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LC–MS characterization, anti-kinetoplastide and cytotoxic activities of natural products from Eugenia jambolana Lam. and Eugenia uniflora

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 836-841页

作者： Celestina Elba Sobral de Souza Ana Raquel Pereira da Silva Janaina Esmeraldo Rocha Maria Celeste Vega Gomez Míriam Rolóm Cathia Coronel José Galberto Martins da Costa Manoel L.C.Netto larissa a.rolim Henrique Douglas Melo Coutinho Laboratório de Microbiologia e Biologia Molecular Universidade Regional do Cariri Center for the Development of Scientific Research Moisés Bertoni Foundation/Díaz Gill Laboratories Laboratório de Pesquisa de Produtos Naturais Universidade Regional do Cariri Centro Universitário Dr.Leao Sampaio–UNILEAO Universidade Federal do Vale do Sao Francisco–UNIVASF

Objective: To evaluate the trypanocidal, leishmanicidal and cytotoxic activity of Eugenia jambolana(E. jambolana) and Eugenia uniflora(E. uniflora) extracts and ***: The products were characterized by LC–MS. Antiparasitic assays were performed and cytotoxicity was evaluated in fibroblastos. In vitro assays were performed using spectrophotometric evaluation. All assays were performed in ***: The results showed that the extracts and the tannic fraction from E. jambolana inhibited 100% of the epimastigote lines. The ethanolic extract was the most efficient in all concentrations tested against the three parasite strains. In the cytotoxicity assay the flavonoid fraction showed low toxicity. All E. uniflora samples showed cytotoxicity at the highest concentration tested, but the extract showed no toxic effect on the fibroblasts at the lowest concentration. The flavonoid and tannic fractions were more efficient against Leishmania braziliensis promastigotes compared to the extract. However, the extracts and the tannic fraction were more effective against Leishmania infantum strains. The effect on epimastigote cells was observed at all concentrations tested, with all E. uniflora samples. However, the samples were more effective at the highest concentration, where there was inhibition in 100% of the Trypanosoma cruzi ***: The species E. jambolana and E. uniflora presented antiparasitic activity against all tested parasite strains, indicating that these species can serve as an alternative therapy as they were efficient in the tests performed. The E. uniflora extract and the E. jambolana flavonoid fraction presented a low cytotoxicity, opening the floor for new biological studies.

关键词： Antiparasitic effect Cytotoxicity Eugenia jambolana Eugenia uniflora

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Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： larissa M.G.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

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Benefits of heterospecific aggregation on necromass: in fluence of temperature, group density, and compositi on on fitness-related traits

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Insect Science 2021年第1期28卷 144-152页

作者： larissa Komo Valery Hedouin Damien Charabidze CHU Lille EA 7367—UTML—Unite de Taphonomie Medico-LegaleUniversity of Lille59000 LilleFrance

Necrophagous blowflies(Diptera:Calliphoridae)such as Calliphora vicina,a cold-tolerant species,and L ucilia serie ata,a warm-adapted species,are pioneer carrion・*** these two species have different temperature preferences,larvae aggregate actively and often feed simultaneously on *** hypothesis to be tested was that *** benefits from the association with *** at lower temperatures(i.e.,15℃)and that *** derives greater benefits from this association at higher temperatures(i.e.,28℃).Therefore,both species were raised at these two constant temperatures from first instars to adults under three different conditions:monospecific low-density,monospecific high-density,and heterospecific *** time until larval migration,surface area of puparia,and survival rates were determined for each *** between these fitness-related traits were found between species,temperatures,group densities,and species *** 28°C,*** larvae bred in heterospecific groups migrated significantly earlier and in higher numbers than that under same density conspecific con・ditions,with a lower mortality *** 15°C,both species benefited from high-density heterospecific associations,expressed by faster development and larger *** conclusion,necrophagous larvae benefited from heterospecific aggregations at suboptima 1 temperatures by adapting their migration time to that of the faster *** temperature changes throughout the day and over the year,the beneficiary of such a collective association also *** costs involved and deviations to the temperature-size rule highlight the complexity of the carrion ecosystem.

