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Glucose measurement via Raman spectroscopy of graphene:Principles and operation

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Nano Research 2022年第10期15卷 8697-8704页

作者： Alireza Ahmadianyazdi Ngoc Hoang lan nguyen Jie Xu Vikas Berry Department of Mechanical and Industrial Engineering University of Illinois at ChicagoChicagoIllinois 60607USA Department of Chemical Engineering University of Illinois at ChicagoChicagoIllinois 60607USA

The sensitivity of graphene’s Raman characteristics to external perturbations can be exploited for sensing *** apply this principle,Raman spectroscopy of graphene in contact with a chemical/biological analyte is recorded to unravel a correlation between analyte’s physical/chemical/biological properties and electronic properties(Fermi energy and dopants level)of *** an example,we demonstrate the principle and operation of glucose measurement using graphene’s Raman spectroscopy,utilizing both affinity and enzymatic detection *** the affinity detection,we monitor Raman spectrum of graphene in contact with a glucose containing sample to quantify the attachment of glucose onto 1-pyrene boronic acid(PBA)functionalized *** is revealed that glucose covalent bond to PBA induces n-type doping in graphene and increases its Fermi level following the Hill–langmuir *** the enzymatic detection,we show that graphene’s Fermi energy shifts due to the biocatalytic oxidation of glucose by immobilized glucose oxidase(GOx)*** a result,graphene becomes p-doped with increasing glucose *** attribute this sensitivity to a re-distribution of ionic charges within the electric double layer(EDL)of graphene upon introducing the glucose *** model explains both our affinity and enzymatic glucose detection *** glucose detection,our graphene Raman spectroscopy-based sensor(GRS)may extend its applications to a broader range of remote and non-invasive detection without the need to employ electronics such as field-effect transistors.

关键词： graphene Raman spectroscopy glucose affinity detection glucose oxidase

How to duplicate the procedural success of coronary interventions by the radial approach:tips and tricks in the selection and manipulations of guides

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Journal of Geriatric Cardiology 2007年第1期4卷 17-19页

作者： Thach nguyen lan nguyen St Mary Medical Center Hobart IN 46342 USA

　　In this issue of the Journal of Geriatric Cardiology;Jing et al. showed off their near perfect results of percutaneous coronary interventions (PCI) through transfemoral approach (TFA) and transradial approach (TRA... 详细信息

关键词： How to duplicate the procedural success of coronary interventions by the radial approach LAD

First Records of Megophrys daweimontis Rao and Yang, 1997 and Amolops vitreus(Bain, Stuart and Orlov, 2006)(Anura: Megophryidae, Ranidae) from Vietnam

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Asian Herpetological Research 2015年第1期6卷 66-72页

作者： Dzung Trung LE Anh Van PHAM Son Hung lan nguyen Thomas ZIEGLER Truong Quang nguyen Faculty of Biology Hanoi National University of Education Faculty of Biology and Chemistry Tay Bac University AG Zoologischer Garten Kln Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology

Two amphibian species,Megophrys daweimontisandAmolops vitreus,are recorded for the ifrst time from Vietnam, on the basis of a new amphibian collection from Dien Bien and Son La provinces. In addition, acoustic analysis ofA. vitreus is also provided based on the advertisement calls recorded in Muong Nhe Nature Reserve of Dien Bien Province, Vietnam.

关键词： Amolops vitreus Megophrys daweimontis new records advertisement call Dien Bien Province Son La Province

Antidiabetic and antioxidant activities of red seaweed Laurencia dendroidea

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Asian Pacific Journal of Tropical Biomedicine 2019年第12期9卷 501-509页

作者： The Han nguyen Thi Huyen nguyen Van Minh nguyen Thi lan Phuong nguyen Thi Van Anh Tran Anh Duy Do Sang Moo Kim Faculty of Food Technology Nha Trang University02 Nguyen Dinh Chieu StreetNha Trang CityKhanh HoaVietnam Quality Control Department Institute of Vaccines and Medical BiologicalsNha Trang CityKhanh HoaVietnam Faculty of Pharmacy University of Medicine and Pharmacy of Ho Chi Minh City41 Dinh Tien Hoang StreetHo Chi Minh CityVietnam Research Department of Marine Conservation Research Institute for Marine Fisheries224 Le Lai StreetHai Phong CityVietnam Department of Marine Food Science and Technology Gangneung-Wonju National University7 Jukheon-gilGangneung 25457Republic of Korea

