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Key genes and regulatory networks for diabetic retinopathy based on hypoxia-related genes:a bioinformatics analysis

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1411-1417页

作者： Cai-Han Yu Cai-Xia Wu Dai Li lan-lan gong Xu-Dong Lyu Jie Yang Department of Ophthalmology Xianning Central HospitalThe First Affiliated Hospital of Hubei University of Science and TechnologyXianning 437100Hubei ProvinceChina School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100Hubei ProvinceChina School of Optometry Hubei University of Science and TechnologyXianning 430071Hubei ProvinceChina

AIM:To prevent neovascularization in diabetic retinopathy(DR)patients and partially control disease ***:Hypoxia-related differentially expressed genes(DEGs)were identified from the GSE60436 and GSE102485 datasets,followed by gene ontology(GO)functional annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** candidate drugs were screened using the CMap ***,a protein-protein interaction(PPI)network was constructed to identify hypoxia-related hub genes.A nomogram was generated using the rms R package,and the correlation of hub genes was analyzed using the Hmisc R *** clinical significance of hub genes was validated by comparing their expression levels between disease and normal groups and constructing receiver operating characteristic curve(ROC)***,a hypoxia-related miRNA-transcription factor(TF)-Hub gene network was constructed using the NetworkAnalyst online ***:Totally 48 hypoxia-related DEGs and screened 10 potential candidate drugs with interaction relationships to upregulated hypoxia-related genes were identified,such as ruxolitinib,meprylcaine,and *** addition,8 hub genes were also identified:glycogen phosphorylase muscle associated(PYGM),glyceraldehyde-3-phosphate dehydrogenase spermatogenic(GAPDHS),enolase 3(ENO3),aldolase fructose-bisphosphate C(ALDOC),phosphoglucomutase 2(PGM2),enolase 2(ENO2),phosphoglycerate mutase 2(PGAM2),and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3).Based on hub gene predictions,the miRNA-TF-Hub gene network revealed complex interactions between 163 miRNAs,77 TFs,and hub *** results of ROC showed that the except for GAPDHS,the area under curve(AUC)values of the other 7 hub genes were greater than 0.758,indicating their favorable diagnostic ***:PYGM,GAPDHS,ENO3,ALDOC,PGM2,ENO2,PGAM2,and PFKFB3 are hub genes in DR,and hypoxia-related hub genes exhibited favorable diagnostic perform

关键词： diabetic retinopathy hypoxia-related genes hub genes miRNA-TF-Hub gene drug prediction

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干眼新疗法:神经刺激促进自身泪液分泌

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中华实验眼科杂志 2024年第4期42卷 305-308页

作者：龚岚王吴双复旦大学附属眼耳鼻喉科医院眼科上海200031

干眼是一种常见的眼表疾病,通常由泪液分泌不足或质量不佳引起。干眼的治疗方法已有很多,但相当一部分患者治疗效果不理想,神经刺激疗法为这一难题带来了崭新的解决方案。神经刺激疗法的核心原理是通过刺激鼻部神经,借助鼻泪反射通路来... 详细信息

干眼是一种常见的眼表疾病,通常由泪液分泌不足或质量不佳引起。干眼的治疗方法已有很多,但相当一部分患者治疗效果不理想,神经刺激疗法为这一难题带来了崭新的解决方案。神经刺激疗法的核心原理是通过刺激鼻部神经,借助鼻泪反射通路来促进泪液分泌。与传统干眼治疗方法相比,神经刺激疗法的独特之处在于能够促使人体自身天然泪液的分泌,而不是简单地进行成分的外源性补充。从理论上讲,这种方法有望更有效地恢复泪膜的稳定性。神经刺激促进泪液分泌是一种有前景的干眼治疗新选择,许多相关设计已成功转化,陆续完成临床试验、上市,并正在不断地改进。在实际临床应用中,神经刺激疗法能显著促进使用后即刻的泪液分泌,亦有文献报道了其长期应用能够改善干眼的症状及体征,在干眼治疗中具有很好的应用前景。建议广大眼科临床医师及研究者关注神经刺激疗法在干眼治疗中的应用和研究,未来的研究方向应更着重于探讨神经刺激疗法改善干眼症状和体征的长期作用,探索神经刺激疗法如何融入已有的干眼诊疗规范中,推广神经刺激疗法以造福更多的干眼患者。

