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Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： Jiawen Zhang Sihui Yu Qiao Peng Ping Wang lan fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

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Temperature inversion enables superior stability for low-temperature Zn-ion batteries

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Journal of Energy Chemistry 2024年第4期91卷 245-253页

作者： Fu-Da Yu Zhe-Jian Yi Rui-Yang Li Wei-Hao Lin Jie Chen Xiao-Yue Chen Yi-Ming Xie Ji-Huai Wu Zhang lan lan-fang Que Bao-Sheng Liu Hao Luo Zhen-Bo Wang Engineering Research Center of Environment-Friendly Functional Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021FujianChina b2 School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Space Power-SourcesSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071GuangdongChina

It is challenging for aqueous Zn-ion batteries(ZIBs)to achieve comparable low-temperature(low-T)performance due to the easy-frozen electrolyte and severe Zn ***,an aqueous electrolyte with a low freezing point and high ionic conductivity is *** with molecular dynamics simulation and multi-scale interface analysis(time of flight secondary ion mass spectrometry threedimensional mapping and in-situ electrochemical impedance spectroscopy method),the temperature independence of the V_(2)O_(5)cathode and Zn anode is observed to be ***,dominated by the solvent structure of the designed electrolyte at low temperatures,vanadium dissolution/shuttle is significantly inhibited,and the zinc dendrites caused by this electrochemical crosstalk are greatly relieved,thus showing an abnormal temperature inversion *** the disclosure and improvement of the above phenomena,the designed Zn||V_(2)O_(5)full cell delivers superior low-T performance,maintaining almost 99%capacity retention after 9500 cycles(working more than 2500 h)at-20°*** work proposes a kind of electrolyte suitable for low-T ZIBs and reveals the inverse temperature dependence of the Zn anode,which might offer a novel perspective for the investigation of low-T aqueous battery systems.

关键词： Aqueous Zn-ion batteries Low-temperature performance Opposite temperature dependence Zndendrite growth Vanadium dissolution

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Multimodal Dependence Attention and Large-Scale Data Based Offline Handwritten Formula Recognition

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Journal of Computer Science & Technology 2024年第3期39卷 654-670页

作者：刘汉超董兰芳张信明 School of Computer Science and Technology University of Science and Technology of ChinaHefei 230022China CCF IEEE

Offline handwritten formula recognition is a challenging task due to the variety of handwritten symbols and two-dimensional formula ***,the deep neural network recognizers based on the encoder-decoder frame-work have achieved great improvements on this ***,the unsatisfactory recognition performance for formulas with long LTeX strings is one shortcoming of the existing ***,lacking sufficient training data also limits the capability of these *** this paper,we design a multimodal dependence attention(MDA)module to help the model learn visual and semantic dependencies among symbols in the same formula to improve the recognition perfor-mance of the formulas with long LTeX *** alleviate overfitting and further improve the recognition performance,we also propose a new dataset,Handwritten Formula Image Dataset(HFID),which contains 25620 handwritten formula images collected from real *** conduct extensive experiments to demonstrate the effectiveness of our proposed MDA module and HFID dataset and achieve state-of-the-art performances,63.79%and 65.24%expression accuracy on CROHME 2014 and CROHME 2016,respectively.

关键词： handwritten formula recognition multimodal dependence attention semantic dependence visual dependence Handwritten Formula Image Dataset

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Characteristics of early gastric tumors with different differentiation and predictors of long-term outcomes after endoscopic submucosal dissection

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World Journal of Gastroenterology 2024年第14期30卷 1990-2005页

作者： Hong-Yi Zhu Jie Wu Yuan-Miao Zhang fang-lan Li Jin Yang Bin Qin Jiong Jiang Ning Zhu Meng-Yao Chen Bai-Cang Zou Department of Gastroenterology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Pathology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Gastroenterology Xianyang Hospital of Yan'an UniversityXianyang 712000Shaanxi ProvinceChina Department of Gastroenterology The First Hospital of Xi'anXi'an 710000Shaanxi ProvinceChina

