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Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

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Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： Jiawen Zhang Sihui Yu Qiao Peng Ping wang lan fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

Guidelines for integrating ecological and biological engineering technologies for control of severe erosion in mountainous areas-A case study of the Xiaojiang River Basin,China

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International Soil and Water Conservation Research 2017年第4期5卷 335-344页

作者： Songtang He Daojie wang Yingchao fang Huijuan lan Key Laboratory of Mountain Hazards and Earth Surface Processes Chinese Academy of SciencesChengdu 610041China Institute of Mountain Hazards and Environment Chinese Academy of Science&Ministry of Water ConservancyChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China

Ecological environment issues caused by soil erosion have always been the attractive and significant problems all over the *** the background of global warming,debris flow,landslide,and other intense gravitational erosion activities have become aggravated,which leads to the decrease of biological diversity,ecosystem stability,resistance,productivity,and the like,which presents new challenges to traditional measures of soil and water *** article,based on research conducted on controlling mountain hazard on the Xiaojiang River basin over the last 30 years,summarizes the managerial achievement of typical ecological engineering technologies and analyzes the principles and application of each type of *** results indicated that established ecological engineering technologies play a significant role in the prevention and treatment of intense gravitational erosion caused by mountain ***,there are still a great deal of limitation of application condition and maneuverability during management *** to furtherly develop the rational combining pattern between ecological engineering(*** hedgerow)and geotechnical engineering(*** dam)and how to strengthen the risk control and improve management strategy will be the key points for preventing intense gravitational erosion in future by ecological engineering.

关键词： Soil and water conservation Ecological engineering Gravitational erosion Risk control Mountain hazards

Tao-Hong-Si-Wu Decoction promotes angiogenesis after cerebral ischaemia in rats via platelet microparticles

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Chinese Journal of Natural Medicines 2020年第8期18卷 620-627页

作者： CHEN fang-fang wang Meng-Meng XIA Wen-Wen PENG Dai-Yin HAN lan School of Pharmacy Anhui University of Chinese MedicineHefei 230012China Anhui Province Key Laboratory of Chinese Medicinal Formula Hefei 230012China Key Laboratory of Xin’an Medicine Ministry of EducationAnhui University of Chinese MedicineHefei 230012China

Platelet microparticles(PMPs)are membrane particles derived from the platelet membrane that enter into the blood *** sought to explore the therapeutic effects of Tao-Hong-Si-Wu Decoction(THSWD)on angiogenesis in a rat model of cerebral ischaemia-reperfusion(I/R).The protective effect of THSWD on I/R rats was observed morphologically by immunohistochemical expression of VEGF and CD34,along with immunofluorescence results of co-expression of Brd U and v ***,PMPs from different groups of rats were extracted,and cytokine array analysis was used to screen for angiogenesis associated *** results showed that THSWD can promote the expression of VEGF,CD34,Brd U and v *** array analysis revealed the changes in the expression of 29 related angiogenic proteins in the total protein of PMPs,which involved the Notch signalling *** with model group,the expression levels of NICD and Hes-1 in the THSWD group were significantly *** the context of I/R,the angiogenesis-related proteins of PMPs are *** may involve the promotion of activation of the Notch signalling pathway to achieve therapeutic effects on cerebral ischaemia.

关键词： Tao-Hong-Si-Wu Decoction Platelet microparticles Cerebral ischaemia–reperfusion Angiogenesis

Preparation and Evaluation of iPP/GO Microfiltration Membrane with Enhanced Antifouling Property

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Chemical Research in Chinese Universities 2018年第5期34卷 833-838页

作者： wang fang ZHAO Yajing wang Xin LI Yingdong CHENG lan LI Pingli School of Chemical Engineering and Technology Tianjin University Tianjin 300350 P. R. China Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin University Tianfin 300350 P. R. China Qingdao Institute for Ocean Engineering of Tianjin University Qingdao 266235 P. R. China