关键词： carrion ecology development rhythm flies forensic entomology lifehistory traits mutualism

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Dental stem cells:The role of biomaterials and scaffolds in developing novel therapeutic strategies

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World Journal of Stem Cells 2020年第9期12卷 897-921页

作者： Cornelia larissa Granz Ali Gorji Epilepsy Research Center Westfälische Wilhelms-Universität MünsterMünster 48149Germany Department of Neurosurgery and Department of Neurology Westfälische Wilhelms-UniversitätMünster 48149Germany Shefa Neuroscience Research Center Khatam Alanbia HospitalTehran ***Iran Neuroscience Research Center Mashhad University of Medical SciencesMashhad ***Iran

Dental stem cells(DSCs)are self-renewable cells that can be obtained easily from dental tissues,and are a desirable source of autologous stem *** use of DSCs for stem cell transplantation therapeutic approaches is attractive due to their simple isolation,high plasticity,immunomodulatory properties,and multipotential *** appropriate scaffolds loaded with favorable biomolecules,such as growth factors,and cytokines,can improve the proliferation,differentiation,migration,and functional capacity of DSCs and can optimize the cellular morphology to build tissue constructs for specific *** enormous variety of scaffolds have been used for tissue engineering with *** these,the scaffolds that particularly mimic tissue-specific micromilieu and loaded with biomolecules favorably regulate angiogenesis,cell-matrix interactions,degradation of extracellular matrix,organized matrix formation,and the mineralization abilities of DSCs in both in vitro and in vivo *** represent a promising cell source for tissue engineering,especially for tooth,bone,and neural tissue *** purpose of the present review is to summarize the current developments in the major scaffolding approaches as crucial guidelines for tissue engineering using DSCs and compare their effects in tissue and organ regeneration.

关键词： Cell transplantation Regenerative medicine Tissue engineering Neural crest Angiogenesis Biomolecules

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Longman and Norton:The Anthologies of World Literature and the Effects on the Literary Landscapes

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Journal of Foreign Languages and Cultures 2023年第1期7卷 5-15页

作者： larissa Moreira Fidalgo Fluminense Federal University

By establishing a critical dialogue with the observations of David Damrosch in Comparing the Literatures:Literary Studies in a Global Age concerning the challenges posed to Comparatism by the current state of the discipline,the question that we will address in the present work is,above all,a position on what it means to make a comparative study in a scenario marked by the reemergence of the phenomenon of world literature in literary *** directing our attention to The Longman Anthology of World Literature and The Norton Anthology of World Literature,we were able to see how both still describe an unequal system of legitimation and aesthetic configuration based on a Eurocentric division between the"inside"and the"outside."And it is precisely in the ethical and political implications of this process of opening"'to the world that lies our proposal for approaching world literature.

关键词： world literature comparative literature transnational literary experience transnationalization of culture and literature

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Understanding the indicative factors of university/college closings

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Journal of Management Analytics 2022年第3期9卷 330-350页

作者： larissa Adamiec Deborah Cernauskas Andrew Kumiega College of Business Benedictine UniversityLisleILUSA Vision Analytics LisleILUSA Illinois Institute of Technology ChicagoILUSA

Higher education has been in a financially precarious position for many years –facing either a total transformation or elimination. Tuition increases and fewercollege-age students from shifting demographics are primary reasons for thefinancial distress. Alternative financial stability models have assumed linearvariable relationships and improperly calculate the probability of *** have historically relied upon models such as those developed byEdmit and the Department of Education which are inadequate at separatingfinancially sound from unsound universities. We used an Automated MachineLearning approach utilizing multiple models to explain the relationship betweenmetrics and the probability of default/closure allowing for more informedmanagerial decisions. This research, although applied to the homogeneousgroup of small liberal arts universities, can be applied to online and stateuniversities and will allow the opportunity to take preventive steps to mitigatethe likelihood of closing due to financial distress.

