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Lipopolysa.cha.ide mouse models for Pa.kinson's disea.e resea.ch:a.critica. a.pra.sa.

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Neura. Regenera.ion Resea.ch 2022年第11期17卷 2413-2417页

作者： Isa.c Deng larisa Bobrovska.a Hea.th a.d Biomedica. Innova.ion Clinical and Health SciencesUniversity of South AustraliaAdelaideAustralia

Pa.kinson's disea.e,the most common movement disorder,ha. a.strong neuroinfla.ma.ory *** is evident by increa.ed pro-infla.ma.ory cytokines in the serum,a.d the presence of a.tiva.ed microglia. cells,a.d infla.ma.ory cytokines in the substa.tia.nigra.of post-mortem bra.ns a. well a. cerebrospina. fluid of Pa.kinson's disea.e *** centra. a.d periphera. neuroinfla.ma.ory a.pects of Pa.kinson's disea.e ca. be investiga.ed in vivo via.a.ministra.ion of the infla.ma.en lipopolysa.cha.ide,a.component of the cell wa.l of gra.-nega.ive *** this mini-review,we will critica.ly eva.ua.e different routes of lipopolysa.cha.ide a.ministra.ion(including intra.a.a. systemic a.d ste reota.ic),their releva.ce to clinica. Pa.kinson's disea.e a. well a. the recent findings in lipopolysa.cha.ide mouse *** will a.so sha.e our own expe riences with systemic a.d intra.tria.a. lipopolysa.cha.ide models in C57BL/6 mice a.d will discuss the usefulness of lipopolysa.cha.ide mouse models for future resea.ch in the field.

关键词： C57BL/6 mice intra.a.a. models lipopolysa.cha.ide models neuroinfla.ma.ion Pa.kinson's disea.e stereota.ic models substa.tia.nigra systemic models

Ma.a.ement of Control Impa.ts Ba.ed on Ma.imizing the Sprea. of Influence

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Interna.iona. Journa. of a.toma.ion a.d computing 2019年第3期16卷 341-353页

作者： a.exa.der Tselykh Vla.isla. Va.ilev larisa Tselykh Institute of Computer Technologies a.d Informa.ion Sa.ety Southern Federal University.Rostov-on-Don 344006.Russia Depa.tment of Economics a.d Business Rostov State University of EconomicsRostov-on-Don 344002.Russia

The choice of fulcrums for control of socio-economic systems represented by direc ted weighted signed gra.hs is a.topic of current *** a.ticle proposes a.new method for identifying nodes of impa.t a.d influentia. nodes,which will provide a.gua.a.teed positive system response over the growth *** ta.k is posed a. a. optimiza.ion problem to ma.imize the ra.io of the norms of the a.cumula.ed increments of the growth vector a.d the exogenous impa.t *** a.gorithm is reduced to solving a.qua.ra.ic progra.ming problem with nonlinea. *** selection of the most effective vertices is ba.ed on the cumula.ive ga.ns of the component projections onto the solution *** exa.ples a.c provided to illustra.e the effectiveness of the proposed method.

关键词： Directed weighted gra.hs control impa.t sprea. of influence optimiza.ion a.gorithm growth model

Cha.ge Point Detection for Process Da.a.a.a.ytics a.plied to a.Multipha.e Flow Fa.ility

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 1737-1759页

作者： Rebecca.Gedda.larisa Beilina.Ruomu Ta. Depa.tment of Ma.hema.ica. Sciences Chalmers University of TechnologySE-42196GothenburgSweden and ABB Corporate Research CentreLadenburgGermany Depa.tment of Ma.hema.ica. Sciences Chalmers University of Technology and University of GothenburgGothenburgSweden a.B Corpora.e Resea.ch Center LadenburgGermany

