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mLife 2024年第1期3卷 1-13页

作者： Wiliam B.Whitman Maria Chuvochina Brian P.Hedlund Konstantinos T.Konstantinidis Marike Palmer Luis M.Rodriguez-R lain Sutcliffe Fengping Wang Deparment of Microbioogy University of GeorgiaAthensGeorgiaUAA Schoolof Chemistry and Molecular Biosciences Australian CentreforEogenomicsThe Universty of QueenslandSt LuciaAustralia University of Nevada Las Vegas Las VegasNevadaUSA Schol of Civil and Environmental Engineering and School of Biological SciencesGeorgia Institute of TechnologyAtlantaGeorgiaUSA Department of Microbiology University of ManitobaWinnipegManitobaCanada School of Life Sciences University of Nevada Las VegasLas VegasNevadaUSA Department of Microbiology and Digital Science Center(DiSC) University of InnsbruckInnsbruckAustria Faculty of Health&Life Sciences Northumbria UniversityNewcastle upon TyneUK School of Oceanography International Center for Deep Life InvestigationShanghai Jiao Tong UniversityShanghaiChina

The SeqCode,formally called the Code of Nomenclature of Prokaryotes Described from Sequence Data,is a new code of nomenclature in which genome sequences are the nomenclatural types for the names of prokaryotic *** similar to the International Code of Nomenclature of Prokaryotes(ICNP)in structure and rules of priority,it does not require the deposition of type strains in international culture ***,it allows for the formation of permanent names for uncultured prokaryotes whose nearly complete genome sequences have been obtained directly from environmental DNA as well as other prokaryotes that cannot be deposited in culture *** the diversity of uncultured prokaryotes greatly exceeds that of readily culturable prokaryotes,the SeqCode is the only code suitable for naming the majority of prokaryotic *** start date of the SeqCode was January 1,2022,and the online Registry(https://***)was created to ensure valid publication of *** SeqCode recognizes all names validly published under the ICNP before *** that date,names validly published under the SeqCode compete with ICNP names for *** a result,species can have only one name,either from the SeqCode or ICNP,enabling effective communication and the creation of unified taxonomies of uncultured and cultured *** SeqCode is administered by the SeqCode Committee,which is comprised of the SeqCode Community and elected administrative *** with an interest in the systematics of prokaryotes is encouraged to join the SeqCode Community and participate in the development of this resource.

关键词： genome sequences metagenome-assembled genomes nomenclature SeqCode

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环球科学 2024年第6期 32-33页

作者：伊恩·斯图尔特不详

佛罗里达州是美国一个正在“自我崩溃”的州。在城市街道、宁静的郊区和柑橘园中,通往真实而隐秘的佛罗里达州的大门正在打开。从南部的礁岛到北部与佐治亚州的交界处,几乎整个阳光之州的地下,都是由洞穴组成的奇异世界。这是因为佛罗... 详细信息

佛罗里达州是美国一个正在“自我崩溃”的州。在城市街道、宁静的郊区和柑橘园中,通往真实而隐秘的佛罗里达州的大门正在打开。从南部的礁岛到北部与佐治亚州的交界处,几乎整个阳光之州的地下,都是由洞穴组成的奇异世界。这是因为佛罗里达州建设在一层巨大的石灰岩岩层上。

关键词：佐治亚州佛罗里达州柑橘园石灰岩隐秘

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Tension and Resolution: Dynamic, Evolving Populations of Organelle Genomes within Plant Cells

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Molecular Plant 2019年第6期12卷 764-783页

作者： lain G.Johnston School of Biosciences University of Birmingham Birmingham UK Birmingham Institute for Forest Research University of Birmingham Birmingham UK

Mitochondria and plastids form dynamic, evolving populations physically embedded in the fluctuating environment of the plant cell. Their evolutionary heritage has shaped how the cell controls the genetic structure and the physical behavior of its organelle populations. While the specific genes involved in these processes are gradually being revealed, the governing principles underlying this controlled behavior remain poorly understood. As the genetic and physical dynamics of these organelles are central to bioenergetic performance and plant physiology, this challenges both fundamental biology and strategies to engineer better-performing plants. This article reviews current knowledge of the physical and genetic behavior of mitochondria and chloroplasts in plant cells. An overarching hypothesis is proposed whereby organelles face a tension between genetic robustness and individual control and responsiveness, and different species resolve this tension in different ways. As plants are immobile and thus subject to fluctuating environments, their organelles are proposed to favor individual responsiveness, sacrificing genetic robustness. Several notable features of plant organelles, including large genomes, mtDNA recombination, fragmented organelles, and plastid/mitochondrial differences may potentially be explained by this hypothesis. Finally, the ways that quantitative and systems biology can help shed light on the plethora of open questions in this field are highlighted.