Isotactic polypropylene（iPP） and graphene oxide（GO）, dispersed in dibutyl phthalate（DBP） and dioctyl phthalate（DOP）, were blended to prepare organic-inorganic-blended microfiltration membranes using thermally induced phase separation（TIPS）. These membranes were characterized by scanning electron microscopy（SEM）, Fourier transform infrared spectroscopy（FTIR）, contact angle measurements, mechanical properties, permeation tests, and porosity measurements. The morphology studied by SEM shows larger pores of the GO-blended membranes when compared to those of unmodified iPP membranes. Composite iPP/GO membranes achieve better performance in terms of water fluxes and pure water fluxes recovery ratio due to the hydrophilic nature of GO when compared with the pure iPP membranes. The addition of GO increases the permeability and the tensile strength by 352.98% and 123%, respectively, and also decreases the contact angle from 125° to 52.33°. We concluded that the composite membrane with 0.3% GO has the best antifouling ability of the membranes tested because it has the highest values of mean pore radius, porosity, and water flux observed in this study.

关键词： Isotactic polypropylene(iPP) Graphene oxide Thermally induced phase separation Microfiltmtion membrane Antifouling

IP-10 and fractalkine induce cytotoxic phenotype of murine NK cells

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Science Bulletin 2016年第3期61卷 202-211页

作者： fang Liu Junfang Qin Hongyao Zhang Ning Li Meihua Shan lan lan Yue wang Key Lab of-Animal Models and Neurodegenerative Diseases Medical School of Nankai University Tianjin 300071 China State Key Laboratory of Medical Chemical Biology of NankaiUniversity Tianjin 300071 China Tianjin Cancer Hospital of Tianjin Medical University Tianjin 300060 China

We characterized the murine NK cell subsets of the tumor microenvironment （TME） with low expressions of CD16 and NKG2D and investigated the chemokines that deter CD 16~~w NKG2Dl^w subsets. Our results demonstrated the activation of primary and KY- 1 NK cell by ligands and found that exogenous CXCL10/interferon-gamma-induced protein 10 （IP-10） and fractalkine （FKN） can up-regulate the expression of CD 16 and NKG2D. Moreover, both IP-10 and FKN are shown to facilitate migration, adhesion and cyto- toxicity of NK cell subsets of the TME, due to the up-regu- lated CD16 and NKG2D. Overall, our data provide a new path by which to enhance murine NK cell cytotoxic potential and improve the quality of NK cells of the TME.

关键词： Chemokines NK cell Activating receptors Tumor microenvironment

General decay asymptotic stability of neutral stochastic differential delayed equations with Markov switching

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Frontiers of Mathematics in China 2019年第4期14卷 793-818页

作者： Guangqiang lan fang XIA College of Mathematics and Physics Beijing University of Chemical Technology Beijing 100029 China

The p-th moment and almos t sure st ability with general decay rate of the exact solutions of neutral stochastic differential delayed equations with Markov switching are investigated under given conditions. Two exampl... 详细信息

关键词： Neutral stochastic differential delayed equations with Markov switching (NSDDEswMS) global solution general decay rate, p-th moment stability almost sure st ability

Ultrasonic vibration assisted tungsten inert gas welding of dissimilar metals 316L and L415

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International Journal of Minerals,Metallurgy and Materials 2020年第7期27卷 943-953页

作者： Hong-xia lan Xiu-fang Gong Sen-feng Zhang Liang wang Bin wang Li-ping Nie School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China State Key Laboratory of Long-life High Temperature Materials Dong Fang Turbine Co.Ltd.Deyang 618000China China National Erzhong Group Deyang Wanhang Die Forging Co. Ltd.Deyang 618000China School of Engineering Southwest Petroleum UniversityNanchong 637800China