关键词：干眼疗法泪液神经刺激泪腺功能单位鼻泪反射

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基于脂质组学对5种常见禽蛋蛋黄脂质差异的研究

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中国家禽 2024年第3期46卷 71-78页

作者：赵航朱磊王冉龚兰江苏省农业科学院农产品质量安全与营养研究所江苏省食品质量安全重点实验室江苏南京210014 江苏农林职业技术学院江苏镇江212400

为研究鸭蛋、鹅蛋、鹌鹑蛋、鸽蛋及鸡蛋蛋黄所含脂质的差异,采用超高效液相色谱串联质谱对5种禽蛋黄进行脂质组学分析。结果显示,共检测到6类、26个亚类的1303种脂类。鸭与鸽的蛋黄、鸡与鹌鹑的蛋黄脂质成分相近,鹅蛋与其他蛋黄脂质成... 详细信息

为研究鸭蛋、鹅蛋、鹌鹑蛋、鸽蛋及鸡蛋蛋黄所含脂质的差异,采用超高效液相色谱串联质谱对5种禽蛋黄进行脂质组学分析。结果显示,共检测到6类、26个亚类的1303种脂类。鸭与鸽的蛋黄、鸡与鹌鹑的蛋黄脂质成分相近,鹅蛋与其他蛋黄脂质成分差异最大。鸡蛋黄鞘脂含量最丰富,鹌鹑蛋黄的甘油磷脂含量最高,鸽蛋黄甘油酯含量最低,鸭蛋黄及鸽蛋黄的甘油二酯与甘油三酯含量比值最高,鸭蛋黄及鸽蛋黄中ω-3多不饱和脂肪酸含量较高。与鸡蛋黄相比,其他禽蛋有33个脂质存在极显著差异(P<0.05、VIP≥1并且FC≥10或FC≤0.1)。研究表明,不同禽蛋黄含有的脂质存在显著差异,当对比甘油酯比例及ω-3多不饱和脂肪酸含量时,鸭蛋黄和鸽蛋黄较鸡蛋黄、鹅蛋黄、鹌鹑蛋黄有优势。

关键词：鸡蛋鸭蛋鹅蛋鹌鹑蛋鸽蛋非靶向脂质组学甘油磷脂甘油三酯 ω-3多不饱和脂肪酸

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Graphene oxide-derived single-atom catalysts for electrochemical energy conversion

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Rare Metals 2022年第5期41卷 1703-1726页

作者： Jian-Bin Liu Hai-Sheng gong gong-lan Ye Hui-Long Fei State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Sustainable electrochemical energy conversion is considered as a promising solution to energy crises and environmental issues. Owing to their maximized utilization efficiency and excellent catalytic performance, single-atom catalysts(SACs) have obtained tremendous attention in the field of electrochemical energy conversion. In the last few years, graphene oxide(GO) has been considered to be a promising precursor for fabricating graphene-supported SACs due to its advantageous features such as large surface area, high density of intrinsic defects, and scalability. In this review, the recent advances in the preparation of graphene oxide-derived single-atom catalysts(GO-SACs) and their diverse electrochemical applications are ***, the synthetic strategies of GO-SACs are discussed with focuses on the advantages and shortages of each method. Subsequently, the electrochemical applications of GO-SACs in various energy conversion processes,including the oxygen reduction reaction(ORR), oxygen evolution reaction(OER), hydrogen evolution reaction(HER), nitrogen reduction reaction(NRR), and carbon dioxide reduction reaction(CO;RR), are discussed in detail. Finally, the remaining challenges and future prospects in the fabrication and application of GO-SACs are presented.