关键词： mitochondria plastids chloroplasts plants evolution organelle DNA

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Small molecule activators of the p53 response

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Journal of Molecular Cell Biology 2019年第3期11卷 245-254页

作者： Marcus J.G.W.Ladds Sonia lain Department of Microbiology Tumor and Cell BiologyBiomedicumSolnavagen 9Karolinska Institutet17165StockholmSweden SciLifeLab Tomtebodavagen 23A171 65SoinaStockholmSweden

Drugging the p53 pathway has been a goal for both academics and pharmaceutical companies since the designation of p53 as the'guardian of the genome'.Through growing understanding of p53 biology,we can see multiple routes for activation of both wild-type p53 function and restoration of mutant p53?In this review,we focus on small molecules that activate wild-type p53 and that do so in a nongenotoxit *** particular,we will describe potential approaches to targeting proteins that alter p53 stability and function through posttranslational modification,affect p53's subcellular localization,or target RNA synthesis or the synthesis of *** plethora of pathways for exploitation of p53,as well as the wide-ranging response to p53 activation,makes it an attractive target for anti-cancer therapy.

关键词： cancer p53 small molecule cell biology cancer therapy

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Observer-based fault detection scheme for a class of discrete time-delay systems

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Journal of Systems Engineering and Electronics 2004年第3期15卷 288-294页

作者：钟麦英张承慧 Ding Steven X lain James ControlScienceandEngineeringSchool ShandongUniversityJinan250061P.R.China Gerhard-Mercator-UniversityDuisburg Germany DepartmentofMechanicalEngineering TheUniversityofHongKongP.R.China

In this contribution, robust fault detection problems for discrete time-delay systems with l2-norm bounded unknown inputs are studied. The basic idea of our study is first to introduce a state-memoryless observer-based fault detection filter (FDF) as the residual generator and then to formulate such a FDF design problem as an Hen optimization problem in the sense of increasing the sensitivity of residual to the faults, while simultaneously enhancing the robustness of residual to unknown input as well as plant input. The main results consist of the formulation of such a residual generation optimization problem, solvability conditions and the derivation of an analytic solution. The residual evaluation problem is also considered, which includes the determination of residual evaluation function and threshold. A numerical example is used to demonstrate the proposed fault detection scheme.

关键词： residual generator robustness unknown input time-delay system post-filter.

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Defining the Functional Network of Epigenetic Regulators in Arabidopsis thaliana

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Molecular Plant 2009年第4期2卷 661-674页

作者： Chongyuan Luo Brittany G. Durgin Naohide Watanabe Eric lain Biotechnology Center for Agriculture and the Environment Rutgers The State University of New Jersey 59 Dudley Road New Brunswick NJ 08901 USA Department of Plant Biology and Pathology Rutgers The State University of New Jersey 59 Dudley Road New Brunswick NJ 08901 USA

Development of ChiP-chip and ChlP-seq technologies has allowed genome-wide high-resolution profiling of chromatin-associated marks and binding sites for epigenetic regulators. However, signals for directing epigenetic modifiers to their target sites are not understood. In this paper, we tested the hypothesis that genome location can affect the involvement of epigenetic regulators using Chromatin Charting （CC） Lines, which have an identical transgene construct inserted at different locations in the Arabidopsis genome. Four CC lines that showed evidence for epigenetic silencing of the luciferase reporter gene were transformed with RNAi vectors individually targeting epigenetic regulators LHP1, MOM1, CMT3, DRD1, DRM2, SUVH2, CLF, and HD1. Involvement of a particular epigenetic regulator in silencing the transgene locus in a CC line was determined by significant alterations in luciferase expression after suppression of the regulator＇s expression. Our results suggest that the targeting of epigenetic regulators can be influenced by genome location as well as sequence context. In addition, the relative importance of an epigenetic regulator can be influenced by tissue identity. We also report a novel approach to predict interactions between epigenetic regulators through clustering analysis of the regulators using alterations in gene expression of putative downstream targets, including endogenous loci and transgenes, in epigenetic mutants or RNAi lines. Our data support the existence of a complex and dynamic network of epigenetic regulators that serves to coordinate and control global gene expression in higher plants.

关键词： Cell differentiation specialization chromatin structure and remodeling chromosome organization epigenetics aene silencina Arabidopsis.

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Room Temperature Ferromagnetism in Ga1-xHoxN （x=0.0 and 0.05） Diluted Magnetic Semiconductor Thin Films

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Chinese Journal of Chemical Physics 2012年第3期25卷 313-317,373,374页

作者： Ghulam Murtaza Rai Muhammad Azhar Iqbal Yong-bing Xu lain Gordon Will Qasim Mahmood Department of Physics University of the Punjab Lahore 54590 Pakistan Spintronics Laboratory Department of Electronics The University of York York Y010 5DD UK

Holmium doped GaN diluted magnetic semiconductor thin films have been prepared by thermal evaporation technique and subsequent ammonia annealing. X-ray diffraction mea- surements reveal all peaks belong to the purely hexagonal wurtzite structure. Surface mor- phology and composition analysis were carried out by scanning electron microscopy and energy dispersive spectroscopy respectively. The room temperature ferromagnetic proper- ties of Gal-xHoxN （x=0.0, 0.05） films were analyzed using vibrating sample magnetometer at room temperature. Magnetic measurements showed that the undoped films （i.e. GaN） exhibited diamagnetic behavior, while the Ho-doped （Gao.95Hoo.05N） film exhibited a ferro- magnetic behavior.