Cha.ge point detection becomes increa.ingly importa.t beca.se it ca. support da.a.a.a.ysis by providing la.els to the da.a.in a. unsupervised *** the context of process da.a.a.a.ytics,cha.ge points in the time series of process va.ia.les ma. ha.e a. importa.t indica.ion a.out the process *** exa.ple,in a.ba.ch process,the cha.ge points ca. correspond to the opera.ions a.d pha.es defined by the ba.ch *** identifying cha.ge points ca. a.sist la.elling the time series *** unsupervised a.gorithms ha.e been developed for cha.ge point detection,including the optimisa.ion a.proa.hwhich minimises a.cost functionwith certa.n pena.ties to sea.ch for the cha.ge *** Ba.esia. a.proa.h is a.other,which uses Ba.esia. sta.istics to ca.cula.e the posterior proba.ility of a.specific sa.ple being a.cha.ge *** pa.er investiga.es how the two a.proa.hes for cha.ge point detection ca. be a.plied to process da.a.*** a.dition,a.new type of cost function using Tikhonov regularisation is proposed for the optimisa.ion a.proa.h to reduce irreleva.t cha.ge points ca.sed by ra.domness in the *** novelty lies in using regularisation-ba.ed cost functions to ha.dle ill-posed problems of noisy *** results demonstra.e tha. cha.ge point detection is useful for process da.a.a.a.ytics beca.se cha.ge points ca. produce da.a.segments corresponding to different opera.ing modes or va.ying conditions,which will be useful for other ma.hine lea.ning ta.ks.

关键词： Cha.ge point detection unsupervisedma.hine lea.ning optimisa.ion Ba.esia. sta.istics Tikhonov regularisation

Microstructures,Strength Cha.a.teristics a.d Wea. Beha.ior of the Fe-ba.ed P/M Composites a.ter Sintering or Infiltra.ion with Cu–Sn a.loy

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Journa. of Ma.eria.s Science & Technology 2015年第12期31卷 1226-1231页

作者： larisa N.Dya.hkova.Eugene E.Feldshtein Institute of Powder Meta.lurgy Belarusian National Academy of Sciences Depa.tment of Mecha.ica. Engineering University of Zielona Góra

Some properties of the Fe-ba.ed P/M composites sintered a.d reinforced by infiltra.ion with Cu-Sn a.loy were *** is shown tha. the ha.dness of the sintered ma.eria. is 2.5 times lower,tensile strength is 1.7 times lower a.d the wea. resista.ce is 2.5-3.3 times lower in compa.ison with those of the infiltra.ed *** presence of pores on the friction surfa.e of the sintered ma.eria. a.fects the fea.ures of the wea. *** to the specific morphology of copper in the infiltra.ed ma.eria.,the phenomenon of selective ma.s tra.sfer is observed a.d worn surfa.es ha.e a.spongy-ca.illa.y texture.

关键词： Meta. ma.rix composites(MMCs) Sintering Infiltra.ion Strength cha.a.teristics Wea.

a.texture-modified dessert with high nutritiona. va.ue designed for people with dyspha.ia.effect of refrigera.ion a.d frozen stora.e

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Food Science a.d Huma. Wellness 2024年第1期13卷 462-471页

作者： Ma.ía.Ca.ta.ena.larisa Giura.Dia.a.a.sorena.Icia. a.tia.a.a. Depa.tment of Nutrition Food Science and PhysiologyFaculty of Pharmacy and NutritionUniversidad de NavarraC/Irunlarrea s/nPamplona 31008Spain Center for Nutrition Resea.ch University of Navarrac/Irunlarrea 1Pamplona 31008Spain Instituto de Investiga.ión Sa.ita.ia.de Na.a.ra IDISNAPamplona 31008Spain Na.iona. Centre for Food Technology a.d Sa.ety(CNTa.—Technology a.d Knowledge for Food Sector Competitiveness NavarreCrta-Na 134-km 53San Adrian 31570Spain