关键词： Single-atom catalysts Graphene oxide Electrocatalysis Energy conversion

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PSA study of the effect of extreme snowfall on a floating nuclear power plant:case study in the Bohai Sea

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Nuclear Science and Techniques 2023年第11期34卷 212-225页

作者： lan‑Xin gong Qing‑Zhu Liang Chang‑Hong Peng School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China

This study presents a probabilistic safety analysis(PSA)method for the external event of extreme snowfall on a floating nuclear power plant(FNPP)deployed in the Bohai *** utilized the Weibull and Gumbel extreme value distributions to fit the collected meteorological data and obtained a hazard curve for the event of an extreme snowfall where the FNPP is located,providing a basis for the frequency of extreme snowfall-initiating *** analysis indicates that extreme snowfall primarily affects the ventilation openings of the equipment,leading to the failure of devices such as the diesel ***,extreme snowfall can result in a loss of off-site power(LOOP).Therefore,the developed extreme snowfall PSA model is mainly based on the LOOP event tree,considering responses such as snowfall removal by *** calculations indicate a core damage frequency(CDF)of 1.13×10^(-10) owing to extreme snowfall,which is relatively *** results of the cut-set analysis indicate that valve failures in the core makeup tank(CMT),passive residual heat removal system(PRS),and in-containment refueling water storage tank(IRWST)significantly contribute to the CDF.

关键词： Floating nuclear power plant(FNPP) ACP100 Extreme snow PSA External hazard

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Meibomian gland dysfunction model induced with complete Freund’s adjuvant in C57BL/6 mice

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International Journal of Ophthalmology(English edition) 2020年第11期13卷 1705-1712页

作者： Yang Lu Yue Yin lan gong Department of Ophthalmology and Vision Science Eye&ENT Hospital of Fudan UniversityShanghai 200031China

AIM:To establish a new inflammatory animal model of meibomian gland dysfunction(MGD)in C57BL/6 ***:C57BL/6 mice were randomly divided into complete Freund’s adjuvant(CFA)group(14 animals,14 eyes),naphthazolin hydrochloride(NH)group(14 animals,14 eyes)and control group(14 animals,14 eyes).In CFA group,CFA was used in eyelid conjunctiva injection;in NH group,NH eye drops were used twice a day;control group was injected with equal dose of saline at the same time point and same site with animals in CFA *** meibomian gland orifices score(MGOS)was evaluated on a scale of 0 to 3 in the middle five meibomian gland orifices of the upper and lower eyelid using slit *** the successful induction of each animal model,intense pulsed light(IPL)was introduced on each mouse in CFA and NH *** red O(ORO),hematoxylin and eosin(H&E)staining were performed before and after successful induction of CFA,NH and control ***:At 12wk after CFA injection,inflammatory cell infiltration and fiber necrosis was observed,with acinar density and duct dilatation significantly lower compared with control *** NH group,the meibomian gland acini were relatively smaller and deformed compared with control group,the number of meibomian gland acini was also slightly *** inflammatory cell or fiber necrosis was observed in NH *** three times of IPL treatment(5/10 mice in each group,and the other 5 mice served as non-IPL control),MGOS was significantly lower in IPL-treated mice in NH group(P<0.01).After three times of IPL treatment,the MGOS of NH group was significantly lower than that in the CFA group(P<0.01).CONCLUSION:We develop a novel animal model that studies the role of inflammation in the development of MGD and IPL *** model indicates that persistent inflammatory state may be the cause of MGD and weaken the therapeutic effect of IPL.

关键词： meibomian gland dysfunction complete Freund's adjuvant inflammation acinar atrophy intense pulsed light

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高效液相色谱法测定4-脱甲氧柔红霉素有关物质

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安徽化工 2024年第4期50卷 135-137页

作者：张依兰公剑邹泓南京正大天晴制药有限公司研究院分析所江苏南京210046

目的:建立4-脱甲氧柔红霉素有关物质检查的高效液相色谱方法。方法:采用十八烷基硅烷键合硅胶为填料的Welch Ultimate AQ-C18(250 mm×4.6 mm,5μm)色谱柱对杂质进行定量分析;以0.1%磷酸水溶液为流动相A,以甲醇-乙腈(50∶50)为流动相B;... 详细信息