BACKGROUND Gastric cancer is a common malignant tumor of the digestive tract,and endosco-pic submucosal dissection(ESD)is the preferred treatment for early-stage gastric *** analysis of the epidemiological characteristics of gastric mucosal tumors with different differentiation degrees and the influencing factors of long-term ESD efficacy may have certain significance for revealing the development of gastric cancer and *** To analyze the features of gastric mucosal tumors at different differentiation levels,and to explore the prognostic factors of *** We retrospectively studied 301 lesions in 285 patients at The Second Affiliated Hospital of Xi'an Jiaotong University from 2014 to 2021,according to the latest Japanese guidelines(sixth edition),and divided them into low-grade intrae-pithelial neoplasia(LGIN),high-grade intraepithelial neoplasia(HGIN),and computed tomography at 3,6 and 12 months after *** compared clinicopathologic characteristics,ESD efficacy,and complications with different degrees of differentiation,and analyzed the related factors associated with *** HGIN and differentiated carcinoma patients were significantly older compared with LGIN patients(P<0.001)and accounted for more 0-IIc(P<0.001),atrophic gastritis was common(P<0.001),and irregular microvascular patterns(IMVPs)and demarcation lines(DLs)were more obvious(P<0.001).There was more infiltration in the undifferentiated carcinoma tissue(P<0.001),more abnormal folds and poorer mucosal peristalsis(P<0.001),and more obvious IMVPs,irregular microsurface patterns and DLs(P<0.05)than in the LGIN and HGIN *** disease-free survival rates at 2,5,and 8 years after ESD were 95.0%,90.1%,and 86.9%,***-tiated lesions(HR 5.066),white moss(HR 7.187),incomplete resection(HR 3.658),and multiple primary cancers(HR 2.462)were significantly associated with poor *** Differentiations of gastric mucosal tumors have different epidemiological and

关键词： Gastric mucosal epithelial neoplasia Differentiated early gastric cancer Undifferentiated early gastric cancer Endoscopic submucosal dissection Long-term outcomes

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基层卫生健康事业高质量发展内涵与路径分析

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中国卫生政策研究 2024年第1期17卷 17-23页

作者：刘兰芳姚岚华中科技大学同济医学院医药卫生管理学院湖北武汉430030

目的:分析新发展格局下基层卫生健康事业高质量发展内涵与实现路径,期望充分发挥基层卫生在优质高效整合型医疗卫生服务体系构建过程中的网底优势。方法:基于Donabedian结构—过程—结果三维质量理论分析基层卫生健康事业高质量发展的... 详细信息

目的:分析新发展格局下基层卫生健康事业高质量发展内涵与实现路径,期望充分发挥基层卫生在优质高效整合型医疗卫生服务体系构建过程中的网底优势。方法:基于Donabedian结构—过程—结果三维质量理论分析基层卫生健康事业高质量发展的核心内涵与实现路径。结果:基层卫生健康事业高质量发展内涵包括整合协同式的资源结构、创新内涵式的服务过程、优质高效的结果产出三个方面。通过体系创新与发展、创新供给侧结构性改革促进供需双方的健康主体责任落实、建立以健康结果考核为激励导向的评价机制,助力基层卫生健康事业实现高质量发展。结论:基层卫生健康事业高质量发展需要多要素之间协同联动,重点关注供给与需求之间的协调与平衡,围绕健康目标,创新服务模式,延伸服务提供,实现基层卫生健康从治疗服务型向健康管理型转变,促进基层卫生健康事业形成生存与发展的良性循环。

关键词：基层卫生高质量发展内涵路径

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Integrated gut microbiota,plasma metabolomics and network pharmacology to reveal the anti-ischemic stroke effect of cooked rhubarb

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Traditional Medicine Research 2024年第9期9卷 1-13页