Dyspha.ia.is commonly a.socia.ed with ma.nutrition a.d a. increa.ed choking *** overcome these complica.ions,food designed for people with dyspha.ia.should ha.e a. a.propria.e texture a.d a.high nutritiona. *** this study,six formula.ions of a.stra.berry dessert enriched in protein(ca.cium ca.eina.e)a.d fiber(whea. dextrin or inulin)were developed using different hydrocolloids(xa.tha. gum,ca.boxymethyl cellulose or modified sta.ch)to provide desira.le texture a.d *** va.ue wa. ca.cula.ed a.d tota. phenolic content a.d a.tioxida.t a.tivity of the sa.ples were ***-extrusion test,rheologica. mea.urements a.d sensory a.a.ysis were performed in refrigera.ed a.d frozen sa.ples to cha.a.terize their textura. a.d viscoela.tic *** high content in protein(14.7 g/100 g)a.d fiber(7.9-8.7 g/100 g)ma.e possible to use the cla.ms“high protein”a.d“high fiber”.Phytochemica.s supplied by stra.berries contributed to the a.tioxida.t properties of the *** ta.gent ra.ged 0.28-0.35 for a.l the formula.ions,indica.ing a.wea. gel beha.ior,which could be considered sa.e to *** formula.ions with dextrin in combina.ion with ca.boxymethyl cellulose or xa.tha. gum seemed to be less susceptible to structura. cha.ges during frozen *** work provides insights for the development of a.nutrient-dense dessert tha. meets the requirements of people with dyspha.ia.

关键词： Ma.nutrition Texture-modified-food Hydrocolloids Viscoela.tic properties Food texture

Evolution of structure a.d physica. properties in a.-substituted Ba.hexa.errites

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Chinese Physics B 2016年第1期25卷 706-711页

作者： a.ex Trukha.ov larisa Pa.ina.Sergei Trukha.ov Vita.ii Turchenko Moha.ed Sa.em Na.iona. University of Science a.d Technology MISiS 119049MoscowLeninsky Prospckt4Russia SSPa.Scientific a.d Pra.tica. Ma.eria.s Resea.ch Centre of Na. of Bela.us 220072 RBMinsk19 P.Brovki Str.Russia Joint Institute for Nuclea. Resea.ch 141980Dubna6 Joliot-Curie StreetRussia

The investiga.ions of the crysta. a.d ma.netic structures of the Ba.e12_xa.xO19 （x = 0.1-1.2） solid solutions ha.e been performed with powder neutron diffra.tometry. Ma.netic properties of the Ba.e12_xa.xOt9 （x = 0.1-1.2） solid solutions ha.e been mea.ured by vibra.ion sa.ple ma.netometry a. different tempera.ures under different ma.netic fields. The a.omic coordina.es a.d la.tice pa.a.eters ha.e been Rietveld refined. The inva. effect is observed in low tempera.ure ra.ge （from 4.2 K to 150 K）. It is expla.ned by the therma. oscilla.ion a.ha.monicity of a.oms. The increa.e of microstress with decrea.ing tempera.ure is found from Rietveld refinement. The Curie tempera.ure a.d the cha.ge of tota. ma.netic moment per formula.unit a.e found for a.l compositions of the Ba.et2_xa.xO19 （x = 0.1-1.2） solid solutions. The ma.netic structure model is proposed. The most likely rea.ons a.d the mecha.ism of ma.netic structure forma.ion a.e discussed.

关键词： ba.ium hexa.errites neutron diffra.tion crysta. a.d ma.netic structures

Unusua. self-a.sembled na.oa.grega.ion of the therma.ly sta.le meta.-free slipped-cofa.ia. J-type phtha.ocya.ine dimer

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Chinese Chemica. Letters 2017年第1期28卷 89-91页

作者： a.exa.der Yu.Tolbin larisa G.Tomilova Institute of Physiologica.ly a.tive Compounds Russian Academy of Sciences Depa.tment of Chemistry M. V. Lomonosov Moscow State University

Na.oa.grega.ion of the therma.ly sta.le bis（2-hydroxy-9（10）,16（17）,23（24）-tri-tert-butylphtha.ocya.ine） of J-type wa. observed by the field emission sca.ning electron microscopy（FE-SEM）. Ordered pha.es, represented a. threa.s composed of a.out 200 nm dia.eter circles were discovered, unlike the pa.ent dimeric ma.nesium complex, in which simila. circles combine together to give visua.ly distinguisha.le zones with widths of a.out 600 nm a.d the sa.e dista.ce between them.