关键词： bankruptcy prediction statistics decision analysis machine learning forecasting applications random forest

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Zoology, Celibacy, and the Heterosexual Imperative： Notes on Teaching Lu Xun＇s ＂Loner＂ as a Queer Text

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2013年第3期7卷 441-458页

作者： Ari larissa Heinrich Department of Literature University of California San Diego CA 92093 USA

This essay reflects on the reception of Lu Xun＇s short story ＂The Loner＂（Gudu zhe, alternately translated as ＂The Lone Wolf, The Misanthrope,＂ and ＂The Isolate＂） in American classrooms, where students have sometimes wondered whether that character might be read as ＂queer.＂ It suggests that the title character＇s unusual and self-imposed celibacy is probably best explained by his belief, in a very general sense, in the foundational values of zoology as practiced in Japan and China in the late nineteenth and early twentieth centuries, and thus that the story may be a better gateway to understanding the ways in which Lu Xun envisioned the mixed impact of new political economies on private life than a source text for queer studies. At the same time, however, this essay emphasizes that in ＂The Loner,＂ as elsewhere, accounting for the ＂heterosexual imperative＂ of early zoology （e.g., with its emphases on animal husbandry, propagation, reproduction） can have meaningful consequences for ＂queering＂ interpretations of received texts from literature, history of science, and beyond.

关键词： queer Lu Xun zoology celibacy modem Chinese literature "TheLoner," pedagogy

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Opportunities for agent based modeling of retinal stem cell transplantation

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Neural Regeneration Research 2022年第9期17卷 1978-1980页

作者： larissa M.DePamphilis Troy Shinbrot Maribel Vazquez Department of Biomedical Engineering RutgersThe State University of New JerseyPiscatawayNJUSA

Late stage blindness and visual impairment(BVI)affects over 400 mi l l ion adul ts *** disabilities severely impact the ability of adults to function independently,reduce their quality of life,and worsen socio-economic burdens on health care ***,the World Health Organization projects worldwide BVI from degenerated retina to more than double by the year 2050(Bourne et al.,2021).To understand the clinical problem,consider Figure 1A depicting the retina’s seven neuronal cell types that interconnect across three nuclear *** photoreceptors of the outer nuclear layer(ONL)are light sensitive neurons that absorb and convert photons into bioelectrical signals.

关键词： Figure outer convert

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Student self-assessment versus preceptor assessment at the midpoint of a family medicine clerkship

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Family Medicine and Community Health 2017年第1期5卷 65-70页

作者： William Huang larissa Grigoryan Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA

Objective:To study how student self-assessment compared with the faculty’s assessment on our family medicine clerkship and to explore the effect of demographic factors on the ***:Students and their faculty preceptors assessed the students’achievement of clerk-ship objectives at mid *** performed Mann-Whitney U tests to compare student ratings and faculty ratings for each clerkship *** performed linear regression analyses to in-vestigate the effect of medical school year and student sex on student ratings and the effect of sex concordance or sex difference of the faculty-student pair on faculty ***:Two hundred one students completed the family medicine clerkship between July 2015 and June *** ratings were higher than student ratings for all 12 clerkship objec-tives(P<0.05 for all comparisons).Third-year students rated themselves higher than second-year students for nine of the clerkship *** was no difference in student ratings between female students and male students and no difference in faculty ratings whether there was a sex-concordant or a sex-different preceptor-student ***:Our findings add to the knowledge of the mid-clerkship feedback process offered by different *** study is needed to investigate how students use this feedback to improve for the remainder of the clerkship.

关键词： Education medical undergraduate clinical clerkship student self-assessment

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With newer tools for gene editing, is it time to revisit genetic therapy for cystic fibrosis?

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Genes & Diseases 2021年第2期8卷 168-180页

作者： Anuj Gupta Ankita Gupta larissa Boyd Barts and the London School of Medicine and Dentistry Institution address-Garrod BuildingTurner StreetWhitechapelE12ADUnited Kingdom University of Birmingham Birmingham Medical schoolEdgbastonB152TTUnited Kingdom Barts and the London School of Medicine and Dentistry Garrod BuildingTurner StreetWhitechapelE12ADUnited Kingdom

Cystic Fibrosis(CF)is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator(CFTR)gene on chromosome *** abnormalities affect the chloride channels in the mucus producing epithelial cells. With these channels not working properly,water is unable to leave the cells to enter the mucus;thus,leading to sticky mucus which obstructs airways and ducts in the body.

关键词： cystic airway properly

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