 2017年第1期19卷 52-56页

作者： Gunilla Maim Trine B Haugen lars rylander Aleksander Giwercman Molecular Reproductive Research Department of Translational Medicine Lund University Skane University Hospitar Maimo Sweden Faculty of Health Sciences Oslo and Akershus University College of Applied Sciences Oslo Norway Division of Occupational and Environmental Medicine Lund University Lund Sweden.

A high sperm DNA fragmentation index （DFI） is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The association between the major melatonin metabolite, urine 6-sulfatoxymelatonin （aMT6s）, and DFI was analyzed in 110 Oslo men （south of the Arctic Circle） and 86 Tromsoe men （north of the Arctic Circle）. Two semen analyses, summer and winter, and four urine samples （early/late summer; early/late winter）, were analyzed. The associations between aMT6s in urine and DFI were characterized in a cross-sectional and longitudinal manner using correlation analysis and linear regression. Regardless of season and location, no significant correlations between aMT6s and DFI were observed. The correlation coefficients for associations between changes over time （early winter-early summer） in aMT6s and DFI were for the total cohort： rho = -0.08 （P = 0.322）, for the Oslo cohort： rho = -0.07 （P = 0.485）, and for the Tromsoe cohort： rho = -0.14 （P = 0.273）, respectively. Similar results were seen when comparing late winter and late summer. There was no any statistically significant correlation between changes over time in aMT6s and DFI for men with DFI below and above the median value （10%）, respectively. The seasonal variation in melatonin excretion seems not to have any impact on DFh

关键词： male infertility melatonin semen quality sperm DNA index

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Gene-environment interaction and male reproductive function

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Asian Journal of Andrology 2010年第3期12卷 298-307,I0007页

作者： Jonatan Axelsson Jens Peter Bonde Yvonne L. Giwercman lars rylander Aleksander Giwercman Reproductive Medicine Centre Skane University Hospital Malmo 20502 Sweden Division of Occupational and Environmental Medicine Lund University Lund 22185 Sweden Department of Occupational Medicine Copenhagen University Bispebjerg Hospital Copenhagen NV2400 Denmark Department of Clinical Sctences Malmo Lund University Malmo 20502 Sweden

As genetic factors can hardly explain the changes taking place during short time spans, environmental and lifestyle-related factors have been suggested as the causes of time-related deterioration of male reproductive function. However, considering the strong heterogeneity of male fecundity between and within populations, genetic variants might be important determinants of the individual susceptibility to the adverse effects of environment or lifestyle. Although the possible mechanisms of such interplay in relation to the reproductive system are largely unknown, some recent studies have indicated that specific genotypes may confer a larger risk of male reproductive disorders following certain exposures. This paper presents a critical review of animal and human evidence on how genes may modify environmental effects on male reproductive function. Some examples have been found that support this mechanism, but the number of studies is still limited. This type of interaction studies may improve our understanding of normal physiology and help us to identify the risk factors to male reproductive malfunction. We also shortly discuss other aspects of gene-environment interaction specifically associated with the issue of reproduction, namely environmental and lifestyle factors as the cause of sperm DNA damage. It remains to be investigated to what extent such genetic changes, by natural conception or through the use of assisted reproductive techniques, are transmitted to the next generation, thereby causing increased morbidity in the offspring.

关键词： endocrine disruption gene-environment interaction persistent organic pollutants semen quality testicular cancer

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Single semen analysis as a predictor of semen quality： clinical and epidemiological implications

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Asian Journal of Andrology 2009年第6期11卷 723-730页

作者： lars rylander Boel Wetterstrand Trine B Haugen Gunilla Malm Johan Malm Cathrine Bjorsvik Trine Henrichsen Thomas Saether Aleksander Giwercman Reproductive Medicine Centre Maltao University Hospital Lund University Maltao SE-20502 Sweden Division of Occupational and Environmental Medicine Lund University Lund SE-22185 Sweden Faculty of Health Sciences Oslo University College Oslo NO-O130 Norway Andrology Laboratory Dept of Gynecology and Obstetrics Rikshospitalet University Hospital Oslo N0-0027 Norway Department of Clinical Chemistry Malmo University Hospital Malmo SE-20502 Sweden Department of Molecular Biosciences University of Oslo Oslo N0-0316 Norway

It is generally thought that a single ejaculate is a bad predictor of semen quality of a subject, because of significant intra-individual variation. Therefore, we investigated the degree to which the results of a first semen analysis differ from that of a second analysis among men from a how the two different semen results mirrored the overall general population in Norway. In addition, we analysed semen quality assessment. A total of 199 volunteers participated in the study and delivered two semen samples with an interval of 6 months. The semen parameters were determined according to the World Health Organization （WHO） 1999 guidelines, which were also used to determine whether semen quality was normal or abnormal. In addition, the DNA fragmentation index （DFI） was determined using the Sperm Chromatin Structure Assay. The two samples from each individual were very similar with regard to standard semen parameters and DFI （rs： 0.67-0.72）, and there were no significant systematic differences between the two samples. The result of the first sample （normal/abnormal） was highly predictive of the overall conclusion based on the two samples （sperm concentration： in 93% of the cases （95% confidence interval [CI]： 89%-96%）; sperm motility： in 85% of the cases （95% CI： 79%-89%）; overall semen quality： in 85% of the cases （95% CI： 80%-90%）. In epidemiological studies, one ejaculate is a sufficient indicator of semen quality in a group of subjects. In a clinical situation, when the question is whether the semen quality is normal or not, the first ejaculate will, in at least 85% of cases, give a correct overall conclusion.

关键词： DNA fragmentation intra-individual semen quality semen volume sperm concentration sperm motility

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