关键词： Na.oa.grega.ion Phtha.ocya.ine J-type dimer Electron microscopy

a.R TIGHTNESS OF STRa. Ba.E CONSTRUCTION

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Journa. of Green Building 2015年第1期10卷 99-113页

作者： larisa Broja. Ben Weil Peggi L.Clouston University of Ljublja.a Faculty of ArchitectureZoisova 12SI-1000 Ljubljana Dept.of Environmenta. Conserva.ion University of MassachusettsAmherst MA 01003

Stra. ba.e construction offers a.renewa.le,susta.na.le a.d proven a.terna.ive to ma.nstrea. building methods;still,little is known a.out its a.rflow *** this end,the intent of this pa.er is to eva.ua.e a.rtightness of fully constructed a.d pla.tered stra. ba.e wa.ls a. well a. individua. pla.n stra. *** first experiment enta.led mea.uring the influence of stra. ba.e orienta.ion on a.rflow cha.a.teristics with the finding tha. stra. ba.e considered a.one ha. poor a.r flow-reta.ding cha.a.teristics a.d tha. pla.ter is the prima.y a.r ba.rier.a.second experiment involved thirty pla.tered stra. ba.e specimens using three different pla.ter *** this experiment,a.cra.k gra.ing system wa. developed a.d is herein proposed a. a.tool to eva.ua.e pla.ter performa.ce a. a. a.r ba.rier.a.third experiment va.ida.ed the cra.k gra.e system through a.plica.ion on four fully constructed stra. ba.e *** use of the cra.k gra.ing system wa. demonstra.ed on a.ca.e study stra. ba.e house in Ra.omlje,Slovenia.where the predicted a.r tightness results were va.ida.ed through compa.ison to results of blower door tests.

关键词： Stra. ba.e a.r tightness edge fla. pla.ter ma.eria. cra.k gra.ing systema.r

Yin a.d Ya.g of mesenchyma. stem cells a.d a.la.tic a.emia

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World Journa. of Stem Cells 2017年第12期9卷 219-226页

作者： larisa Broglie Da.id Ma.golis Jeffrey a.Medin Depa.tment of Pedia.rics Medical College of Wisconsin Depa.tments of Pedia.rics a.d Biochemistry Medical College of Wisconsin

a.quired a.la.tic a.emia.a.) is a.bone ma.row fa.lure syndrome cha.a.terized by periphera. cytopenia. a.d bone ma.row hypopla.ia. It is ultima.ely fa.a. without trea.ment, most commonly from infection or hemorrha.e. Current trea.ments focus on suppressing immune-media.ed destruction of bone ma.row stem cells or repla.ing hema.opoietic stem cells(HSCs) by tra.spla.ta.ion. Our incomplete understa.ding of the pa.hogenesis of a. ha. limited development of ta.geted trea.ment options. Mesenchyma. stem cells(MSCs) pla. a.vita. role in HSC prolifera.ion; they a.so modula.e immune responses a.d ma.nta.n a. environment supportive of hema.opoiesis. Some of the observed clinica. ma.ifesta.ions of a. ca. be expla.ned by mesenchyma. dysfunction. MSC infusions ha.e been shown to be sa.e a.d ma. offer new a.proa.hes for the trea.ment of this disorder. Indeed, infusions of MSCs ma. help suppress a.to-rea.tive, T-cell media.ed HSC destruction a.d help restore a. environment tha. supports hema.opoiesis. Sma.l pilot studies using MSCs a. monothera.y or a. a.juncts to HSC tra.spla.ta.ion ha.e been a.tempted a. trea.ments for a.. Here we review the current understa.ding of the pa.hogenesis of a. a.d the function of MSCs, a.d suggest tha. MSCs should be a.ta.get for further resea.ch a.d clinica. tria.s in this disorder.

关键词： Hema.opoiesis Ta.geted thera.ies Stem cells Hema.opoietic stem cell tra.spla.ta.ion a.la.tic a.emia Mesenchyma. stem cells