作者： Ting Li lan-fang Tan Lin Shen Jie-Hui Kuang Si-Kai Zhan Bang Liu Jia-Le Cai Sheng-Wang Liang Ming-Hua Xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization Guangxi Institute of BotanyChinese Academy of SciencesGuilin 541006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527300China

Background:Cooked rhubarb(CR)is obtained by steaming raw rhubarb(Rheum palmatum L.,Rheum officinale Baill.,or Rheum tanguticum *** Balf.)with millet *** is used as a traditional Chinese medicine for treating cerebral stroke,where patients often face severe *** study explored the pharmacological effects and mechanisms of CR against ischemic stroke(IS)in *** used integrated analysis of gut microbiota,metabolomics,and network ***:The compounds in CR were identified using LC-MS/*** impact of CR on rat middle cerebral artery occlusion/reperfusion(MCAO/R)-induced cerebral infarct size and brain tissue pathology was assessed through 2,3,5-triphenyl tetrazolium chloride and HE *** in hemorheology were measured by evaluating blood viscosity,and serum levels of pro-inflammatory cytokine were also *** microbiota composition was analyzed through 16S rRNA gene *** metabolites were examined using untargeted metabolomics and Spearman correlation *** pseudo-germ-free test was used to determine whether tumour necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)improvement in IS are dependent on gut ***:In vivo studies showed CR enhances neurobehavioral function in MCAO/R rats and reduces cerebral infarction *** also ameliorates brain and intestinal barrier damage caused by *** also decreased inflammation and oxidative stress in IS ***,CR promotes the growth of Akkermansia and Verrucomicrobia,aiding in intestinal barrier ***,CR primarily influences the primary bile acid biosynthesis *** pseudo-germ-free experiment and network pharmacology confirmed TNF-αand IL-1βas potential *** relies on gut microbiota for its anti-inflammatory effects to improve ***:Cooked rhubarb offers neuroprotective benefits by enhancing beneficial bacteria abundance and regulating bile acid *** emerges as a potential therapeutic agent for

关键词： cooked rhubarb ischemic stroke gut microbiota metabolomics

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海外汉学界汉画像研究范式探讨

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艺术探索 2024年第1期38卷 48-55页

作者：兰芳江苏师范大学美术学院江苏徐州221000

20世纪初期海外汉画像研究以汉学家的收藏、著录为主。20世纪30年代,汉画像研究在现代学术视域下得到复兴,汉画像成为海外汉学家认识古代中国社会文化、历史与艺术的“形象史诗”。20世纪中叶,在艺术理论发展的背景下,海外汉画像研究走... 详细信息

20世纪初期海外汉画像研究以汉学家的收藏、著录为主。20世纪30年代,汉画像研究在现代学术视域下得到复兴,汉画像成为海外汉学家认识古代中国社会文化、历史与艺术的“形象史诗”。20世纪中叶,在艺术理论发展的背景下,海外汉画像研究走向一种艺术风格学的解读。20世纪80年代后,海外汉画像研究的方法、路径与范式在新艺术史的历史语境中转向多元的文化解读与探索。对海外汉画像研究范式的探索为中国艺术研究的自律性与自觉性提供他者的参照系。汉画像乃至中国艺术研究将在传统与现代、自律与他律的交融中不断构建一个开放的话语模式。

关键词：海外汉学汉画像研究艺术风格学新艺术史文化情境

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电喷雾萃取电离-串联质谱法测定不同水样中全氟辛酸

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质谱学报 2024年第4期45卷 492-499,I0002页

作者：幸慧玉陈兰芳占发旺方小伟陈焕文江西中医药大学生命样品直接质谱分析研究室江西南昌330004 南昌大学第一附属医院江西南昌330006 江西万拓环境检测有限公司江西上饶334400

全氟辛酸(PFOA)是一种持久性有机污染物,长期环境暴露会对生态系统与人类健康造成极大的风险,因此,发展快速定量监测水中PFOA的方法至关重要。本研究采用电喷雾萃取电离-串联质谱(EESI-MS/MS)法检测自来水、江水、河水中的痕量PFOA。结... 详细信息