Objective:To investigate antidiabetic and antioxidant activities of the extract and fractions from Vietnamese red seaweed Laurencia ***:The seaweed Laurencia dendroidea was extracted by using microwave-assisted extraction method in 80%*** seaweed extract was then fractionated using different solvents(n-hexane,chloroform,ethyl acetate,butanol and water).These obtained fractions were evaluated forα-glucosidase inhibitory and antioxidant *** activities were tested using DPPH,nitric oxide radical scavenging and metal chelating *** enzyme inhibition mode was determined using Lineweaver-Burk *** acidic and thermal stabilities,the ethyl acetate fraction was treated at pH 2.0 and 100℃,*** residual inhibitory activity of the fraction was calculated based on the initial inhibitory *** in vivo antidiabetic activity,mice were divided into four groups,including normal control,diabetic control,diabetic mice treated with ethyl acetate fraction and diabetic mice treated with *** glucose level of treated mice during acute and prolonged treatments was *** evaluate the toxicity of the ethyl acetate fraction,the body weight changes and activities of liver function enzymes(aspartate transaminase,alanine transaminase and gammaglutamyl transferase)were carried ***:The extract of Laurencia dendroidea showed strongα-glucosidase inhibitory and DPPH radical scavenging *** concentrations affected bothα-glucosidase inhibitory and antioxidant activities.A 80%aqueous methanol was the suitable solvent for extraction of enzyme inhibitors and *** solvent fractions,ethyl acetate fraction had the highest inhibitory activities againstα-glucosidase with a mixed type of inhibition and the strongest antioxidant activities,and was stable under acidic and thermal *** ethyl acetate fraction treated diabetic mice significantly reduced blood glucose level compare

关键词： α-Glucosidase inhibitor Antidiabetic Antioxidant Red seaweeds Vietnam

Same fur,different animals

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Journal of Geriatric Cardiology 2007年第3期4卷 186-187页

作者： lan nguyen Priscilla Wan Thach nguyen BS in Aeronautics University of Texas in DallasDallas TXUSA University of Texas in Dallas Dallas TXUSA Director of Cardiology Community Health SystemSt Mary Medical CenterHobart INUSA

　　Slow flow is not an uncommon phenomenon for cardiologists. It can happen in many clinical scenarios, requires different tools of investigation and responds to various modalities of treatment.……

关键词： PCI Same fur,different animals

Sulphur vacancy defects engineered metal sulfides for amended photo(electro)catalytic water splitting: A review

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Journal of Materials Science & Technology 2023年第21期152卷 50-64页

作者： Kusum Sharma Abhinandan Kumar Tansir Ahamad Quyet Van Le Pankaj Raizada Archana Singh lan Huong nguyen Sourbh Thakur Van-Huy nguyen Pardeep Singh School of Advanced Chemical Sciences Shoolini UniversitySolanHimachal Pradesh 173212India Department of Chemistry College of ScienceKing Saud UniversitySaudi Arabia Department of Materials Science and Engineering Korea University145AnamroSeongbuk-guSeoul 02841Republic of Korea Advanced Materials and Processes Research Institute Hoshangabad RoadBhopalMP 462026India Faculty of Biology and Environment Ho Chi Minh City University of Food Industry(HUFI)140 Le Trong Tan StreetTay Thanh WardTan Phu DistrictHo Chi Minh CityVietnam Department of Organic Chemistry Bioorganic Chemistry and BiotechnologySilesian University of TechnologyB.Krzywoustego 444-100 GliwicePoland Faculty of Allied Health Sciences Chettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkam-603103Tamil NaduIndia

Vacancy engineering in metal sulfides has garnered enormous attention from researchers because of their outstanding ability to modulate the optical and physiochemical properties of ***,in the case of sulfides,the catalytic activity is drastically hindered by the quick reassembly of excitons and the photocorrosion *** designing and generating S-vacancies in metal sulfides has emerged as a potential strategy for attaining adequate water splitting to generate H_(2) and O_(2) because of the simulta-neous improvement in the optoelectronic ***,developing efficient catalysts that manifest optimal photo(electro)catalytic performance for large-scale applicability remains ***,it is of utmost interest to explore the insightful features of creating S-vacancy and study their impact on catalytic *** review article aims to comprehensively highlight the roles of S-vacancy in sulfides for amended overall water-splitting *** photocatalytic features of S-vacancies modulated metal sulfides are deliberated,followed by various advanced synthetic and characterization techniques for effectual generation and identification of vacancy *** specific aspects of S-vacancies in refin-ing the optical absorption range charge carrier dynamics,and photoinduced surface chemical reactions are critically examined for overall water splitting ***,the vouchsafing outlooks and op-portunities confronting the defect-engineered(S-vacancy)metal sulfides-based photocatalysts have been summarized.