目的:建立4-脱甲氧柔红霉素有关物质检查的高效液相色谱方法。方法:采用十八烷基硅烷键合硅胶为填料的Welch Ultimate AQ-C18(250 mm×4.6 mm,5μm)色谱柱对杂质进行定量分析;以0.1%磷酸水溶液为流动相A,以甲醇-乙腈(50∶50)为流动相B;流速:1.0 mL·min^(-1);检测波长:254 nm;柱温:35℃。结果:主峰与杂质峰、各杂质峰间均能达到基线分离。4-脱甲氧柔红霉素在0.15~2.45μg·mL^(-1)浓度范围内与峰面积呈良好的线性关系(r=0.999 9),检测限为0.021μg·mL^(-1)。结论:该方法灵敏、准确,专属性良好,适用于4-脱甲氧柔红霉素的质量控制。

关键词： 4-脱甲氧柔红霉素 HPLC法有关物质

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Recent advances in single metal atom-doped MoS_(2) as catalysts for hydrogen evolution reaction

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Tungsten 2020年第2期2卷 147-161页

作者： Rui Liu Hui‑Long Fei gong‑lan Ye College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082China State Key Laboratory for Chemo/Biosensing and Chemometrics Hunan UniversityChangsha 410082China

The development of low-cost and highly efficient electrocatalysts for hydrogen evolution reaction(HER)is critical to the wide-spread applications of water splitting *** recent years,many efforts are devoted to exploring HER catalysts with high activity and stability based on non-precious *** from the advantages of two-dimensional(2D)materials with unique physicochemical properties along with the single-atom catalysts with high activity,excellent stability and maximized atom utility efficiency,a new category of catalysts with 2D materials confining single atoms have shown great promises as high-performance HER *** this review,MoS_(2),as one of the typical 2D materials,doped with various single metal atoms as HER catalysts are fully discussed,including different synthetic strategies,catalytic performances and mechanisms toward HER as well as the major challenges ahead.

关键词： Molybdenum disulfide Single atom catalysts Hydrogen evolution reaction

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A Novel Mutation of Notch homolog protein 2 gene in a Chinese Family with Hajdu-Cheney Syndrome

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Chinese Medical Journal 2017年第23期130卷 2883-2884页

作者： Ruo-lan gong Jing Wu Tong-Xin Chen Department of Allergy and Immunology Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Division of Immunology Institute of Pediatric Translational Medicine Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Hajdu-Cheney syndrome （HCS） is a rare disorder which is characterized by developmental delay, craniofacial anomalies, congenital heart defects, hearing deficit, polycystic kidneys, and bone abnormalities, including ... 详细信息

关键词： Acroosteolysis Hajdu-Cheney Syndrome Notch homolog protein 2 gene Osteoporosis

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黄帝内针治疗眼部顽疾经验

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上海中医药杂志 2024年第6期58卷 17-22页

作者：骆肖群龚岚方金刘力红复旦大学附属华山医院上海200040 复旦大学附属眼耳鼻喉科医院上海200031 北京市丰台中西医结合医院北京100072 广西中医药大学广西南宁530200

黄帝内针源自《黄帝内经》,在杨真海先生的努力下,始普及传播。黄帝内针的特点是简易、安全、实用、高效,操作手法相对简单,不需人为补泻,不用提插捻转,不讲得气与否,易学习、易掌握。介绍黄帝内针的中医学术思想及其治疗眼部顽疾的临... 详细信息

黄帝内针源自《黄帝内经》,在杨真海先生的努力下,始普及传播。黄帝内针的特点是简易、安全、实用、高效,操作手法相对简单,不需人为补泻,不用提插捻转,不讲得气与否,易学习、易掌握。介绍黄帝内针的中医学术思想及其治疗眼部顽疾的临床经验,认为黄帝内针可改善各类过敏性和免疫性相关疾病所致眼部损害,适合现今社会广为推广。并举验案4则。

关键词：眼部疾病黄帝内针针灸非药物疗法中医药疗法临床应用

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