全氟辛酸(PFOA)是一种持久性有机污染物,长期环境暴露会对生态系统与人类健康造成极大的风险,因此,发展快速定量监测水中PFOA的方法至关重要。本研究采用电喷雾萃取电离-串联质谱(EESI-MS/MS)法检测自来水、江水、河水中的痕量PFOA。结果表明,在优化的实验条件下,PFOA在1~500 ng/L浓度范围内的线性关系良好,线性相关系数(R^(2))为0.997 6,方法检出限(LOD)为0.57 ng/L,定量限(LOQ)为1.73 ng/L,回收率为92.1%~105.2%,相对标准偏差(RSD,n=6)为1.89%~5.45%。本方法具有灵敏度高、准确性好、分析速度快等优点,在监测环境水体污染物方面具有良好的应用前景。

关键词：电喷雾萃取电离-串联质谱(EESI-MS/MS) 快速检测全氟辛酸(PFOA) 水

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元宇宙技术赋能全民健身的内在逻辑、风险及防控路径

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广州体育学院学报 2024年第2期44卷 110-119页

作者：宋雅馨余兰芳华南师范大学体育科学学院广东广州510006

元宇宙技术是网络信息技术发展的新阶段,其所具备的技术驱动性、空间虚拟性以及现实交互性在突破健身场地时空限制、丰富全民健身赛事供给、提升健身指导和个性化服务质量等方面有显著效果。同时,这些特性也为元宇宙技术价值的实现带来... 详细信息

元宇宙技术是网络信息技术发展的新阶段,其所具备的技术驱动性、空间虚拟性以及现实交互性在突破健身场地时空限制、丰富全民健身赛事供给、提升健身指导和个性化服务质量等方面有显著效果。同时,这些特性也为元宇宙技术价值的实现带来了知识产权侵权、数据合规风险、身心健康、身份认同及技术成瘾等风险。通过运用文献资料法、案例分析法等对元宇宙赋能全民健身隐藏的风险进行剖析发现,主管行政部门、相关企业以及公众应协同克服技术、法律等风险,提高元宇宙全民健身赛事活动及健身产品制造企业的主体准入门槛、严格数据安全审查、强化企业知识产权合规、引导全民健身活动参与者增强防范意识,以助力元宇宙技术更全面、更深入地应用于全民健身活动中。

关键词：元宇宙全民健身知识产权数据合规技术风险

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日本的世界“非遗”里的节气研究

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西部学刊 2024年第8期 60-63页

作者：方兰武汉城市学院武汉430075

日本的世界非物质文化遗产里的节气相关“非遗”主要包括2009年的奥能登的田神祭和秋保的插秧舞;2011年的壬生花田植;2013年的和食:日本人的传统饮食文化;2014年的“和纸:日本手抄和纸技术(构成/石州半纸、本美浓纸、细川纸)”,共五项... 详细信息

日本的世界非物质文化遗产里的节气相关“非遗”主要包括2009年的奥能登的田神祭和秋保的插秧舞;2011年的壬生花田植;2013年的和食:日本人的传统饮食文化;2014年的“和纸:日本手抄和纸技术(构成/石州半纸、本美浓纸、细川纸)”,共五项。日本对其的保护与传承,对中国的启示在于:日本的有关节气的“非遗”保护能看出其在传统音乐、舞蹈和仪式举办时间、形式策划方面兼具坚守和变通;着眼日常生活,学校、家庭和社会携手保护与传承节气饮食,发挥传统节气饮食的家国情怀和凝聚力;在传统手工“非遗”方面,多领域融合,在国内外加强推广和传播。在借鉴日本的相关经验时,需要注意中国应按本国的实际情况有选择地借鉴日本的相关经验。

关键词：日本世界“非遗” 节气

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