Ultrasonic vibration assisted tungsten inert gas welding was applied to joining stainless steel 316 L and low alloy high strength steel *** effect of ultrasonic vibration on the microstructure and mechanical properties of a dissimilar metal welded joint of 316 L and L415 was systematically *** microstructures of both heat affected zones of L415 and weld metal were substantially refined,and the clusters ofδferrite in traditional tungsten inert gas(TIG)weld were changed to a dispersive distribution via the ultrasonic *** ultrasonic vibration promoted the uniform distribution of elements and decreased the micro-segregation tendency in the *** the application of ultrasonic vibration,the average tensile strength and elongation of the joint was improved from 613 to 650 MPa and from 16.15%to31.54%,*** content ofΣ3 grain boundaries around the fusion line zone is higher and the distribution is more uniform in the ultrasonic vibration assisted welded joint compared with the traditional one,indicating an excellent weld metal crack resistance.

关键词： ultrasonic vibration dissimilar metal welding microstructure mechanical properties micro-segregation electron backscatter diffraction

Performance Analysis of Hybrid Distribution in Human-Centric Multimedia Networking

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Chinese Journal of Electronics 2016年第4期25卷 761-767页

作者： HU Yuxiang DONG fang lan Julong National Digital Switching System Engineering and Technological Research Center

With the booming of Human-centric multimedia networking(HMN),there are rising amount of human-made multimedia that needs to distribute to consumers with higher speed and *** distribution of Client/Server(C/S) and Peer-to-Peer(P2P) have been successfully deployed on the Internet and the practical benefits have been widely reported,while its theoretical performance remains unknown for mass data delivery *** paper presents an analytical and experimental study on the performance of accelerating large-scale hybrid distribution over the *** particular,this paper focuses on the user behavior in HMN and establishes a user behavior model based on the Kermack-McK endrick model in *** expressions of average delay in HMN are then derived based on C/S,P2 P and hybrid distribution,*** simulation shows how to design and deploy a hybrid distribution system of HMN that helps to bridge the gap between system ultilization and quality of service,which provides direct guidance for practical system design.

关键词： Hybrid distribution Peer-to-peer Client/server Behaviour model Performance analysis

Ferroptosis regulating lipid peroxidation metabolism in the occurrence and development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2781-2792页

作者： lan-Mei wang Wei-Wei Zhang Ying-Yang Qiu fang wang Department of Clinical Laboratory Anqiu People's HospitalWeifang 262123Shandong ProvinceChina Department of Gastroenterology Feicheng People's HospitalTai’an 271600Shandong ProvinceChina Yong Loo Lin School of Medicine National University of Singapore119077Singapore Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the world,and its occurrence and development involve complex biological *** death,as a new cell death mode,has attracted wide attention in recent ***,the regulatory mechanism of iron death in gastric cancer and its effect on lipid peroxidation metabolism remain *** To explore the role of iron death in the development of gastric cancer,reveal its relationship with lipid peroxidation,and provide a new theoretical basis for revealing the molecular mechanism of the occurrence and development of gastric *** The process of iron death in gastric cancer cells was simulated by cell culture model,and the occurrence of iron death was detected by fluorescence microscopy and flow *** changes of gene expression related to iron death and lipid peroxidation metabolism were analyzed by high-throughput sequencing *** addition,a mouse model of gastric cancer was established,and the role of iron death in vivo was studied by histology and immunohistochemistry,and the level of lipid peroxidation was *** methods comprehensively and deeply reveal the regulatory mechanism of iron death on lipid peroxidation metabolism in the occurrence and development of gastric *** Iron death was significantly activated in gastric cancer cells,and at the same time,associated lipid peroxidation levels increased *** high-throughput sequencing analysis,it was found that iron death regulated the expression of several genes related to lipid *** vivo experiments demonstrated that increased iron death in gastric cancer mice was accompanied by a significant increase in lipid *** This study confirmed the important role of iron death in regulating lipid peroxidation metabolism in the occurrence and development of gastric *** activation of iron death significantly increased lipid peroxidation levels,revealing it

关键词： Ferroptosis Lipid peroxidation Gastric cancer Lipid metabolism Systematic review