关键词： S-vacancy Photo(electro)catalysis Metal sulfides Water splitting Engineering Identification of S-vacancies

Network rewiring,adaptive resistance and combating strategies in breast cancer

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Cancer Drug Resistance 2019年第4期2卷 1106-1126页

作者： Constance Gaya Cremers lan K.nguyen Department of Biochemistry and Molecular Biology School of Biomedical SciencesMonash UniversityClaytonVictoria 3800Australia Biomedicine Discovery Institute Monash UniversityClaytonVictoria 3800Australia

Resistance to targeted anti-cancer drugs is a complex phenomenon and a major challenge in cancer *** is becoming increasingly evident that a form of acquired drug resistance known as“adaptive resistance”is a common cause of treatment failure and patient relapse in many *** classical resistance mechanisms that are acquired via genomic alterations,adaptive resistance is instead driven by non-genomic changes involving rapid and dynamic rewiring of signalling and/or transcriptional networks following therapy,enabled by complex pathway crosstalk and feedback *** network rewiring allows tumour cells to adapt to the drug treatment,circumvent the initial drug challenge and continue to survive in the presence of the *** its great clinical importance,adaptive resistance remains largely under-studied and poorly *** review is focused on recent findings which provide new insights into the mechanisms underlying adaptive resistance in breast cancer,highlighting how breast tumour cells rewire intracellular signalling pathways to overcome the stress of initial targeted *** particular,we investigate adaptive resistance to targeted inhibition of two major oncogenic signalling axes frequently dysregulated in breast cancer,the PI3K-AKT-mTOR and RAS-MAPK signalling pathways;and discuss potential combination treatment strategies that overcome such *** addition,we highlight application of quantitative and computational modelling as a novel integrative and powerful approach to gain network-level understanding of network rewiring,and rationally identify and prioritise effective drug combinations.

关键词： Network rewiring adaptive resistance PI3K signalling MAPK signalling breast cancer mathematical modelling systems analysis

Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions

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Neural Regeneration Research 2020年第4期15卷 739-747页

作者： lan Huong nguyen William Ong Kai Wang Mingfeng Wang Dean Nizetic Sing Yian Chew School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Blizard Institute Barts&The London School of MedicineQueen Mary University of LondonLondonUK NUS Synthetic Biology for Clinical and Technological Innovation(SynCTI) Life Sciences InstituteNational University of SingaporeSingapore

MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific *** overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which may enhance axonal remyelination after nerve injuries in the central nervous system(CNS).As such,the delivery of miR-219/miR-338 to the CNS to promote oligodendrocyte precursor cell differentiation,maturation and myelination could be a promising approach for nerve ***,nerve injuries in the CNS also involve other cell types,such as microglia and ***,we investigated the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in *** found that miR-219/miR-338 diminished microglial expression of pro-inflammatory cytokines and suppressed astrocyte *** addition,we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in ***,our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve *** experimental procedures were approved by the Institutional Animal Care and Use Committee(IACUC),Nanyang Technological University(approval No.A0309 and A0333)on April 27,2016 and October 8,2016.

关键词： central nervous system electrospinning gene silencing glia hydrogel myelination nanofibers oligodendroglial polycaprolactone spinal cord injury

Seroprotection after hepatitis B vaccination amongst infants aged between 12 and 24 months in Ho Chi Minh City, Vietnam

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Asian Pacific Journal of Tropical Medicine 2020年第7期13卷 295-300页

作者： Giao Huynh Quang Vinh Bui Ngoc lan nguyen Le An Pham Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Department of Pediatrics University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Department of Microbiology and Parasitology University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Center for training of Family Medicine University of Medicine and Pharmacy at Ho Chi Minh City Vietnam

Objective:To assess levels of HBs Ab amongst infants who received hepatitis B vaccine in the Expanded Program on Immunization in ***:A cross-sectional study was carried out at 16 community health centers from February 2016 to July *** infants were tested for HBs Ab and HBs *** questionnaires were used to collect relevant information about the demographics of the parents/caregivers and their infants after physical ***:A total of 199 eligible infants were selected with a mean age of(17.3±4.5)*** antibody levels with HBs Ab≥10 m IU/m L were detected in 68.3%of *** these,antibody levels from 10 to 99 m IU/m L were 48.5%of those tested and antibody levels≥100 ml U/m L were recorded as 51.5%.No cases were recorded of being infected with hepatitis B *** rate of positive HBs Ab level in those who were not wasting and≥18 months old was less than that among those who were<18 months old(OR 0.49,95%CI:0.26-0.92,P<0.05)while the infants with wasting and<18 months were less likely to be positive HBs Ab than those who were not wasting and of the same age group(OR 0.15,95%CI:0.04-0.55,P<0.05).Conclusions:Seroprotection against hepatitis B virus was low in the infants tested(at 68.3%),which suggests that the hepatitis B vaccine should be administered with one additional dose for infants between 12 and 24 months of age,particularly those with wasting.

关键词： Hepatitis B virus Hepatitis B Vaccine Vaccination Expanded Program on Immunization