关键词： Diluted magnetic semiconductor Holmium doping X-ray diffraction Scan-ning electron microscopy Room temperature ferromagnetism

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通过高通量研究识别用于本征陡坡晶体管的原子级薄孤立能带沟道材料

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Science Bulletin 2024年第10期69卷 1427-1436页

作者：屈恒泽张胜利曹江吴振华柴扬李卫胜李连忠任文才王欣然曾海波 MIIT Key Laboratory of Advanced Display Materials and Devices College of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Microelectronics Device and Integrated Technology Institute of Microelectronics of Chinese Academy of SciencesBeijing 100029China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong 999077China National Laboratory of Solid State Microstructures School of Electronic Science and Engineering and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Integrated Circuits Nanjing UniversitySuzhou 215163China Suzhou Laboratory Suzhou 215009China

Developing low-power FETs holds significant importance in advancing logic circuits,especially as the feature size of MOSFETs approaches sub-10 ***,this has been restricted by the thermionic limitation of SS,which is limited to 60 mV per decade at room ***,we proposed a strategy that utilizes 2D semiconductors with an isolated-band feature as channels to realize subthermionic SS in *** high-throughput calculations,we established a guiding principle that combines the atomic structure and orbital interaction to identify their sub-thermionic transport *** guides us to screen 192 candidates from the 2D material database comprising 1608 ***,the physical relationship between the sub-thermionic transport performances and electronic structures is further revealed,which enables us to predict 15 systems with promising device performances for low-power applications with supply voltage below 0.5 *** work opens a new way for the low-power electronics based on 2D materials and would inspire extensive interests in the experimental exploration of intrinsic steep-slope MOSFETs.

关键词： 2D materials Electronic band structures Transport properties Steep-slope transistors DFT-NEGF calculations

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Investigation of dynamics of discrete framed structures by a numerical wave-based method and an analytical homogenization approach

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Chinese Journal of Aeronautics 2017年第1期30卷 66-74页

作者： Zhou Changwei Sun Xiangkun Mohamed Ichchou Abdel-Malek Zine Jean-Pierre lainé Stephane Hans Claude Boutin Laboratory of Tribology and Systems Dynamics Ecole Centrale de Lyon Ecully 69134 France Institut Camille Jordan Ecole Centrale de Lyon Ecully 69134 France Laboratory of Tribology and Systems Dynamics Ecole Nationale des Travaux Publics de l'Etat Vaulx-en-Velinx 69518 France

In this article, the analytical homogenization method of periodic discrete media（HPDM）and the numerical condensed wave finite element method（CWFEM） are employed to study the longitudinal and transverse vibrations of framed structures. The valid frequency range of the HPDM is re-evaluated using the wave propagation feature identified by the CWFEM. The relative error of the wavenumber by the HPDM compared to that by the CWFEM is illustrated in functions of frequency and scale ratio. A parametric study on the thickness of the structure is carried out where the dispersion relation and the relative error are given for three different thicknesses. The dynamics of a finite structure such as natural frequency and forced response are also investigated using the HPDM and the CWFEM.

关键词： Framed structures Homogenization method Periodic structures Wave finite element method Wave propagation

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High-Resolution Infrared-Vacuum Ultraviolet Photoion and Pulsed Field Ionization-Photoelectron Methods for Spectroscopic Studies of Neutrals and Cations

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Chinese Journal of Chemical Physics 2008年第3期21卷 193-201页

作者： Xi Xing Beth Reed Mi Kyung Bahng Peng Wang Hin Koo Woo Sun Jong Baek Chee Shing lain Cheuk Yiu Ng Department of Chemistry University of California Davis Davis California 95616 USA

We show that by scanning the frequency of a single mode infrared （IR） optical parametric oscillator （IR- OPO） laser to excite the molecular species of interest and fixing the frequency of a vacuum ultraviolet （VUV） laser to photoionize the IR excited species, high-resolution IR spectra of polyatomic neutrals can be obtained with high sensitivity. The fact that this IR-VUV-photoion （IR-VUV-PI） method is based on VUV photoionization probe, and thus, allows the identification of the neutral IR absorber, makes it applicable for IR spectroscopy measurements of isotopemers, radicals, and clusters, which usually exist as impure samples. The highly resolved IR-VUV-PI measurements achieved using the single mode IR-OPO laser have made possible the selection of single rovibrational states of CH3X （X=Br and I）, C2H4, and C3H4 for VUV-pulsed field ionization-photoelectron （VUV-PFI-PE） measurements, resulting in rovibrationally resolved photoelectron spectra for these polyatomic molecules. These experiments show that the signal- to-noise ratios of the IR-VUV-PI and IR-VUV-PFI-PE spectra obtained by employing the high-resolution IR-OPO laser are significantly higher than those observed in previous IR-VUV-PI and IR-VUV-PFI-PE studies using a low-resolution IR-OPO laser. Further improvement in sensitivity of IR-VUV-PI and IR- VUV-PFI-PE measurements by using the collinear arrangement of IR-VUV lasers and molecular beam is discussed.

关键词： Vacuum ultraviolet Infrared Pulse-field photoelectron High resolution

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